Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: Device for centerless round grinding of round, cylindrical work pieces, having a grinding wheel with an axis of rotation, a regulation wheel for pressing of the work piece against the grinding wheel with an axis of rotation, a workrest blade for putting on the work piece and/or a truing device for the grinding wheel and/or a truing device for the regulation wheel, arranged in such a way on a machine bed, in particular in an assembly surface inclined in the space, that the grinding wheel and the regulation wheel and the workrest blade touch the work piece at the moment of grinding, whereas the work piece is arranged in a grinding gap being formed by the adjoining regulation wheel, grinding wheel and workrest blade, whereas the grinding wheel and/or the regulation wheel and/or the truing device for the grinding wheel and/or the truing device for the regulation wheel respectively are arranged on a hydraulic and/or electromotive driven carriage, which is at least longitudinally adjustable along a longitudinal mo

Abstract: The invention relates to a method for producing an ultrasound sensor (20) for a motor vehicle, in which method, for the ultrasound sensor (20), a diaphragm (23) for emitting ultrasound signals in an emitting direction (21) and a sensor housing (24) are provided, in and/or on which sensor housing the diaphragm (23) is fastened, wherein the sensor housing (24) has a front side (25), which points in the emitting direction (21) of the diaphragm (23), and a rear side (26), which points in a rearward direction (27) which is opposite to the emitting direction (21), and wherein, on the front side (25), the sensor housing (24) is formed with a front-side opening (28) for the diaphragm (23), wherein the front side (25) of the sensor housing (24) is connected to a cap (52) which is composed of a foil and by way of which the front-side opening (28) of the sensor housing (24) is covered in the emitting direction (21), wherein the diaphragm (23) is inserted at least regionally into a receptacle (53) of the cap (52) and, he

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. In one embodiment, the invention provides methods of treating a subject suffering from a complement mediated coagulation disorder, such as disseminated intravascular coagulation. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: A hydraulic unit includes two pressure connections for supplying devices, in particular hydraulic rescue devices, including a first hydraulic circuit with a first pump arrangement and a first pressure connection and a second hydraulic circuit with a second pump arrangement and a second pressure connection, wherein the pump arrangements are driven at the same time by a common drive, and wherein by a first valve switch the first hydraulic circuit can be connected to the second hydraulic circuit and by a second valve switch the second hydraulic circuit can be connected to the first hydraulic circuit. The valve switches include a spring acting in the direction of an initial position and from the first hydraulic circuit or from the second hydraulic circuit a first control line runs to the first valve switch and from the second hydraulic circuit or from the first hydraulic circuit a second control line runs to the second valve switch.

Abstract: The invention relates to a method for producing an ultrasound sensor (20) for a motor vehicle, in which method, for the ultrasound sensor (20), a diaphragm (23) for emitting ultrasound signals in an emitting direction (21) and a sensor housing (24) are provided, in and/or on which sensor housing the diaphragm (23) is fastened, wherein the sensor housing (24) has a front side (25), which points in the emitting direction (21) of the diaphragm (23), and a rear side (26), which points in a rearward direction (27) which is opposite to the emitting direction (21), and wherein, on the front side (25), the sensor housing (24) is formed with a front-side opening (28) for the diaphragm (23), wherein the front side (25) of the sensor housing (24) is connected to a cap (52) which is composed of a foil and by way of which the front-side opening (28) of the sensor housing (24) is covered in the emitting direction (21), wherein the diaphragm (23) is inserted at least regionally into a receptacle (53) of the cap (52) and, he

Abstract: The present invention provides modified von Willebrand Factor molecules, methods for their preparation and uses thereof. The invention further provides pharmaceutical compositions for treating coagulation disorders.

Abstract: The present invention relates to MASP-3 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-3 dependent complement activation.

Abstract: In one aspect, the invention provides methods for reducing proteinuria in a human subject suffering, or at risk of developing Immunoglobulin A Nephropathy (IgAN). The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory antibody effective to inhibit MASP-2-dependent complement activation.

Abstract: The invention relates to a castor with at least one wheel (16, 18), a housing (10) carrying the at least one wheel (16, 18), and a runner pin (14) which is arranged so as to be movable to a limited extent in a substantially vertically oriented housing opening (12) and which serves to connect the castor to an object, wherein the housing (10) accommodates a brake device which frees the at least one wheel (16, 18) in a state in which the castor is loaded by a weight via the runner pin (14) and which acts with a braking effect on the at least one wheel (16, 18) in a state when not loaded by a weight.

Abstract: The invention relates to an ultrasonic sensor device (1) for a motor vehicle, comprising ultrasonic sensor (7) which comprises a pot-shaped membrane (6) for emitting and/or receiving ultrasonic signals as well as a sensor housing (10), comprising a stiffening element (3) arranged around the membrane (6) and comprising a holder (4), which is designed for holding the sensor housing (10) on a back side of a trim element of the motor vehicle, wherein the stiffening element (3) and the holder (4) are designed to be integrally formed from a uniform material.

Abstract: The invention relates to an ultrasonic sensor device (1) for a motor vehicle, comprising an ultrasonic sensor (2), which has a membrane (5) for emitting and/or receiving ultrasonic waves, and comprising a stiffening unit (15) for attachment to a trim element (27) of the motor vehicle and for stiffening the trim element (27), wherein the stiffening unit (15) has a through-opening (17) for the membrane (5) of the ultrasonic sensor (2), wherein the stiffening unit (15) is formed from at least two separate stiffening elements (18 to 21) for attachment to a trim element (27).

Abstract: In various embodiments the invention provides anti-mucin-like protein (MLP) monoclonal antibodies, compositions and methods for detecting MLP as a biomarker for mucin-secreting type of cancer such as ovarian or pancreatic cancer.

Abstract: In one aspect, the present invention provides methods for preventing, treating, reverting and/or delaying angiogenesis in a mammalian subject suffering from, or at risk for developing, an angiogenesis-dependent disease or condition, comprising administering to the subject an amount of a MASP-2 inhibitory agent effective to inhibit angiogenesis. In some embodiments of these aspects of the invention, the MASP-2 inhibitory agent is a MASP-2 antibody or fragment thereof.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and/or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.

Abstract: The invention relates to an ultrasonic sensor device (1) for a motor vehicle, comprising an ultrasonic sensor (2), which comprises a pot-shaped membrane (21) for emitting and/or receiving ultrasonic signals, comprising a decoupling ring (6), which is arranged to fit around the membrane (21) in contact with an outer circumference (34) of the membrane (21), and comprising a stiffening element (13), which is arranged around the decoupling ring (6), wherein the decoupling ring (6) comprises a circumferential first radial decoupling region (32) which is in contact with the outer circumference (34) of the membrane (21) as well as a second radial decoupling region (33) with an axial face (37) which is in contact with an axial face (38) of the stiffening element (13).

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. In one embodiment, the invention provides methods of treating a subject suffering from a complement mediated coagulation disorder, such as disseminated intravascular coagulation. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.