Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: A multi-sensory attention alert device for a vehicle includes a sensor arrangement, a warning signal emission arrangement for emitting haptic, acoustic and optical warning signals to the vehicle driver, and a control unit for analyzing and assessing the recorded measurement values and for controlling the warning signal emission arrangement. The direction of a potential source of danger can be indicated by emitting warning signals that address multiple sensory organs of the driver, and the direction of an interface can be indicated whose operation, by the driver, constitutes a counter measure for avoiding the dangerous situation.

Abstract: In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and/or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a human subject suffering from TMA associated with hematopoietic stem cell transplant. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.

Abstract: Genetically modified mammals are described which lack the mannan binding lectin associated serine protease MASP-2, together with methods and constructs for their production. Such mammals are useful as models for disorders of the complement system, and in the identification of treatments for such disorders. Also described are mammals which lack the associated protein MAp19; such mammals may also lack MASP-2.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (Clq-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: An ultrasonic sensor (1) comprises a housing (2) and a diaphragm (4), to which a piezo-electric element (6) is fastened, and an electric connector region (8) which has an earth connector (24). A layer made from an electrically non-conducting material is arranged between the diaphragm (4) and the piezo-electric element (6), and the diaphragm (4) is connected to the earth connector (24) in an electrically conducting manner.

Abstract: The invention relates to a method for producing an ultrasound sensor (20) for a motor vehicle, in which method, for the ultrasound sensor (20), a diaphragm (23) for emitting ultrasound signals in an emitting direction (21) and a sensor housing (24) are provided, in and/or on which sensor housing the diaphragm (23) is fastened, wherein the sensor housing (24) has a front side (25), which points in the emitting direction (21) of the diaphragm (23), and a rear side (26), which points in a rearward direction (27) which is opposite to the emitting direction (21), and wherein the sensor housing (24) is, on the rear side (26), formed with a rear-side installation opening (29) for components of the ultrasound sensor (20), wherein the diaphragm (23) is inserted into the sensor housing (24) through the rear-side installation opening (29) in the emitting direction (21), and said diaphragm is placed, through an interior space (30) of the sensor housing (24), into an installed position at the front side (25) of the sensor

Abstract: The invention relates to an ultrasonic sensor arrangement (2) for a motor vehicle (1), comprising a trim element (3), in particular a bumper, comprising a radiator grill (4), and at least one first and one second ultrasonic sensor (5, 6) each comprising a membrane (11) for emitting and/or receiving ultrasonic signals, wherein the first ultrasonic sensor (5) with its membrane (11) is arranged on a back side of the trim element (3) so that the membrane (11) of the first ultrasonic sensor (5) is configured for emitting and/or receiving ultrasonic sensor signals through the trim element (3) and the second ultrasonic sensor (6) is arranged on the radiator grill (4). By detuning means (7, 9) the second ultrasonic sensor (6) is detuned and hereby its emission and/or receiving behavior adapted to the emission and/or receiving behavior of the first ultrasonic sensor (5).

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: The invention relates to a castor with at least one wheel (16, 18), a housing (10) carrying the at least one wheel (16, 18), and a runner pin (14) which is arranged so as to be movable to a limited extent in a substantially vertically oriented housing opening (12) and which serves to connect the castor to an object, wherein the housing (10) accommodates a brake device which frees the at least one wheel (16, 18) in a state in which the castor is loaded by a weight via the runner pin (14) and which acts with a braking effect on the at least one wheel (16, 18) in a state when not loaded by a weight.

Abstract: A hydraulic unit includes two pressure connections for supplying devices, in particular hydraulic rescue devices, including a first hydraulic circuit with a first pump arrangement and a first pressure connection and a second hydraulic circuit with a second pump arrangement and a second pressure connection, wherein the pump arrangements are driven at the same time by a common drive, and wherein by a first valve switch the first hydraulic circuit can be connected to the second hydraulic circuit and by a second valve switch the second hydraulic circuit can be connected to the first hydraulic circuit. The valve switches include a spring acting in the direction of an initial position and from the first hydraulic circuit or from the second hydraulic circuit a first control line runs to the first valve switch and from the second hydraulic circuit or from the first hydraulic circuit a second control line runs to the second valve switch.

Abstract: The invention relates to a diaphragm (1) for an ultrasonic transducer having a diaphragm body (2) which is made of metallic material and is provided on an outer surface region (5; 8) with a coating (10). In order to make it possible for the diaphragm surface to be provided with a particularly damage-resistant coating, the coating (10) has a transparent form such that the surface region (5; 8) of the diaphragm body (2) is visible through the coating (10).

Abstract: The invention relates to an ultrasonic sensor device (1) for a motor vehicle, comprising an ultrasonic sensor (2), which has a membrane (5) for emitting and/or receiving ultrasonic waves, and comprising a stiffening unit (15) for attachment to a trim element (27) of the motor vehicle and for stiffening the trim element (27), wherein the stiffening unit (15) has a through-opening (17) for the membrane (5) of the ultrasonic sensor (2), wherein the stiffening unit (15) is formed from at least two separate stiffening elements (18 to 21) for attachment to a trim element (27).

Abstract: A system for use in a motor vehicle wherein a navigation system and a control unit. The control unit is designed such that, using a list of goods stored in the control unit, a route of stops for purchasing the goods which can be depicted by the navigation system is produced. Furthermore, a near-field receiver and/or near-field transponder for detecting goods is present in the motor vehicle and can be or is connected to the control unit such that an additional list having detected goods can be transmitted to the control unit and the stored list can be updated by the additional list. A dynamic examination and possibly a dynamic adaptation of the route for purchasing the various goods depicted in the navigation system are thus possible.

Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

Abstract: A multi-sensory attention alert device for a vehicle includes a sensor arrangement, a warning signal emission arrangement for emitting haptic, acoustic and optical warning signals to the vehicle driver, and a control unit for analyzing and assessing the recorded measurement values and for controlling the warning signal emission arrangement. The direction of a potential source of danger can be indicated by emitting warning signals that address multiple sensory organs of the driver, and the direction of an interface can be indicated whose operation, by the driver, constitutes a counter measure for avoiding the dangerous situation.