Patents by Inventor Hans Wolfgang Hoffken
Hans Wolfgang Hoffken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10316304Abstract: The invention relates to chimeric endonucleases, comprising a endonuclease and a heterologous DNA binding domain comprising one or more Zn2C6 zinc fingers, as well as methods of targeted integration, targeted deletion or targeted mutation of polynucleotides using chimeric endonucleases.Type: GrantFiled: November 26, 2010Date of Patent: June 11, 2019Assignee: BASF PLANT SCIENCE COMPANY GMBHInventors: Andrea Hlubek, Christian Biesgen, Hans Wolfgang Höffken
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Patent number: 9587257Abstract: The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to the method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.Type: GrantFiled: February 2, 2016Date of Patent: March 7, 2017Assignee: BASF SEInventors: Bernhard Hauer, Hans Wolfgang Höffken, Cecilia Kvarnström Branneby, Helmut Schwab, Sabine Feichtenhofer, Marlene Buchebner, Brigitte Pohn
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Publication number: 20160168602Abstract: The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to the method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.Type: ApplicationFiled: February 2, 2016Publication date: June 16, 2016Inventors: Bernhard Hauer, Hans Wolfgang Höffken, Cecilia Kvarnström Branneby, Helmut Schwab, Sabine Feichtenhofer, Marlene Buchebner, Brigitte Pohn
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Patent number: 9109200Abstract: The invention relates to the use of an enzyme preparation which catalyzes the degradation of formaldehyde for reducing the formaldehyde content in a formaldehyde-containing formulation. In a preferred embodiment, the enzyme preparation contains a formaldehyde dismutase from a Pseudomonas putida strain. Further, the invention refers to a process for reducing the formaldehyde content in cross-linking agents for textile finishing or in polymer dispersions used, e.g. in construction chemistry. Further the invention relates to the use of an enzyme preparation which catalyzes the degradation of aldehydes for reducing the formaldehyde content in an aldehyde-containing formulation. Furthermore, the invention relates to a novel variant of the formaldehyde dismutase from Pseudomonas putida.Type: GrantFiled: March 31, 2010Date of Patent: August 18, 2015Assignee: BASF SEInventors: Andrea Piatesi, Tilo Habicher, Michael Büschel, Li-Wen Wang, Jürgen Reichert, Rainer Packe-Wirth, Kai-Uwe Baldenius, Erich Kromm, Stefan Häfner, Carsten Schwalb, Hans Wolfgang Höffken
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Publication number: 20140100338Abstract: The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to said method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.Type: ApplicationFiled: December 9, 2013Publication date: April 10, 2014Applicant: BASF SEInventors: Bernhard Hauer, Hans Wolfgang Höffken, Cecilia Kvarnström Branneby, Helmut Schwab, Sabine Feichtenhofer, Marlene Buchebner, Brigitte Pohn
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Patent number: 8658400Abstract: The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants.Type: GrantFiled: December 16, 2009Date of Patent: February 25, 2014Assignee: BASF SEInventors: Nina Schneider, Hans Wolfgang Höffken
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Patent number: 8617858Abstract: The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to the method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.Type: GrantFiled: July 17, 2009Date of Patent: December 31, 2013Assignee: BASF SEInventors: Bernhard Hauer, Hans Wolfgang Höffken, Cecilia Kvarnström Branneby, Helmut Schwab, Sabine Feichtenhofer, Marlene Buchebner, Brigitte Pohn
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Publication number: 20120324603Abstract: The invention relates to chimeric endonucleases, comprising an endonuclease and a heterologous DNA binding domain, as well as methods of targeted integration, targeted deletion or targeted mutation of polynucleotides using chimeric endonucleases.Type: ApplicationFiled: November 26, 2010Publication date: December 20, 2012Applicant: BASF Plant Sceience Company GmbHInventors: Andrea Hlubek, Christian Biesgen, Hans Wolfgang Höffken
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Publication number: 20120284877Abstract: The invention relates to chimeric endonucleases, comprising a endonuclease and a heterologous DNA binding domain comprising one or more Zn2C6 zinc fmgers, as well as methods of targeted integration, targeted deletion or targeted mutation of polynucleotides using chimeric endonucleases.Type: ApplicationFiled: November 26, 2010Publication date: November 8, 2012Applicant: BASF Plant Science Company GmbHInventors: Andrea Hlubek, Christian Biesgen, Hans Wolfgang Höffken
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Publication number: 20120028333Abstract: The invention relates to the use of an enzyme preparation which catalyzes the degradation of formaldehyde for reducing the formaldehyde content in a formaldehyde-containing formulation. In a preferred embodiment, the enzyme preparation contains a formaldehyde dismutase from a Pseudomonas putida strain. Further, the invention refers to a process for reducing the formaldehyde content in cross-linking agents for textile finishing or in polymer dispersions used, e.g. in construction chemistry. Further the invention relates to the use of an enzyme preparation which catalyzes the degradation of aldehydes for reducing the formaldehyde content in an aldehyde-containing formulation. Furthermore, the invention relates to a novel variant of the formaldehyde dismutase from Pseudomonas putida.Type: ApplicationFiled: March 31, 2010Publication date: February 2, 2012Inventors: Andrea Piatesi, Tilo Habicher, Michael Büschel, Li-Wen Wang, Jürgen Reichert, Rainer Packe-Wirth, Kai-Uwe Baldenius, Erich Kromm, Stefan Häfner, Carsten Schwalb, Hans Wolfgang Höffken
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Publication number: 20110250655Abstract: The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors and recombinant microorganisms that contain said sequences; to a method for the biocatalytic synthesis of substituted, optically active alcohols and to the use of said mutants; and particularly to a method for manufacturing duloxetine alcohol or duloxetine, comprising a synthesis step catalyzed biocatalytic by said mutants.Type: ApplicationFiled: December 16, 2009Publication date: October 13, 2011Applicant: BASF SEInventors: Nina Schneider, Hans Wolfgang Höffken
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Publication number: 20110137002Abstract: The invention relates to a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. According to said method, at least one polyacrylic acid ester is provided and incubated with at least one enzyme selected from enzymes (EC 3.1) acting on ester bindings, until the ester groups contained in the polyacrylic acid ester are partially or fully hydrolytically split, and optionally the modified polymer obtained thereby is isolated. The invention also relates to the enzymes used and mutants thereof, nucleic acids coding for the enzymes, vectors comprising the nucleic acids, micro-organisms comprising the vectors, and the use of the enzymes, the vectors or the micro-organisms for carrying out a method for the enzyme-catalysed hydrolysis of polyacrylic acid esters. The present application also relates to polymer reaction products that can be obtained by the method, and methods for producing esterases.Type: ApplicationFiled: July 17, 2009Publication date: June 9, 2011Applicant: BASF SEInventors: Bernhard Hauer, Hans Wolfgang Höffken, Cecilia Kvarnström Branneby, Helmut Schwab, Sabine Feichtenhofer, Marlene Buchebner, Brigitte Pohn
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Patent number: 6900319Abstract: The invention relates to a compound of the formula I: or a salt thereof with a physiologically tolerated acid, or stereoisomers thereof, wherein R1, R2, A, B, C and D have the meanings described in the specification.Type: GrantFiled: March 19, 2002Date of Patent: May 31, 2005Assignee: Abbott GmbH & Co. KGInventors: Hans-Joachim Boehm, Hans Wolfgang Höffken, Wilfried Hornberger, Stefan Koser, Helmut Mack, Thomas Pfeiffer, Werner Seitz, Thomas Zierke
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Patent number: 6878536Abstract: Genes of purine biosynthesis from Ashbya gossypii are used in microbial riboflavin synthesis.Type: GrantFiled: February 15, 2002Date of Patent: April 12, 2005Assignee: BASFInventors: Markus Pompejus, Harald Seulberger, Hans Wolfgang Höffken, Jose Luis Revuelta Doval, Alberto Jimenez, Maria Angeles Santos Garcia
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Patent number: 6740647Abstract: Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.Type: GrantFiled: June 21, 2000Date of Patent: May 25, 2004Assignee: Abbott GmbH & Co., KGInventors: Dorit Baucke, Udo Lange, Helmut Mack, Werner Seitz, Hans Wolfgang Höffken, Wilfried Hornberger
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Publication number: 20030027309Abstract: Genes of purine biosynthesis from Ashbya gossypii are used in microbial riboflavin synthesis.Type: ApplicationFiled: February 15, 2002Publication date: February 6, 2003Inventors: Markus Pompejus, Harald Seulberger, Hans Wolfgang Hoffken, Jose Luis Revuelta Doval, Alberto Jimenez, Maria Angeles Santos Garcia
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Publication number: 20030004308Abstract: Compounds of the formula 1Type: ApplicationFiled: April 29, 2002Publication date: January 2, 2003Inventors: Hans-Joachim Bohm, Stefan Koser, Helmut Mack, Thomas Pfeiffer, Werner Seitz, Hans Wolfgang Hoffken, Wilfried Hornberger
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Publication number: 20020169318Abstract: The invention relates to a compound of the formula I 1Type: ApplicationFiled: March 19, 2002Publication date: November 14, 2002Inventors: Hans-Joachim Bohm, Hans Wolfgang Hoffken, Wilfried Hornberger, Stefan Koser, Helmut Mack, Thomas Pfeiffer, Werner Seitz, Thomas Zierke
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Patent number: 6455671Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.Type: GrantFiled: December 16, 1996Date of Patent: September 24, 2002Assignee: Abbott LaboratoriesInventors: Hans-Joachim Böhm, Stefan Koser, Helmut Mack, Thomas Pfeiffer, Werner Seitz, Hans Wolfgang Höffken, Wilfried Hornberger
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Patent number: 6444817Abstract: Compounds of the formula where A, B, D, R1 and R2 have the meanings stated in the description, are described. The compounds are suitable for controlling diseases. The novel compounds are prepared via compounds of the formula H2N—CH2—G—M.Type: GrantFiled: October 8, 1999Date of Patent: September 3, 2002Assignee: Abbott LaboratoriesInventors: Hans-Joachim Böhm, Hans Wolfgang Höffken, Wilfried Hornberger, Stefan Koser, Helmut Mack, Thomas Pfeiffer, Werner Seitz, Thomas Zierke