Patents by Inventor Hans Wolfgang Hoffken

Hans Wolfgang Hoffken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dipeptide benzamidine as a kininogenase inhibitor
    Patent number: 6440937
    Abstract: Compounds of the formula I where R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: August 27, 2002
    Assignee: Abbott Laboratories
    Inventors: Dorit Baucke, Udo Lange, Helmut Mack, Thomas Pfeiffer, Werner Seitz, Thomas Zierke, Hans Wolfgang Höffken, Wilfried Hornberger
  • Genes of purine biosynthesis from Ashbya gossypii and the use thereof in microbial riboflavin synthesis
    Patent number: 6391603
    Abstract: Genes of purine biosynthesis from Ashbya gossypii are used in microbial riboflavin synthesis.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: May 21, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Markus Pompejus, Harald Seulberger, Hans Wolfgang Höffken, Jose Luis Revuelta Doval, Alberto Jimenez, Maria Angeles Santos Garcia
  • Thrombin inhibitors
    Patent number: 6114358
    Abstract: Compounds of the formula ##STR1## where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: September 5, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Dorit Baucke, Udo Lange, Helmut Mack, Werner Seitz, Thomas Zierke, Hans Wolfgang Hoffken, Wilfried Hornberger
  • Thrombin muteins as antidotes for thrombin inhibitors
    Patent number: 6060300
    Abstract: The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.
    Type: Grant
    Filed: August 4, 1998
    Date of Patent: May 9, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Martin Raditsch, Thomas Friedrich, Claus Bollschweiler, Martin Schmidt, Hans Wolfgang Hoffken, Jurgen Schweden, Klaus Rubsamen
  • Dipeptide amidines as thrombin inhibitors
    Patent number: 6030972
    Abstract: Compounds of the formula ##STR1## where A, B, D, R.sup.1 and R.sup.2 have the meanings stated in the description, are described. The compounds are suitable for controlling diseases.The novel compounds are prepared via compounds of the formulaH.sub.2 N--CH.sub.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: February 29, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Joachim Bohm, Hans Wolfgang Hoffken, Wilfried Hornberger, Stefan Koser, Helmut Mack, Thomas Pfeiffer, Werner Seitz, Thomas Zierke
  • Thrombin inhibitors
    Patent number: 5932567
    Abstract: Thrombin inhibitors of the formula ##STR1## where R.sup.1, A, B and D have the meaning indicated in the description, and intermediates for the preparation thereof are described.The compounds I are suitable for controlling diseases.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: August 3, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Werner Seitz, Helmut Mack, Thomas Zierke, Hans-Joachim Bohm, Hans Wolfgang Hoffken, Stefan Koser, Thomas Pfeiffer, Wilfried Hornberger
  • Dipeptide p-amidinobenzylamides with N-terminal sulfonyl or aminosulfonyl radicals
    Patent number: 5852051
    Abstract: Compounds of the formula I ##STR1## in which R.sup.1, A and B have the meanings stated in the description, and the preparation thereof are described. The novel compounds are suitable for controlling diseases.
    Type: Grant
    Filed: June 5, 1997
    Date of Patent: December 22, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Joachim Bohm, Stefan Koser, Helmut Mack, Thomas Pfeiffer, Werner Seitz, Hans Wolfgang Hoffken, Wilfried Hornberger, Thomas Zierke