Abstract: The object of the invention is to provide a medicament which is suitable for the treatment of tumors, such as via topical administration.

Abstract: The invention concerns a new pharmaceutical agent for oral or topical administration in the treatment of protozoal diseases, in particular of leishmaniasis, which contains as the active substance one or several compounds having the general formula I 1

Abstract: The invention concerns a new pharmaceutical agent for oral or topical administration in the treatment of protozoal diseases, in particular of leishmaniasis, which contains as the active substance one or several compounds having the general formula I in which R1 is a saturated or monounsaturated or polyunsaturated hydrocarbon residue with 12 to 20 C atoms and R2, R3 and R4 denote independently of one another hydrogen, a C1-C5 alkyl group, a C3-C6 cycloalkyl group or a C1-C5 hydroxyalkyl group whereby two of the residues R2, R3 and R4 can together form a C2-C5 alkylene group which, if desired, can be substituted with an —O—, —S— or NR5 group, in which R5 is hydrogen, a C1-C5 alkyl group, a C3-C6 cycloalkyl group or a C1-C5 hydroxyalkyl group as well as, if desired the usual pharmaceutical auxiliary, diluting, carrier or/and filling substances.

Abstract: The invention concerns a new pharmaceutical agent for oral or topical administration in the treatment of protozoal diseases, in particular of leishmaniasis, which contains as the active substance one or several compounds having the general formula I ##STR1## in which R.sup.1 is a saturated or monounsaturated or polyunsaturated hydrocarbon residue with 12 to 20 C atoms and R.sup.2, R.sup.3 and R.sup.4 denote independently of one another hydrogen, a C.sub.1 -C.sub.5 alkys group, a C.sub.3 -C.sub.6 cycloalkyl group or a C.sub.1 -C.sub.5 hydroxyalkyl group whereby two of the residues R.sup.2, R.sup.3 and R.sup.4 can together form a C.sub.2 -C.sub.5 alkylene group which, if desired, can be substituted with an --O--, --S-- or NR.sup.5 group, in which R.sup.5 is hydrogen, a C.sub.1 -C.sub.5 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group or a C.sub.1 -C.sub.5 hydroxyalkyl group as well as, if desired the usual pharmaceutical auxiliary, diluting, carrier or/and filling substances.

Abstract: Cytotoxic therapeutic compositions contain as active ingredients compounds of the formulaR--Y--PO.sup..theta..sub.2 --X--R.sub.1wherein R is a saturated or unsaturated hydrocarbon radical of 12 to 14 carbon atoms which may also be halogen-substituted, X is oxygen, --NH-- or --NR.sub.2 --, Y is oxygen or --NH-- and R.sub.1 has diverse meanings or physiologically acceptable salts thereof.

Abstract: The present invention concerns liposomes with a negative excess charge and pharmaceutical compositions produced therefrom. The liposomes contain 30 to 50 mol % cholesterol, 49 to 56 mol % phospholipids and 1 to 14 mol % of one or several compounds of the general formula I ##STR1## or salts thereof in relation to the total lipid components of the liposomes, in which R.sup.1 and R.sup.2 are the same or different and represent hydrogen, C.sub.1 -C.sub.4 alkyl groups or saturated or unsaturated C.sub.8 -C.sub.24 acyl groups which are unbranched or branched or/and unsubstituted or substituted, provided that at least one of the residues R.sup.1 and R.sup.2 is an acyl group as defined above. A process for the production of the liposomes in accordance with the invention is also provided.

Abstract: The present invention provides compounds of the formula: ##STR1## wherein R is a erucyl, brassidyl or nervonyl radical, R.sup.1, R.sup.2 and R.sup.3 are defined in the specification, A is a valency bond or a radical as defined in the specification, and X is an oxygen atom when A is a valency bond or is an oxygen or sulphur atom when A is another radical.The present invention also provides a process for the preparation of the compounds of general formula (I) and pharmaceutical compositions containing them which can be used for the treatment of protozoal and fungal diseases, auto-immune diseases and bone marrow damage.

Abstract: The use of alkylphosphoric acid compounds of Formula IR--Y--PO.sub.2.sup..crclbar. --X--R.sub.1 Iwhere in Formula IR represents a saturated or unsaturated hydrocarbon radical with 12 to 24 carbon atoms or where R represents the group--CH.sub.2 --CHR.sub.3 --CH.sub.2 --Z--R.sub.4 and R.sub.3 is a C.sub.1 -C.sub.6 -alkoxy group or a C.sub.1 -C.sub.6 -alkoxymethyl group,Z represents oxygen or sulphur and R.sub.4 represents a C.sub.1 -C.sub.24 -alkyl radical,X is an oxygen atom, NH or NR.sub.2 and Y is an oxygen atom or NH, R.sub.1 is a C.sub.1 -C.sub.8 -alkyl group, or where R.sub.1 represents a C.sub.2 -C.sub.8 -alkyl group which is unsaturated and/or substituted by halogen, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, tri-C.sub.1 -C.sub.6 -alkylamino, hydroxy, carboxy, C.sub.3 -C.sub.8 -cycloalkyl or phenyl for the preparation of a pharmaceutical composition for combating psoriasis disorders.

Abstract: A composition useful as a medicament with improved penetration of cell membranes comprising an active material and a compound of general formula: ##STR1## wherein either residue R.sub.1 or R.sub.2 is an alkyl, alkylene, alkynyl or alkoxy group of 3-7 carbon atoms, and the other residue is a hydrogen atom, together with pharmaceutical additives and dilution agents.

Abstract: The invention relates to compositions containing hexadecylphosphocholine the use of these in treating various cancers.

Abstract: The invention relates to pharmaceutical compositions containing synthetic, substantially pure phosphatidyl serine and phosphatidyl choline and a substance or a mixture of substances having biological activity. The invention also relates to mixtures comprising synthetic, substantially pure phosphatidyl serine and phosphatidyl choline, and also to processes for the manufacture of the pharmaecutical compositions, and the use thereof.

Abstract: Compounds related to phospholipids and a method for their preparation are sclosed.

Abstract: Cytotoxically-effective medicaments containing hexadecylphosphocholine as active material.

Abstract: The invention concerns D-mannitol derivatives of the general formula I ##STR1## wherein R.sup.1 and R.sup.2 are the same or different, and when R.sup.1 R.sup.2 are the same, signify a straight-chained or branched alkyl, alkenyl or alkynyl group with 6 to 24 carbon atoms, which can contain cycloalkyl radicals with 3 to 6 carbon atoms, aryl radicals, benzyloxy, allyloxy, mesyloxy and/or halogen substituents and, when R.sup.1 and R.sup.2 are different, signify a straight-chained or branched alkyl group with 1 to 24 carbon atoms, which can contain cycloalkyl radicals with 3 to 6 carbon atoms, aryl radicals, benzyloxy, allyloxy, mesyloxy and/or halogen substituents, or a straight-chained or branched alkenyl or alkynyl group with 3 to 24 carbon atoms, which can contain cycloalkyl radicals with 3 to 6 carbon atoms, aryl radicals, benzyloxy, allyloxy, mesyloxy and/or halogen substituents, and R.sup.1 can also be trityl.

Abstract: Compounds related to phospholipids and a method for their preparations.

Abstract: The invention concerns derivatives of N,N-bis(2-chloroethyl)-phosphoric acid amide of general formula I ##STR1## wherein X and Y are the same or different and signify oxygen or NR.sup.3, R.sup.1 and R.sup.2 are the same or different and R.sup.1 signifies the radical CH.sub.2 (OR.sup.4)--CH.sub.2 --CH.sub.2 --, CH.sub.2 (OR.sup.4)--CH(CH.sub.3)--CH.sub.2 -- or CH.sub.2 (OR.sup.4)--CH(OR.sup.5)--CH.sub.2 -- and, when X is an NR.sup.3 group, can also be hydrogen, R.sup.2 possesses one of the meanings of R.sup.1 or is ethyl, propyl, allyl, propenyl, chloroethyl, methyl or benzyl, R.sup.3 is hydrogen, methyl, ethyl, propyl or allyl and wherein the radicals R.sup.4 and R.sup.

Abstract: The mannite derivatives have the formula (1) wherein R' and R.sup.2, idenal or different, represent when they are identical a straight or branched alkyl, alkenyl or alkynyl group containing from 5 to 24 atoms of carbon which may be substituted by a cycloalkyl residue having from 3 to 6 atoms of carbon, an aryl, benzyloxy, allyloxy, mesyloxy residue and/or halogen atoms and when R' and R.sup.2 are different, they represent a straight or branched alkyl group with 1 to 24 atoms or carbon, which may be substituted by a cycloalkyl residue having from 3 to 6 atoms of carbon, an aryl, benzyloxy, allyloxy, mesyloxy residue and/or halogen atoms, with the possibility for R' of being also a trityl group. From said mannite derivatives, it is possible to obtain in a simple way and with good yields the phospholipids in the form of their optical stereo isomers.

Abstract: New glycerol-3-phosphoric acid halogenoalkyl esters of the general formula I ##STR1## in which R denotes the radical R.sub.1 or an acyl radical --COR.sub.1, R.sub.1 denotes a straight-chain or branched, saturated or unsaturated alkyl group having 1 to 25 C atoms, R.sub.3 is a halogen atom, y is an integer from 2 to 12 and X.sup..sym. denotes one equivalent of a monovalent or divalent cation, as intermediate products for the preparation of phospholipids (glycerolphosphatides), a process for their preparation, and a process for subjecting them to further conversion, are described.

Abstract: Filter for the removal of apolar organic substances from gases containing an absorbent comprising at least one compound of the following formula: ##STR1## wherein one of X1, X2, and X3 is a phosphoric acid, phosphoric acid ester, or phosphatidyl moiety and two of the groups X1, X2, and X3 are independently selected from saturated fatty acid ester moieties and saturated alcohol (8 to 20 carbon atoms) ether moieties.

Abstract: Propane-1,3-diol phosphatides of the formula ##STR1## are prepared from the corresponding 1-alkanoyl-propanediols by conversion o an intermediate alkanoyl-propanediol-phosphoric acid .beta.-bromoethyl ester with .beta.-bromoethylphosphoric acid dichloride, and amination of the intermediate. They are biodegradable surfactants useful in detergent compositions and as emulsifiers in foods. In the formula, n is an integer and 9 to 25, R.sub.1 and R.sub.2 may be hydrogen or alkyl having up to six carbon atoms, and R.sub.3, R.sub.4, R.sub.5 may be hydrogen or methyl, but at least one of R.sub.3, R.sub.4, and R.sub.5 is hydrogen when R.sub.1 and R.sub.2 are both hydrogen.