Abstract: This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Abstract: A heat exchanging thermal liquid container system that comprises a main body at least partially defining a liquid reservoir structured and operable to retain a liquid, and a phase change material (PCM) liner comprising a PCM liner PCM having a selected melting temperature, and/or at least one PCM pod. Each of the at least one PCM pod(s) comprising a respective PCM pod PCM having a respective selected melting temperature. Wherein the PCM liner and/or the at least one PCM pod are disposable within the liquid reservoir such that when a liquid is disposed within the liquid reservoir the liquid will contact at least one of the PCM liner and the at least one PCM pod such that thermal energy can be exchanged between the liquid and the respective at least one of the PCM liner PCM and the at least one PCM pod PCM.

Abstract: The present disclosure provides an inflatable kayak. The inflatable kayak includes an inflatable floor having two ends defined upward; two inflatable gunwales arranged on the left and right sides of the inflatable floor, the height of the upper edge at both ends of the inflatable gunwale being higher than the height at the middle of the inflatable gunwale, allowing the height of the prow and the stern of the inflatable kayak to be no less than the height at the middle of the inflatable kayak; and a reinforcing assembly including a bottom reinforcing layer, a prow hatchway cover, and a stern hatchway cover, the bottom reinforcing layer at least covering the joints of the inflatable floor and the two inflatable gunwales. The prow hatchway cover connects the two inflatable gunwales at the prow, and the stern hatchway cover connects the two inflatable gunwales at the stern.

Abstract: A heat exchanging thermal liquid container system that comprises a main body at least partially defining a liquid reservoir structured and operable to retain a liquid, and a phase change material (PCM) liner comprising a PCM liner PCM having a selected melting temperature, and/or at least one PCM pod. Each of the at least one PCM pod(s) comprising a respective PCM pod PCM having a respective selected melting temperature. Wherein the PCM liner and/or the at least one PCM pod are disposable within the liquid reservoir such that when a liquid is disposed within the liquid reservoir the liquid will contact at least one of the PCM liner and the at least one PCM pod such that thermal energy can be exchanged between the liquid and the respective at least one of the PCM liner PCM and the at least one PCM pod PCM.

Abstract: A beverage container lid comprising a body having drinking hole and an air hole, and a slide-seal automatic Open and Close retention mechanism that comprises a sealing arm pivotally connected to the body, a movement and position retention linkage structured and operable to move the sealing arm between an Opened and a Closed position, a control mechanism slidingly disposed within the body and operably connected to the movement and position retention linkage such that movement of the control mechanism will control movement of the sealing arm between the Opened and Closed positions, and a biasing device structured and operable to exert constant force on the sealing arm, such that force exerted by the biasing device in combination with the structure and operation of the movement and position retention linkage will selectively retain the sealing arm in the Opened position and in the Closed position.

Abstract: The present invention is based on the discovery of genetic engineered induced pluripotent stem cells (iPSCs) that produce one or more therapeutic entities such as antibodies and nucleic acids that when administered to a subject, will treat or prevent disease. The present invention also combines EMV technology with iPSC technology creating a powerful new drug delivery platform.

Abstract: Provided is a method of manufacturing fiber with aligned porous structure, an apparatus, and applications of the fiber. The apparatus comprises: a fiber extrusion unit, a freezing unit, and a collection unit for collecting the frozen fibers, wherein fibers extruded from the fiber extrusion unit pass through the freezing unit. Continuous and large scale preparation of such fiber with aligned porous structure is achieved by combining directional freezing and solution spinning.

Abstract: A liquid level detecting method is provided. Firstly, a receiving component is provided, wherein the receiving component includes a transmissive container for containing a liquid and a marking component located on a rear surface of the transmissive container. Then, a camera captures a receiving component image of the receiving component from a front surface of the transmitting container, wherein the receiving component image includes a transmissive container image and a marking component image. Then, the marker component image is analyzed downward from an end portion to obtain multiple width values of multiple position points of the marker component image. Then, a width difference between each width value and a width average of the marking component image is obtained. Then, a position point whose width difference value is not within a preset range is determined. Then, according to the position point, a liquid level of the liquid is determined.

Abstract: A liquid level detecting method is provided. Firstly, a receiving component is provided, wherein the receiving component includes a transmissive container for containing a liquid and a marking component located on a rear surface of the transmissive container. Then, a camera captures a receiving component image of the receiving component from a front surface of the transmitting container, wherein the receiving component image includes a transmissive container image and a marking component image. Then, the marker component image is analyzed downward from an end portion to obtain multiple width values of multiple position points of the marker component image. Then, a width difference between each width value and a width average of the marking component image is obtained. Then, a position point whose width difference value is not within a preset range is determined. Then, according to the position point, a liquid level of the liquid is determined.

Abstract: A vehicle message managing method includes: providing an operation message of a tire through a tire sensor; receiving the operation message through the tire sensor setting tool, or receiving at least one outer message through the tire sensor setting tool; transmitting at least one of the operation message and the outer message to a remote server; storing and analyzing at least one of the operation message and the outer message and generating an analyzing result.

Abstract: A drinking container system with multiple temperature zones, wherein the container system includes a main body having a sidewall and a bottom that define a phase change material (PCM) module receptacle, and a phase change material (PCM) module having a sidewall that defines a beverage chamber. The PCM module is disposable within the PCM module receptacle such that a beverage egress flow path is defined between the main body sidewall and the PCM module sidewall. The flow path formed in the container can make the beverage achieve the desired drinking temperature. The PCM module sidewall is at least partially filled with a phase change material and is structured and operable to provide a plurality temperature zones within the beverage chamber. Each temperature zone is operable to maintain a temperature of a respective portion of a liquid disposed within the beverage chamber within a respective temperature range.

Abstract: This disclosure provides systems, methods, and apparatus related to freeze casting. In one aspect, a method comprises providing an apparatus. The apparatus comprises a container and a cooling surface. A bottom of the container comprises a wedge. The wedge comprises a first substantially planar surface and a second substantially planar surface with an angle between the first and the second substantially planar surfaces. An interior bottom of the container comprises the second substantially planar surface. The cooling surface is in contact with the first substantially planar surface. A slurry is deposited on the second substantially planar surface, the slurry comprising a plurality of particles in a liquid. The cooling surface is cooled to cool the slurry at a specified cooling rate.

Abstract: This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Abstract: Polymer conjugates characterized in that the backbone of the polymer is an anionic polymer and hydrophobic moieties are covalently attached to the polymer backbone are useful for preparing drug encapsulated polymer hydrotropes and compositions. Such materials are useful in methods for delivering the drug into cells, and for the treatment and alleviation of diseases and disorders such as cancer.

Abstract: Apparatus and associated methods may relate to a system for predicting a respirator fit by comparing a respirator model in a deformed state to a specific facial model. In an illustrative example, an internal measurement may be calculated between an inside part of the respirator model and the facial model. The internal measurement may be compared against a predetermined threshold to determine a fit of the respirator model, for example. In various implementations, the internal measurement may be a distance and/or a volume between the respirator and facial model. In some implementations, a 3D representation of the respirator model may be displayed upon a 3D representation of the facial model. In some implementations, a color-coded facial display may characterize areas of comfort and discomfort with respect to the respirator model. For example, areas of comfort and discomfort may be objectively determined in view of an applied pressure by the respirator.

Abstract: A heat exchanging thermal liquid container system that comprises a main body at least partially defining a liquid reservoir structured and operable to retain a liquid, and a phase change material (PCM) liner comprising a PCM liner PCM having a selected melting temperature, and/or at least one PCM pod. Each of the at least one PCM pod(s) comprising a respective PCM pod PCM having a respective selected melting temperature. Wherein the PCM liner and/or the at least one PCM pod are disposable within the liquid reservoir such that when a liquid is disposed within the liquid reservoir the liquid will contact at least one of the PCM liner and the at least one PCM pod such that thermal energy can be exchanged between the liquid and the respective at least one of the PCM liner PCM and the at least one PCM pod PCM.

Abstract: Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.

Abstract: Devices, methods, and systems for generating an operational user interface for a building management system are described herein. One method includes generating a widget using geometrical information associated with a building information modeling object and relationship information associated with the building information modeling object, assigning a state variable to the widget by analyzing properties of the building information modeling object or an ontology definition of the building information modeling object, associating the state variable with a point from the building operation system by mapping the point to the state variable, and changing the state variable based on input received from a user.