Abstract: Apparatus and associated methods relate to determining a fit-quality metric for a mask/face combination based upon a calculated dead-space volume between a virtual mask and a virtual face virtually aligned so as to create an integrity seal circumscribing a mouth and nose region. In an illustrative embodiment, an interactive virtual fitting system may receive a three-dimensional (3D) virtual face associated with a person. The system may retrieve 3D models of various respirators selected by user determined criteria. The system may then compute a fit-quality metric for each of the retrieved 3D models. The potential wearer may then be presented with the metrics for review. The potential wearer may select a respirator based upon these computed metrics. A virtual fitting of many respirators may advantageously reduce the time needed for selecting a properly fitting respirator while simultaneously ensuring that the selected respirator may be comfortable and well fitting.

Abstract: Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-?-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.

Abstract: This disclosure provides systems, methods, and apparatus related to freeze casting. In one aspect, a method comprises providing an apparatus. The apparatus comprises a container and a cooling surface. A bottom of the container comprises a wedge. The wedge comprises a first substantially planar surface and a second substantially planar surface with an angle between the first and the second substantially planar surfaces. An interior bottom of the container comprises the second substantially planar surface. The cooling surface is in contact with the first substantially planar surface. A slurry is deposited on the second substantially planar surface, the slurry comprising a plurality of particles in a liquid. The cooling surface is cooled to cool the slurry at a specified cooling rate.

Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Abstract: Apparatus and associated methods relate to determining a fit-quality metric for a mask/face combination based upon a calculated dead-space volume between a virtual mask and a virtual face virtually aligned so as to create an integrity seal circumscribing a mouth and nose region. In an illustrative embodiment, an interactive virtual fitting system may receive a three-dimensional (3D) virtual face associated with a person. The system may retrieve 3D models of various respirators selected by user determined criteria. The system may then compute a fit-quality metric for each of the retrieved 3D models. The potential wearer may then be presented with the metrics for review. The potential wearer may select a respirator based upon these computed metrics. A virtual fitting of many respirators may advantageously reduce the time needed for selecting a properly fitting respirator while simultaneously ensuring that the selected respirator may be comfortable and well fitting.

Abstract: Apparatus and associated methods may relate to a system for predicting a respirator fit by comparing a specific respirator model to a specific facial model in a dynamic position. In an illustrative example, one or more dynamic positions may be generated by actual user movement and/or simulated user movement. For example, a facial model may be generated by altering a static model in view of actual and/or simulated movements. In various implementations, a facial model may be compared against a variety of respirator models from a respirator model database. In some implementations, a 3D representation of the respirator model may be displayed upon a 3D representation of the facial model. In some implementations, a color-coded facial display may characterize areas of comfort and discomfort with respect to the respirator model. For example, areas of comfort and discomfort may be objectively determined in view of an applied pressure by the respirator.

Abstract: This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to co-polymer polyglutamate amino acid conjugates useful for a variety of anti-cancer drug delivery applications.

Abstract: Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-?-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.

Abstract: Apparatus and associated methods may relate to a system for predicting a respirator fit by comparing a respirator model in a deformed state to a specific facial model. In an illustrative example, an internal measurement may be calculated between an inside part of the respirator model and the facial model. The internal measurement may be compared against a predetermined threshold to determine a fit of the respirator model, for example. In various implementations, the internal measurement may be a distance and/or a volume between the respirator and facial model. In some implementations, a 3D representation of the respirator model may be displayed upon a 3D representation of the facial model. In some implementations, a color-coded facial display may characterize areas of comfort and discomfort with respect to the respirator model. For example, areas of comfort and discomfort may be objectively determined in view of an applied pressure by the respirator.

Abstract: Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.

Abstract: Polymer conjugates characterized in that the backbone of the polymer is an anionic polymer and hydrophobic moieties are covalently attached to the polymer backbone are useful for preparing drug encapsulated polymer hydrotropes and compositions. Such materials are useful in methods for delivering the drug into cells, and for the treatment and alleviation of diseases and disorders such as cancer.

Abstract: Methods, systems and Devices for operating a surveillance system are described herein. One method includes determining a plurality of parameters of a video camera installed at a particular location in a facility based on a projection of an image captured by the video camera onto a virtual image captured by a virtual video camera placed at a virtual location in a building information model of the facility corresponding to the particular location, determining a two-dimensional geometry of the facility based on the building information model, wherein the geometry includes a plurality of spaces, determining a coverage of the video camera based on a portion of the plurality of parameters and the geometry, determining which spaces of the plurality of spaces are included in the coverage, and associating each space included in the coverage with a respective portion of the image.

Abstract: A display panel includes a scan driving circuit. The scan driving circuit includes multiple shift-registers coupled in serial. At least one of the shift-registers includes a control circuit, a pumping circuit and an output circuit. The control circuit controls a voltage at a first control node according to a start-up signal and controls a voltage at a second control node according to a reset signal. The pumping circuit is coupled to the control circuit for pumping up the voltage at the first control node. The output circuit is coupled to the pumping circuit and the control circuit for outputting multiple gate driving signals at multiple output nodes in response to the voltage at the first control node. One of the output gate driving signals is provided to a following stage of shift-register as the start-up signal thereof.

Abstract: A process for sensor placement and analysis using a virtual environment includes receiving into a computer processor a model of an area, a position in the model that represents a placement of a virtual sensor, and an orientation of the virtual sensor. A shadow map of the area is generated as a function of the position and orientation of the virtual sensor. The shadow map is used to determine one or more portions of the area that can be sensed by the virtual sensor. The area of the model that is covered as a function of the position and orientation of the virtual sensor is determined, and information relating to the area of the model that is covered as a function of the position and orientation of the virtual sensor is transmitted to an output device.

Abstract: Devices, methods, and systems for generating an operational user interface for a building management system are described herein. One method includes generating a widget using geometrical information associated with a building information modeling object and relationship information associated with the building information modeling object, assigning a state variable to the widget by analyzing properties of the building information modeling object or an ontology definition of the building information modeling object, associating the state variable with a point from the building operation system by mapping the point to the state variable, and changing the state variable based on input received from a user.

Abstract: A method includes representing a building structure and component systems using a structural set of ontologies to create a building ontology, representing audit tasks and audit processes using an audit ontology, and presenting an ordered set of audit tasks to an auditor using the structural set of ontologies and the audit ontology, enabling the auditor to complete an audit process and populate data about instances in the building ontology representing a specific building.

Abstract: A system for automatically determining the placement of cameras receives data relating to a plurality of polygons. T polygons represent one or more of a surveillance area, a non-surveillance area, a blank area, and an obstacle. The system selects one or more initial cameras, including one or more initial camera positions, initial camera orientations, and initial camera features, wherein the initial camera positions and the initial camera orientations cause one or more fields of view of the initial cameras to cover at least a part of the surveillance area. The system alters one or more of a number of cameras, an orientation of the cameras, a location of the cameras, a type of the cameras, and a crossover of two or more cameras. The system uses a fitness function to evaluate all of the cameras and all of the camera positions, and selects one or more cameras and the locations and orientations of the one or more cameras as a function of the fitness function.

Abstract: A process for sensor placement and analysis using a virtual environment includes receiving into a computer processor a model of an area, a position in the model that represents a placement of a virtual sensor, and an orientation of the virtual sensor. A shadow map of the area is generated as a function of the position and orientation of the virtual sensor. The shadow map is used to determine one or more portions of the area that can be sensed by the virtual sensor. The area of the model that is covered as a function of the position and orientation of the virtual sensor is determined, and information relating to the area of the model that is covered as a function of the position and orientation of the virtual sensor is transmitted to an output device.

Abstract: Apparatus and associated methods may relate to a system for predicting a respirator fit by comparing a respirator model in a deformed state to a specific facial model. In an illustrative example, an internal measurement may be calculated between an inside part of the respirator model and the facial model. The internal measurement may be compared against a predetermined threshold to determine a fit of the respirator model, for example. In various implementations, the internal measurement may be a distance and/or a volume between the respirator and facial model. In some implementations, a 3D representation of the respirator model may be displayed upon a 3D representation of the facial model. In some implementations, a color-coded facial display may characterize areas of comfort and discomfort with respect to the respirator model. For example, areas of comfort and discomfort may be objectively determined in view of an applied pressure by the respirator.

Abstract: Apparatus and associated methods may relate to a system for predicting a respirator fit by comparing a specific respirator model to a specific facial model in a dynamic position. In an illustrative example, one or more dynamic positions may be generated by actual user movement and/or simulated user movement. For example, a facial model may be generated by altering a static model in view of actual and/or simulated movements. In various implementations, a facial model may be compared against a variety of respirator models from a respirator model database. In some implementations, a 3D representation of the respirator model may be displayed upon a 3D representation of the facial model. In some implementations, a color-coded facial display may characterize areas of comfort and discomfort with respect to the respirator model. For example, areas of comfort and discomfort may be objectively determined in view of an applied pressure by the respirator.