Abstract: Disclosed in the present invention are a compound having a BRD4 inhibitory activity, a preparation method therefor and the use thereof. The structure of the compound having the BRD4 inhibitory activity of the present invention is as shown in formula I, and the definition of each substituent is as described in the description and claims. The compound of the present invention has a high bromodomain protein inhibitory activity, in particular a BRD4-targeting inhibitory activity, and can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Abstract: The invention discloses a bionic laminated thermal insulation material, which imitates a multi-thin laminated and thin-layer micro-pore structure of Sequoia sempervirens bark with fire resistance, corrosion resistance and excellent thermal insulation performance. A low thermal conductivity microporous powder is used as main raw material, while reinforcing agent, plasticizer and porosity agent are added to form microporous thin-layer units, and each thin-layer unit is bonded and laminated to make a laminated thermal insulation material. The thermal conductivity of the finished products is as low as 0.02˜0.05 W/m·k, with good thermal insulation and mechanical properties, which can be used in a temperature range below 1000° C., with better thermal insulation and energy-saving effect and toughness than ordinary thermal insulation materials, significantly reducing the thickness of the insulation layer, and can be widely used in industrial furnaces, thermal engineering devices, insulation pipes and other fields.

Abstract: The present disclosure provides a testis-targeted lycopene (LYC)/ZIF-90 nanocomposite and a preparation method and use thereof, belonging to the technical field of targeted drugs. In the present disclosure, a ZIF-90 metal-organic framework (MOF) material is combined with LYC through aldol condensation; when entering areas of inflammatory response and oxidative stress response, ZIF-90 may disintegrate and collapse in a slightly-acidic environment, releasing the LYC, thereby avoiding easy oxidation of the LYC and improving a bioavailability of the LYC; in addition, the disintegrated and collapsed ZIF-90 may also be utilized by organisms, thus greatly reducing a damage to the organisms. Moreover, the LYC/ZIF-90 nanocomposite is further loaded with follicle-stimulating hormone (FSH).

Abstract: The present disclosure relates to a device and a system for testing flatness. The device for testing flatness includes a base, a testing platform, and a ranging sensor. The testing platform is assembled on the base. The testing platform includes a supporting structure. The supporting structure is disposed on the side of the testing platform away from the base and is used to support a to-be-tested board. The structure matches the structure of the to-be-tested board. The ranging sensor is disposed on the side of the testing platform away from the base. After the to-be-tested board is placed on the testing platform, the ranging sensor is used to test distances between a number N of to-be-tested positions on the to-be-tested board and the ranging sensor, to obtain N pieces of distance information, and the N pieces of distance information are used to determine the flatness of the to-be-tested board, where N is an integer greater than 2.

Abstract: A file connection method and apparatus, terminal device, and storage medium are provided. The file connection method is applied to a file system. The file system includes a plurality of devices. Metadata of a target file is separately stored in metabases of the plurality of devices. The method includes: A current device determines a device that accesses the target file last time, a device in which the file is located, and a connection record based on the stored metadata of the target file, and the current device obtains file data of the target file from at least one of the device that accesses the target file last time and the device in which the file is located; and the current device displays to-be-displayed content based on at least one of the connection record of the target file and the file data of the target file.

Abstract: Techniques are disclosed for implementing cross-zone communication for computing zones executing different coding protocols. A server computer system may receive, via a proxy layer of a first instance of an application executing within a first computing zone according to a first set of coding protocols, a request for a service executed via a second instance of the application in a second computing zone according to a second, different set of coding protocols. The system may alter, via a remote layer of the first instance, a set of data specified in the request to comply with the second, set of protocols. The system may transmit, via the remote layer of the first instance to a remote layer of the second instance, the altered set of data. The system may advantageously provide a simplified development interface allowing for both development and testing within a local environment without deployment of multiple different services.

Abstract: The following is directed to an abrasive particle having a body including a core and a coating overlying at least a portion of the core. The coating can include a content of lithium. In an embodiment, the coating can further include silicon, oxygen, or a combination thereof.

Abstract: There are provided systems and methods for pairwise graph querying, merging, and computing for account linking. A service provider may provide an account graph system to identify pairwise similarities between different accounts based on shared data that may be identified through one or more linking characteristics. When providing pairwise graph similarities, a service provider may receive a query identifying two or more accounts and/or an account with a parameter for graph exploration and querying. The service provider may utilize connection, link, or relationship graphs, queried and generated using a graph database, to determine pairwise similarities between the designated seed account and one or more selected accounts. The graph may include vertices for different queried data points and edges connecting such queries, where directionality of the edges or other vectors may be used to identify links or hops between accounts for data querying and exploration.

Abstract: A folding device is provided. The folding device includes a bearing and fixing mechanism (1) configured to bear and fix a main body portion (21) of a to-be-folded device (2); a folding mechanism (3) located on at least one side of the bearing and fixing mechanism (1), the folding mechanism (3) being rotatably connected to the bearing and fixing mechanism (1) and configured to bear and fix a to-be-folded portion (22) of the to-be-folded device (2); and a driving mechanism (4) connected to the folding mechanism (3), the driving mechanism (4) being configured to drive the folding mechanism (3) to turn relative to the bearing and fixing mechanism (1), so as to fold the to-be-folded portion (22) to a side in a thickness direction of the main body portion (21). The folding device can fold automatically, and manual folding is avoided.

Abstract: The present application provides a driving method, a driving device, and a display terminal of a display panel. The display panel includes light emitting elements. The driving method includes: obtaining a grayscale data of a displayed image; determining a target current level from preset multiple current levels according to the grayscale data; determining a pulse width modulation signal according to the grayscale data; and driving the light emitting elements to emit light according to the target current level and the pulse width modulation signal.

Abstract: A current limiting circuit includes a first voltage terminal, a second voltage terminal, a first transistor and a current limiting module. An input terminal of the first transistor is electrically connected to the first voltage terminal, and an output terminal of the first transistor is electrically connected to the second voltage terminal. The current limiting module is electrically connected to the input terminal of the first transistor and a control terminal of the first transistor. The current limiting module is configured to control voltage difference between the control terminal of the first transistor and the input terminal of the first transistor for controlling a state of the first transistor so that a current limiting value of the current limiting circuit is adjustable.

Abstract: The disclosure discloses a drive circuit included a first transistor electrically connected to a first control terminal, a first voltage terminal, and a first node; an inductor electrically connected to the first node and a second voltage terminal; a first diode electrically connected to a grounding terminal and the first node; a first capacitor electrically connected to a second voltage terminal and the grounding terminal; and a discharging circuit module electrically connected to the first node and the grounding terminal to provide a discharging circuit to discharge the capacitor.

Abstract: A driving circuit is provided and includes a first transistor electrically connected to a first control terminal, a first voltage terminal and a first node; and a second transistor electrically connected to a second control terminal, the first node and a ground terminal; and an inductor, a first terminal thereof is electrically connected to the first node, and a second terminal thereof is electrically connected to a second voltage terminal; and a shunt module electrically connected to the first node and the ground terminal, and the shunt module is configured to provide a current loop to shunt a current flowing through the second transistor.

Abstract: A light-emitting diode (LED) panel and a driving method thereof are disclosed. The LED panel includes a clock generation module configured to provide a clock signal; a control module including a plurality of output terminal groups, wherein, each of the output terminal groups includes at least one first output terminal, and the control module is configured to output electrical signals through different output terminal groups in sequence in a same frame time according to the clock signal; and a plurality of LED modules, wherein, each of the LED modules is correspondingly connected to the at least one first output terminal by one to one, and the LED modules are configured to emit light in sequence according to the electrical signals.

Abstract: A driver chip, a display panel, and a driving method thereof are provided. The driver chip uses a pulse width modulation module and a pulse amplitude modulation module to control a waveform and a strength of a data signal respectively, which can obtain more display grayscales, a to-be-displayed brightness of a light emitting unit is larger, and a gradation level of the light-emitting unit is better. The pulse amplitude modulation module can modulate the strength of the data signal, can compensate the pixels, and improve the display quality of the display panel.

Abstract: The present application discloses a warp execution method used for SPs of an SM of a GPU and an associated GPU.

Abstract: The present application discloses a GPU and a method of the same. The GPU includes: a plurality of streaming multiprocessor (SMs), each including: a plurality of streaming processors (SPs), each including a register, wherein each SP has a predetermined upper bound of warp number, and the register has a predetermined upper bound of register capacity; and a global dispatcher, including: a register occupancy status table, for recording the warp number and an occupancy status of the register of each SP of each SM; a TB (TB) dispatch module, for dispatching the TB to a first SM of the SMs according to a warp type classification table and the register occupancy status table; and a warp dispatch module, for dispatching a plurality of warps to the plurality of SPs of the first SM according to the warp type classification table and the register occupancy status table.

Abstract: A GPU and a GPU method are provided. The GPU includes stream multiprocessors, an available hardware resource table, resource comparator, stream scheduler, and global dispatcher. Each stream multiprocessor executes at least one thread block. The available hardware resource table records hardware resources available to the stream multiprocessors. The resource comparator selects from first-priority kernel codes in the kernel streams at least one first dispatchable kernel code whose required hardware resources are less than hardware resources available to the stream multiprocessors according to the available hardware resource table. The stream scheduler selects from the at least one first dispatchable kernel code a kernel code as a selected kernel code. The global dispatcher dispatches thread blocks in the selected kernel code to the stream multiprocessors for execution and updates the available hardware resource table according to usage conditions of hardware resources of the stream multiprocessors.