Patents by Inventor Harm Mulder

Harm Mulder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11946080
    Abstract: Disclosed herein is one or more subtilisin variants, nucleic acids encoding same, and compositions and methods related to the production and uses thereof, including one or more subtilisin variants that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Grant
    Filed: June 18, 2017
    Date of Patent: April 2, 2024
    Assignee: DANISCO US INC.
    Inventors: Richard R. Bott, David A. Estell, Frits Goedegebuur, Harm Mulder, Sina Pricelius
  • Patent number: 11946081
    Abstract: Disclosed herein is one or more subtilisin variant. nucleic acid encoding same. and compositions and methods related to the production and use thereof. including one or more Bacillus gibsonii-clade subtilisin variant that has improved soil removal compared to one or more reference subtilisin.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: April 2, 2024
    Assignee: Danisco US Inc.
    Inventors: Lilia Maria Babe, Lydia Dankmeyer, Frits Goedegebuur, Thijs Kaper, Harm Mulder, Sina Pricelius
  • Patent number: 11898177
    Abstract: Disclosed are compositions and methods relating to variant maltohexaose-forming alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
    Type: Grant
    Filed: July 12, 2021
    Date of Patent: February 13, 2024
    Assignee: DANISCO US INC.
    Inventors: Luis G Cascao-Pereira, David A Estell, Marc Anton Bernhard Kolkman, Harm Mulder
  • Publication number: 20230257728
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Application
    Filed: February 9, 2023
    Publication date: August 17, 2023
    Inventors: Lilia Maria Babe, Lydia Dankmeyer, David A. Estell, Frits Goedegebuur, Thijs Kaper, Harm Mulder, Sina Pricelius
  • Publication number: 20230028935
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability compared to one or more reference subtilisin.
    Type: Application
    Filed: November 25, 2019
    Publication date: January 26, 2023
    Inventors: Lilia Maria BABE, Viktor Yuryevich ALEKSEYEV, Joshua Roy BASLER, H. Billur ENGIN, David A. ESTELL, Roopa Santosh GHIRNIKAR, Frits GOEDEGEBUUR, Thijs KAPER, Harm MULDER, Sina PRICELIUS, Nils Henning REDESTIG, Sander VAN STIGT THANS
  • Patent number: 11499146
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more Bacillus gibsonii-clade subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: November 15, 2022
    Assignee: DANISCO US INC.
    Inventors: Lilia Maria Babe, Richard R. Bott, David A. Estell, Harm Mulder, Frits Goedegebuur, Jian Yao, Sina Pricelius, Miles Scotcher
  • Patent number: 11492571
    Abstract: A phosphate-free automatic dishwashing cleaning composition comprising a protease wherein the protease has at least 80%, preferably at least 85%, more preferably at least 90% and especially at least 96% identity with the amino acid sequence of SEQ ID NO:1 or with the amino acid sequence of SEQ ID NO:2 and wherein the protease comprises amino acid substitutions selected from the group consisting of: (i) at least two amino acid substitutions selected from the group consisting of: X198G/A/K/L/Q/R/T/V/S/L, X207Q, X211Q/N and X212Q in combination with at least three amino acid substitutions selected from the group consisting of: X039E, X074D, X099R, X126A, X127E and X128G; or (ii) X039E-X074D-X099R-X116R-X126A-X127E-X128G-X211Q; X039E-X074D-X099R-X126A-X127E-X128G-X211N; X039E-X074D-X099R-X126A-X127E-X128G-X211Q; X039E-X074D-X099R-X126A-X127E-X128G-X207Q; or (iii) any of the proteases of (i) and (ii) further comprising at least one amino acid substitution selected from X242D and X256E; or (iv) X039E-X074D-X099R
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: November 8, 2022
    Assignee: The Procter & Gamble Company
    Inventors: Philip Frank Souter, Eva Maria Perez-Prat Vinuesa, Michelle Jackson, Carly Pickering, Viktor Yuryevich Alekseyev, Lilia Maria Babe, Frits Goedegebuur, Thijs Kaper, Sina Pricelius, Sander Van Stigt Thans, Harm Mulder, Nils Henning Redestig, Lydia Dankmeyer, Michael Stoner, Adam Garske, Roopa Santosh Ghirnikar
  • Publication number: 20220220419
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Application
    Filed: May 20, 2020
    Publication date: July 14, 2022
    Inventors: Viktor Yuryevich ALEKSEYEV, Lilia Maria BABE, Lydia DANKMEYER, Adam GARSKE, Roopa Santosh GHIRNIKAR, Frits GOEDEGEBUUR, Thijs KAPER, Harm MULDER, Sina PRICELIUS, Nils Henning REDESTIG, Michael STONER, Sander VAN STIGT THANS
  • Patent number: 11384348
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: July 12, 2022
    Assignee: DANISCO US INC
    Inventors: Marc Kolkman, Frits Goedegebuur, Lilia Maria Babe, Rie Mejldal, Harm Mulder, Anja Hemmingsen Kellett-Smith, Richard R Bott, Miles Christopher Scotcher
  • Publication number: 20220002696
    Abstract: Disclosed are compositions and methods relating to variant maltohexaose-forming alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
    Type: Application
    Filed: July 12, 2021
    Publication date: January 6, 2022
    Inventors: LUIS G. CASCAO-PEREIRA, DAVID A. ESTELL, MARC ANTON BERNHAR KOLKMAN, HARM MULDER
  • Publication number: 20210363470
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Application
    Filed: May 24, 2019
    Publication date: November 25, 2021
    Inventors: Viktor Yuryevich ALEKSEYEV, Lilia Maria BABE, Billur H. ENGIN, David A. ESTELL, Frits GOEDEGEBUUR, Thijs KAPER, Harm MULDER, Sina PRICELIUS, Sander Van Stigt THANS
  • Publication number: 20210214703
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Application
    Filed: May 24, 2019
    Publication date: July 15, 2021
    Inventors: Viktor Yuryevich ALEKSEYEV, Lilia Maria BABE, Billur H. ENGIN, David A. ESTELL, Frits GOEDEGEBUUR, Thijs KAPER, Harm MULDER, Sina PRICELIUS, Sander Van Stigt THANS
  • Publication number: 20210122997
    Abstract: A phosphate-free automatic dishwashing cleaning composition comprising a protease wherein the protease has at least 80%, preferably at least 85%, more preferably at least 90% and especially at least 96% identity with the amino acid sequence of SEQ ID NO:1 or with the amino acid sequence of SEQ ID NO:2 and wherein the protease comprises amino acid substitutions selected from the group consisting of: (i) at least two amino acid substitutions selected from the group consisting of: X198G/A/K/L/Q/R/T/V/S/L, X207Q, X211Q/N and X212Q in combination with at least three amino acid substitutions selected from the group consisting of: X039E, X074D, X099R, X126A, X127E and X128G; or (ii) X039E-X074D-X099R-X116R-X126A-X127E-X128G-X211Q; X039E-X074D-X099R-X126A-X127E-X128G-X211N; X039E-X074D-X099R-X126A-X127E-X128G-X211Q; X039E-X074D-X099R-X126A-X127E-X128G-X207Q; or (iii) any of the proteases of (i) and (ii) further comprising at least one amino acid substitution selected from X242D and X256E; or (iv) X039E-X074D-X099R
    Type: Application
    Filed: October 9, 2020
    Publication date: April 29, 2021
    Inventors: Philip Frank SOUTER, Eva Maria PEREZ-PRAT VINUESA, Michelle JACKSON, Carly PICKERING, Viktor Yuryevich ALEKSEYEV, Lilia Maria BABE, Frits GOEDEGEBUUR, Thijs KAPER, Sina PRICELIUS, Sander VAN STIGT THANS, Harm MULDER, Nils Henning REDESTIG, Lydia DANKMEYER, Michael STONER, Adam GARSKE, Roopa Santosh GHIRNIKAR
  • Publication number: 20200392477
    Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
    Type: Application
    Filed: December 19, 2017
    Publication date: December 17, 2020
    Inventors: Lilia Maria Babe, Lydia Dankmeyer, David A. Estell, Frits Goedegebuur, Thijs Kaper, Harm Mulder, Sina Pricelius
  • Publication number: 20200248160
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Application
    Filed: December 4, 2019
    Publication date: August 6, 2020
    Inventors: MARC KOLKMAN, FRITS GOEDEGEBUUR, LILIA MARIA BABE, RIE MEJLDAL, HARM MULDER, ANJA HEMMINGSEN KELLETT-SMITH, RICHARD R BOTT, MILES CHRISTOPHER SCOTCHER
  • Patent number: 10731144
    Abstract: The present invention provides methods and compositions for the production of mature proteases in bacterial host cells. The compositions include polynucleotides encoding serine protease sequences with modified or heterologous propeptide regions; polypeptides comprising serine proteases with modified or heterologous propeptide regions; expression cassettes, DNA constructs, vectors, and chromosomes comprising such polynucleotides; and bacterial host cells comprising such polynucleotides. The methods include methods for enhancing the production of mature proteases in bacterial host cells (e.g. Bacillus sp. host cells). The produced proteases find use in the industrial production of enzymes, suitable for use in various industries, including but not limited to the cleaning, animal feed and textile processing industry.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: August 4, 2020
    Assignee: DANISCO US INC
    Inventors: Lilia Maria Babe, Carol Marie Fioresi, Frits Goedegebuur, Harm Mulder
  • Publication number: 20200172837
    Abstract: The present disclosure relates to serine proteases and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Application
    Filed: August 6, 2019
    Publication date: June 4, 2020
    Inventors: Marc Kolkman, Frits Goedegebuur, Harm Mulder, Lilia Maria Babe
  • Patent number: 10533165
    Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: January 14, 2020
    Assignee: DANISCO US INC
    Inventors: Marc Kolkman, Rie Mejldal, Frits Goedegebuur, Lilia Maria Babe, Anja Hemmingsen Kellett-Smith, Harm Mulder, Richard R. Bott, Miles Christopher Scotcher
  • Publication number: 20200002693
    Abstract: Disclosed are compositions and methods relating to variant maltohexaose-forming alpha-amylases. The variant alpha-amylases are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
    Type: Application
    Filed: September 17, 2019
    Publication date: January 2, 2020
    Inventors: Luis G. Cascao-Pereira, David A. Estell, Marc Anton Bernhard Kolkman, Harm Mulder
  • Publication number: 20190330610
    Abstract: Disclosed herein is one or more subtilisin variant. nucleic acid encoding same. and compositions and methods related to the production and use thereof. including one or more Bacillus gibsonii-clade subtilisin variant that has improved soil removal compared to one or more reference subtilisin.
    Type: Application
    Filed: December 19, 2017
    Publication date: October 31, 2019
    Inventors: Lilia Maria Babe, Lydia Dankmeyer, Frits Goedegebuur, Thijs Kaper, Harm Mulder, Sina Pricelius