Abstract: An implantable device covers and seals an enteroatmospheric fistula or other short-tract opening in tissue and assists in healing the fistula. The implantable device may include a cap that is configured to be positioned on a first side of the tissue and to substantially cover a first opening of the short-tract fistula. The implantable device may also include an anchor member operably connected to the cap. The anchor member may be configured to be positioned on a second side of the tissue and to substantially cover a second opening of the short-tract fistula. Also, the implantable device may include a plug structure operably connected to the cap and the anchor member. The plug structure may be configured to fill the short-tract fistula.

Abstract: Tissue removal probes comprise an elongated member, a drive shaft rotatably disposed within the member, and a rotatably tissue removal element mounted to the distal end of the drive shaft. One tissue removal element comprises a plurality of tissue-cutting filaments affixed at proximal and distal ends of the tissue removal element. The cutting filaments may have optional hinge points that allow the distal end of the tissue removal element to be inverted, thereby transforming the tissue removal element from a tissue-cutting device to a tissue-grasping device. Another tissue removal element may have a blunted tip to prevent distal tissue trauma and an irrigation port to provide irrigation fluid to the removed tissue and/or tissue removal element. Another tissue removal element has a proximal and distal spiral grooves that are oppositely pitched, so that removed tissue can be collected in the middle of the tissue removal element.

Abstract: Tissue removal probes comprise an elongated member, a drive shaft rotatably disposed within the member, and a rotatable tissue removal element mounted to the distal end of the drive shaft. One tissue removal element comprises a plurality of tissue-cutting filaments affixed at proximal and distal ends of the tissue removal element. The cutting filaments may have optional hinge points that allow the distal end of the tissue removal element to be inverted, thereby transforming the tissue removal element from a tissue-cutting device to a tissue-grasping device. Another tissue removal element may have a blunted tip to prevent distal tissue trauma and an irrigation port to provide irrigation fluid to the removed tissue and/or tissue removal element. Another tissue removal element has a proximal and distal spiral grooves that are oppositely pitched, so that removed tissue can be collected in the middle of the tissue removal element.

Abstract: Disclosed herein are implantable fistula treatment devices and methods. In some embodiments, a distal anchor for an implantable fistula treatment device may comprise a suture and multiple foldable members including at least a distal-most foldable member and a proximal-most foldable member. The distal-most foldable member may comprise a suture attachment structure. The proximal-most foldable member may be configured to couple to a surface of a body lumen at a distal opening of a fistula.

Abstract: A device for bridging a neck of an aneurysm, comprises a junction region, one or more radially extending array elements secured to the junction region, each array element having an unfolded shape and a delivery shape; and a cover attached to the junction region, and extending over the delivery shape of the array elements, wherein each array element is attached at one end to the junction region and the array elements are constructed and arranged to unfold the cover when assuming their unfolded shape, and wherein the device further comprises a tip, and each array element is attached at another end to the tip, the tip comprising an opening through which a vaso-occlusive device or occlusion fluid may be delivered.

Abstract: This is a surgical device usually delivered through an intravascular catheter. It may be used in several ways. It may, for instance, be used to open a clear passageway adjacent thrombus to allow both blood and medication to bypass the clot. It may be used to pierce and to remove thrombus. These thrombus are often found in tortuous vasculature. The device includes several sections. The device has a core element, typically a core wire. Placed around the distal end of the core element is a collapsible but preferably self expanding proximal cage assembly and a distal filter, preferably a self-expanding cage assembly or other filter component. The various portions of those components are preferably radio-opaque. The proximal end of the proximal cage is typically is affixed to an actuator in such a way as to allow expansion of the cage after deployment.

Abstract: Disclosed herein are implantable fistula treatment devices and related methods. In some embodiments, an anorectal fistula treatment device may comprise a disc-shaped distal anchor comprising a concave side and a convex side, an outer edge region, an inner sealing region protruding from the concave side, and an attachment region configured for attachment to a connecting member. The inner sealing region may have a greater thickness than at least a portion of the attachment region and the outer edge region may be oriented at an acute angle to the inner sealing region. The distal anchor may have a tapered edge and the outer edge region and inner sealing region may be configured to form separate seals against tissue about a distal opening of an anorectal fistula.

Abstract: A device for bridging a neck of an aneurysm, comprises a junction region, one or more radially extending array elements secured to the junction region, each array element having an unfolded shape and a delivery shape; and a cover attached to the junction region, and extending over the delivery shape of the array elements, wherein each array element is attached at one end to the junction region and the array elements are constructed and arranged to unfold the cover when assuming their unfolded shape, and wherein the device further comprises a tip, and each array element is attached at another end to the tip, the tip comprising an opening through which a vaso-occlusive device or occlusion fluid may be delivered.

Abstract: In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.

Abstract: Disclosed herein are implantable fistula treatment devices and related methods. In some embodiments, a distal anchor for an implantable fistula treatment device may comprise a suture and a plurality of foldable members including at least a distal-most foldable member and a proximal-most foldable member. The distal-most foldable member may comprise a suture attachment structure. The distal-most foldable member may comprise a distal first average dimension substantially parallel to the longitudinal axis of the suture, a distal second average dimension orthogonal to the distal first average dimension, and a distal third average dimension orthogonal to the distal first and second average dimensions. The distal first average dimension may be no greater than 30% of the greater of the distal second and third average dimensions. The proximal-most foldable member may be configured to couple to a surface of a body lumen at a distal opening of a fistula.

Abstract: A tissue removal device and method of using the device to remove tissue from a patient is provided. The tissue removal device comprises a tissue removal probe and a sheath slidable relative to the probe. The probe has a tissue removal element, and the sheath has a portion that exposes the tissue removal element. The sheath distal end may be pre-shaped to bend when slid distal to the probe. The probe may have a window through which the tissue removal element is exposed.

Abstract: In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.

Abstract: In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.

Abstract: A device for removing blood clots and methods of making and using the same. The clot pulling device may include a shaft and one or more strut members that each may include a loop region. The proximal ends of the strut members may be attached to the shaft and the distal ends of the strut members may be coupled to the shaft.

Abstract: Disclosed herein is an implantable fistula closure device. The device may include an expandable longitudinally segmented body including a proximal end and a distal end. The segmented body may further include a plurality of porous bodies and a connecting member operably joining together the plurality of porous bodies. The plurality of porous bodies includes a first porous body with a proximal end and a distal end and a second porous body with a proximal end and a distal end, and the connecting member operably connects the proximal end of the first porous body with the distal end of the second porous body.

Abstract: A device for bridging a neck of an aneurysm, comprises a junction region, one or more radially extending array elements secured to the junction region, each array element having an unfolded shape and a delivery shape; and a cover attached to the junction region, and extending over the delivery shape of the array elements, wherein each array element is attached at one end to the junction region and the array elements are constructed and arranged to unfold the cover when assuming their unfolded shape, and wherein the device further comprises a tip, and each array element is attached at another end to the tip, the tip comprising an opening through which a vaso-occlusive device or occlusion fluid may be delivered.

Abstract: An apparatus for delivering bone cement into a vertebra includes a cannula and a mix and delivery device pivotally coupled to the cannula. The mix and deliver provides a single device in which a flowable compound may be mixed and the dispensed into the vertebrae through the cannula. The mix and delivery device includes a piston, slidably disposed within a barrel of the device, for advancing the bone cement through an outlet communicating with the cannula. An actuating device, which exerts a pressure, is connected to an inlet on the mix and delivery device (either directly or through a tube). The pressure created by the actuating device is used to advance the piston within the mix and delivery device.

Abstract: This is a composite guidewire for use with a catheter for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni—Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. The invention includes multi-section guidewire assemblies having super-elastic alloy or stainless steel ribbon braided reinforcements along a least a portion of the core. A variation of the inventive guidewire includes a braid and a tie layer (and one or more lubricious polymers on the tie layer exterior) to enhance the guidewire's suitability for use within catheters and within the interior of vascular lumen.

Abstract: Apparatus and methods for delivering prosthetic segments to a body lumen, utilize a device having an elongated flexible member including proximal and distal ends, a plurality of prosthetic segments releasably arranged axially along the elongated flexible member near the distal end and an outer sheath slidably disposed over at least a portion of the prosthetic segments. The apparatus further includes a separator disposed on the outer sheath and adapted to engage the prosthetic segments. The separator is also adapted to be retracted proximally over the prosthetic segments and advanced distally to separate a proximal group of the prosthetic segments from a distal group of the prosthetic segments which are to be deployed in the body lumen.

Abstract: This is a surgical device usually delivered through an intravascular catheter. It may be used in several ways. It may, for instance, be used to open a clear passageway adjacent thrombus to allow both blood and medication to bypass the clot. It may be used to pierce and to remove thrombus. These thrombus are often found in tortuous vasculature. The device includes several sections. The device has a core element, typically a core wire. Placed around the distal end of the core element is a collapsible but preferably self expanding proximal cage assembly and a distal filter, preferably a self-expanding cage assembly or other filter component. The various portions of those components are preferably radio-opaque. The proximal end of the proximal cage is typically is affixed to an actuator in such a way as to allow expansion of the cage after deployment.