Abstract: Apparatus and methods for delivering prosthetic segments to a body lumen, utilize a device having an elongated flexible member including proximal and distal ends, a plurality of prosthetic segments releasably arranged axially along the elongated flexible member near the distal end and an outer sheath slidably disposed over at least a portion of the prosthetic segments. The apparatus further includes a separator disposed on the outer sheath and adapted to engage the prosthetic segments. The separator is also adapted to be retracted proximally over the prosthetic segments and advanced distally to separate a proximal group of the prosthetic segments from a distal group of the prosthetic segments which are to be deployed in the body lumen.

Abstract: An embolism treatment device includes an elongated core wire having a coil tip coupled to the distal end of the core wire and a cage assembly substantially coaxial to the core wire, having a first deployment shape and a second expanded shape. The core wire is freely moveable axially through the cage assembly. The device additionally includes an inner coil surrounding the core wire within the cage assembly and an actuator element, having a first position and a second position, located proximally to the cage assembly, wherein when the actuator element is in the first position, the cage assembly is in the first deployment shape and when the actuator element is in the second position, the cage assembly is in the second expanded shape.

Abstract: Disclosed herein is an implantable fistula closure device. The device may include an expandable longitudinally segmented body including a proximal end and a distal end. The segmented body may further include a plurality of porous bodies and a connecting member operably joining together the plurality of porous bodies. The plurality of porous bodies includes a first porous body with a proximal end and a distal end and a second porous body with a proximal end and a distal end, and the connecting member operably connects the proximal end of the first porous body with the distal end of the second porous body.

Abstract: In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.

Abstract: An system for reducing a fracture in an vertebral body is disclosed herein. The system may include incremental implant elements and a delivery device. The incremental implant elements are configured for percutaneous delivery into, and accumulation within, a volume of the vertebral body. The delivery device is configured to percutaneously deliver the incremental implant elements into the volume of the vertebra body in an incremental fashion. As the incremental implant elements are incrementally delivered into the volume of the vertebra body, the accumulation of the incremental members in the volume of the vertebra body places the fracture in the vertebra body in a reduced state.

Abstract: An intramedullary bone fixation device is disclosed herein. The device includes a first longitudinally extending member, a second longitudinally extending member, and a coupling member. The first longitudinally extending member includes a connector end and a bone engagement end opposite the connector end. The second longitudinally extending member includes a connector end and a bone engagement end opposite the connector end. The coupling member is configured to engage the connector ends of the respective longitudinally extending members, thereby coupling the first longitudinally extending member to the second longitudinally extending member. The device may be provided in an kit form at least partially unassembled. The device may be delivered into a fracture and fully assembled within the fracture or adjacent bone via percutaneous or minimally invasive surgical procedures. The device, on account of its configuration and assembly, may be considered modular in some cases.

Abstract: In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.

Abstract: An apparatus for mixing and dispensing a multi-component compound. The device includes a tubular body with an internal chamber for mixing the multi-component compound. Disposed within and extending beyond the tubular body is a rod having a mixing disc located near a distal end. Also disposed within the tubular body is a moveable piston with a central opening through which the rod may pass.

Abstract: Devices and methods are provided for treating a bone structure (such as, e.g., reducing a bone fracture, e.g., a vertebral compression fracture, or stabilizing adjacent bone structure, e.g., vertebrae) is provided. The device comprises rigid or semi-rigid members, each of which comprises a common base and a plurality of ribs that extent along the a longitudinal portion of the common base. The device is configured to be placed in a collapsed state by engaging the pluralities of ribs of the members in an interposed arrangement, and configured to be placed in a deployed state by disengaging the pluralities of ribs. The ribs can be any shape, e.g., flutes, that allows opposing ribs to intermesh with one another. In this manner, the device has a relatively small profile when placed in the collapsed state, so that it can be introduced through small openings within the bone structure, while preserving the shear strength of the members during deployment of the device.

Abstract: In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.

Abstract: In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.

Abstract: A device for removing blood clots and methods of making and using the same. The clot pulling device may include a shaft and one or more strut members that each may include a loop region. The proximal ends of the strut members may be attached to the shaft and the distal ends of the strut members may be coupled to the shaft.

Abstract: Devices, kits, and methods are provided for treating a bone structure, e.g., a vertebra, with a compression fracture. Wedges can be introduced into the bone structure in a direction that is lateral to the compression fracture, and stacked on tope of each to apply forces to the bone structure to reduce the compression fracture. The wedges can be introduced into the bone structure using a cannula. The wedges can be introduced as wedge pairs, in which case, a subsequent wedge pair can be introduced between a previously introduced wedge pair in order to drive the previously introduced wedges apart to create the stacking arrangement. Optionally, the wedges can be provided with longitudinal bores, in which case, they can be introduced into the bone structure, over a guide member that is threaded through the bores.

Abstract: This is a device for bridging the neck of either an aneurysm in the vasculature and stabilizing the presence of vaso-occlusive devices (such as helically wound coils) in that aneurysm. The closure patch may be delivered either from the exterior of the distal end of a catheter or delivered from the catheter lumen. It is preferably implanted by the severance of an included electrolytically severable joint. The retainer assembly itself typically has a number of radially projecting elements which are, in turn, attached to a scrim-like fabric, preferably collagen-coated Dacron, extending among the various radially projecting elements. The closure patch is intended to be resident within the aneurysm after it is deployed. After deployment, the aneurysm may be at least partially filled with vaso-occlusive devices such as helically wound coils.

Abstract: An apparatus for delivering bone cement into a vertebra includes a cannula and a syringe pivotally coupled to the cannula. Preferably, the syringe is pivotally coupled to the cannula by a pivot fitting that may be detachable from one or both of the cannula and the syringe. The syringe includes a piston slidable in a barrel for advancing the bone cement through an outlet communicating with the cannula. A shaft and cable arrangement or a fluid-driven system may be used to advance the piston within the syringe. The cannula is inserted into a vertebra, and is connected to the syringe. The syringe is pivoted to a desired position, and bone cement is delivered from the syringe through the cannula and into the vertebra.

Abstract: Compositions comprising devices for retrieving objects from a subject, for example the subject's vasculature, are described. In particular, devices including a catheter shaft having a lumen through which a core wire extends are provided. Proximal and distal junction members are disposed around the core wire and at least one junction member is permanently and slidably attached to the core wire. In addition, the device includes a retrieval element as well as a stop element that is attached to the core wire distal to the catheter shaft. Also described are methods of making and using these devices.

Abstract: An apparatus for delivering bone cement into a vertebra includes a cannula and a syringe pivotally coupled to the cannula. Preferably, the syringe is pivotally coupled to the cannula by a pivot fitting that may be detachable from one or both of the cannula and the syringe. The syringe includes a piston slidable in a barrel for advancing the bone cement through an outlet communicating with the cannula. A shaft and cable arrangement or a fluid-driven system may be used to advance the piston within the syringe. The cannula is inserted into a vertebra, and is connected to the syringe. The syringe is pivoted to a desired position, and bone cement is delivered from the syringe through the cannula and into the vertebra.

Abstract: Compositions comprising devices for retrieving objects from a subject, for example the subject's vasculature, are described. Also described are methods of making and using these devices.

Abstract: In one embodiment, a neck bridge for bridging the neck of an aneurysm includes a junction region, a number of radially extending array elements attached to the junction region, and a cover attached to one or both of the junction region and an array element. The array elements are configured to be positioned within the aneurysm after the neck bridge is deployed from a delivery device. In a second embodiment, the neck bridge includes a junction region and a braided or mesh-like structure secured to the junction region. The braided or mesh-like structure is made from an elastic material.

Abstract: Disclosed herein are methods of occluding a selected target site using rapidly expanding materials.