Patents by Inventor Harold Kleanthous

Harold Kleanthous has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant bicistronic vectors
    Patent number: 8486417
    Abstract: This invention relates to bicistronic flavivirus vectors, methods of using such vectors in the prevention and treatment of disease, and methods of making such vectors.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: July 16, 2013
    Assignee: Sanofi Pasteur Biologics, LLC
    Inventors: Simon Delagrave, Nathan Brown, Harold Kleanthous, Farshad Guirakhoo, Alexander Rumyantsev
  • Replication-Defective Flavivirus Vaccines and Vaccine Vectors
    Publication number: 20110135686
    Abstract: This invention provides replication-defective flavivirus vaccines and vaccine vectors, and corresponding compositions and methods.
    Type: Application
    Filed: March 16, 2009
    Publication date: June 9, 2011
    Applicant: Sanofi Pasteur Biologics Co.
    Inventors: Konstantin V. Pugachev, Alexander A. Rumyantsev, Maryann Giel-Moloney, Harold Kleanthous
  • Recombinant Rhinovirus Vectors
    Publication number: 20110091501
    Abstract: The invention provides rhinovirus vectors, which can be used in the delivery of immunogens, such as influenza virus immunogens, and corresponding compositions and methods.
    Type: Application
    Filed: March 27, 2009
    Publication date: April 21, 2011
    Applicant: SANOFI PASTEUR BIOLOGICS CO.
    Inventors: Kirill Kalnin, Yanhua Yan, Maryann Giel-Moloney, Harold Kleanthous
  • Chimeric flavivirus vectors
    Publication number: 20110014229
    Abstract: The invention provides chimeric flavivirus vectors including foreign peptides inserted into the envelope proteins of the vectors and methods of using these vectors.
    Type: Application
    Filed: July 14, 2009
    Publication date: January 20, 2011
    Applicant: Sanofi Pasteur Biologics Co.
    Inventors: Harold Kleanthous, Charles Miller, Larisa Oros
  • Novel Neutralizing Immunogen (NIMIV) of Rhinovirus and its Use for Vaccine Applications
    Publication number: 20100297169
    Abstract: The invention relates to methods and compositions for preventing or treating human rhinovirus infection.
    Type: Application
    Filed: October 1, 2007
    Publication date: November 25, 2010
    Applicant: Sanofi Pasteur Biologics Co.
    Inventors: Kirill Kalnin, Yanhua Yan, Harold Kleanthous
  • Recombinant Rhinovirus Vectors
    Publication number: 20100239605
    Abstract: The invention provides recombinant rhinovirus vectors including, for example, influenza virus antigens. Also provided by the invention are corresponding pharmaceutical compositions and methods.
    Type: Application
    Filed: October 1, 2007
    Publication date: September 23, 2010
    Applicant: Sanofi Pasteur Biologics Co.
    Inventors: Kirill Kalnin, Yanhua Yan, Harold Kleanthous
  • Recombinant Bicistronic Flavivirus Vectors
    Publication number: 20100034849
    Abstract: This invention relates to bicistronic flavivirus vectors, methods of using such vectors in the prevention and treatment of disease, and methods of making such vectors.
    Type: Application
    Filed: January 31, 2008
    Publication date: February 11, 2010
    Applicant: Sanofi Pasteur Biologics Co.
    Inventors: Simon Delagrave, Nathan Brown, Harold Kleanthous, Farshad Guirakhoo, Alexander Rumyantsev
  • Chimeric flavivirus vectors
    Patent number: 7569383
    Abstract: The invention provides chimeric flavivirus vectors including foreign peptides inserted into the envelope proteins of the vectors and methods of using these vectors.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: August 4, 2009
    Assignee: Acambis Inc.
    Inventors: Harold Kleanthous, Charles Miller, Larisa Oros
  • Identification of polynucleotides encoding novel helicobacter polypeptides in the helicobacter genome
    Publication number: 20030158396
    Abstract: The invention provides Helicobacter polypeptides that can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
    Type: Application
    Filed: June 15, 2001
    Publication date: August 21, 2003
    Inventors: Harold Kleanthous, Amal Al-Garawi, Charles Miller, Jean-Francois Tomb, Raymond P. Oomen
  • Helicobacter GHPO 1360 and GHPO 750 polypeptides and corresponding polynucleotide molecules
    Publication number: 20030143242
    Abstract: The invention provides Helicobacter polypeptides, designated GHPO 1360 and GHPO 750, which can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
    Type: Application
    Filed: January 3, 2002
    Publication date: July 31, 2003
    Inventors: Harold Kleanthous, Ling Lissolo, Jean-Francois Tomb, Charles Miller, Amal Al-Garawi
  • Helicobacter polypeptides and corresponding polynucleotide molecules
    Publication number: 20030124141
    Abstract: The invention provides Helicobacter polypeptides that can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
    Type: Application
    Filed: November 16, 2001
    Publication date: July 3, 2003
    Inventors: Rainer Haas, Harold Kleanthous, Jean-Francois Tomb, Charles Miller, Amal Al-Garawi, Stefan Odenbreit, Thomas Meyer
  • Use of Salmonella vectors for vaccination against helicobacter infection
    Patent number: 6585975
    Abstract: The invention provides a method of immunization against Helicobacter, involving mucosal administration of an attenuated Salmonella vector including a nucleic acid molecule encoding a Helicobacter antigen, and parenteral administration of a soluble Helicobacter antigen, co-administered with a suitable parenteral adjuvant. Also provided by the invention are attenuated Salmonella vectors for use in this method.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: July 1, 2003
    Assignee: Acambis, Inc.
    Inventors: Harold Kleanthous, Patricia Londono-Arcila, Donna Freeman, Cynthia K. Lee, Thomas P. Monath
  • Helicobacter antigens and corresponding DNA fragments
    Publication number: 20030069404
    Abstract: The invention provides Helicobacter polypeptides that can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
    Type: Application
    Filed: November 5, 2001
    Publication date: April 10, 2003
    Inventors: Rainer Haas, Harold Kleanthous, Thomas F. Meyer, Stefan Odenbreit, Amal A. Al-Garawi, Charles A. Miller
  • Chimeric flavivirus vectors
    Publication number: 20030044773
    Abstract: The invention provides chimeric flavivirus vectors including foreign peptides inserted into the envelope proteins of the vectors and methods of using these vectors.
    Type: Application
    Filed: May 31, 2002
    Publication date: March 6, 2003
    Inventors: Harold Kleanthous, Charles Miller, Larisa Oros
  • HELICOBACTER POLYPEPTIDES AND CORRESPONDING POLYNUCLEOTIDE MOLECULES
    Publication number: 20030023066
    Abstract: The invention provides Helicobacter polypeptides that can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
    Type: Application
    Filed: April 1, 1997
    Publication date: January 30, 2003
    Inventors: RAINER HAAS, HAROLD KLEANTHOUS, JEAN-FRANCOIS TOMB, CHARLES MILLER, AMAL AL-GARAWI, STEFAN ODENBREIT, THOMAS MEYER
  • Identification of polynucleotides encoding novel helicobacter polypeptides in the helicobacter genome
    Publication number: 20020160456
    Abstract: The invention provides Helicobacter polypeptides that can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
    Type: Application
    Filed: June 29, 2001
    Publication date: October 31, 2002
    Inventors: Harold Kleanthous, Amal Al-Garawi, Charles Miller, Jean-Francois Tomb, Raymond P. Oomen
  • Identification of polynucleotides encoding novel helicobacter polypeptides in the helicobacter genome
    Publication number: 20020115078
    Abstract: The invention provides Helicobacter polypeptides that can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
    Type: Application
    Filed: June 18, 2001
    Publication date: August 22, 2002
    Inventors: Harold Kleanthous, Amal Al-Garawi, Charles Miller, Jean-Francois Tomb, Raymond P. Oomen
  • 76 KDA HELICOBACTER POLYPEPTIDES AND CORRESPONDING POLYNUCLEOTIDE MOLECULES
    Publication number: 20020044949
    Abstract: The invention provides 76 kDa Helicobacter polypeptides, which can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
    Type: Application
    Filed: April 1, 1997
    Publication date: April 18, 2002
    Inventors: HAROLD KLEANTHOUS, LING LISSOLO, JEAN-FRANCOIS TOMB, CHARLES MILLER, AMAL AL-GARAWI
  • HELICOBACTER GHPO 1360 AND GHPO 750 POLYPEPTIDES AND CORRESPONDING POLYNUCLEOTIDE MOLECULES
    Publication number: 20020026035
    Abstract: The invention provides Helicobacter polypeptides, designated GHPO 1360 and GHPO 750, which can be used in vaccination methods for preventing or treating Helicobacter infection, and polynucleotides that encode these polypeptides.
    Type: Application
    Filed: April 1, 1997
    Publication date: February 28, 2002
    Inventors: HAROLD KLEANTHOUS, LING LISSOLO, JEAN-FRANCOIS TOMB, CHARLES MILLER, AMAL AL-GARAWI
  • Multimeric, recombinant urease vaccine
    Patent number: 5837240
    Abstract: Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: November 17, 1998
    Assignee: OraVax-Merieux Co.
    Inventors: Cynthia K. Lee, Thomas P. Monath, Samuel K. Ackerman, William D. Thomas, Gopalan Soman, Harold Kleanthous, Richard A. Weltzin, Jacques Pappo, Thomas Ermak, Farshad Guirakhoo, Hitesh Bhagat, Ilene Sussman