Patents by Inventor Harri Jukarainen
Harri Jukarainen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240226053Abstract: A controlled release pharmaceutical composition for eye injection for ophthalmic care. The composition comprises at least one active pharmaceutical ingredient and at least one biocompatible polymer and at least one biocompatible solvent. The composition, which is capable of forming an in-situ implant composition, comprises an injectable solution, suspension, emulsion or dispersion. The formulation can be injected through a needle that is suitable in size for an eye injection. The present compositions can be used for treatment of ophthalmic conditions, including glaucoma, dry and wet age-related macular degeneration, diabetic retinopathy, dry eye syndrome, and uveitis.Type: ApplicationFiled: February 21, 2022Publication date: July 11, 2024Inventors: Harri Jukarainen, Jukka Tuominen, Jonathan Glen, Robert Watson
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Publication number: 20240173163Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).Type: ApplicationFiled: November 30, 2023Publication date: May 30, 2024Applicant: Bayer OyInventors: Heikki LYYTIKÄINEN, Ilkka JUTILA, Ulla Calvo ALONSO, Harri JUKARAINEN, Taina TRÄDER, Andrew MACLEOD, Michael NOBLE, David WHITAKER
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Publication number: 20240130997Abstract: A controlled release pharmaceutical composition for eye injection for ophthalmic care. The composition comprises at least one active pharmaceutical ingredient and at least one biocompatible polymer and at least one biocompatible solvent. The composition, which is capable of forming an in-situ implant composition, comprises an injectable solution, suspension, emulsion or dispersion. The formulation can be injected through a needle that is suitable in size for an eye injection. The present compositions can be used for treatment of ophthalmic conditions, including glaucoma, dry and wet age-related macular degeneration, diabetic retinopathy, dry eye syndrome, and uveitis.Type: ApplicationFiled: February 21, 2022Publication date: April 25, 2024Inventors: Harri Jukarainen, Jukka Tuominen, Jonathan Glen, Robert Watson
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Patent number: 11872155Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).Type: GrantFiled: February 17, 2020Date of Patent: January 16, 2024Assignee: Bayer OyInventors: Heikki Lyytikäinen, Ilkka Jutila, Ulla Calvo Alonso, Harri Jukarainen, Taina Träder, Andrew MacLeod, Michael Noble, David Whitaker
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Publication number: 20240009116Abstract: The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material. A further object of the invention is to fabricate drug-containing T-intrauterine systems (IUS) with the drug incorporated within the entire backbone of the medical device by using 3D printing technique, based on fused deposition modelling (FDM™). Indomethacin was used to prepare drug-loaded poly-caprolactone (PCL)-based filaments with different drug contents 5-40 wt %, namely 5%, 15% and 30% wt %:of Indomethacin.Type: ApplicationFiled: June 5, 2023Publication date: January 11, 2024Inventors: Harri JUKARAINEN, Jyrki PIHLAJA, Savante HOLMBERG, Tuula VALO, Anu-Liisa HONKA, Jenny HOLLAENDER
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Patent number: 11744798Abstract: An injectable pharmaceutical formulation includes nanofibrillar cellulose hydrogel wherein the content of nanofibrillar cellulose in the pharmaceutical formulation is the range of 1-8% (w/w), and pharmaceutical compound. The injectable pharmaceutical formulation can provide a sustained release of a pharmaceutical compound in a subject. Use of nanofibrillar cellulose for preparing the injectable pharmaceutical formulation is also disclosed.Type: GrantFiled: September 9, 2020Date of Patent: September 5, 2023Assignee: UPM-KYMMENE CORPORATIONInventors: Markus Nuopponen, Lauri Paasonen, Anne Meriluoto, Jukka Rissanen, Harri Jukarainen
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Patent number: 11432958Abstract: The present invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a movable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2).Type: GrantFiled: March 9, 2020Date of Patent: September 6, 2022Assignee: Bayer OyInventors: Heikki Lyytikäinen, Ilkka Jutila, Ulla Calvo Alonso, Harri Jukarainen, Taina Tjäder, Andrew Macleod, Michael Noble, David Whitaker
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Patent number: 11389537Abstract: A drug delivery system for sustained delivery of bioactive agents, the system includes a matrix including nanofibrillated cellulose derived from plant based material and at least one bioactive agent, and at least one support selected from synthetic polymers, bio compounds and natural polymers. Also, methods for the manufacture of the system and methods of using it.Type: GrantFiled: November 15, 2012Date of Patent: July 19, 2022Assignee: UPM-KYMMENE CORPORATIONInventors: Antti Laukkanen, Ruzica Kolakovic, Leena Peltonen, Timo Laaksonen, Jouni Hirvonen, Heikki Lyytikainen, Harri Jukarainen, Prijo Kortesuo
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Publication number: 20210085602Abstract: An injectable pharmaceutical formulation includes nanofibrillar cellulose hydrogel wherein the content of nanofibrillar cellulose in the pharmaceutical formulation is the range of 1-8% (w/w), and pharmaceutical compound. The injectable pharmaceutical formulation can provide a sustained release of a pharmaceutical compound in a subject. Use of nanofibrillar cellulose for preparing the injectable pharmaceutical formulation is also disclosed.Type: ApplicationFiled: September 9, 2020Publication date: March 25, 2021Inventors: Markus NUOPPONEN, Lauri PAASONEN, Anne MERILUOTO, Jukka RISSANEN, Harri JUKARAINEN
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Publication number: 20200283568Abstract: Provided herein is a bioresorbable polyester wherein the metal content of the polyester is >0 ppm and <40 ppm, a controlled release pharmaceutical composition containing such polyesters, and a kit for injecting a controlled release pharmaceutical composition. Also provided herein is a method of purifying a bioresorbable polyester with a metal content >0 ppm comprising the steps of: i) dissolving the polyester in an organic solvent to form a polyester-solvent solution, wherein the organic solvent comprises at least one heteroatom selected from oxygen, nitrogen, sulphur and phosphorus; ii) precipitating the polyester from the polyester-solvent solution by combining the polyester-solvent solution with an organic non-solvent, said non-solvent being an alcohol; and (iii) separating the precipitated polyester from the solvent and non-solvent to obtain a purified polyester.Type: ApplicationFiled: November 20, 2018Publication date: September 10, 2020Inventors: Jonathan Glen, Harri Jukarainen, Jukka Tuominen
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Publication number: 20200206021Abstract: The present invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a movable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2).Type: ApplicationFiled: March 9, 2020Publication date: July 2, 2020Applicant: Bayer OyInventors: Heikki Lyytikäinen, Ilkka Jutila, Ulla Calvo Alonso, Harri Jukarainen, Taina Tjäder, Andrew Macleod, Michael Noble, David Whitaker
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Publication number: 20200179159Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).Type: ApplicationFiled: February 17, 2020Publication date: June 11, 2020Applicant: Bayer OyInventors: Heikki LYYTIKÄINEN, Ilkka JUTILA, Ulla Calvo ALONSO, Harri JUKARAINEN, Taina TRÄDER, Andrew MACLEOD, Michael NOBLE, David WHITAKER
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Patent number: 10583035Abstract: The present invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8 a) and a second end (8 b), a movable slider (5) arranged in said longitudinal opening (8) and having a first end (5 a) and a second end (5 b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2).Type: GrantFiled: July 11, 2017Date of Patent: March 10, 2020Assignee: Bayer OyInventors: Heikki Lyytikäinen, Ilkka Jutila, Ulla Calvo Alonso, Harri Jukarainen, Taina Tjäder, Andrew Macleod, Michael Noble, David Whitaker
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Patent number: 10561524Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).Type: GrantFiled: February 7, 2018Date of Patent: February 18, 2020Assignee: Bayer OyInventors: Heikki Lyytikäinen, Ilkka Jutila, Ulla Calvo Alonso, Harri Jukarainen, Taina Träder, Andrew Macleod, Michael Noble, David Whitaker
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Patent number: 10532025Abstract: The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time.Type: GrantFiled: May 18, 2018Date of Patent: January 14, 2020Assignee: Bayer OyInventors: Bernd Duesterberg, Manja Ahola, Jyrki Pihlaja, Heikki Lyytikäinen, Harri Jukarainen, Satu Kleemola, Tero Parkatti, Tuula Valo, Ina Gröticke, Bernhard Lindenthal, Ulrike Fuhrmann
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Patent number: 10500381Abstract: The present invention provides a novel drug delivery system for the controlled release of therapeutically active substances at a predetermined, essentially constant release rate over a prolonged period of time. The delivery system comprises at least one core comprising said therapeutically active substance(s), at least one membrane encasing the core and an intermediary layer of a substantially inert material, wherein the intermediary layer is applied between the core and the membrane or between two membrane layers.Type: GrantFiled: January 22, 2013Date of Patent: December 10, 2019Assignee: BAYER OYInventors: Heikki Lyytikäinen, Harri Jukarainen
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Publication number: 20180263899Abstract: The invention relates to a method for contraception and for reducing menstrual problems and inducing amcnorrhca, whcrcin an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time.Type: ApplicationFiled: May 18, 2018Publication date: September 20, 2018Applicant: Bayer OyInventors: Bernd Duesterberg, Manja Ahola, Jyrki Pihlaja, Heikki Lyytikäinen, Harri Jukarainen, Satu Kleemola, Tero Parkatti, Tuula Valo, Ina Gröticke, Bernhard Lindenthal, Ulrike Fuhrmann
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Patent number: 9999592Abstract: The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time.Type: GrantFiled: July 3, 2013Date of Patent: June 19, 2018Assignee: Bayer OyInventors: Bernd Duesterberg, Manja Ahola, Jyrki Pihlaja, Heikki Lyytikäinen, Harri Jukarainen, Satu Kleemola, Tero Parkatti, Tuula Valo, Ina Gröticke, Bernhard Lindenthal, Ulrike Fuhrmann
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Publication number: 20180161196Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).Type: ApplicationFiled: February 7, 2018Publication date: June 14, 2018Applicant: Bayer OyInventors: Heikki LYYTIKÄINEN, Ilkka JUTILA, Ulla Calvo ALONSO, Harri JUKARAINEN, Taina TRÄDER, Andrew MACLEOD, Michael NOBLE, David WHITAKER
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Patent number: 9949869Abstract: The present invention relates to novel intrauterine systems and to methods for manufacturing these systems. An intrauterine system according to the invention comprises a reservoir and a continuous, closed and flexible frame. The frame comprises a thermoplastic polyurethane elastomer made of a polycarbonate diol, 1,6-hexamethylenediisocyanate, and a chain extender.Type: GrantFiled: September 30, 2010Date of Patent: April 24, 2018Assignee: BAYER OYInventors: Taina Tjäder, Ulla Calvo Alonso, Pirjo Inki, Harri Jukarainen, Ilkka Jutila, Pirjo Kortesuo, Juha Lehtinen, Eeva Lukkari-Lax, Heikki Lyytikäinen, Joachim Moede, Hannu Nikander, Pirjo Sallinen, Faisal Shafiq, Wolfgang Kaufhold, Christian Wamprecht