Patents by Inventor Harri Jukarainen
Harri Jukarainen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170367876Abstract: The present invention relates to novel intrauterine systems and to methods for manufacturing these systems. An intrauterine system according to the invention comprises a reservoir and a continuous, closed and flexible frame.Type: ApplicationFiled: August 1, 2017Publication date: December 28, 2017Inventors: Pirjo Kortesuo, Ulla Calvo-Alonso, Pirjo lnki, Harri Jukarainen, llkka Jutila, Juha Lehtinen, Eeva Lukkari-Lax, Heikki Lyytikäinen, Joachim Moede, Hannu Nikander, Pirjo Sallinen, Taina Tjäder, Andrew Macleod, Michael Noble, David Whitaker
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Publication number: 20170312219Abstract: The invention is related to an improved method of contraception, for preventing or suppressing abnormal and/or irregular endometrial bleeding and achieving a rapid induction of amenorrhea by using an intrauterine delivery system comprising controlled release levonorgestrel over a prolonged period of time and at a therapeutic level required for contraception, and a sufficient amount of NSAID capable of suppressing abnormal and/or irregular endometrial bleedingType: ApplicationFiled: July 14, 2017Publication date: November 2, 2017Applicant: Bayer OyInventors: Bernd Duesterberg, Manja Ahola, Jyrki Pihlaja, Heikki Lyytikäinen, Harri Jukarainen, Satu Kleemola, Tero Parkatti, Tuula Valo, Ina Gröticke, Bernhard Lindenthal, Ulrike Fuhrmann
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Patent number: 9707123Abstract: The present invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a movable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2).Type: GrantFiled: January 6, 2015Date of Patent: July 18, 2017Assignee: Bayer OyInventors: Heikki Lyytikäinen, Ilkka Jutila, Ulla Calvo Alonso, Harri Jukarainen, Taina Tjäder, Andrew Macleod, Michael Noble, David Whitaker
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Publication number: 20170196728Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).Type: ApplicationFiled: March 27, 2017Publication date: July 13, 2017Applicant: Bayer OyInventors: Heikki LYYTIKÄINEN, Ilkka JUTILA, Ulla Calvo ALONSO, Harri JUKARAINEN, Taina TRÄDER, Andrew MACLEOD, Michael NOBLE, David WHITAKER
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Patent number: 9615965Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).Type: GrantFiled: August 23, 2016Date of Patent: April 11, 2017Assignee: Bayer OyInventors: Heikki Lyytikäinen, Ilkka Jutila, Ulla Calvo Alonso, Harri Jukarainen, Taina Träder, Andrew MacLeod, Michael Noble, David Whitaker
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Publication number: 20160361193Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).Type: ApplicationFiled: August 23, 2016Publication date: December 15, 2016Applicant: Bayer OyInventors: Heikki LYYTIKÄINEN, Ilkka JUTILA, Ulla Calvo ALONSO, Harri JUKARAINEN, Taina TRÄDER, Andrew MACLEOD, Michael NOBLE, David WHITAKER
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Patent number: 9452082Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).Type: GrantFiled: November 22, 2013Date of Patent: September 27, 2016Assignee: Bayer OyInventors: Heikki Lyytikäinen, Ilkka Jutila, Ulla Calvo Alonso, Harri Jukarainen, Taina Träder, Andrew Macleod, Michael Noble, David Whitaker
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Publication number: 20150359802Abstract: The present invention for the treatment of endometriosis relates to providing a parenteral dosage form (delivery system) for the controlled release of an aromatase inhibitor (AI) in a daily release rate that does not induce stimulation of the ovaries by negative feed-back of the pituitary-ovarian-axis (which would cause secretion of gonadotropins and stimulation of ovarian follicular growth) and a gestagen in a daily release rate below the ovulation inhibition dose that provides contraceptive efficacy based on local effects (e.g. reducing and thickening of the cervical mucus impairing sperm ascension, effects on the endometrium and on tubal motility impairing implantation and egg transport).Type: ApplicationFiled: June 18, 2015Publication date: December 17, 2015Inventors: Arto PAKKALIN, Rudolf KNAUTHE, Heinz SCHMITZ, Christine TALLING, Harri JUKARAINEN, Henriikka KOROLAINEN
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Publication number: 20150119372Abstract: The present invention describes intrauterine use of 18-methyl-15?,16?-methylene-19-nor-20-spirox-4-en-3-ones of the general formula (1) wherein R6 and R7 are hydrogen or a methylene group, in the treatment of menorrhagia, of uterine haemorrhages in general, and an intrauterine system for said use, comprising a compound of formula 1.Type: ApplicationFiled: April 19, 2013Publication date: April 30, 2015Inventors: Norbert Schmees, Lars Röse, Tuula Valo, Katja Prelle, Reinhard Nubbemeyer, Henriikka Korolainen, Harri Jukarainen
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Publication number: 20150114402Abstract: The present invention relates to an inserter for an intrauterine system, comprising a handle (3) having a longitudinal opening (8) at its first end, said opening (8) having a longitudinal axis parallel to the longitudinal axis of the inserter, a first end (8a) and a second end (8b), a movable slider (5) arranged in said longitudinal opening (8) and having a first end (5a) and a second end (5b), a plunger (2) attached to the handle (3) and having a longitudinal axis, and an insertion tube (6) having a first end, a second end and a longitudinal axis essentially parallel to the longitudinal axis of the plunger (2), the insertion tube (6) being, along said longitudinal axis, movably arranged around the plunger (2).Type: ApplicationFiled: January 6, 2015Publication date: April 30, 2015Inventors: Heike Lyyikainen, Iikka Jutila, Calvo Alonson, Harri Jukarainen, Taina Tjader, Andrew Macleod, Michael Noble, David Whitaker
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Publication number: 20150065472Abstract: The present invention describes intrauterine use of 18-methyl-15?,16?-methylene-19-nor-20-spirox-4-en-3-ones of the general formula (1) in contraception and gynaecological treatment, and an intrauterine system comprising compounds of formula 1.Type: ApplicationFiled: April 19, 2013Publication date: March 5, 2015Applicant: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Norbert Schmees, Lars Röse, Tuula Valo, Katja Prelle, Reinhard Nubbemeyer, Henriikka Korolainen, Harri Jukarainen
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Publication number: 20150051481Abstract: The present invention relates to novel intrauterine systems and to methods for manufacturing these systems. An intrauterine system according to the invention comprises a reservoir and a continuous, closed and flexible frame.Type: ApplicationFiled: October 24, 2013Publication date: February 19, 2015Applicant: Bayer OYInventors: Pirjo KORTESUO, Ulla Calvo-Alonso, Pirjo Inki, Harri Jukarainen, Ilkka Jutila, Juha Lehtinen, Eeva Lukkari-Lax, Heikki Lyytikäinen, Joachim Moede, Hannu Nikander, Pirjo Sallinen, Taina Tjäder, Andrew Macleod, Michael Noble, David Whitaker
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Publication number: 20140350488Abstract: The present invention provides a novel drug delivery system for the controlled release of therapeutically active substances at a predetermined, essentially constant release rate over a prolonged period of time. The delivery system comprises at least one core comprising said therapeutically active substance(s), at least one membrane encasing the core and an intermediary layer of a substantially inert material, wherein the intermediary layer is applied between the core and the membrane or between two membrane layers.Type: ApplicationFiled: January 22, 2013Publication date: November 27, 2014Inventors: Heíkkí Lyytikäinen, Harri Jukarainen
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Publication number: 20140322327Abstract: A drug delivery system for sustained delivery of bioactive agents, the system includes a matrix including nanofibrillated cellulose derived from plant based material and at least one bioactive agent, and at least one support selected from synthetic polymers, bio compounds and natural polymers. Also, methods for the manufacture of the system and methods of using it.Type: ApplicationFiled: November 15, 2012Publication date: October 30, 2014Applicant: UPM-KYMMENE CORPORATIONInventors: Antti Laukkanen, Ruzica Kolakovic, Leena Peltonen, Timo Laaksonen, Jouni Hirvonen, Heikki Lyytikainen, Harri Jukarainen, Prijo Kortesuo
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Publication number: 20140309598Abstract: The present invention relates to the field of drug delivery systems. More particularly, the invention relates to osmotically active intravaginal delivery systems for the controlled release of therapeutically active substances to the vaginal cavity.Type: ApplicationFiled: November 1, 2012Publication date: October 16, 2014Applicant: BAYER OYInventors: Manja Ahola, Stefan Bracht, Harri Jukarainen, Pirjo Kortesuo, Heikki Lyytikäinen, Mikael Stolt
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Publication number: 20140127280Abstract: The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a combination of progestogen or a drug having a progestogenic activity and at least one therapeutically active substance capable of preventing or suppressing abnormal and/or irregular endometrial bleeding over a prolonged period of time.Type: ApplicationFiled: July 3, 2013Publication date: May 8, 2014Inventors: Bernd Duesterberg, Manja Ahola, Jyrki Pihlaja, Heikki Lyytikäinen, Harri Jukarainen, Satu Kleemola, Tero Parkatti
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Publication number: 20140076328Abstract: The present invention relates to an inserter for an intrauterine system comprising a handle (3), and an insertion tube (6) having a first end and a second end, and being arranged in connection with the handle. The inserter is characterized in that the first end of the insertion tube (6) comprises at least one frame slot for receiving a frame of the intrauterine system. The invention also relates to a kit comprising an inserter according to the present invention and an intrauterine system, wherein the intrauterine system (1) comprises a therapeutic component (1b) and a continuous, closed frame (1a), the therapeutic component (1b) being connected to the frame (1a) at least one point, and therapeutic component (1b) of the intrauterine system (1) is at least mainly arranged inside the first end of the insertion tube (6) and the frame (1a) of the intrauterine system (1) is at least mainly arranged outside the first end of the insertion tube (6).Type: ApplicationFiled: November 22, 2013Publication date: March 20, 2014Applicant: Bayer OyInventors: Heikki Lyytikäinen, Ilkka Jutila, Ulla Calvo Alonso, Harri Jukarainen, Taina Träder, Andrew Macleod, Michael Noble, David Whitaker
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Publication number: 20130131027Abstract: The present invention for the treatment of endometriosis relates to providing a parenteral dosage form (delivery system) for the controlled release of an aromatase inhibitor (AI) in a daily release rate that does not induce stimulation of the ovaries by negative feed-back of the pituitary-ovarian-axis (which would cause secretion of gonadotropins and stimulation of ovarian follicular growth) and a gestagen in a daily release rate below the ovulation inhibition dose that provides contraceptive efficacy based on local effects (e.g. reducing and thickening of the cervical mucus impairing sperm ascension, effects on the endometrium and on tubal motility impairing implantation and egg transport).Type: ApplicationFiled: March 28, 2011Publication date: May 23, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Arto Pakkalin, Rudolf Knauthe, Heinz Schmitz, Christine Talling, Harri Jukarainen, Henriikka Korolainen
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Publication number: 20120272969Abstract: The present invention relates to novel intrauterine systems and to methods for manufacturing these systems. An intrauterine system according to the invention comprises a reservoir and a continuous, closed and flexible frame. The frame comprises a thermoplastic polyurethane elastomer made of a polycarbonate diol, 1,6-hexamethylenediisocyanate, and a chain extender.Type: ApplicationFiled: September 30, 2010Publication date: November 1, 2012Applicant: BAYER OYInventors: Taina Tjäder, Ulla Calvo Alonso, Pirjo Inki, Harri Jukarainen, Ilkka Jutila, Pirjo Kortesuo, Juha Lehtinen, Eeva Lukkari-Lax, Heikki Lyytikäinen, Joachim Moede, Hannu Nikander, Pirjo Sallinen, Faisal Shafiq, Wolfgang Kaufhold, Christian Wamprecht
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Patent number: 8044161Abstract: The present invention relates to the use of tocopherol as a co-catalyst in the ring opening polymerisation of cyclic siloxanes. The present invention further relates to a method for manufacturing hydrophilic polysiloxanes, wherein a hydrido-containing cyclic siloxane is reacted with a hydrophilic molecule comprising a carbon-carbon double bond, having the general formula (I) H2C?CH—(CHR)n—O—(CHR1CR2R3)mR4 or (II) H2C?CH—(CHR)n—R5, wherein n is an integer from 0 to 4, m is an integer from 0 to 5, R, R1, R2, R3 and R4 are each independently hydrogen or a C1 to C6 alkyl, R5 is a saturated cyclic hydrocarbon containing carbonyl group, in the presence of a first catalyst to obtain a monomer, and polymerising said monomer in the presence of a second catalyst and tocopherol as a co-catalyst.Type: GrantFiled: March 11, 2008Date of Patent: October 25, 2011Assignee: Bayer Shering Pharma OyInventors: Emilia Tiitinen, Harri Jukarainen