Patents by Inventor Harry Smith

Harry Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5981535
    Abstract: A method for the treatment of cerebrovascular disorders and/or disorders associated with cerebral senility and/or allergic disorders, proliferative skin disorders, and bronchodilation which method comprises the administration of an effective, non-toxic amount of a compound of formula (I): ##STR1## or if appropriate a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 each independently represent alkyl or a moiety of formula (a):--(CH.sub.2).sub.m --A (a)wherein m represents zero or an integer 1, 2 or 3; A represents a substituted or unsubstituted cyclic hydrocarbon radical; andR.sup.3 represents a halogen atom, a nitro group, or a group --NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 each independently represents hydrogen, alkyl or alkylcarbonyl or R.sup.4 and R.sup.5 together with the nitrogen to which they are attached forming an optionally substituted, heterocyclic group; certain novel compounds falling within formula (I) and compositions comprising such compounds.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 9, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Barbara Ann Spicer, Harry Smith, Harald Maschler
  • Patent number: 5945579
    Abstract: Provided are trnasgenic plants comprising cells transformed or transfected with a recombinant DNA construct containing a coding sequence which encodes phytochrome A, which when expressed, causes the stimulation of phytochrome A and confers upon said plant the ability to undergo proximity-conctitional dwarfing Also provided are a recombinant DNA construct containing a coding sequence encoding phytochrome A, which when expressed, is effective in conferring the trait of proximity-conditional dwarfing on plants comprising cells transformed ar tansfected with this construct, a method for conferring proximity-conditional dwarfing upon plants, transgenic plants produced by this method, and seeds obtained by growing such plants.
    Type: Grant
    Filed: October 5, 1995
    Date of Patent: August 31, 1999
    Assignee: The University of Leicester
    Inventor: Harry Smith
  • Patent number: 5734051
    Abstract: A method for the treatment of cerebrovascular disorders and/or disorders associated with cerebral senility and/or other disorders which method comprises the administration of an effective, non-toxic amount of a compound of formula (I): ##STR1## or if appropriate a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 each independently represent alkyl or a moiety of formula (a):--(CH.sub.2).sub.m --A (a)whereinm represents zero or an integer 1, 2 or 3;A represents a substituted or unsubstituted cyclic hydrocarbon radical; andR.sup.3 represents a halogen atom, a nitro group, or a group --NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 each independently represents hydrogen, alkyl or alkylcarbonyl or R.sup.4 and R.sup.5 together with the nitrogen to which they are attached forming an optionally substituted, heterocyclic group; certain novel compounds falling within formula (I) and compositions comprising such compounds.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 31, 1998
    Assignee: Beecham Group
    Inventors: Barbara Ann Spicer, Harry Smith, Harald Maschler
  • Patent number: 5331100
    Abstract: Self-building laundry detergents are organic polyamine amides, which contain a plurality of carboxylate radicals and an amide ester. These compounds are useful individually as detergents or as components in detergent compositions.
    Type: Grant
    Filed: November 27, 1987
    Date of Patent: July 19, 1994
    Assignee: Dowbrands Inc.
    Inventors: Harry A. Smith, Donald A. Tomalia
  • Patent number: 5133967
    Abstract: A toning composition which employs one or more of the propylene and butylene oxide-based glycol ethers with propylene glycol for removing sebum from the skin of a user without stinging and without dissolving and removing to any significant degree the intercellular lipids critical to the retention of moisture in the skin.
    Type: Grant
    Filed: June 24, 1991
    Date of Patent: July 28, 1992
    Assignee: The Dow Chemical Company
    Inventor: Harry A. Smith
  • Patent number: 5075986
    Abstract: An attachment assembly for securing large excavation teeth on large earth excavation equipment including an excavation tooth, an adaptor having a tapered nose piece at one end thereof for carrying the tooth and defining means rearwardly of the nose piece for securing the adaptor to the excavation implement, a pin for securing the tooth in place on the nose piece and a wear cap adapted to be carried by an engage the adaptor so as to abut a rear portion of the tooth for reducing wear of the adaptor during use. The wear cap defines a forward tooth abutment surface, a first inclined lower surface adapted to abut a first portion of the adaptor rearwardly of the nose piece, a second inclined lower surface spaced from the first inclined lower surface and adapted to abut a second portion of the adaptor and an opened channel disposed between the first and second inclined surfaces and extending transversely through the wear cap.
    Type: Grant
    Filed: February 8, 1991
    Date of Patent: December 31, 1991
    Assignee: H & L Tooth Company
    Inventors: Harry Smith, Chuck Clendenning, Paul Millspaugh
  • Patent number: 5066047
    Abstract: A laminar structure, for example an identity card, comprises a photograph and a supported hologram. A moisture-impermeable barrier layer and an adhesive layer are disposed between the hologram and the photograph, so that the photograph can be secured to the hologram while the former is still wet. The supported hologram, the barrier and adhesive layers and the photograph are sandwiched between first and second sheets. The hologram is sufficiently adhered to the photograph that, if an attempt is made to separate the supported hologram from the photograph, fracture will occur within the hologram or between the hologram and its support sheet, so that at least part of the hologram will remain attached to the photograph, so that it is not possible to detach the hologram from the photograph, leaving the hologram attached to the first sheet, and thus substitute a different photograph in the laminar structure.
    Type: Grant
    Filed: September 5, 1990
    Date of Patent: November 19, 1991
    Assignee: Polaroid Corporation
    Inventors: Dennis R. Mailloux, Harry A. Smith, Neal F. Kelly
  • Patent number: 4769383
    Abstract: A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is a hydrogen atom or a C.sub.1-6 alkyl group, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are selected from hydrogen, hydroxyl, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy and C.sub.1-4 alkanoyl; G is a hydrogen atom or a hydroxyl group, and m and n are independently integers of from 1 to 3, with the proviso that when G is a hydroxyl grup, m or n is 1;is useful in the treatment of asthma.
    Type: Grant
    Filed: September 10, 1986
    Date of Patent: September 6, 1988
    Assignee: Beecham Group p.l.c.
    Inventors: Harry Smith, Derek R. Buckle
  • Patent number: 4699711
    Abstract: The invention relates to novel O,O'-, O,S'- or S,S'-dithiodialkylene-bis(mono- or dihydrocarbyl carbamothioates) and S,S'-dithiodialkylene-bis(mono- or dihydrocarbyl carbamodithioate). The novel compounds of this invention are useful as collectors in the froth flotation of sulfide mineral ores.
    Type: Grant
    Filed: June 6, 1986
    Date of Patent: October 13, 1987
    Assignee: Dow Chemical Company
    Inventors: Roger W. Bergman, Harry A. Smith
  • Patent number: 4618461
    Abstract: The invention relates to novel O,O'-, O,S'- or S,S'-dithiodialkylene-bis(mono- or dihydrocarbyl carbamothioates) and S,S'-dithiodialkylene-bis(mono- or dihydrocarbyl carbamodithioate). The novel compounds of this invention are useful as collectors in the froth flotation of sulfide mineral ores.
    Type: Grant
    Filed: July 25, 1983
    Date of Patent: October 21, 1986
    Assignee: The Dow Chemical Company
    Inventors: Roger W. Bergman, Harry A. Smith
  • Patent number: 4454136
    Abstract: Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen or C.sub.1-6 alkyl, and R.sub.2 is hydroxy, C.sub.1-4 alkylsulphonyloxy or p-toluenesulphonyloxy are useful for the prophylaxis and treatment of diseases due to allergic response in mammals. Processes for their preparation are described.
    Type: Grant
    Filed: September 15, 1981
    Date of Patent: June 12, 1984
    Assignee: Beecham Group Limited
    Inventors: Derek R. Buckle, Harry Smith
  • Patent number: 4428754
    Abstract: This invention is a method of preventing phase separation of hydrous ethanol and liquid hydrocarbon fuels comprising the addition of an effective amount of a phase separation inhibitor selected from the group of N,N-bis(hydroxyalkyl)alkyl amide represented by the formula: ##STR1## wherein R is a C.sub.10-20 alkyl group and R' is a C.sub.1-5 alkylene group.
    Type: Grant
    Filed: March 1, 1982
    Date of Patent: January 31, 1984
    Assignee: The Dow Chemical Company
    Inventor: Harry A. Smith
  • Patent number: 4427686
    Abstract: A compound of the formula (I): ##STR1## wherein R.sub.1 is hydrogen or C.sub.1-6 alkyl;R.sub.2, R.sub.3 and R.sub.4 are the same or different and are chosen from hydrogen, hydroxyl, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy and C.sub.1-4 alkanoyl;G is H or OH; andm and n are independently 1 to 3; with the proviso that when G is OH, one of m or n is 1; is useful in the prophylaxis and treatment of diseases whose symptoms are controlled by the mediators of the allergic response, for example asthma, hay fever, rhinitis and allergic eczema.
    Type: Grant
    Filed: December 8, 1981
    Date of Patent: January 24, 1984
    Assignee: Beecham Group Limited
    Inventors: Derek R. Buckle, Harry Smith
  • Patent number: 4405620
    Abstract: Compounds of the formula (I), or pharmaceutically acceptable salts thereof ##STR1## wherein X is phenyl, optionally substituted by one halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy; or pyridyl; R.sub.1 is hydrogen or C.sub.1-6 alkyl; and n is 1 to 6, pharmaceutical compositions containing them and a process for their preparation. These compounds are useful in the prophylaxis or treatment of diseases due to a histamine-mediated allergic response.
    Type: Grant
    Filed: January 19, 1981
    Date of Patent: September 20, 1983
    Assignee: Beecham Group Limited
    Inventors: Derek R. Buckle, Harry Smith
  • Patent number: 4394133
    Abstract: This invention is a method of preventing phase separation of hydrous ethanol and liquid hydrocarbon fuel mixtures comprising the addition of an effective amount of a phase separation inhibitor selected from the group of alkyl acetates which have:(a) a solubility parameter of about 8.4 to 9.8 (cal/cc).sup.1/2 ; and(b) a dipole moment of about 1.75 to 1.90 debye.
    Type: Grant
    Filed: March 1, 1982
    Date of Patent: July 19, 1983
    Assignee: The Dow Chemical Company
    Inventor: Harry A. Smith
  • Patent number: 4384085
    Abstract: Poly(.epsilon.-caprolactam) is prepared with less than 3 percent water-extractable material by carrying out the polymerization reaction in a vessel, the interior surfaces of which are coated with an inert adherent coating of an organic polymer.
    Type: Grant
    Filed: January 6, 1982
    Date of Patent: May 17, 1983
    Assignee: The Dow Chemical Company
    Inventor: Harry A. Smith
  • Patent number: 4380455
    Abstract: This invention is a method of preventing phase separation of hydrous ethanol and liquid hydrocarbon fuel mixtures comprising the addition of an effective amount of dialkyl carbonates.
    Type: Grant
    Filed: March 1, 1982
    Date of Patent: April 19, 1983
    Assignee: The Dow Chemical Company
    Inventor: Harry A. Smith
  • Patent number: 4378360
    Abstract: Compounds of formula (I): ##STR1## wherein R is hydrogen, halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy; R.sub.1 is hydrogen or C.sub.1-6 alkyl; and n is 1 to 6 and pharmaceutically acceptable salts thereof; pharmaceutical compositions containing them; a process for their preparation; and their use in treating allergy.
    Type: Grant
    Filed: April 15, 1981
    Date of Patent: March 29, 1983
    Assignee: Beecham Group Limited
    Inventors: Derek R. Buckle, Harry Smith, John M. Tedder
  • Patent number: 4366306
    Abstract: .epsilon.-Caprolactam is melt polymerized in the presence of water and from about 0.01 mole percent to less than about 0.6 mole percent of an amine boiling at a temperature greater than 245.degree. C. An amine may be a primary or secondary amine wherein the NH has attached thereto, for example alkyl radicals, cycloalkyl radicals, and the like. The resultant polymer has a methanol extractable content of 3 weight percent or less.
    Type: Grant
    Filed: October 29, 1980
    Date of Patent: December 28, 1982
    Assignee: The Dow Chemical Company
    Inventor: Harry A. Smith
  • Patent number: 4351928
    Abstract: A four-component composition is disclosed comprising a hydroxyl-bearing polymer; a liquid, amino- or hydroxyaromatic diluent having an atmospheric boiling point of about 150.degree. C. or greater; an aminoplast or phenolic resin capable of curing the hydroxyl-bearing polymer and a strong acid catalyst for the reaction between the first and third components. Optionally, a pigment may be added to the composition.
    Type: Grant
    Filed: October 26, 1981
    Date of Patent: September 28, 1982
    Assignee: The Dow Chemical Company
    Inventor: Harry A. Smith