Patents by Inventor Hartmuth C. Kolb

Hartmuth C. Kolb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Large scale synthesis of 1,2,4- and 1,3,4-oxadiazole carboxylates
    Patent number: 6951946
    Abstract: Disclosed are efficient and scalable processes for preparing 1,2,4- and 1,3,4-oxadiazole carboxylates from readily available starting materials.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: October 4, 2005
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hartmuth C. Kolb, Ramanaiah C. Kanamarlapudi, Paul F. Richardson
  • Water as promoter in the nucleophilic substitution of chloride
    Patent number: 6891068
    Abstract: Disclosed is a one step method for preparing a ?-substituted sulfide by treating a ?-halosulfide with a nucleophile in water.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: May 10, 2005
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hartmuth C. Kolb, Zhi-Cai Shi, Zhi-Min Wang
  • Tyrosine phosphatase scafold synthesis
    Publication number: 20040225146
    Abstract: Disclosed are 4-(difluoromethylene)phosphonate cinnamic acid derivatives as a molecular scaffold for the preparation of protein tyrosine phosphatase inhibitors. The invention also relates to a process for the combinatorial preparation of protein tyrosine phospatase inhibitors possessing a 4-(difluoromethylene)phosphonate cinnamic acid/ester molecular scaffold.
    Type: Application
    Filed: May 5, 2003
    Publication date: November 11, 2004
    Inventors: Hartmuth C. Kolb, Paul F. Richardson, Ramanaiah C. Kanamarlapudi
  • Modified safe and efficient process for the environmentally friendly synthesis of imidoesters
    Patent number: 6806380
    Abstract: Disclosed is a safe, efficient and environmentally friendly method for preparing imidoesters.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: October 19, 2004
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hartmuth C. Kolb, Ramanaiah C. Kanamarlapudi, Paul F. Richardson, Gaznabi Khan
  • Novel PPAR-gamma agonists as agents for the treatment of type II diabetes
    Publication number: 20040171656
    Abstract: Disclosed are compounds of the formula: 1
    Type: Application
    Filed: March 10, 2004
    Publication date: September 2, 2004
    Inventors: Hartmuth C. Kolb, Gerard McGeehan, Zhi-Cai Shi, Laxma Reddy Kolla, Cullen Cavallaro
  • PPAR-&ggr; agonists as agents for the treatment of type II diabetes
    Patent number: 6713514
    Abstract: N-(substituted)carbamoylaryl- and heteroaryl substituted aminopropanoic and butanoic acid compounds which are highly selective agonists for the PPAR-&ggr; receptor or prodrugs of agonists for the PPAR-&ggr; receptor, and are useful in the treatment of Type II diabetes (NIDDM).
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: March 30, 2004
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hartmuth C. Kolb, Gerard McGeehan, Zhi-Cai Shi, Laxma Reddy Kolla, Cullen Cavallaro
  • Large scale synthesis of 1,2,4- and 1,3,4-oxadiazole carboxylates
    Publication number: 20040019215
    Abstract: Disclosed are efficient and scalable processes for preparing 1,2,4- and 1,3,4-oxadiazole carboxylates from readily available starting materials.
    Type: Application
    Filed: March 19, 2003
    Publication date: January 29, 2004
    Inventors: Hartmuth C. Kolb, Ramanaiah C. Kanamarlapudi, Paul F. Richardson
  • One step synthesis of 1,2,3-triazole carboxylic acids
    Patent number: 6642390
    Abstract: Disclosed is a one step method for preparing a 1,2,3-triazole carboxylic acid by treating an azide with a &bgr;-ketoester in the presence of a base.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: November 4, 2003
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Hartmuth C. Kolb, Cullen Cavallaro, Zhi-Cai Shi, Alexander Gontcharov, Zhi-Min Wang, Paul F. Richardson, Ramanaiah C. Kanamarlapudi
  • Modified safe and efficient process for the environmentally friendly synthesis of lmidoesters
    Publication number: 20030153728
    Abstract: Disclosed is a safe, efficient and environmentally friendly method for preparing imidoesters.
    Type: Application
    Filed: October 2, 2002
    Publication date: August 14, 2003
    Inventors: Hartmuth C. Kolb, Ramanaiah C. Kanamarlapudi, Paul F. Richardson, Gaznabi Khan
  • Large scale synthesis of optically pure aziridines
    Publication number: 20030153771
    Abstract: Disclosed is an efficient, inexpensive method for the preparation of chiral aziridines on a large scale.
    Type: Application
    Filed: September 27, 2002
    Publication date: August 14, 2003
    Inventors: Hartmuth C. Kolb, Ramanaiah C. Kanamarlapudi, Paul F. Richardson, Gaznabi Khan
  • One step synthesis of 1,2,3-triazole carboxylic acids
    Publication number: 20030135050
    Abstract: Disclosed is a one step method for preparing a 1,2,3-triazole carboxylic acid by treating an azide with a &bgr;-ketoester in the presence of a base.
    Type: Application
    Filed: July 11, 2002
    Publication date: July 17, 2003
    Inventors: Hartmuth C. Kolb, Cullen Cavallaro, Zhi-Cai Shi, Alexander Gontcharov, Zhi-Min Wang, Paul F. Richardson, Ramanaiah C. Kanamarlapudi
  • Amide library formation using a “by-product-free” activation/coupling sequence
    Patent number: 6562944
    Abstract: Disclosed is an improved method for preparing an activated carboxylic acid in the form of a pentafluorophenyl ester, an improved method for making a carboxamide from a pentaflourophenyl ester, and a carboxamide and carboxamide library prepared using both of these methods.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: May 13, 2003
    Assignee: Lexicon Pharmaceuticals
    Inventors: Hartmuth C. Kolb, Qun Sun
  • Sulfonyl linker for the creation of libraries via immobilization of amines
    Patent number: 6451918
    Abstract: Disclosed are novel compounds of which function as a sulfonyl linker between a target molecule and a polymer solid support, novel sulfonyl aziridine scaffold intermediates to optimize the regioselectivity associated with the nucleophilic substitution of these aziridines, a method for making derivatized aziridine, and a method for making derivatized amines.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: September 17, 2002
    Assignee: Coelacanth Corporation
    Inventors: Hartmuth C. Kolb, Gerard McGeehan