Patents by Inventor Harvey W. Ko
Harvey W. Ko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11298055Abstract: A noninvasive glucose monitoring device includes a drive-and-sense coil and an electronic oscillator with multiple circuits electrically connected to the coil. The drive-and-sense coil may be embedded in either a finger clip or a finger push button. The device measures bioimpedance with a magnetic field coil outside a user's finger. The coil measures blood and glucose electrical conductivity without penetrating the finger. No blood extraction is required. A noninvasive method of measuring glucose in-vivo includes placing the drive-and-sense coil next to a subject's finger and inducing magnetic fields in blood in the subject's finger. A change in mutual impedance between the drive-and-sense coil and the blood is measured at predetermined frequencies and glucose content is calculated from the change in mutual impedance according to a predetermined correlation for each frequency.Type: GrantFiled: July 14, 2021Date of Patent: April 12, 2022Inventor: Harvey W. Ko
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Publication number: 20220015669Abstract: A noninvasive glucose monitoring device includes a drive-and-sense coil and an electronic oscillator with multiple circuits electrically connected to the coil. The drive-and-sense coil may be embedded in either a finger clip or a finger push button. The device measures bioimpedance with a magnetic field coil outside a user's finger. The coil measures blood and glucose electrical conductivity without penetrating the finger. No blood extraction is required. A noninvasive method of measuring glucose in-vivo includes placing the drive-and-sense coil next to a subject's finger and inducing magnetic fields in blood in the subject's finger. A change in mutual impedance between the drive-and-sense coil and the blood is measured at predetermined frequencies and glucose content is calculated from the change in mutual impedance according to a predetermined correlation for each frequency.Type: ApplicationFiled: July 14, 2021Publication date: January 20, 2022Inventor: Harvey W. Ko
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Patent number: 9370309Abstract: A magnetoencephalogram (MEG) system is provided for use with a head. The MEG system includes a shell, and three three-axis gradiometers and a computing portion. Each three-axis gradiometer detects a magnetic field vector from a magnetic dipole in the head and generates a respective detected signal based on the respective magnetic field vector. Each three-axis gradiometer is disposed at a respective position of the shell. The computing portion determines a location of the magnetic dipole based on the first detected signal, the second detected signal and the third detected signal.Type: GrantFiled: November 18, 2011Date of Patent: June 21, 2016Assignee: The Johns Hopkins UniversityInventors: Harvey W. Ko, Ibolja Cernak, Michael P. McLoughlin
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Publication number: 20140005518Abstract: A magnetoencephalogram (MEG) system is provided for use with a head. The MEG system includes a shell, and three three-axis gradiometers and a computing portion. Each three-axis gradiometer detects a magnetic field vector from a magnetic dipole in the head and generates a respective detected signal based on the respective magnetic field vector. Each three-axis gradiometer is disposed at a respective position of the shell. The computing portion determines a location of the magnetic dipole based on the first detected signal, the second detected signal and the third detected signal.Type: ApplicationFiled: November 18, 2011Publication date: January 2, 2014Applicant: The John Hopkins UniversityInventors: Harvey W. Ko, Ibolja Cernak, Michael P. McLoughlin
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Publication number: 20110049390Abstract: A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.Type: ApplicationFiled: November 4, 2010Publication date: March 3, 2011Inventors: George M. Murray, Cheryl S. Schein, David R. Kohler, Jennifer L. Sample, Jennifer A. Nix, Protagoras N. Cutchis, Adam K. Arabian, Harvey W. Ko, Micah A. Carlson, Michael P. McLoughlin
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Patent number: 7830515Abstract: A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.Type: GrantFiled: June 18, 2008Date of Patent: November 9, 2010Assignee: The Johns Hopkins UniversityInventors: George M. Murray, Cheryl S. Schein, David R. Kohler, Jennifer L. Sample, Jennifer A. Nix, Protagoras N. Cutchis, Adam K. Arabian, Harvey W. Ko, Micah A. Carlson, Michael P. McLoughlin
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Patent number: 7494769Abstract: A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.Type: GrantFiled: April 16, 2003Date of Patent: February 24, 2009Assignee: The Johns Hopkins UniversityInventors: George M. Murray, Cheryl S. Schein, David R. Kohler, Jennifer L. Sample, Jennifer A. Nix, Protagoras N. Cutchis, Adam K. Arabian, Harvey W. Ko, Micah A. Carlson, Michael P. McLoughlin
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Publication number: 20080254502Abstract: A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.Type: ApplicationFiled: June 18, 2008Publication date: October 16, 2008Inventors: George M. Murray, Cheryl S. Schein, David R. Kohler, Jennifer L. Sample, Jennifer A. Nix, Protagoras N. Cutchis, Adam K. Arabian, Harvey W. Ko, Micah A. Carlson, Michael P. McLoughlin
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Patent number: 7283868Abstract: An electromagnetic bioimpedance measurement apparatus uses an alternating magnetic field to induce electrical eddy currents in biological tissue. The eddy currents produce secondary magnetic fields that have the effect of changing the mutual inductance between the tissue and the coil that applied to the initial magnetic field. The amplitude of the resultant voltage, as measured by the same coil or a different receiver coil, is proportional to the conductivity of the tissue. A simple, marginally stable oscillator circuit is used to generate the current into the coil. Nearfield holographic signal processing is then used for holographic image formation. Bioimpedance is used to distinguish between normal tissue and cancerous tissue, especially cancerous prostate tissue. An invasive embodiment includes driven needle electrodes that are inserted into the body segment to be tested. Noninvasive embodiments include single or multiple coils arranged on a probe shaft.Type: GrantFiled: April 5, 2001Date of Patent: October 16, 2007Assignee: The Johns Hopkins UniversityInventors: Harvey W. Ko, Dexter G. Smith
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Patent number: 7126148Abstract: A system for detecting neutron radiation. A liquid cocktail mixture comprised of a neutron absorber and a scintillator is housed in a TeflonĀ® tube having a mirror at one end of the tube and a windowed portal at the other end of the tube. Neutrons that penetrate the tube react with the neutron absorber producing ionization that excites a scintillator to produce photons. A photo-multiplier tube is coupled with the windowed portal for receiving photons and converting the photons to electrical signals. A processing device is coupled to the photo-multiplier output for receiving and analyzing the electrical signals so as to provide a measurement pertaining to the presence and relative strength of neutron radiation. The tube can be adapted to function as a portable survey instrument. Alternatively, the tube can be stretched to cover large apertured areas. In such implementations a wavelength shifter is employed to convert light emitted to another wavelength giving a multiplier effect necessary for long light guides.Type: GrantFiled: July 17, 2003Date of Patent: October 24, 2006Assignee: The Johns Hopkins UniversityInventors: George M. Murray, Harvey W. Ko, Glen Southard
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Patent number: 6969605Abstract: A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined.Type: GrantFiled: July 16, 2001Date of Patent: November 29, 2005Assignee: The Johns Hopkins UniversityInventors: Charles W. Anderson, C. Brent Bargeron, Richard C. Benson, Micah A. Carlson, Allan B. Fraser, John D. Groopman, Harvey W. Ko, David R. Kohler, Terry E. Phillips, Paul T. Strickland
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Patent number: 6806465Abstract: A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a time series output by the mass spectrometer for a received sample and identifies one or more agents contained in the sample.Type: GrantFiled: January 15, 2002Date of Patent: October 19, 2004Assignee: The Johns Hopkins UniversityInventors: Charles W. Anderson, Peter F. Scholl, Ronald G. Chappell, Wayne A. Bryden, Harvey W. Ko, Scott A. Ecelberger
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Patent number: 6765527Abstract: A harmonic radar nonlinear junction detector system for detecting concealed weapons, electronics, and other man-made objects utilizing state-of-the art wireless technology, circuit fabrication, signal synthesis, and computer processing techniques to detect and characterize man-made objects possessing nonlinear junctions. The system transmits a pair of low power waveforms and a receiver within the system is coherently tuned to harmonics of the transmitted frequencies of the waveforms to detect man-made metal objects and electronics that contain non-linear junctions. The receiver is also capable of receiving inter-modulation products reflected from the man-made objects that are a result of using two incident signals. The system uses two signal sources generating user-definable waveforms of variable frequencies in order to provide enhanced discrimination and target identification abilities via the processing of returned inter-modulation products.Type: GrantFiled: January 31, 2002Date of Patent: July 20, 2004Assignee: The Johns Hopkins UniversityInventors: Daniel G. Jablonski, Harvey W. Ko, Douglas A. Oursler, Dexter G. Smith, David M. White
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Publication number: 20040051048Abstract: A system for detecting neutron radiation. A liquid cocktail mixture comprised of a neutron absorber and a scintillator is housed in a Teflon® tube having a mirror at one end of the tube and a windowed portal at the other end of the tube. Neutrons that penetrate the tube react with the neutron absorber producing ionization that excites a scintillator to produce photons. A photo-multiplier tube is coupled with the windowed portal for receiving photons and converting the photons to electrical signals. A processing device is coupled to the photo-multiplier output for receiving and analyzing the electrical signals so as to provide a measurement pertaining to the presence and relative strength of neutron radiation. The tube can be adapted to function as a portable survey instrument. Alternatively, the tube can be stretched to cover large apertured areas.Type: ApplicationFiled: July 17, 2003Publication date: March 18, 2004Inventors: George M. Murray, Harvey W. Ko, Glen Southard
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Publication number: 20030179126Abstract: A harmonic radar nonlinear junction detector system for detecting concealed weapons, electronics, and other man-made objects utilizing state-of-the art wireless technology, circuit fabrication, signal synthesis, and computer processing techniques to detect and characterize man-made objects possessing nonlinear junctions. The system transmits a pair of low power waveforms and a receiver within the system is coherently tuned to harmonics of the transmitted frequencies of the waveforms to detect man-made metal objects and electronics that contain non-linear junctions. The receiver is also capable of receiving inter-modulation products reflected from the man-made objects that are a result of using two incident signals. The system uses two signal sources generating user-definable waveforms of variable frequencies in order to provide enhanced discrimination and target identification abilities via the processing of returned inter-modulation products.Type: ApplicationFiled: January 31, 2002Publication date: September 25, 2003Inventors: Daniel G. Jablonski, Harvey W Ko, Douglas A Oursler, Dexter G Smith, David M White
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Patent number: 6600320Abstract: A unique time-domain electromagnetic system and data processing technique which, using low frequency electromagnetic fields, can localize, in three-dimensions, the position of buried metallic objects is disclosed. The measurement system uses time-domain electromagnetic techniques on a scanning frame similar to a X-Y plotter. The system collects magnetic data over a large area above the buried object. The spatial information of the field detected on the ground is then processed with an unique ‘nearfield holographic’ data processing method to reconstruct the field image of the buried object.Type: GrantFiled: August 13, 2001Date of Patent: July 29, 2003Assignee: The Johns Hopkins UniversityInventors: Yanping Guo, Harvey W. Ko, Carl V. Nelson, David M. White
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Publication number: 20030055358Abstract: An electromagnetic bioimpedance measurement apparatus uses an alternating magnetic field to induce electrical eddy currents in biological tissue. The eddy currents produce secondary magnetic fields that have the effect of changing the mutual inductance between the tissue and the coil that applied to the initial magnetic field. The amplitude of the resultant voltage, as measured by the same coil or a different receiver coil, is proportional to the conductivity of the tissue. A simple, marginally stable oscillator circuit is used to generate the current into the coil. Nearfield holographic signal processing is then used for holographic image formation. Bioimpedance is used to distinguish between normal tissue and cancerous tissue, especially cancerous prostate tissue. An invasive embodiment includes driven needle electrodes that are inserted into the body segment to be tested. Noninvasive embodiments include single or multiple coils arranged on a probe shaft.Type: ApplicationFiled: August 22, 2002Publication date: March 20, 2003Inventors: Harvey W. Ko, Dexter G Smith
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Publication number: 20030020011Abstract: A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a time series output by the mass spectrometer for a received sample and identifies one or more agents contained in the sample.Type: ApplicationFiled: January 15, 2002Publication date: January 30, 2003Inventors: Charles W. Anderson, Peter F. Scholl, Ronald G. Chappell, Wayne A. Bryden, Harvey W. Ko, Scott A. Ecelberger
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Publication number: 20030006899Abstract: Disclosed is a method for detecting unwanted dissemination of acrosolized agents into an HVAC system in a building by detecting the sound of the dissemination at the time it occurs. To be able to distinguish the sound of the dissemination event from the ambient background noise of the HVAC system, sound extraction techniques, e.g., high pass filtering and an adaptive variance estimator, are utilized which can detect the event's noise from within the ambient background noise of the system. A microphone continually monitors background sound levels and senses the additional sound resulting from the activation of the aerosol delivery system, which has a unique sound “signature”. Once an event is detected, defensive actions, e.g., activating additional sensors, closing all air vents, and shutting off the HVAC system, can be taken.Type: ApplicationFiled: January 15, 2002Publication date: January 9, 2003Inventors: Amir-Homayoon Najmi, Dexter G. Smith, Michael P. McLoughlin, Harvey W. Ko
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Publication number: 20020030492Abstract: A unique time-domain electromagnetic system and data processing technique which, using low frequency electromagnetic fields, can localize, in three-dimensions, the position of buried metallic objects is disclosed. The measurement system uses time-domain electromagnetic techniques on a scanning frame similar to a X-Y plotter. The system collects magnetic data over a large area above the buried object. The spatial information of the field detected on the ground is then processed with an unique ‘nearfield holographic’ data processing method to reconstruct the field image of the buried object.Type: ApplicationFiled: August 13, 2001Publication date: March 14, 2002Inventors: Yanping Guo, Harvey W. Ko, Carl V. Nelson, David M. White