Abstract: A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined.

Abstract: A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined.

Abstract: A unique time-domain electromagnetic system and data processing technique which, using low frequency electromagnetic fields, can localize, in three-dimensions, the position of buried metallic objects is disclosed. The measurement system uses time-domain electromagnetic techniques on a scanning frame similar to a X-Y plotter. The system collects magnetic data over a large area above the buried object. The spatial information of the field detected on the ground is then processed with an unique `nearfield holographic` data processing method to reconstruct the field image of the buried object.

Abstract: An apparatus and method for the passive, non-invasive magnetoencephalographic (MEG) localization and tracking of sources of magnetic signals in the brain is disclosed. The apparatus and method uses a multi-axis magnetic gradiometer to detect the magnetic field, field gradient, and polarization emanating from neuronal sources in the brain under either normal or pathological conditions.

Abstract: An apparatus and method for non-invasive sensing of bone healing is disclosed. The apparatus and method uses an electromagnetic field to measure impedance changes at and about the bone fracture site during the healing process. The impedance change at the fracture site is a direct indication of the mechanical strength of the fracture site. A multi-coil sensor array is taught, which may be sutured to the patient's skin or mounted onto a plug that is inserted through a window in the cast.

Abstract: A method for noninvasively sensing bone mass loss associated with osteoporosis is disclosed. The method uses an electromagnetic field to measure impedance (or conductivity) changes in the bone. A decrease in conductivity is indicative of osteoporosis.

Abstract: An apparatus and method for non-invasively sensing physiological changes in the brain is disclosed. The apparatus and method uses an electromagnetic field to measure localized impedance changes in brain matter and fluid. The apparatus and method has particular application in providing time-trend measurements of the process of brain edema associated with head trauma.

Abstract: An apparatus and method for non-invasively sensing physiological changes in the brain is disclosed. The apparatus and method uses an electromagnetic field to measure localized impedance changes in brain matter and fluid. Various spatial and temporal techniques are used to localize impedance changes in the brain. The apparatus and method has particular application in locating and providing time-trend measurements of the process of brain edema or the process of hydrocephalus.

Abstract: An apparatus and method for non-invasive sensing of bone healing is disclosed. The apparatus and method uses an electromagnetic field to measure impedance changes at the bone fracture site during the healing process. The impedance change at the fracture site is a direct indication of the mechanical strength of the fracture site.