Abstract: A gold nanoparticle-based assay for the detection of a target molecule, such as Hepatitis C Virus (HCV) RNA in serum samples, that uses positively charged gold nanoparticles (AuNPs) in solution based format. The assay has been tested on 74 serum clinical samples suspected of containing HCV RNA, with 48 and 38 positive and negative samples respectively. The developed assay has a specificity and sensitivity of 96.5% and 92.6% respectively. The results obtained were confirmed by Real-Time PCR, and a concordance of 100% for the negative samples and 89% for the positive samples has been obtained between the Real-Time PCR and the developed AuNPs based assay. Also, a purification method for the HCV RNA has been developed using HCV RNA specific probe conjugated to homemade silica nanoparticles. These silica nanoparticles have been synthesized by modified Stober method. This purification method enhanced the specificity of the developed AuNPs assay.

Abstract: A menstrual device having a storage volume. The menstrual device has a frame and a fluid barrier seal layer attached to the exterior surface of the frame. The menstrual device has an expanded configuration that includes an at rest configuration and a deployed configuration. The menstrual device has a compact configuration where the menstrual device is confined to a size, shape and/or geometry smaller than an expanded configuration such that it can be more easily inserted into the body. The menstrual device in a compact configuration is contained within an applicator, where the applicator assists in ejecting the menstrual device into the body.

Abstract: A compact applicator has a two-piece telescoping plunger. The compact applicator, with such telescoping plunger has a full-size barrel region while maintaining an overall applicator length that is the same and/or slightly shorter than current known compact applicators. In a non-deployed configuration, the inner sleeve of the plunger is generally telescoped within the outer sleeve of the plunger, and the outer sleeve of the plunger is generally telescoped within the applicator barrel.

Abstract: A gold nanoparticle-based colorimetric assay kit for nucleic acids from viral, bacterial and other microorganisms that detects unamplified or amplified polynucleotides in clinical specimens using unmodified AuNPs and oligotargeter polynucleotides that bind to a pathogen's nucleic acids. A method for detecting a pathogen comprising contacting a sample suspected of containing microbes with a polynucleotide that binds to pathogen nucleic acid and with gold nanoparticles, detecting the aggregation of nanoparticles, and detecting pathogen polynucleotides in the sample when the nanoparticles aggregate (solution color becomes blue) in comparison with a control or a negative sample not containing the virus when nanoparticles do not aggregate (solution color remains red).

Abstract: A temperature sensing device comprising a plurality of thermocouples in a hollow tube, where the thermocouples sensing tips contact the outer wall of the tube, and a heat flux source that heats the hollow tube. The hollow tube is inserted through a cross section of a pipe perpendicular to the longitudinal axis of the pipe. The apparatus measures a void fraction in a two-phase flow of a liquid-gas mixture flowing through the pipe. A process of measuring void fraction whereby the hollow tube is heated to an initial temperature, and in the presence of a liquid-gas mixture flow through the pipe the difference is calculated between the initial temperature of the tube and the temperature during liquid-gas mixture flow, to determine the void fraction in the two-phase flow of liquid-gas mixture through the pipe.

Abstract: A temperature sensing device comprising a plurality of thermocouples in a hollow tube, where the thermocouples sensing tips contact the outer wall of the tube, and a heat flux source that heats the hollow tube. The hollow tube is inserted through a cross section of a pipe perpendicular to the longitudinal axis of the pipe. The apparatus measures a void fraction in a two-phase flow of a liquid-gas mixture flowing through the pipe. A process of measuring void fraction whereby the hollow tube is heated to an initial temperature, and in the presence of a liquid-gas mixture flow through the pipe the difference is calculated between the initial temperature of the tube and the temperature during liquid-gas mixture flow, to determine the void fraction in the two-phase flow of liquid-gas mixture through the pipe.

Abstract: A technique for estimating the location of a wireless terminal at an unknown location in a geographic region is disclosed. The technique is based on the recognition that there are location-dependent traits of electromagnetic signals. In environments where multiple antennas are radiating the same signal, as in the case of distributed antennas or host-repeater configurations, one or more possible locations of the wireless terminal can be designated as improbable based on i) a measure of the propagation delay of a signal traveling between a) a base station and b) the wireless terminal or an infrastructure antenna, or ii) the maximum distance at which a signal is detectable by the wireless terminal. Additionally, the applicable set of values for the location-dependent traits is selected based on similar criteria.

Abstract: The reconfigurable radio direction finder system and method uses a reconfigurable antenna to electronically cycle through a plurality of different antenna configurations to determine a signal direction. Specifically, the reconfigurable antenna is cycled through N different antenna configurations, where N is an integer greater than one, where each antenna configuration has a pointing direction associated therewith defined by an elevation angle ?n of an n-th antenna configuration, where n is an integer between 1 and N, and an azimuthal angle ?n of the n-th antenna configuration. A received signal strength of the radio signal is measured for each of the antenna configurations as a power output of the n-th antenna configuration, Pn.

Abstract: A temperature sensing device comprising a plurality of thermocouples in a hollow tube, where the thermocouples sensing tips contact the outer wall of the tube, and a heat flux source that heats the hollow tube. The hollow tube is inserted through a cross section of a pipe perpendicular to the longitudinal axis of the pipe. The apparatus measures a void fraction in a two-phase flow of a liquid-gas mixture flowing through the pipe. A process of measuring void fraction whereby the hollow tube is heated to an initial temperature, and in the presence of a liquid-gas mixture flow through the pipe the difference is calculated between the initial temperature of the tube and the temperature during liquid-gas mixture flow, to determine the void fraction in the two-phase flow of liquid-gas mixture through the pipe.

Abstract: A temperature sensing device comprising a plurality of thermocouples in a hollow tube, where the thermocouples sensing tips contact the outer wall of the tube, and a heat flux source that heats the hollow tube. The hollow tube is inserted through a cross section of a pipe perpendicular to the longitudinal axis of the pipe. The apparatus measures a void fraction in a two-phase flow of a liquid-gas mixture flowing through the pipe. A process of measuring void fraction whereby the hollow tube is heated to an initial temperature, and in the presence of a liquid-gas mixture flow through the pipe the difference is calculated between the initial temperature of the tube and the temperature during liquid-gas mixture flow, to determine the void fraction in the two-phase flow of liquid-gas mixture through the pipe.

Abstract: The inertial system for gravity difference measurement uses COTS nano accelerometer and a strapdown Global Navigation Satellite System (GNSS)-aided inertial measurement unit (IMU). The former has low measurement noise density, while the latter is used to analytically stabilize the platform. Stochastic modeling of the gravity anomaly is utilized (as opposed to the deterministic modeling of causes and effects) to simplify the algorithm. The algorithm aims at finding relative changes between points, as opposed to absolute values at the points, which allows for high relative precision required in many applications.

Abstract: The geo-security method and system uses spatio-temporal radio channel information during authentication to grant permission to access, use and/or operate the intended device. The geo-security method and system uses a wideband radio channel impulse response (or transfer function of radio channel) from antenna of RF source to antenna of a RF receiver at the device position to determine the legitimacy of the intended device's location.

Abstract: A ring laser gyroscope (RLG) includes moveable mirrors and a Micro-Electro-Mechanical Systems (MEMS) actuator coupled to the moveable mirrors to cause a respective displacement thereof that induces a phase modulation on counter-propagating light beams relative to one another. The induced phase modulation creates an optical path difference between the counter-propagating light beams corresponding to a virtual rotation that reduces the lock-in of the RLG.

Abstract: An optical rotation sensor includes a Fabry Perot laser having an active gain medium for generating first and second light beams, a closed optical path through which the first and second light beams counter-propagate and first and second mirrors coupled to respective ends of the closed optical path. The first minor is a ring mirror having a complex valued reflectivity that varies with a rotation rate of a frame within which the optical rotation sensor is placed. A detector is coupled to an output of the Fabry Perot laser to measure an output intensity thereof.

Abstract: The present invention relates to a method for purifying lactoferrin, which is a pharmacologically important milk protein having various physiological activities, from a secretory fluid containing lactoferrin.

Abstract: Caching of an immutable buffer that has its data and address prevented from changing during the lifetime of the immutable buffer. A first computing entity maintains a cache of the immutable buffer and has a strong reference to the immutable buffer. So long as any entity has a strong reference to the immutable buffer, the immutable buffer is guaranteed to continue to exist for the duration of the strong reference. A second computing entity communicates with the first computing entity to obtain a strong reference to the immutable buffer and thereafter read data from the immutable buffer. Upon reading the data from the cache, the second computing entity demotes the strong reference to a weak reference to the immutable buffer. A weak reference to the immutable buffer does not guarantee that the immutable buffer will continue to exist for the duration of the weak reference.