Patents by Inventor Hazel Joan Dyke

Hazel Joan Dyke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxamic and carboxylic acid derivatives
    Publication number: 20040176362
    Abstract: The invention relates to hydroxamic and carboxylic acid derivatives.
    Type: Application
    Filed: March 17, 2004
    Publication date: September 9, 2004
    Inventors: Duncan Batty, Verity Margaret Sabin, Robert John Watson, Hazel Joan Dyke, Andrew Sharpe, Richard John Davenport, David Alan Owen, Andrew Douglas Baxter
  • Hydroxamic acid derivatives
    Patent number: 6787536
    Abstract: The invention encompasses novel compounds which are inhibitors of matrix metalloproteinase, ADAM or ADAM-TS enzymes, and which are useful for the treatment of diseases mediated by those enzymes, including degenerative diseases and certain cancers.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: September 7, 2004
    Assignee: Darwin Discovery Limited
    Inventors: Duncan Robert Hannah, Hazel Joan Dyke, Andrew Sharpe, Andrew Douglas Baxter
  • Hydroxamic and carboxylic acid derivatives
    Patent number: 6734189
    Abstract: The invention relates to hydroxamic and carboxylic acid derivatives. Compounds of the formula: are disclosed. These compounds are useful for the treatment of diseases mediated by inhibitors of matrix metalloproteinase, ADAM, ADAM-TS enzymes, and/or TNF&agr;-mediated diseases including degenerative diseases and certain cancers.
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: May 11, 2004
    Assignee: Darwin Discovery, Ltd.
    Inventors: Duncan Batty, Verity Margaret Sabin, Robert John Watson, Hazel Joan Dyke, Andrew Sharpe, Richard John Davenport, David Alan Owen, Andrew Douglas Baxter
  • Adenosine derivatives and methods of administration
    Patent number: 6677316
    Abstract: A method of treating a patient suffering from or susceptible to ischemic heart disease, peripheral vascular disease or stroke or which subject is suffering pain, a CNS disorder or sleep apnea which comprises administering a therapeutically effective amount of an adenosine derivative which is an agonist at the adenosine A1 receptor and which exhibits little or no agonist activity of the A3 receptor.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: January 13, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: David Edmund Bays, Richard Peter Charles Cousins, Hazel Joan Dyke, Colin David Eldred, Brian David Judkins, Martin Pass, Andrew Michael Kenneth Pennell
  • Hydroxamic acid derivatives
    Publication number: 20030216404
    Abstract: The invention encompasses novel compounds which are inhibitors of matrix metalloproteinase, ADAM or ADAM-TS enzymes, and which are useful for the treatment of diseases mediated by those enzymes, including degenerative diseases and certain cancers.
    Type: Application
    Filed: June 12, 2003
    Publication date: November 20, 2003
    Inventors: Duncan Robert Hannah, Hazel Joan Dyke, Andrew Sharpe, Andrew Douglas Baxter
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6642254
    Abstract: N-oxides of formula (i) wherein R1 is CH3, CH2F, CHF2 or CF3; R2 is CH3 or CF3; R3 is F, Cl, Br, CN or CH3; and R4 is H, F, Cl, Br, CN or CH3; and pharmaceutically-acceptable salts thereof, are useful as therapeutic agents, e.g., for the treatment of inflammatory diseases.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: November 4, 2003
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, John Gary Montana
  • 2-(purin-9-yl)-tetrahydrofuran-3, 4-diol derivatives
    Patent number: 6610665
    Abstract: There are disclosed according to the invention, compounds of formula (I) wherein R1, R2 and R3 are defined in the specification. Additionally, processes of preparing the compounds of formula (I), formulations containing same, and the administration of said compounds or formulations thereof in the treatment of inflammatory diseases are also disclosed.
    Type: Grant
    Filed: August 29, 2000
    Date of Patent: August 26, 2003
    Assignee: Smithkline Beecham Corporation
    Inventors: David Edmund Bays, Chuen Chan, Caroline Mary Cook, Brian Cox, Richard Peter Charles Cousins, Hazel Joan Dyke, Frank Ellis, Joanna Victoria Geden, Stephen Swanson
  • Quinolone derivatives
    Publication number: 20030105073
    Abstract: Quinolone derivatives of formula (1) are described: 1
    Type: Application
    Filed: October 22, 2002
    Publication date: June 5, 2003
    Inventors: Alan Findlay Haughan, Hazel Joan Dyke, George Martin Buckley, Natasha Davies, Duncan Robert Hannah, Marianna Dilani Richard, Andrew Sharpe, Sophie Caroline Williams
  • Adenosine derivatives
    Publication number: 20030096788
    Abstract: A method of treating a patient suffering from or susceptible to ischemic heart disease, peripheral vascular disease or stroke or which subject is suffering pain, a CNS disorder or sleep apnea which comprises administering a therapeutically effective amount of an adenosine derivative which is an agonist at the adenosine A1 receptor and which exhibits little or no agonist activity of the A3 receptor.
    Type: Application
    Filed: August 13, 2002
    Publication date: May 22, 2003
    Applicant: Glaxo Wellcome Inc.
    Inventors: David Edmund Bays, Richard Peter Charles Cousins, Hazel Joan Dyke, Colin David Eldred, Brian David Judkins, Martin Pass, Andrew Michael Kenneth Pennell
  • Hydroxamic and carboxylic acid derivatives
    Publication number: 20030092727
    Abstract: Pharmacologically active compounds are provided as well as pharmaceutical compositions and methods for treating cancer; inflammation; an autoimmune, infectious or ocular disease; or age-related macular degeneration in a mammal.
    Type: Application
    Filed: October 25, 2002
    Publication date: May 15, 2003
    Inventors: Duncan Robert Hannah, Hazel Joan Dyke, Robert John Watson, John Fraser Keily, Andrew Douglas Baxter
  • 2-(purin-9-yl)-Tetrahydrofuran-3,4-diol derivatives
    Patent number: 6534486
    Abstract: A series of 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives with broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: March 18, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: David George Allen, Chuen Chan, Caroline Mary Cook, Richard Peter Charles Cousins, Brian Cox, Hazel Joan Dyke, Frank Ellis, Joanna Victoria Geden, Heather Hobbs, Suzanne Elaine Keeling, Alison Judith Redgrave, Stephen Swanson, Caroline Whitworth, David Bays
  • Hydroxamic and carboxylic acid derivatives
    Publication number: 20030032652
    Abstract: The invention relates to hydroxamic and carboxylic acid derivatives.
    Type: Application
    Filed: September 6, 2002
    Publication date: February 13, 2003
    Inventors: Duncan Batty, Verity Margaret Sabin, Robert John Watson, Hazel Joan Dyke, Andrew Sharpe, Richard John Davenport, David Alan Owen, Andrew Douglas Baxter
  • Hydroxamic and carboxylic acid derivatives
    Patent number: 6506773
    Abstract: Pharmacologically active compounds are provided as well as pharmaceutical compositions and methods for treating cancer; inflammation; an autoimmune, infectious or ocular disease; or age-related macular degeneration in a mammal.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: January 14, 2003
    Assignee: Darwin Discovery Ltd.
    Inventors: Duncan Robert Hannah, Hazel Joan Dyke, Robert John Watson, John Fraser Keily, Andrew Douglas Baxter
  • Adenosine derivatives
    Patent number: 6492348
    Abstract: A compound of formula (I) which is an agonist at the adenosine Al receptor, wherein Y, Z, and W represent heteroatoms, and salts and solvates thereof, in particular, physiologically acceptable solvates and salts thereof for use in therapy.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: December 10, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: David Edmund Bays, Richard Peter Charles Cousins, Hazel Joan Dyke, Colin David Eldred, Brian David Judkins, Martin Pass, Andrew Michael Kenneth Pennell
  • Heterocyclic compounds and their therapeutic use
    Publication number: 20020183358
    Abstract: N-oxides of formula (i) 1
    Type: Application
    Filed: May 16, 2002
    Publication date: December 5, 2002
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Hydroxamic and carboxylic acid derivatives
    Patent number: 6469020
    Abstract: The invention relates to hydroxamic and carboxylic acid derivatives. Compounds of the formula: are disclosed. These compounds are useful for the treatment of diseases mediated by inhibitors of matrix metalloproteinase, ADAM, ADAM-TS enzymes, and or INF&agr;-mediated diseases including degenerative diseases and certain cancers.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: October 22, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Duncan Batty, Verity Margaret Sabin, Robert John Watson, Hazel Joan Dyke, Andrew Sharpe, Richard John Davenport, David Alan Owen, Andrew Douglas Baxter
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6455561
    Abstract: The present invention pertains to compositions and methods for treating disease states which are capable of being modulated by inhibition of phosphodiesterase IV or Tumour Necrosis Factor, or that is a pathological condition associated with a function of phosphodiesterase IV, eosinophil accumulation or a function of the eosinophil, said method comprising administering to a person or animal in need of such treatment an effective amount of the compound of a formula wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is CH2OCH3 or 2 or 3-tetrahydrofuranyl; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C) R4 is C 1-3 alkyl; and R5 and R6, which may be the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: September 24, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, Christopher Lowe, John Gary Montana
  • Bicyclic aryl carboxamides and their therapeutic use
    Publication number: 20020094987
    Abstract: Compounds of the formula (i) 1
    Type: Application
    Filed: January 14, 2002
    Publication date: July 18, 2002
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6410559
    Abstract: N-oxides of formula (i) wherein R1 is CH3, CH2F, CHF2 or CF3; R2 is CH3 or CF3; R3 is F, Cl, Br, CN or CH3; and R4 is H, F, Cl, Br, CN or CH3; and pharmaceutically-acceptable salts thereof, are useful as therapeutic agents, e.g., for the treatment of inflammatory diseases.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: June 25, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6403791
    Abstract: A compound of the formula wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is C1-6 alkyl, cycloalkyl or NR4R5; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C) NR4R5 is a nitrogen-containing heterocyclic ring; R6 is C1-3 alkyl; and R7 and R8, which are the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: June 11, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, Alan Findlay Haughan, Christopher Lowe, George Martin Buckley, Richard John Davenport, Andrew Sharpe, Hannah Jayne Kendall, Verity Margaret Sabin, John Gary Montana, Catherine Louise Picken