Patents by Inventor Hazel Joan Dyke

Hazel Joan Dyke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxamic acid derivatives
    Publication number: 20020037900
    Abstract: The invention encompasses novel compounds which are inhibitors of matrix metalloproteinase, ADAM or ADAM-TS enzymes, and which are useful for the treatment of diseases mediated by those enzymes, including degenerative diseases and certain cancers.
    Type: Application
    Filed: May 15, 2001
    Publication date: March 28, 2002
    Inventors: Duncan Robert Hannah, Hazel Joan Dyke, Andrew Sharpe, Andrew Douglas Baxter
  • Bicyclic aryl carboxamides and their therapeutic use
    Patent number: 6353010
    Abstract: Compounds of the formula (i) have therapeutic utility via inhibition of TNF or phosphodiesterase.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: March 5, 2002
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Publication number: 20020022645
    Abstract: The present invention pertains to compositions and methods for treating disease states which are capable of being modulated by inhibition of phosphodiesterase IV or Tumour Necrosis Factor, or that is a pathological condition associated with a function of phosphodiesterase IV, eosinophil accumulation or a function of the eosinophil, said method comprising administering to a person or animal in need of such treatment an effective amount of the compound of a formula 1
    Type: Application
    Filed: October 12, 2001
    Publication date: February 21, 2002
    Inventors: Hazel Joan Dyke, Christopher Lowe, John Gary Montana
  • Hydroxamic and carboxylic acid derivatives
    Publication number: 20020022635
    Abstract: A phacologically actve compound of forula (1) 1
    Type: Application
    Filed: May 15, 2001
    Publication date: February 21, 2002
    Inventors: Duncan Robert Hannah, Hazel Joan Dyke, Robert John Watson, John Fraser Keily, Andrew Douglas Baxter
  • Hydroxamic and carboxylic acid derivatives
    Publication number: 20020013333
    Abstract: A pharmacologically active compound of formula (I) 1
    Type: Application
    Filed: May 15, 2001
    Publication date: January 31, 2002
    Inventors: Duncan Batty, Verity Margaret Sabin, Robert John Watson, Hazel Joan Dyke, Andrew Sharpe, Richard John Davenport, David Alan Owen, Andrew Douglas Baxter
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6331556
    Abstract: A compound of the formula wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is CH2OCH3 or 2 or 3-tetrahydrofuranyl; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C)  R4 is C1-3 alkyl; and R5 and R6, which may be the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: December 18, 2001
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, Christopher Lowe, John Gary Montana
  • Benzothiazole compounds and their therapeutic use
    Patent number: 6313116
    Abstract: Compounds that are inhibitors of phosphodiesterase and have therapeutic utility, are of formula (i) wherein R1 is C3-6 cycoalkyl, or C1-3 alkyl optionally substituted with one or more fluorine atoms; R2 is C1-6 alkyl, C3-6 cycloalkyl, CF3, CH2CF3, C2F5 or NR4R5; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C) NR4R5 is a nitrogen-containing heterocyclic ring; R6 is C1-3 alkyl; and R7 and R8, which are the same or different, are each H, C1-3 alkyl, halogen, CF3 or CN, provided that both are not H; or a pharmaceutically-acceptable salt thereof
    Type: Grant
    Filed: February 9, 2001
    Date of Patent: November 6, 2001
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, Andrew Sharpe, Hannah Jayne Kendall, Richard John Davenport, Verity Margaret Sabin, George Martin Buckley, Marianna Dilani Richard, Alan Findlay Haughan
  • Heterocyclic compounds and their therapeutic use
    Publication number: 20010031777
    Abstract: A compound of the formula 1
    Type: Application
    Filed: February 9, 2001
    Publication date: October 18, 2001
    Inventors: Hazel Joan Dyke, Christopher Lowe, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Publication number: 20010025049
    Abstract: N-oxides of formula (i) 1
    Type: Application
    Filed: March 30, 2001
    Publication date: September 27, 2001
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6262070
    Abstract: N-oxides of formula (i) wherein R1 is CH3, CH2F, CHF2 or CF3; R2 is CH3 or CF3; R3 is F, Cl, Br, CN or CH3; and R4 is H, F, Cl, Br, CN or CH3; and pharmaceutically-acceptable salts thereof, are useful as therapeutic agents, e.g. for the treatment of inflammatory diseases.
    Type: Grant
    Filed: November 3, 1999
    Date of Patent: July 17, 2001
    Assignee: Darwin Discovery Ltd.
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Heterocyclic compounds and their therapeutic use
    Patent number: 6169090
    Abstract: The compound, according to formula (i) wherein X and Y are independently CH, N or N-oxide, provided that X and Y do not both represent CH; Z is CO or CS; R1 is alkyl, optionally substituted with one or more halogens; and R2, R3, R4 and R5 are each various organic groups. Such compounds have therapeutic utility, via inhibition of phosphodiesterase IV.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: January 2, 2001
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, Verity Margaret Sabin, Andrew Sharpe, Alan Findlay Haughan, Christopher Lowe, George Buckley, John Montana
  • Quinolines and their therapeutic use
    Patent number: 6069151
    Abstract: Compounds of the formula ##STR1## have therapeutic utility, as inhibitors of phosphodiesterase IV and TNF release.
    Type: Grant
    Filed: June 17, 1998
    Date of Patent: May 30, 2000
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, John Gary Montana, Alan Findlay Haughan, Verity Margaret Sabin
  • Benzofuran-4-carboxamides and their therapeutic use
    Patent number: 6066657
    Abstract: A compound of formula (i) ##STR1## has therapeutic utility via inhibition of phosphodiesterase and THF release.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: May 23, 2000
    Assignee: Darwin Discovery, Ltd.
    Inventors: Hazel Joan Dyke, John Gary Montana, Christopher Lowe, Karen Ann Runcie, Alan Findlay Haughan, Verity Margaret Sabin, Duncan Hannah, Louise Picken, Andrew Sharpe
  • Benzofuran carboxamides and their therapeutic use
    Patent number: 5972936
    Abstract: Compounds having the formula (i), ##STR1## wherein the groups R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined herein. The compounds of the present invention can be utilized to treat disease states capable of being modulated by inhibition of proteins which mediate cellular activity, such as tumor necrosis factor (TNF) and/or phosphodiesterase IV (PDE IV).
    Type: Grant
    Filed: May 20, 1997
    Date of Patent: October 26, 1999
    Assignee: Darwin Discover Limited
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Benzofuran carboxamides and their therapeutic use
    Patent number: 5925636
    Abstract: Compounds having the formula (i), ##STR1## wherein the groups R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined herein. The compounds of the present invention can be utilized to treat disease states capable of being modulated by inhibition of proteins which mediate cellular activity, such as tumor necrosis factor (TNF) and/or phosphodiesterase IV (PDE IV).
    Type: Grant
    Filed: May 20, 1997
    Date of Patent: July 20, 1999
    Assignee: Darwin Discovery Limited
    Inventors: Hazel Joan Dyke, Christopher Lowe, John Gary Montana
  • Xanthines and their therapeutic use
    Patent number: 5919789
    Abstract: Compounds of the formula (i) ##STR1## have therapeutic utility via inhibition of TNF or phophodiesterase.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: July 6, 1999
    Assignee: Darwin Discovery Limited
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Quinoline sulfonamides and their therapeutic use
    Patent number: 5834485
    Abstract: The subject invention pertains to quinolinesulfonamides. The subject compounds can be used to treat disease states, such as those that are associated with proteins that mediate cellular activity, for example, by inhibiting phosphodiesterase IV (PDE IV) or tumor necrosis factor (TNF). The invention also pertains to methods of treating disease states, including those states capable of being modulated by inhibition of PDE IV or TNF.
    Type: Grant
    Filed: May 20, 1997
    Date of Patent: November 10, 1998
    Assignee: Chiroscience Limited
    Inventors: Hazel Joan Dyke, John Gary Montana
  • Quinoline carboxanides and their therapeutic use
    Patent number: 5804588
    Abstract: The subject invention concerns novel compounds of the general formula (i) ##STR1## that are useful in treating disease states, such as those states associated with proteins that mediate cellular activity. The compounds of the subject invention can be used, for example, to inhibit tumor necrosis factor and/or phosphodiesterase IV, The subject invention also concerns methods for treating disease states using the compounds of the invention.
    Type: Grant
    Filed: May 20, 1997
    Date of Patent: September 8, 1998
    Assignee: Chiroscience Limited
    Inventors: Hazel Joan Dyke, John Gary Montana, Christopher Lowe, Hannah Jayne Kendall, Verity Margaret Sabin
  • Benzofuran sulphonanmides
    Patent number: 5773467
    Abstract: Benzofuran carboxides and sulphonamides have therapeutic utility, e.g. in the treatment of inflammation and asthma, by virtue of their ability to inhibit phosphodiesterases and tumor necrosis factor.
    Type: Grant
    Filed: December 5, 1996
    Date of Patent: June 30, 1998
    Assignee: Chiroscience, Ltd.
    Inventors: Hazel Joan Dyke, Hannah Jayne Kendall, Christopher Lowe, John Gary Montana
  • Quinolones and their therapeutic use
    Patent number: 5753666
    Abstract: 1-Alkyl-substituted-quinolone-3-carboxamides have therapeutic utility via inhibition of Phosphodiesterase IV esterase and/or Tumor Necrosis Factor activity.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: May 19, 1998
    Assignee: Chiroscience Limited
    Inventors: Steven Colin Beasley, John Gary Montana, Hazel Joan Dyke, Alan Findlay Haughan, George Martin Buckley, Andrew Douglas Baxter