Patents by Inventor Hector Martinez

Hector Martinez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250136927
    Abstract: The invention relates to a composition for preparing a 3D scaffold for culturing cells and tissue, such as human cells and tissue. In particular embodiments, the present invention relates to a composition comprising a biocompatible polymer suitable for the preparation of a hydrogel, and a modified extracellular matrix (ECM) protein that is unreactive towards the biocompatible polymer, such that, after preparation of a hydrogel, the modified ECM protein is not covalently bound to the hydrogel. Compositions of the invention are suitable for use in 3D bioprinting, tissue engineering, drug screening, disease modelling and methods of treatment such as tissue regeneration.
    Type: Application
    Filed: September 13, 2022
    Publication date: May 1, 2025
    Applicants: The University Court of the University of Glasgow, Imperial College Innovations Limited, Cellink Bioprinting AB
    Inventors: Oana DOBRE, Sara TRUJILLO-MUNOZ, Matthew John DALBY, Manuel SALMERON-SANCHEZ, Liliang OUYANG, Molly STEVENS, Adel Itedal Namro REDWAN, Volodymyr KUZMENKO, Erik GATENHOLM, Hector MARTINEZ
  • Patent number: 12269217
    Abstract: A bioprinter (1) comprising at least one printhead (4a, 4b, 4c) with nozzle (5), a printbed (20) onto which the printhead (4a, 4b, 4c) is arranged to print an ink, an ultrasonic sensor arrangement arranged at the printbed (20), a controller (7) arranged to control movement of the printhead/nozzle (4a, 4b, 4c; 5) and to perform calibration of the printhead/nozzle (4a, 4b, 5 4c; 5) based on information from the ultrasonic sensor arrangement.
    Type: Grant
    Filed: May 3, 2021
    Date of Patent: April 8, 2025
    Assignee: Cellink Bioprinting AB
    Inventors: Anton Andren, Peter Faltpihl, Erik Sternå, Adam Micha, Ali Cakir, Hector Martinez, Erik Gatenholm
  • Publication number: 20250099932
    Abstract: A material mixing cartridge for a dispensing system comprises a dispensing chamber, with a material dispensing outlet and a dispensing actuator for dispensing material through the material dispensing outlet. The mixing cartridge further comprises at least two material compartments for receiving material to be mixed, and at least one material transfer channel which is adapted for material transfer between the at least two material compartments and the dispensing chamber The mixing cartridge further comprises at least one valve arranged to regulate material flow between a material compartment and the dispensing chamber via the at least one material transfer channel.
    Type: Application
    Filed: January 24, 2023
    Publication date: March 27, 2025
    Inventors: Mateusz Piotrzkowski, Anders Dahl, Ginger Lohman, Erik Gatenholm, Hector Martinez
  • Publication number: 20250001701
    Abstract: The present disclosure relates to a bioprinter system comprising a printbed, at least one of exchangeable and/or fixed toolhead, a cell culture monitor device, the device comprising a camera arranged to provide images of a cell culture or construct at the printbed, and a processing element arranged to monitor cell status at the printbed based on the provided images.
    Type: Application
    Filed: September 11, 2024
    Publication date: January 2, 2025
    Applicant: Cellink Bioprinting AB
    Inventors: Hector Martinez, Erik Gatenholm
  • Patent number: 12092530
    Abstract: A material cartridge arrangement (100, 101) for a dispensing system, comprising a material cartridge (2) having a first end (2a), an opposing second end (2b) and an ink material channel (5) extending between the first and second ends in the material cartridge (2), the ink material channel (5) being bounded by an ink material channel wall/walls (9) extending between the first (2a) and second ends (2b). An ink material pressurising device (3) is arranged to cause ink material hold in the ink material channel (5) to flow in a direction from said first end (2a) towards said second end (2b) and through an ink material outlet. At least one temperature sensing element (16) is arranged at a position along the direction of extension of the ink material channel (5) and arranged to measure a temperature at the ink material channel wall (9).
    Type: Grant
    Filed: August 31, 2021
    Date of Patent: September 17, 2024
    Assignee: Cellink Bioprinting AB
    Inventors: Erik Gatenholm, Hector Martinez, Ginger Lohman, Mateusz Piotrzkowski, Bryan Jones, Eric Bronnenkant, Kyung Hun Jung
  • Publication number: 20240226377
    Abstract: The present invention relates to silk fibroin bioinks specifically formulated for use in 3D bioprinting and the production of ex-vivo models capable of supporting hematopoiesis and the production of platelets and blood cells.
    Type: Application
    Filed: February 24, 2022
    Publication date: July 11, 2024
    Inventors: Alessandra BALDUINI, Christian Andrea DI BUDUO, Pierre-Alexandre LAURENT, Erik GATENHOLM, Hector MARTINEZ, Itedale REDWAN-NAMRO, Volodymyr KUZMENKO
  • Publication number: 20240157629
    Abstract: Bioprinters use biological inks (i.e. bioinks) to produce biomaterials such as cell cultures (including 3D cell cultures), living tissues, and organs. Bioprinters as described by the present invention include those capable of performing high-throughput industrial scale assays, applications, and development while maintaining precision.
    Type: Application
    Filed: March 14, 2022
    Publication date: May 16, 2024
    Inventors: Hector Martinez, Patrick Thayer, Erik Gatenholm, Holger Eickhoff
  • Publication number: 20240131220
    Abstract: The present invention relates to silk fibroin bioinks specifically formulated for use in 3D bioprinting and the production of ex-vivo models capable of supporting hematopoiesis and the production of platelets and blood cells.
    Type: Application
    Filed: February 24, 2022
    Publication date: April 25, 2024
    Inventors: Alessandra BALDUINI, Christian Andrea DI BUDUO, Pierre-Alexandre LAURENT, Erik GATENHOLM, Hector MARTINEZ, Itedale REDWAN-NAMRO, Volodymyr KUZMENKO
  • Patent number: 11931966
    Abstract: Systems and methods for optical assessments of bioink printability are described. The systems and methods include the use of hardware, software and optical targets to aid in the evaluation of bioink printability. The optical targets are developed and fabricated from 3D printable materials determined to be “nozzle fidelic” and/or materials that possess well characterized thermosensitivity. The optical targets make it possible to rapidly compare and evaluate bioink printability and can be easily customized and tailored for specific applications.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: March 19, 2024
    Assignee: CELLINK BIOPRINTING AB
    Inventors: Patrick Thayer, Hany Abushall, Hector Martinez, Erik Gatenholm
  • Patent number: 11826951
    Abstract: A three-dimensional (3D) bioprinting method and system are disclosed. The method includes disposing/immersing a printing platform or surface into a first bioink, such as a bioink resin, curing one or more layer of the first bioink resin onto the printing platform or surface, and removing the printing platform or surface from the first bioink resin. The process is repeated with a second bioink resin such that the second bioink resin is cured on top of the one or more layer of first bioink resin, and can be further repeated with a third or even fourth bioink resin. By varying constituents of one or more or each bioink resin (such as living cell type or polymer), complex, multilayered tissues can be engineered. A system capable of performing the method is also disclosed.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: November 28, 2023
    Assignee: Cellink AB
    Inventors: Christen J. Boyer, Hector Martinez, Erik Gatenholm
  • Publication number: 20230166455
    Abstract: A bioprinter (1) comprising at least one printhead (4a, 4b, 4c) with nozzle (5), a printbed (20) onto which the printhead (4a, 4b, 4c) is arranged to print an ink, an ultrasonic sensor arrangement arranged at the printbed (20), a controller (7) arranged to control movement of the printhead/nozzle (4a, 4b, 4c; 5) and to perform calibration of the printhead/nozzle (4a, 4b, 5 4c; 5) based on information from the ultrasonic sensor arrangement.
    Type: Application
    Filed: May 3, 2021
    Publication date: June 1, 2023
    Inventors: Anton Andren, Peter FALTPIHL, Erik STERNÅ, Adam MICHA, Ali CAKIR, Hector MARTINEZ, Erik GATENHOLM
  • Patent number: 11648336
    Abstract: The present invention relates to preparation of bioink composed of cellulose nanofibril hydrogel with native or synthetic Calcium containing particles. The concentration of the calcium containing particles can be between 1% and 40% w/v. Such bioink can be 3D Bioprinted with or without human or animal cells. Coaxial needle can be used where cellulose nanofibril hydrogel filled with Calcium particles can be used as shell and another hydrogel based bioink mixed with cells can be used as core or opposite. Such 3D Bioprinted constructs exhibit high porosity due to shear thinning properties of cellulose nanofibrils which provides excellent printing fidelity. They also have excellent mechanical properties and are easily handled as large constructs for patient-specific bone cavities which need to be repaired. The porosity promotes vascularization which is crucial for oxygen and nutrient supply. The porosity also makes it possible for further recruitment of cells which accelerate bone healing process.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: May 16, 2023
    Assignee: Cellink Bioprinting AB
    Inventors: Paul Gatenholm, Hector Martinez, Michela Schettino, Erik Gatenholm
  • Patent number: 11615492
    Abstract: The present disclosure relates to systems and methods for analyzing citationally related content and identifying, based on the analysis, a risk of impliedly overruled content. Embodiments provide for receiving case law data from a document source, for extracting a case triple that includes a first case overruling or abrogating a second case, and a third case citationally related to the second case. Features may be generated from case triple, such as natural processing language features comparing the language in the various cases of the triple, and feeding the generated features to a main classifier. In embodiments, the main classifier classifies the case triple into a class indicating the risk probability that the second case is impliedly overruled by the first case.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: March 28, 2023
    Assignee: Thomson Reuters Enterprise Centre GmbH
    Inventors: Julian Brooke, Kanika Madan, Hector Martinez Alonso, Afsaneh Fazly, Tonya Custis, Isabelle Moulinier, Gayle McElvain, Diane Erickson, Khaled Ammar
  • Patent number: 11590710
    Abstract: The present disclosure relates to a 3D bioprinter (1) comprising a base unit (2). The base unit (2) has a support (3) adapted for mounting of at least one toolhead (4), a communication interface part (5) for communication of data with the at least one toolhead (4), when mounted, and a base unit processing element (7) adapted to communicate with a toolhead processing element (8) of the at least one toolhead over said communication interface part (5). The present disclosure relates further to a 3D bioprinter toolhead. The present disclosure relates further to a method for bioprinting a construct.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: February 28, 2023
    Assignee: Cellink Bioprinting AB
    Inventors: Erik Sternå, Jockum Svanberg, Erik Gatenholm, Hector Martinez
  • Patent number: 11548199
    Abstract: The present disclosure relates to a 3D printer (1) for 3D printing of a construct. The 3D printer (1) has a print bed (2). The 3D printer further comprises at least one actuating tool head (3) with an extrusion element (4), wherein the extrusion element and the print bed are movable in relation to each other. The 3D printer also comprises at least one sensor (5) arranged to sense a force applied to the print bed (2) by the extrusion element (4), or vice versa. The 3D printer additionally comprises a control element (7) arranged to detect when the sensed force exceeds a predetermined value and to record a position of the print bed or extrusion element related to the detection that the predetermined value is exceeded. The present disclosure also relates to corresponding methods and computer programs.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: January 10, 2023
    Assignee: Cellink Bioprinting AB
    Inventors: Erik Sternå, Jockum Svanberg, Erik Gatenholm, Hector Martinez
  • Publication number: 20220349007
    Abstract: The disclosure relates to a method of culturing and analyzing at least one cell in a microchamber configured to allow for optical inspection of the at least one cell, wherein liquid is extracted from the microchamber for analysis, characterized in that the analysis returns information about particles secreted from the at least one cell and that this information can be correlated to the individual cell and/or cell population. The disclosure further relates to a device for use in the method and a system and a computer program for performing one or more of the steps of the method.
    Type: Application
    Filed: April 29, 2022
    Publication date: November 3, 2022
    Inventors: Erik Gatenholm, Hector Martinez, Jonas Schöndube
  • Publication number: 20220249738
    Abstract: The present invention relates to a 3D bioprinted skin tissue model, a method for providing said model and the use of said model. The 3D bioprinted skin tissue model comprises at least one bioink A, at least one cell type A, at least one factor A, wherein the bioink A comprises at least one biopolymer, a thickener, at least one extra-cellular matrix or a decellularized matrix, and optionally a photo initiator and/or cellular additions, the at least one cell type A is an epidermal, dermal and/or hypodermal cell or cell line, and the at least one factor A is a growth factor, protein and/or molecule that stimulates altered or abnormal metabolism of cell type A.
    Type: Application
    Filed: June 15, 2020
    Publication date: August 11, 2022
    Inventors: Isabella Bondesson, Adel Itedal Namro Redwan, Hector Martinez, Erik Gatenholm
  • Publication number: 20220183341
    Abstract: A food manufacturing apparatus 100 for manufacturing a food product 1, in particular a meat or meat replacement product 1, in a 3D printing process, includes a movable carrier substrate 10 extending along a longitudinal substrate direction x and being configured for accommodating the food product 1, a deposition device 20 including a plurality of deposition modules 21, which are arranged along the longitudinal substrate direction x of the carrier substrate 10, wherein each deposition module 21 is arranged for depositing components of the food product 1 on the carrier substrate 10, a conveyor device 30 being arranged for moving the carrier substrate 10 along the longitudinal substrate direction x thereof relative to the deposition modules 21, and a collection device 40 being arranged for collecting the food product 1. Furthermore, a method of manufacturing a food product 1, in particular a meat or meat replacement product, is described.
    Type: Application
    Filed: December 7, 2021
    Publication date: June 16, 2022
    Inventors: Holger EICKHOFF, Gusten DANIELSSON, Hector MARTINEZ, Erik GATENHOLM
  • Patent number: D954955
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: June 14, 2022
    Assignee: Cellink AB
    Inventors: Erik Gatenholm, Héctor Martínez, Niclas Johansson, Sebastian Persson, Adam Micha
  • Patent number: D1049412
    Type: Grant
    Filed: January 10, 2022
    Date of Patent: October 29, 2024
    Assignee: CYTENA BIOPROCESS SOLUTIONS CO., LTD.
    Inventors: Cheng-Han Tsai, Erik Gatenholm, Markus Grip, Isak Folenius, Héctor Martínez, Yeu-Fan Shih, Li-Wei Yeh