Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Examples disclosed herein relate to request authorization and authentication. Examples include to intercept a request from a processing pipeline of a device. The device to determine ether the request is authorized and authentic. The device to generate a cancellation request if the request is not authorized or not authenticated. The device to provide the cancellation request to the processing pipeline of the device.

Abstract: The invention comprises real-time down-hole intelligent communication based on the characterization of signal attenuation caused by a coaxial cable used as a communication medium and by frequency response changes of the electronic components of the transmitters and receivers, generated by the down-hole operating environment. The invention relates to a method for the real-time characterization of the attenuation response of a two-way communication system using a coaxial cable, consisting in: generating test tones for the real-time characterization of the attenuation response of a two-way communication system in the transmission and reception bands, measuring the signals received, estimating noise and the ratio to the communication signal, comparing with reference responses, adjusting the transmission and reception frequencies in order to maintain the communication with the maximum signal-to-noise ratio.

Abstract: The invention relates to a system and a method for measuring electrical energy with functions of pre-pay and data collection by means of an optical recharging device, comprising an electronic pre-pay meter with a supply connection/deconnection module, an optical recharging device, an energy sale-purchase module, a server containing measurement data collection and recharging management software, and a remote communication network.

Abstract: An apparatus for removal of flooring is presented. The flooring removal apparatus comprises a telescopically adjustable top frame with front wheels and a telescopically adjustable vertical rear frame coupled to the rear side of the top frame. The vertical rear frame includes a pair of rear wheels for directional control. The top frame is configured with one or more braces to securely clamp the housing of a jack hammer. An adapter suitable for a particular flooring type is provided for coupling to the tip of the jack hammer.

Abstract: An apparatus for removal of flooring is presented. The flooring removal apparatus comprises a telescopically adjustable top frame with front wheels and a telescopically adjustable vertical rear frame coupled to the rear side of the top frame. The vertical rear frame includes a pair of rear wheels for directional control. The top frame is configured with one or more braces to securely clamp the housing of a jack hammer. An adapter suitable for a particular flooring type is provided for coupling to the tip of the jack hammer.

Abstract: A pet kennel that is structured to receive an animal includes an upper kennel portion and a lower kennel portion that include first and second engagement structures that are slidingly engageable. The upper kennel portion is situated in a first position atop the lower kennel portion offset from one another along a longitudinal axis of the pet kennel. The upper kennel portion is then translated along the longitudinal axis with respect to the lower pet kennel portion toward a second, assembled position to cause the first engagement elements and the second engagement elements to become slidingly engaged and to cause the upper and lower kennel portions to become aligned with one another. The upper kennel portion additionally includes a pair of latches that are engageable with the lower shell portion in the second position of the pet kennel to retain the upper and lower kennel portions in the second position.

Abstract: The present application relates to anti-LOX and anti-LOXL2 antibodies and their use in purification, diagnostic and therapeutic methods. Antibodies include monoclonal antibodies, humanized antibodies and functional fragments thereof. Anti-LOX and anti-LOXL2 antibodies can be used to identify and treat conditions such as a fibrotic condition, angiogenesis, or to prevent a transition from an epithelial cell state to a mesenchymal cell state.

Abstract: A caliper assembly (100) of a disc brake caliper, of the type with a modified braking action, comprising a caliper body (1) suitable to arrange astride of a brake disc, at least one first pad (8) being slidably received in at least one first seat (101) and so as to position itself between a first vehicle side elongated portion (5) and a first braking surface of the brake disk to abut, with a first pad plane (128) thereof, against said first braking surface (3) and to exert a braking action on the brake disc when pressed by the thrust means upon demand for a first friction action exerted by the first pad friction material against said first braking surface (3) causing a braking action, said assembly (100) further comprising a first insert (106) in a separate body from said caliper body (1) and in a separate body to said first pad (8) and particular in a separate body to said first pad plate (102), said first insert (106) comprises a balance wheel body (119) hinged to the caliper body (1) and oscillating in rel

Abstract: Methods and systems for an injection system are provided. An example injection system includes a container for a pharmaceutical that is sealed at a proximal end with a plunger having a pushing surface for engaging an inner surface of the hollow body. A plunger rod extends axially from the proximal end of the container and is covered with a plunger rod cover. Removal of the cover activates the system and allows for delivery of the pharmaceutical product from the container by advancing the plunger within the container towards the seal.

Abstract: The present invention provides novel cycloalkyl-substituted pyrimidine dione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The invention comprises real-time down-hole intelligent communication based on the characterisation of signal attenuation caused by a coaxial cable used as a communication medium and by frequency response changes of the electronic components of the transmitters and receivers, generated by the down-hole operating environment. The invention relates to a method for the real-time characterisation of the attenuation response of a two-way communication system using a coaxial cable, consisting in: generating test tones for the real-time characterisation of the attenuation response of a two-way communication system in the transmission and reception bands, measuring the signals received, estimating noise and the ratio to the communication signal, comparing with reference responses, adjusting the transmission and reception frequencies in order to maintain the communication with the maximum signal-to-noise ratio.

Abstract: The present invention provides novel cycloalkyl-substituted pyrimidine dione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present application relates to anti-LOX and anti-LOXL2 antibodies and their use in purification, diagnostic and therapeutic methods. Antibodies include monoclonal antibodies, humanized antibodies and functional fragments thereof. Anti-LOX and anti-LOXL2 antibodies can be used to identify and treat conditions such as a fibrotic condition, angiogenesis, or to prevent a transition from an epithelial cell state to a mesenchymal cell state.

Abstract: Various systems, methods, and apparatuses for operating a wireless charging device in an electric vehicle are disclosed. One method includes detecting a system fault indicative of one or more faults in the wireless charging device in the electric vehicle or in the transmitter. The method further includes determining a fault severity level from a plurality of fault severity levels based on a type of the system fault detected. A total number of types of system faults can be greater than a total number of the plurality of fault severity levels. The method further includes performing one or more system fault response operation based on the determined fault severity level. Each of the plurality of fault severity levels can be associated with a different set of system fault response operations.