Abstract: Presented are concepts for m classifying a disease or disability of a subject. One such concept comprises obtaining interaction data associated with a subject, the interaction data being representative of the subject's interaction with a movement-based input device. The interaction data is processed with a first machine learning process to determine a set of 5 characteristics for describing the subject. The set of characteristics is then processed with a second machine-learning process to generate a classification result for the subject. An instruction is provided to the subject for directing the subject to interact with the movement-based input device, wherein the instruction defines a challenge comprising a time-varying parameter.

Abstract: An anti-scatter grid (ASG) for X-ray imaging with a surface (S) formed from a plurality of strips (LAM). The plurality of strips including at least two guard strips (Li,L i+1) that are thicker in a direction parallel to said surface than one or more strips l(i) of said plurality of strips (LAM). The one or more strips (li) being situated in between said two guard strips (Li,Li+1).

Abstract: Photon-counting x-ray detectors (3) suffer from a degradation of their performance due to polarization. In order to correct the effects of polarization to the generated x-ray images, the invention suggests (i) exposing the radiation detector (3) to a first radiation pulse emitted by a further radiation source (11) and obtaining a first electric pulse signal generated by the radiation detector (3) in response thereto, (ii) later exposing the 5 radiation detector (3) to a second radiation pulse emitted by the further radiation source (11) during the acquisition of the image and obtaining a second electric pulse signal generated by the radiation detector (3) in response thereto, and (iii) comparing amplitudes of the first and second electric pulse signals and generating the x-ray image based on a result of the comparison. The invention provides a corresponding x-ray device and a corresponding method.

Abstract: The invention relates to a method of Computed Tomography imaging comprising: a. Performing a single acquisition of image data from at least two contrast agents into a blood vessel network, a first contrast agent among said at least two contrast agents having been in said blood vessel network for a longer time than a second contrast agent among said at least two contrast agents, b. Processing said image data using K-Edge detection and/or iodine delineation to separate data associated with each contrast agents in order to obtain a concentration map of each contrast agent, c. Determining from said image data a first part of the blood vessel network comprising both the first contrast agent and the second contrast agent, and a second part of the blood vessel network comprising only the first contrast agent, d. Calculating a partial blood volume map of the first part of the blood vessel network based on the total amount of second contrast agent and on the concentration map of the second contrast agent, e.

Abstract: The present invention relates to phantom device for a dark field imaging system. Although dark field imaging is known to be sensitive to changes in the micro-structure of the tissue of a human subject that may be caused during a disease progression, there may be a need to quantify information provided by an image of the human subject. A detector signal component representing the dark image may be altered by changes of the X-ray spectrum which passes tissue of the human subject comprising micro-structures. This may be caused due to an attenuation of the X-ray radiation previously provided by an X-ray source, wherein the attenuation may be caused by tissue of the human subject, which covers said micro-structure comprising tissue. In order to provide information in clinical practice regarding the influence of attenuation to the X-ray radiation before it passes the micro-structure issue of the human subject, the phantom device for dark field imaging is proposed.

Abstract: The present invention relates to an anti-scatter grid (ASG) assembly comprising a first and a second grid, wherein the second grid is arranged on top of the first grid and comprises a lateral shift. The lamella thickness of the first grid is smaller than the lamella thickness of the second grid. The present invention further relates to a detector arrangement comprising a pixel detector and an ASG assembly arranged on top of the pixel detector.

Abstract: A phantom body (PB) for use in a differential phase contrast imaging apparatus (IM) for calibration of same. The phantom body (PB) allows for simultaneous calibration of three different image signal channels, namely refraction, phase shift and small angle scattering.

Abstract: The present invention relates to phantom device for a dark field imaging system. Although dark field imaging is known to be sensitive to changes in the micro-structure of the tissue of a human subject that may be caused during a disease progression, there may be a need to quantify information provided by an image of the human subject. A detector signal component representing the dark field image may be altered by changes of the X-ray spectrum which passes tissue of the human subject comprising micro-structures. This may be caused due to an attenuation of the X-ray radiation previously provided by an X-ray source, wherein the attenuation may be caused by tissue of the human subject, which covers said micro-structure comprising tissue. In order to provide information in clinical practice regarding the influence of attenuation to the X-ray radiation before it passes the micro-structure issue of the human subject, the phantom device for dark field imaging is proposed.

Abstract: Present invention relates to devices and methods for determining a calcium content by analyzing cardiac spectral CT data. CT projection data (9), obtainable by scanning a cardiac region of a subject using a spectral CT scanning unit, is modelled (12) by applying a material decomposition algorithm to the projection data to provide a calcium-specific component. Tomographic reconstructions (13) of the projection data, to provide a first 3D image (8), and of the calcium-specific component, to provide a second 3D image (6), are performed. The first 3D image (8) is segmented (14) to provide an image mask (5) corresponding to a cardiovascular structure of interest, a part of the second 3D image (6) is selected (15) based on the image mask (5), and a calcium content is calculated (16) in the cardiovascular structure of interest based on the selected part of the second 3D image (6).

Abstract: A method of an image processing apparatus for identifying a type of adipose body tissue within a subject, based on performing a spectral computed tomography (CT) scan of a region of interest of the subject; and using a combination of different image processing techniques to differentiate between at least two adipose tissue types within the region of interest.

Abstract: An X-ray detector (10) for a phase contrast imaging system (100) and a phase contrast imaging system (100) with such detector (10) are provided. The X-ray detector (10) comprises a scintillation device (12) and a photodetector (14) with a plurality of photosensitive pixels (15) optically coupled to the scintillation device (12), wherein the X-ray detector (10) comprises a primary axis (16) parallel to a surface normal vector of the scintillation device (12), and wherein the scintillation device (12) comprises a wafer substrate (18) having a plurality of grooves (20), which are spaced apart from each other. Each of the grooves (20) extends to a depth (22) along a first direction (21) from a first side (13) of the scintillation device (12) into the wafer substrate (18), wherein each of the grooves (20) is at least partially filled with a scintillation material.

Abstract: An apparatus and related method for processing image data supplied by a scanning phase contrast or dark-field imaging apparatus (MA). Beam hardening artifact in phase contrast and dark-field imaging can be reduced by applying a beam hardening processing operation by a beam hardening processing module (BHC) in respect of a plurality of detector readings that contribute signals to the same image pixel position or geometric ray of an imaging region of the apparatus (MA). In one embodiment, a phantom body (PB) is used to acquire calibration data on which the beam hardening processing is based.

Abstract: Apparatus and related method for dark-field imaging. The apparatus operates on projective intensities detected at a detector in different energy channels. An energy weighting is used to improve the signal to noise ratio. The model operates in a logarithmic domain.

Abstract: The invention relates to a photon counting x-ray radiation detection system. The system (31) comprises an x-ray radiation device (2) for providing polychromatic x-ray radiation (4) for traversing an examination zone (5) during a detection period of a scan. A photon counting detection device (6) comprising detection elements (3) detects the x-ray radiation after having traversed the examination zone and measures for each detection element photon counts in one or more energy bins during the detection period. A correction unit (12) estimates for each detection element an amount of a build up charge present in the detection element and corrects the measured photon counts for the detection element based on the estimated amount of the build up charge. This allows the corruption of the photon count rates caused by the build up charges to be compensated and to improve the determination of the photon counts.

Abstract: A phase contrast imaging apparatus (MA) and related image processing method. The imaging apparatus includes a movable arm (AR) that carries a detector (D) and one or more interferometric gratings (G0,G1,G2). The imaging apparatus includes a rigidizer (RGD) to control the rigidity of at least the arm (AR) or a mounting (GM) for the gratings (G0,G1,G2). This allows controlling a drift of a Moiré pattern as detected in a sequence of readouts. A phase of the so controlled Moiré pattern can be used to calibrate the imaging apparatus by using the image processing method.

Abstract: The invention relates to a method of Computed Tomography imaging comprising: a. Performing a single acquisition of image data from at least two contrast agents into a blood vessel network, a first contrast agent among said at least two contrast agents having been in said blood vessel network for a longer time than a second contrast agent among said at least two contrast agents, b. Processing said image data using K-Edge detection and/or iodine delineation to separate data associated with each contrast agents in order to obtain a concentration map of each contrast agent, c. Determining from said image data a first part of the blood vessel network comprising both the first contrast agent and the second contrast agent, and a second part of the blood vessel network comprising only the first contrast agent, d. Calculating a partial blood volume map of the first part of the blood vessel network based on the total amount of second contrast agent and on the concentration map of the second contrast agent, e.

Abstract: Photon-counting x-ray detectors (3) suffer from a degradation of their performance due to polarization. In order to correct the effects of polarization to the generated x-ray images, the invention suggests (i) exposing the radiation detector (3) to a first radiation pulse emitted by a further radiation source (11) and obtaining a first electric pulse signal generated by the radiation detector (3) in response thereto, (ii) later exposing the 5 radiation detector (3) to a second radiation pulse emitted by the further radiation source (11) during the acquisition of the image and obtaining a second electric pulse signal generated by the radiation detector (3) in response thereto, and (iii) comparing amplitudes of the first and second electric pulse signals and generating the x-ray image based on a result of the comparison. The invention provides a corresponding x-ray device and a corresponding method.

Abstract: An imaging system (100) includes a radiation source (110) with a focal spot (204) that emits a beam of x-ray photons that traverses an examination region (106). The imaging system further includes a photon counting detector array (122) that detects a sub-set of the x-ray photons that traverse an examination region. The imaging system further includes a controller (116) that generates and transmits a pause signal, in response to a calculated drop in an intensity of the emitted the beam of x-ray photons below a predetermined intensity level, which causes the photon counting detector array to pause detecting the sub-set of the x-ray photons. The imaging system further includes a counter (136) that counts, for each of a plurality of counting periods, the x-ray photons of the sub-set detected by the photon counting detector array in the corresponding counting period.

Abstract: The invention relates to a method and a pulse processing circuit (100) for the processing of current pulses (CP) generated by incident photons (X) in a piece of converter material, for instance in a pixel (11) of a radiation detector. Deviations of the pulse shape from a reference are detected and used to identify pulse corruption due to pile-up effects at high count rates and/or charge sharing between neighboring pixels. The deviation detection may for instance be achieved by generating, with a pulse shaper (110), bipolar shaped pulses from the current pulse (CP) and/or two shaped pulses of different shapes which can be compared to each other.

Abstract: The present invention is directed towards spectral imaging, wherein a dedicated spectral imaging phantom is scanned with a spectral x-ray device to obtain spectral imaging data of the spectral imaging phantom. Said imaging data of the spectral imaging phantom is used as input for obtaining improved further imaging data of a subject of which a spectral scan is performed subsequent to or simultaneous with the spectral scan of the spectral imaging phantom. Improved further imaging data may be obtained by using the spectral phantom imaging data as input for imaging data correction, for providing a recommendation and/or for further data processing.