Patents by Inventor Heinrich K. Schnoes

Heinrich K. Schnoes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4461766
    Abstract: The invention provides a method for inducing molting in egg-laying hens as a means for extending their productive egg-laying life by administering to the hens an effective amount of a side chain-hydroxylated vitamin D.sub.3 compound.
    Type: Grant
    Filed: March 28, 1983
    Date of Patent: July 24, 1984
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Leslie E. Hart
  • Patent number: 4448721
    Abstract: This invention relates to hydroxylated derivatives of vitamin D.sub.2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D.sub.2 compounds.The vitamin D.sub.2 derivatives would find application in the treatment of or prophylaxsis for various disease states characterized by calcium and phosphorous imbalances and as a substitute for vitamin D.sub.3 and its metabolites in their various applications.
    Type: Grant
    Filed: September 20, 1982
    Date of Patent: May 15, 1984
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Jacek W. Morzycki
  • Patent number: 4448726
    Abstract: This invention is directed to a new class of vitamin D compounds which are characterized by a modified ring A and triene structures and to a method for preparing same. The 7,8-dihydroxy-, 10.19-dihydroxy- and 10-oxo-19-nor-analogs of 25-hydroxyvitamin D.sub.3 are specifically disclosed.
    Type: Grant
    Filed: May 11, 1983
    Date of Patent: May 15, 1984
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, Connie M. Smith
  • Patent number: 4428946
    Abstract: A method for prophylactically treating dairy cattle for parturient paresis by administering to cattle vitamin D derivatives which are characterized by the presence of a hydroxyl group at at least one of the C-1 and C-25 positions and a metabolically stable blocking group at the C-24 position in an amount sufficient to induce said prophylaxsis.
    Type: Grant
    Filed: July 26, 1982
    Date of Patent: January 31, 1984
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Neal A. Jorgensen
  • Patent number: 4367177
    Abstract: A process for preparing 23,25-dihydroxyvitamin D compounds and hydroxy-protected derivatives thereof, and novel intermediates used in the process, are provided.
    Type: Grant
    Filed: April 15, 1981
    Date of Patent: January 4, 1983
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph K. Wichman
  • Patent number: 4360471
    Abstract: A novel vitamin D.sub.3 compound, 23-dehydro-25-hydroxyvitamin D.sub.3, and hydroxy-protected derivatives thereof are provided. The new compound is a side-chain-desaturated analog of 25-hydroxycholecalciferol, and would find application as a substitute for such compound or for vitamin D.sub.3.
    Type: Grant
    Filed: December 11, 1981
    Date of Patent: November 23, 1982
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph K. Wichmann
  • Patent number: 4360472
    Abstract: A novel side chain trihydroxylated vitamin D.sub.3 compound, namely 23,24,25-trihydroxyvitamin D.sub.3 and its acylated and alkylsilyated derivatives are provided. The new compounds are hydroxy analogs of the biologically-active 25-hydroxyvitamin D.sub.3 and would find application as substitutes for such compound or for vitamin D.sub.3.
    Type: Grant
    Filed: December 11, 1981
    Date of Patent: November 23, 1982
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph K. Wichmann
  • Patent number: 4338312
    Abstract: A method for prophylactically treating dairy cattle for parturient paresis by administering to the cattle a 25-hydroxylated vitamin D compound and a 1.alpha.-hydroxylated vitamin D compound in combination in an amount sufficient to induce said prophylaxsis.
    Type: Grant
    Filed: May 11, 1981
    Date of Patent: July 6, 1982
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Neal A. Jorgensen
  • Patent number: 4338250
    Abstract: A process for preparing biologically active 1.alpha.-hydroxyvitamin D compounds from vitamin D compounds by hydroxylation at carbon 1 and subsequent photochemical isomerization, and novel intermediates and products resulting from this process are provided.
    Type: Grant
    Filed: April 27, 1981
    Date of Patent: July 6, 1982
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
  • Patent number: 4336193
    Abstract: The invention provides methods for preparing the various isomeric forms of 25-hydroxyvitamin D.sub.3 -26,23-lactone utilizing cyanohydrin formation with readily prepared steroid materials followed by actinic radiation of the products and recovery of the desired 25-hydroxyvitamin D.sub.3 -26,23-lactone.The invention also provides new intermediate compounds in their various isomeric forms derived during the process for preparing the said vitamin D.sub.3 lactones.25-Hydroxyvitamin D.sub.3 -26,23-lactone is recognized as having vitamin D-like activity and is believed to play an important role in the regulation of calcium and phosphate levels in the animal and human organism. The present invention provides a convenient method for preparing the various isomeric forms of this compound.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: June 22, 1982
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, Joseph K. Wichmann, Mary A. Fivizzani
  • Patent number: 4313942
    Abstract: The invention provides a method for chemically activating vitamin D compounds to obtain active rodenticidal preparations.The activated vitamin D preparation offers an effective and relatively inexpensive rodenticidal material.
    Type: Grant
    Filed: October 9, 1979
    Date of Patent: February 2, 1982
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, Helen Frank
  • Patent number: 4307231
    Abstract: The invention provides a new vitamin D compound, 1.alpha.,25-dihydroxy-vitamin D.sub.3 26,23-lactone.The compound is characterized by vitamin D-like activity.
    Type: Grant
    Filed: July 18, 1980
    Date of Patent: December 22, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Yoko Tanaka, Herbert E. Paaren, Joseph K. Wichmann
  • Patent number: 4307025
    Abstract: The invention provides new derivatives of vitamin D.sub.3, specifically, 1.alpha.,25-dihydroxy-2.beta.-fluorocholecalciferol.The compound is characterized by vitamin D-like activity as measured by its ability to stimulate intestinal calcium transport, mobilization of calcium from bone, increase serum inorganic phosphorous and in their antirachitic activity. The compound, could, therefore, find ready application as a substitute for vitamin D in its various known applications and in the treatment of various metabolic bone diseases.
    Type: Grant
    Filed: February 17, 1981
    Date of Patent: December 22, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Nobuo Ikekawa, Yoko Tanaka, Masuo Morisaki, Jun-ichi Oshida
  • Patent number: 4297289
    Abstract: A method for isotopically labeling carbon-6 of vitamin D and 5,6-trans-vitamin D compounds which comprises reducing the corresponding 6-oxo-cyclovitamin with a tritio- or deutero-borohydride and subjecting the reduction product to acid-catalyzed solvolysis.The 6-labeled compounds find application in the elucidation of vitamin D metabolism and function and in vitamin metabolite analyses.
    Type: Grant
    Filed: July 17, 1980
    Date of Patent: October 27, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, Mary A. Fivizzani
  • Patent number: 4292250
    Abstract: The invention provides new 25-hydroxy vitamin D.sub.2 25-glucuronide derivatives among which is 25-hydroxy vitamin D.sub.2 25-D-glucuronic acid.By virtue of the structural similarity of 25-hydroxy vitamin D.sub.2 25-D-glucuronic acid to 25-hydroxy vitamin D.sub.2, a known biologically potent compound, the glucuronic acid compound should be a ready substitute for 25-hydroxy vitamin D.sub.2 in various therapeutic applications and particularly where the water solubility of the glucuronic acid compound is a necessity or advantage.
    Type: Grant
    Filed: November 17, 1980
    Date of Patent: September 29, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Leon W. LeVan
  • Patent number: 4279826
    Abstract: 23,25-Dihydroxyvitamin D.sub.3 a new derivative of vitamin D.sub.3. The compound is the 23-hydroxylated analog of biologically potent 23-hydroxycholecalciferol and by virtue of such structural similarity should find application as a substitute for such compound or for vitamin D.sub.3.
    Type: Grant
    Filed: September 22, 1980
    Date of Patent: July 21, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Yoko Tanaka, Joseph K. Wichmann
  • Patent number: 4269777
    Abstract: This invention relates to isotopically labeled vitamin D compounds, including radiolabeled vitamin D compounds of high specific activity, methods for their preparation, and novel intermediates in their synthesis.The radiolabeled vitamin D compounds are characterized by high specific activity (up to 160 Ci/mmol) with the process providing a facile and convenient method for synthesizing such compounds.
    Type: Grant
    Filed: May 21, 1979
    Date of Patent: May 26, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. De Luca, Heinrich K. Schnoes, Joseph L. Napoli, Mary A. Fivizzani
  • Patent number: 4265822
    Abstract: A method for preparing 1.alpha.-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds which comprises allylically oxidizing a 5,6-trans-vitamin D compound, subjecting the oxidation product to actinic radiation in the presence of a photosensitizing agent and recovering the 1.alpha.-hydroxylated compound.1.alpha.-hydroxylation is recognized as being essential to impart biological activity to vitamin D compounds and their derivatives. The present invention provides an efficient method for maximizing the yield of 1.alpha.-hydroxylated vitamin D compounds.
    Type: Grant
    Filed: September 10, 1979
    Date of Patent: May 5, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
  • Patent number: 4264513
    Abstract: The invention provides new vitamin D derivatives as well as new intermediate compounds derived during the processes for preparing such new derivatives. The new derivatives have been identified as 1.alpha.-hydroxy-25-keto-27-nor-vitamin D.sub.3 and its acylates.1.alpha.-hydroxy-25-keto-27-nor-vitamin D.sub.3 expresses excellent vitamin D-like activity and would find ready application as a substitute for vitamin D compounds in the treatment of disease states evincing calcium-phosphorous imbalance.
    Type: Grant
    Filed: May 21, 1979
    Date of Patent: April 28, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph L. Napoli, Jr., Mary A. Fivizzani
  • Patent number: 4263214
    Abstract: Fluorine-substituted vitamin D compounds, methods for preparation of such compounds and fluorinated intermediate compounds used in such methods are disclosed. The fluorine-substituted vitamin D compounds are characterized by vitamin D-like activity in stimulating intestinal calcium transport and bone mobilization and in promoting the calcification of rachitic bone.
    Type: Grant
    Filed: August 6, 1979
    Date of Patent: April 21, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph L. Napoli, Jr., Bruce L. Onisko