Abstract: The invention provides a method for inducing molting in egg-laying hens as a means for extending their productive egg-laying life by administering to the hens an effective amount of a side chain-hydroxylated vitamin D.sub.3 compound.

Abstract: This invention is directed to a new class of vitamin D compounds which are characterized by a modified ring A and triene structures and to a method for preparing same. The 7,8-dihydroxy-, 10.19-dihydroxy- and 10-oxo-19-nor-analogs of 25-hydroxyvitamin D.sub.3 are specifically disclosed.

Abstract: This invention relates to hydroxylated derivatives of vitamin D.sub.2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D.sub.2 compounds.The vitamin D.sub.2 derivatives would find application in the treatment of or prophylaxsis for various disease states characterized by calcium and phosphorous imbalances and as a substitute for vitamin D.sub.3 and its metabolites in their various applications.

Abstract: A method for prophylactically treating dairy cattle for parturient paresis by administering to cattle vitamin D derivatives which are characterized by the presence of a hydroxyl group at at least one of the C-1 and C-25 positions and a metabolically stable blocking group at the C-24 position in an amount sufficient to induce said prophylaxsis.

Abstract: A process for preparing 23,25-dihydroxyvitamin D compounds and hydroxy-protected derivatives thereof, and novel intermediates used in the process, are provided.

Abstract: A novel side chain trihydroxylated vitamin D.sub.3 compound, namely 23,24,25-trihydroxyvitamin D.sub.3 and its acylated and alkylsilyated derivatives are provided. The new compounds are hydroxy analogs of the biologically-active 25-hydroxyvitamin D.sub.3 and would find application as substitutes for such compound or for vitamin D.sub.3.

Abstract: A novel vitamin D.sub.3 compound, 23-dehydro-25-hydroxyvitamin D.sub.3, and hydroxy-protected derivatives thereof are provided. The new compound is a side-chain-desaturated analog of 25-hydroxycholecalciferol, and would find application as a substitute for such compound or for vitamin D.sub.3.

Abstract: A method for prophylactically treating dairy cattle for parturient paresis by administering to the cattle a 25-hydroxylated vitamin D compound and a 1.alpha.-hydroxylated vitamin D compound in combination in an amount sufficient to induce said prophylaxsis.

Abstract: A process for preparing biologically active 1.alpha.-hydroxyvitamin D compounds from vitamin D compounds by hydroxylation at carbon 1 and subsequent photochemical isomerization, and novel intermediates and products resulting from this process are provided.

Abstract: The invention provides methods for preparing the various isomeric forms of 25-hydroxyvitamin D.sub.3 -26,23-lactone utilizing cyanohydrin formation with readily prepared steroid materials followed by actinic radiation of the products and recovery of the desired 25-hydroxyvitamin D.sub.3 -26,23-lactone.The invention also provides new intermediate compounds in their various isomeric forms derived during the process for preparing the said vitamin D.sub.3 lactones.25-Hydroxyvitamin D.sub.3 -26,23-lactone is recognized as having vitamin D-like activity and is believed to play an important role in the regulation of calcium and phosphate levels in the animal and human organism. The present invention provides a convenient method for preparing the various isomeric forms of this compound.

Abstract: The invention provides a method for chemically activating vitamin D compounds to obtain active rodenticidal preparations.The activated vitamin D preparation offers an effective and relatively inexpensive rodenticidal material.

Abstract: The invention provides a new vitamin D compound, 1.alpha.,25-dihydroxy-vitamin D.sub.3 26,23-lactone.The compound is characterized by vitamin D-like activity.

Abstract: The invention provides new derivatives of vitamin D.sub.3, specifically, 1.alpha.,25-dihydroxy-2.beta.-fluorocholecalciferol.The compound is characterized by vitamin D-like activity as measured by its ability to stimulate intestinal calcium transport, mobilization of calcium from bone, increase serum inorganic phosphorous and in their antirachitic activity. The compound, could, therefore, find ready application as a substitute for vitamin D in its various known applications and in the treatment of various metabolic bone diseases.

Abstract: A method for isotopically labeling carbon-6 of vitamin D and 5,6-trans-vitamin D compounds which comprises reducing the corresponding 6-oxo-cyclovitamin with a tritio- or deutero-borohydride and subjecting the reduction product to acid-catalyzed solvolysis.The 6-labeled compounds find application in the elucidation of vitamin D metabolism and function and in vitamin metabolite analyses.

Abstract: The invention provides new 25-hydroxy vitamin D.sub.2 25-glucuronide derivatives among which is 25-hydroxy vitamin D.sub.2 25-D-glucuronic acid.By virtue of the structural similarity of 25-hydroxy vitamin D.sub.2 25-D-glucuronic acid to 25-hydroxy vitamin D.sub.2, a known biologically potent compound, the glucuronic acid compound should be a ready substitute for 25-hydroxy vitamin D.sub.2 in various therapeutic applications and particularly where the water solubility of the glucuronic acid compound is a necessity or advantage.

Abstract: 23,25-Dihydroxyvitamin D.sub.3 a new derivative of vitamin D.sub.3. The compound is the 23-hydroxylated analog of biologically potent 23-hydroxycholecalciferol and by virtue of such structural similarity should find application as a substitute for such compound or for vitamin D.sub.3.

Abstract: This invention relates to isotopically labeled vitamin D compounds, including radiolabeled vitamin D compounds of high specific activity, methods for their preparation, and novel intermediates in their synthesis.The radiolabeled vitamin D compounds are characterized by high specific activity (up to 160 Ci/mmol) with the process providing a facile and convenient method for synthesizing such compounds.

Abstract: A method for preparing 1.alpha.-hydroxylated vitamin D compounds from 5,6-trans-vitamin D compounds which comprises allylically oxidizing a 5,6-trans-vitamin D compound, subjecting the oxidation product to actinic radiation in the presence of a photosensitizing agent and recovering the 1.alpha.-hydroxylated compound.1.alpha.-hydroxylation is recognized as being essential to impart biological activity to vitamin D compounds and their derivatives. The present invention provides an efficient method for maximizing the yield of 1.alpha.-hydroxylated vitamin D compounds.

Abstract: The invention provides new vitamin D derivatives as well as new intermediate compounds derived during the processes for preparing such new derivatives. The new derivatives have been identified as 1.alpha.-hydroxy-25-keto-27-nor-vitamin D.sub.3 and its acylates.1.alpha.-hydroxy-25-keto-27-nor-vitamin D.sub.3 expresses excellent vitamin D-like activity and would find ready application as a substitute for vitamin D compounds in the treatment of disease states evincing calcium-phosphorous imbalance.

Abstract: Fluorine-substituted vitamin D compounds, methods for preparation of such compounds and fluorinated intermediate compounds used in such methods are disclosed. The fluorine-substituted vitamin D compounds are characterized by vitamin D-like activity in stimulating intestinal calcium transport and bone mobilization and in promoting the calcification of rachitic bone.