Patents by Inventor Heinrich K. Schnoes

Heinrich K. Schnoes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4260804
    Abstract: A method for chemically synthesizing calcitrioic acid and esters thereof. Calcitroic acid displays antirachitic (vitamin D-like) activity.
    Type: Grant
    Filed: February 20, 1980
    Date of Patent: April 7, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Robert P. Esvelt
  • Patent number: 4260549
    Abstract: An improved method for the preparation of 1.alpha.-hydroxylated vitamin D compounds involving directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors or derivatives thereof, wherein the 1.alpha.-hydroxycyclovitamin D intermediate is solvolyzed directly, without first converting the 1-hydroxy group to a 1-O-acyl function as a protective measure.
    Type: Grant
    Filed: May 21, 1979
    Date of Patent: April 7, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, David E. Hamer
  • Patent number: 4234495
    Abstract: A method for preparing 1.alpha.-hydroxyvitamin D compounds from 1.alpha.-hydroxy-3,5-cyclovitamin D compounds which comprises solvolyzing the 3,5-cyclovitamin D compound, exposing the solvolysis reaction products to actinic radiation in the presence of a photosensitizing agent and recovering the 1.alpha.-hydroxylated vitamin D compounds.1.alpha.-hydroxylation is recognized as being essential to impart biological activity to vitamin D compounds and their derivatives. The present invention provides an efficient method for maximizing the yield of 1.alpha.-hydroxylated vitamin D compounds.
    Type: Grant
    Filed: September 10, 1979
    Date of Patent: November 18, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
  • Patent number: 4230627
    Abstract: Fluorine-substituted vitamin D compounds, methods for preparation of such compounds and fluorinated intermediate compounds used in such methods are disclosed. The fluorine-substituted vitamin D compounds are characterized by vitamin D-like activity in stimulating intestinal calcium transport and bone mobilization and in promoting the calcification of rachitic bone.
    Type: Grant
    Filed: August 6, 1979
    Date of Patent: October 28, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph L. Napoli, Jr., Bruce L. Onisko
  • Patent number: 4229359
    Abstract: Compounds having the structure ##STR1## where X is keto or hydroxy. The compounds display vitamin D like activity and would find appliction in disease states characterized by adverse calcium-phosphorous balance or behavior.
    Type: Grant
    Filed: September 4, 1979
    Date of Patent: October 21, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Yoko Tanaka, Joseph B. Alper
  • Patent number: 4229358
    Abstract: Fluorine-substituted vitamin D compounds, methods for preparation of such compounds and fluorinated intermediate compounds used in such methods are disclosed. The fluorine-substituted vitamin D compounds are characterized by vitamin D-like activity in stimulating intestinal calcium transport and bone mobilization and in promoting the calcification of rachitic bone.
    Type: Grant
    Filed: August 3, 1979
    Date of Patent: October 21, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph L. Napoli, Jr., Bruce L. Onisko
  • Patent number: 4229357
    Abstract: Fluorine-substituted vitamin D compounds, methods for preparation of such compounds and fluorinated intermediate compounds used in such methods are disclosed. The fluorine-substituted vitamin D compounds are characterized by vitamin D-like activity in stimulating intestinal calcium transport and bone mobilization and in promoting the calcification of rachitic bone.
    Type: Grant
    Filed: August 6, 1979
    Date of Patent: October 21, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph L. Napoli, Jr., Bruce L. Onisko
  • Patent number: 4226787
    Abstract: Fluorine-substituted vitamin D compounds, methods for preparation of such compounds and fluorinated intermediate compounds used in such methods are disclosed. The fluorine-substituted vitamin D compounds are characterized by vitamin D-like activity in stimulating intestinal calcium transport and bone mobilization and in promoting the calcification of rachitic bone.
    Type: Grant
    Filed: August 6, 1979
    Date of Patent: October 7, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph L. Napoli, Jr., Bruce L. Onisko
  • Patent number: 4226788
    Abstract: The invention provides new derivatives of vitamin D, 24,24-difluoro-1.alpha.,25-dihydroxycholecalciferol and 24,24-difluoro-1.alpha.,25-dihydroxy-5,6-trans-cholecalciferol and processes for preparing the same.The compounds are characterized by vitamin D-like activity essentially equivalent to the vitamin D-like activity of 1.alpha.,25-dihydrocholecalciferol which is considered to be the hormonal form and most active derivative of vitamin D. The compounds of this invention are characterized by their ability to increase intestinal calcium transport, increase serum calcium and to prevent the development of rickets. These compounds would find ready application as a substitute for vitamin D and in the treatment of disease states evincing metabolic calcium and phosphorus deficiences.
    Type: Grant
    Filed: August 6, 1979
    Date of Patent: October 7, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Nobuo Ikekawa, Yoko Tanaka, Yoshiro Kobayashi
  • Patent number: 4224231
    Abstract: Compounds having the formula ##STR1## where X is selected from keto or hydroxy. The compounds are characterized by vitamin D-like activity and would find application in the treatment of disease states where adverse calcium-phosphorous balance or behavior is encountered.
    Type: Grant
    Filed: September 4, 1979
    Date of Patent: September 23, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Yoko Tanaka, Joseph B. Alper
  • Patent number: 4224230
    Abstract: Fluorine-substituted vitamin D compounds, methods for preparation of such compounds and fluorinated intermediate compounds used in such methods are disclosed. The fluorine-substituted vitamin D compounds are characterized by vitamin D-like activity in stimulating intestinal calcium transport and bone mobilization and in promoting the calcification of rachitic bone.
    Type: Grant
    Filed: August 6, 1979
    Date of Patent: September 23, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph L. Napoli, Jr., Bruce L. Onisko
  • Patent number: 4223131
    Abstract: The invention provides a new derivative of vitamin D, 25-hydroxycholecalciferol-26,23-lactone.The compound is characterized by vitamin D-like activity in its ability to increase serum calcium concentration by mobilizing bone and would find application in disease states requiring the elevation of serum calcium concentration.
    Type: Grant
    Filed: January 26, 1979
    Date of Patent: September 16, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph K. Wichmann
  • Patent number: 4217288
    Abstract: 25-Aza-vitamin D.sub.3, 25-methylvitamin D.sub.3, cholanocalciferol dimethylamide and methods for preparing the same. The compounds are characterized by anti-vitamin D activity and find application where inhibition of the intestinal calcium transport or bone calcium mobilization effects of vitamin D are desirable.
    Type: Grant
    Filed: May 19, 1978
    Date of Patent: August 12, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Bruce L. Onisko
  • Patent number: 4209634
    Abstract: 1.alpha.-hydroxycalcioic acid. The compound displays antirachitic (vitamin D-like) activity and would find application in disease states characterized by adverse calcium-phosphorous balance or behavior.
    Type: Grant
    Filed: December 29, 1978
    Date of Patent: June 24, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Robert P. Esvelt
  • Patent number: 4202829
    Abstract: A method for directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors of derivatives thereof which comprises subjecting such molecules to allylic oxidation utilizing selenium dioxide as the oxidizing agent.
    Type: Grant
    Filed: December 13, 1978
    Date of Patent: May 13, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
  • Patent number: 4201881
    Abstract: The invention provides new derivatives of vitamin D, 24,24-difluoro-1.alpha.,25-dihydroxycholecalciferol and 24,24-difluoro-1.alpha.,25-dihydroxy-5,6-trans-cholecalciferol and processes for preparing the same.The compounds are characterized by vitamin D-like activity essentially equivalent to the vitamin D-like activity of 1.alpha.,25-dihydrocholecalciferol which is considered to be the hormonal form and most active derivative of vitamin D. The compounds of this invention are characterized by their ability to increase intestinal calcium transport, increase serum calcium and to prevent the development of rickets. These compounds would find ready application as a substitute for vitamin D and in the treatment of disease states evincing metabolic calcium and phosphorus deficiencies.
    Type: Grant
    Filed: March 28, 1979
    Date of Patent: May 6, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Nobuo Ikekawa, Yoko Tanaka, Yoshiro Kobayashi
  • Patent number: 4195027
    Abstract: A method for directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors or derivatives thereof which comprises subjecting such molecules to allylic oxidation utilizing selenium dioxide as the oxidizing agent.
    Type: Grant
    Filed: June 12, 1978
    Date of Patent: March 25, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, David E. Hamer, Herbert E. Paaren
  • Patent number: 4188345
    Abstract: Fluorine-substituted vitamin D compounds, methods for preparation of such compounds and fluorinated intermediate compounds used in such methods are disclosed. The fluorine-substituted vitamin D compounds are characterized by vitamin D-like activity in stimulating intestinal calcium transport and bone mobilization and in promoting the calcification of rachitic bone.
    Type: Grant
    Filed: July 26, 1978
    Date of Patent: February 12, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph L. Napoli, Jr., Bruce L. Onisko
  • Patent number: 4035493
    Abstract: A rodenticide suitable for the control of rat and mice populations containing as the active rodenticidal ingredient 1.alpha.-hydroxycholecalciferol or 1.alpha.-hydroxyergocalciferol or 1,25-dihydroxycholecalciferol.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: July 12, 1977
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, John W. Suttie, Helen Frank
  • Patent number: RE30538
    Abstract: 3-Deoxy-1.alpha.-hydroxycholecalciferol. The compound is characterized by vitamin D-like activity.
    Type: Grant
    Filed: March 7, 1977
    Date of Patent: March 3, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Hing-Yat Lam