Abstract: Provided herein is a composition comprising a fusion protein or a fragment or a variant thereof comprising an anti-PD1 antibody or a fragment/variant thereof and a TGF-? trap. Provided herein is a composition comprising a fusion protein or a fragment thereof or a variant thereof comprising an anti-PD1 antibody or a fragment/variant thereof and a ADA2 polypeptide. Also provided herein are methods of using the composition in treating cancer.

Abstract: A reconfigurable polarization rotator is formed of an array of very small liquid crystal (LC) cells (e.g., cells of less than 10 ?m in width, termed “microcells”), referred to hereinafter as “microcells”. Each LC microcell is addressable by a separate electrical voltage input that independently controls the polarization rotation performed by the associated LC microcell. By defining a set of adjacent microcells to be held at the same voltage level, that group may be used to form a polarization rotator window of a proper size for a first fiber array configuration. When a fiber array of a different configuration (say, an array with twice the pitch) is used, a different-sized group of adjacent LC microcells is held at a common voltage level so as to form a reconfigured “window” of a new dimension.

Abstract: In a wavelength selective switch, an input port transmits an input beam, and diffraction grating disperses the input beam into optical channels. A liquid-crystal-on-silicon (LCoS) switch assembly has a phase grating profile and has addressable pixels, which are liquid crystal based. The LCoS switch assembly can selectively direct first-order diffracted beams of the optical channels for output to selected output ports. A tunable optical wedge adjacent the LCoS switch assembly can direct higher-order diffraction beams in the space between the output ports to reduce crosstalk. The wedge is a liquid crystal cell having spaced-apart resistive layers and having liquid crystal material disposed between the layers. In the wedge, the liquid crystal material can produce a phase profile in response to bias voltages applied to the resistive layers, and a beam steering angle of the phase profile can direct at least the second-order diffracted beams towards the port spacing between the ports.

Abstract: A voltage-controlled optical wedge is formed by creating an adjustable voltage gradient along the length of a relatively large-sized LC cell. A pair of bias voltages (AC voltages) are applied at the opposing side terminations of the LC cell, their RMS values selected to create a continuous phase variation along the length of the cell, where a defined phase variation is associated with a specific beam steering angle. Adjustments in the applied bias voltages (specifically, changes in the RMS values of the bias voltages) result in changing the beam steering angle, providing for active, controllable beam steering as a function of time. The LC cell may be configured to provide either a linear or nonlinear continuous phase variation, as preferred for different beam steering applications.

Abstract: A client device that is not originally compliant with a particular security standard (e.g., FIPS) is brought into compliance through the addition of a standard-compliant software-based cryptographic library. In order to adapt the cryptographic library to integrate with the hardware-backed keystore, a non-hardware-backed software keystore is used to store keys used by the cryptographic library. Additionally, in order to provide appropriate security for the software keystore, the software keystore (and/or the keypairs within the software keystore) is protected by a password, and the password is in turn protected by the hardware-backed keystore. Thus, to obtain the password needed to obtain a keypair from the software keystore that is in turn needed to use the cryptographic library, a user must authenticate with the operating system, e.g., by providing biometric credentials.

Abstract: A system and method for creation, auditing and management of legal documents. The method may include confirming if legal documents that have been requested by the system are valid in the jurisdiction where the request is being made. If so, the legal document can be released. If the legal document does not exist, such as with a Power of Attorney (POA), the system may assist to generate a POA and determine if a capacity assessment is required.

Abstract: A module handles beams having multiple channels in an optical network. The module has a dispersion element, a liquid crystal (LC) based switching assembly, and photodetectors. The dispersion element is arranged in optical communication with the beams from inputs and is configured to disperse the beams into the channels across a dispersion direction. The switching assembly is arranged in optical communication with the channels from the dispersion element and is configured to selectively reflect the channels using electrically switchable cells of one or more LC-based switching engines. The photodetectors are arranged in optical communication with the dispersion element, and each are configured to receive selectively reflected channels for optical channel monitoring. Outputs can be arranged in optical communication with the dispersion element and can be configured to receive selectively reflected channels for wavelength selective switching.

Abstract: A voltage-controlled optical wedge is formed by creating an adjustable voltage gradient along the length of a relatively large-sized LC cell. A pair of bias voltages (AC voltages) are applied at the opposing side terminations of the LC cell, their RMS values selected to create a continuous phase variation along the length of the cell, where a defined phase variation is associated with a specific beam steering angle. Adjustments in the applied bias voltages (specifically, changes in the RMS values of the bias voltages) result in changing the beam steering angle, providing for active, controllable beam steering as a function of time. The LC cell may be configured to provide either a linear or nonlinear continuous phase variation, as preferred for different beam steering applications.

Abstract: A reconfigurable polarization rotator is formed of an array of very small liquid crystal (LC) cells (e.g., cells of less than 10 ?m in width, termed “microcells”), referred to hereinafter as “microcells”. Each LC microcell is addressable by a separate electrical voltage input that independently controls the polarization rotation performed by the associated LC microcell. By defining a set of adjacent microcells to be held at the same voltage level, that group may be used to form a polarization rotator window of a proper size for a first fiber array configuration. When a fiber array of a different configuration (say, an array with twice the pitch) is used, a different-sized group of adjacent LC microcells is held at a common voltage level so as to form a reconfigured “window” of a new dimension.

Abstract: A voltage-controlled optical wedge is formed by creating an adjustable voltage gradient along the length of a relatively large-sized LC cell. A pair of bias voltages (AC voltages) are applied at the opposing side terminations of the LC cell, their RMS values selected to create a continuous phase variation along the length of the cell, where a defined phase variation is associated with a specific beam steering angle. Adjustments in the applied bias voltages (specifically, changes in the RMS values of the bias voltages) result in changing the beam steering angle, providing for active, controllable beam steering as a function of time. The LC cell may be configured to provide either a linear or nonlinear continuous phase variation, as preferred for different beam steering applications.

Abstract: A module handles beams having multiple channels in an optical network. The module has a dispersion element, a liquid crystal (LC) based switching assembly, and photodetectors. The dispersion element is arranged in optical communication with the beams from inputs and is configured to disperse the beams into the channels across a dispersion direction. The switching assembly is arranged in optical communication with the channels from the dispersion element and is configured to selectively reflect the channels using electrically switchable cells of one or more LC-based switching engines. The photodetectors are arranged in optical communication with the dispersion element, and each are configured to receive selectively reflected channels for optical channel monitoring. Outputs can be arranged in optical communication with the dispersion element and can be configured to receive selectively reflected channels for wavelength selective switching.

Abstract: A two-step optimization process is utilized to define an optimal phase profile for a LCoS spatial light modulator. The two-step optimization process first utilizes a nonlinear constrained optimization (NCO) program to determine the specific parameters required to obtain an optimal phase profile (hologram), where the “optimal phase profile” is typically defined as that profile which achieves maximum diffraction efficiency for optical switching. Following this first step, phase scaling (and perhaps an adjustment in the number of pixels per period) is employed to slightly modify the values of the optimal phase profile to effectively suppress crosstalk peaks. If any orders still exhibit an unacceptable level of crosstalk, these orders are then subtracted from the phase profile to create the final design.

Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

Abstract: A food preparation device or system which utilizes pre-packaged food containers to prepare a food item for consumption.

Abstract: A two-step optimization process is utilized to define an optimal phase profile for a LCoS spatial light modulator. The two-step optimization process first utilizes a nonlinear constrained optimization (NCO) program to determine the specific parameters required to obtain an optimal phase profile (hologram), where the “optimal phase profile” is typically defined as that profile which achieves maximum diffraction efficiency for optical switching. Following this first step, phase scaling (and perhaps an adjustment in the number of pixels per period) is employed to slightly modify the values of the optimal phase profile to effectively suppress crosstalk peaks. If any orders still exhibit an unacceptable level of crosstalk, these orders are then subtracted from the phase profile to create the final design.

Abstract: A food preparation device or system which utilizes pre-packaged food containers to prepare a food item for consumption. The food preparation device is structured to receive multiple pre-packaged containers. Additionally, the food preparation device includes one or more processors to verify that each of the multiple containers include one or more ingredients for preparing a selected dish, and further that an order in which the multiple containers are individually received in the base corresponds to a sequence in which the individual food items of the multiple containers are to be introduced into a cooking receptacle during preparation of the dish.

Abstract: A multiple wavelength selective switch has an optics assembly to receive a first input optical signal from a first ingress port and a second input optical signal from a second ingress port. A switch assembly has a single switching mechanism to direct the first input optical signal to the optics assembly as a first output optical signal and the second input optical signal to the optics assembly as a second output optical signal. The switch assembly directs the first output optical signal to a first egress port selected from the first set of egress ports and directs the second output optical signal to a second egress port selected from the second set egress ports. The first egress port and the second egress port have the same wavelength channel. The multiple wavelength selective switch supports an arbitrary number of wavelength channels that can be switched at the same time. Each switch assembly directs signals from a set of ingress ports to a set of egress ports sharing the same wavelength channel.

Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

Abstract: A food preparation device or system which includes the following: (i) a base dimensioned to hold food containers and includes a first opening to receive the food containers and a second opening; (ii) an extraction mechanism to extract food items from each container in the base, through the second opening and to a preparation receptacle; (iii) a heating mechanism in the preparation receptacle; and (iv) one or more processors and memory containing instructions that, when executed cause the food preparation device or system to prepare the food items for consumption.

Abstract: A food preparation device or system which includes the following: (i) a base dimensioned to hold food containers and includes a first opening to receive the food containers and a second opening; (ii) an extraction mechanism to extract food items from each container in the base, through the second opening and to a preparation receptacle; (iii) a heating mechanism in the preparation receptacle; and (iv) one or more processors and memory containing instructions that, when executed cause the food preparation device or system to prepare the food items for consumption.