Patents by Inventor Helen Francis-Lang

Helen Francis-Lang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Paks as modifiers of the chk pathway and methods of use
    Publication number: 20060123498
    Abstract: Human PAK genes are identified as modulators of the CHK pathway, and thus are therapeutic targets for disorders associated with defective CHK function. Methods for identifying modulators of CHK, comprising screening for agents that modulate the activity of PAK are provided.
    Type: Application
    Filed: September 15, 2003
    Publication date: June 8, 2006
    Inventors: Helen Francis-Lang, Siobhan Roche, Lickteig Kim
  • Gfats as modifiers of the p53 pathway and methods of use
    Publication number: 20060121457
    Abstract: Human GFAT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of GFAT are provided.
    Type: Application
    Filed: June 2, 2002
    Publication date: June 8, 2006
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke
  • PRMTs as modifiers of the p53 pathway and methods of use
    Patent number: 7049088
    Abstract: Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: May 23, 2006
    Assignee: Exelixis, INC
    Inventors: Lori Friedman, Gregory D. Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel P. Funke, Rolf Peter Ryseck, Lata Jayaraman, David K. Bol, Matthew Lorenzi
  • Rors as modifiers of the p21 pathway and methods of use
    Publication number: 20060101530
    Abstract: Human ROR genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of ROR are provided.
    Type: Application
    Filed: September 15, 2003
    Publication date: May 11, 2006
    Inventors: Helen Francis-Lang, Lori Friedman, Thomas Kidd, Siobhan Roche, Haiquang Zhang
  • Flj20647s as modifiers of the p21 pathway and methods of use
    Publication number: 20060063710
    Abstract: Human FLJ20647 genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of FLJ20647 are provided.
    Type: Application
    Filed: September 15, 2003
    Publication date: March 23, 2006
    Inventors: Helen Francis-Lang, Lori Friedman, Thomas Kidd, Siohan Roche, Kim Lickteig
  • Slc2as as modifiers of the p53 pathway and methods of use
    Publication number: 20060024673
    Abstract: Human SLC2A genes are identified as modulators of the p53 pathway, and thus as therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SLC2A are provided.
    Type: Application
    Filed: June 3, 2002
    Publication date: February 2, 2006
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke
  • PRMTs as modifiers of the p53 pathway and methods of use
    Publication number: 20060024665
    Abstract: Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
    Type: Application
    Filed: September 30, 2005
    Publication date: February 2, 2006
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke, Rolf Ryseck, Lata Jayaraman, David Bol, Matthew Lorenzi
  • RRP sequences and knockout mice and uses thereof
    Patent number: 6972179
    Abstract: RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of p53 or p21, comprising screening for agents that modulate the activity of RRP are provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein. mRRP1 knockout mice are also provided.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: December 6, 2005
    Assignee: Exelixis, Inc.
    Inventors: Lori Friedman, Marcia Belvin, Jeffrey S. Larson, Helen Francis-Lang, Gregory D. Plowman
  • Csnk1gs as modifiers of the p21 pathway and methods of use
    Publication number: 20050251870
    Abstract: Human CSNK1G genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of CSNK1G are provided.
    Type: Application
    Filed: August 6, 2003
    Publication date: November 10, 2005
    Applicant: Exelixis, Inc.
    Inventors: Helen Francis-Lang, Lori Friedman, Thomas Kidd
  • Map3ks as modifiers of the p53 pathway and methods of use
    Publication number: 20050227228
    Abstract: Human MAP3K genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MAP3K are provided.
    Type: Application
    Filed: June 3, 2002
    Publication date: October 13, 2005
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke
  • PRMTs as modifiers of the p53 pathway and methods of use
    Publication number: 20050186566
    Abstract: Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
    Type: Application
    Filed: June 5, 2002
    Publication date: August 25, 2005
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke, Rolf Ryseck, Lata Jayaraman, David Bol, Matthew Lorenzi
  • Chds as modifiers of the p53 pathway and methods of use
    Publication number: 20050170344
    Abstract: Human CHD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of CHD are provided.
    Type: Application
    Filed: June 3, 2002
    Publication date: August 4, 2005
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke, Mario Lioubin
  • Dgks as modifiers of the p53 pathwha and methods of use
    Publication number: 20050112568
    Abstract: Human DGK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53,comprising screening for agents that modulate the activity of DKG are provided.
    Type: Application
    Filed: June 3, 2002
    Publication date: May 26, 2005
    Inventors: Lori Friedman, Gregory Plowman, Mercia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke
  • SCDs as modifiers of the p53 pathway and methods of use
    Publication number: 20030219795
    Abstract: Human SCD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SCD are provided.
    Type: Application
    Filed: February 28, 2003
    Publication date: November 27, 2003
    Inventors: Marcia Belvin, Helen Francis-Lang, Lori Friedman, Gregory D. Plowman, Timothy S. Heuer
  • PDPK1s as modifiers of the p53 pathway and methods of use
    Publication number: 20030215849
    Abstract: Human PDPK1 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PDPK1 are provided.
    Type: Application
    Filed: February 28, 2003
    Publication date: November 20, 2003
    Inventors: Marcia Belvin, Helen Francis-Lang, Lori Friedman, Gregory D. Plowman, Timothy S. Heuer
  • RRP sequences and knockout mice and uses thereof
    Publication number: 20030165497
    Abstract: RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of p53 or p21, comprising screening for agents that modulate the activity of RRP are provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein. mRRP1 knockout mice are also provided.
    Type: Application
    Filed: January 23, 2002
    Publication date: September 4, 2003
    Inventors: Mario N. Lioubin, Lori Friedman, Marcia Belvin, Jeffrey S. Larson, Changyou Chen, Stephanie A. Robertson, Wen Shi, Jocelyn Chan, Danxi Li, Helen Francis-Lang, Gregory D. Plowman, Roel P. Funke, Michael Schoor, Branko Zevnik, Gunther Kauselmann, Hartmut Tintrup
  • MARKs as modifiers of the p53 pathway and methods of use
    Publication number: 20030165809
    Abstract: Human MARK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.
    Type: Application
    Filed: June 3, 2002
    Publication date: September 4, 2003
    Inventors: Lori Friedman, Gregory D. Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel P. Funke, Mario N. Lioubin
  • MSRAs as modifiers of the p53 pathway and methods of use
    Publication number: 20030165966
    Abstract: Human MSRA genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MSRA are provided.
    Type: Application
    Filed: February 28, 2003
    Publication date: September 4, 2003
    Inventors: Marcia Belvin, Helen Francis-Lang, Lori Friedman, Gregory D. Plowman, Timothy S. Heuer
  • LGALS as modifiers of the CHK pathway and methods of use
    Publication number: 20030165965
    Abstract: Human LGALS genes are identified as modulators of the CHK pathway, and thus are therapeutic targets for disorders associated with defective CHK function. Methods for identifying modulators of CHK, comprising screening for agents that modulate the activity of LGALS are provided.
    Type: Application
    Filed: February 28, 2003
    Publication date: September 4, 2003
    Inventors: Helen Francis-Lang, Monique Nicoll, Timothy S. Heuer
  • LRRCAPs as modifiers of the p53 pathway and methods of use
    Publication number: 20030138431
    Abstract: Human LRRCAPS genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of LRRCAPS are provided.
    Type: Application
    Filed: October 21, 2002
    Publication date: July 24, 2003
    Inventors: Marcia Belvin, Lothar Schleithoff, Gregory D. Plowman, Roel P. Funke, Mario N. Lioubin, Danxi Li, Helen Francis-Lang