Abstract: A system for acquiring data in a well may have a tubing placed therein. The system may include a pass-through device. The pass-through device may include a cylindrical housing having a central aperture extending through the cylindrical housing along a central axis thereof. The pass-through device may include a first sensor mounted on the cylindrical housing. The pass-through device may include a first communication device mounted on the cylindrical housing and operatively connected to the first sensor. The system may include a tubing mounting structure secured to the tubing and configured to hold the pass-through device at a desired location within the tubing. The system may include a control device. The control device may include a second communication device configured to communicate with the first communication device. The control device includes a processor operatively connected to the second communication device.

Abstract: Aspects of the disclosure relate to compositions and methods useful for treating ocular ciliopathies, for example Leber congenital amaurosis (LCA). In some embodiments, the disclosure provides isolated nucleic acids comprising a transgene encoding a CEP290 protein fragment, and methods of treating ocular ciliopathies using the same.

Abstract: Methods, systems, and devices for wireless communications are described. To indicate a precoder sequence for uplink transmissions, a base station may transmit a message to a UE that configures a sequence of at least two sets of precoding parameters. Each set of precoding parameters may correspond to an uplink message. For example, a first set of precoding parameters of the sequence may correspond to a first uplink message and a second set of precoding parameters of the sequence may correspond to a second uplink message that is subsequent to the first uplink message in a time domain. The UE may receive the message and transmit, to the base station, the first uplink message using the first set of precoding parameters and the second uplink message using the second set of precoding parameters based on the sequence of the at least two sets of precoding parameters.

Abstract: Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.

Abstract: An additive manufacturing system is disclosed that comprises two or more lasers for precisely heating a fiber-reinforced thermoplastic feedstock and a fiber-reinforced thermoplastic workpiece in preparation for depositing and tamping the feedstock onto the workpiece. The system employs feedforward, a variety of sensors, and feedback to ensure that the feedstock and workpiece are properly heated.

Abstract: Methods and systems are described for analyzing and attesting physical access to a location. In an example, an administrator can create a survey for users in an organization. The survey can be sent to a user device as a notification. The user can complete the survey, and the user's physical access rights can be determined based on the survey answers. When the user attempts to gain access to a location of the organization, the user can provide a digital access badge. The digital access badge can be mapped to the user's access permissions. The user can be granted or denied access depending on whether the user answered the survey and, if answered, what answers the user provided.

Abstract: An additive manufacturing system is disclosed that comprises two or more lasers for precisely heating a fiber-reinforced thermoplastic feedstock and a fiber-reinforced thermoplastic workpiece in preparation for depositing and tamping the feedstock onto the workpiece. The system employs feedforward, a variety of sensors, and feedback to ensure that the feedstock and workpiece are properly heated.

Abstract: An additive manufacturing system is disclosed that comprises two or more lasers for precisely heating a fiber-reinforced thermoplastic feedstock and a fiber-reinforced thermoplastic workpiece in preparation for depositing and tamping the feedstock onto the workpiece. The system employs feedforward, a variety of sensors, and feedback to ensure that the feedstock and workpiece are properly heated.

Abstract: Examples for determining access to restricted features of an application are disclosed. A current working status of a user account and an access policy can be analyzed to determine whether access to the restricted feature should be granted or denied. The functionality can be provided by a library bundled within an application.

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of ghrelin O-acyltransferase (GOAT), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of metabolic disorders (e.g. Prader-Willi syndrome, metabolic syndrome, insulin resistance, impaired glucose tolerance, prediabetes, diabetes mellitus (e.g., type II diabetes mellitus), dysglycemia (e.g., hyperglycemia), obesity (e.g., obesity caused by Prader-Willi syndrome), increased adiposity, poor glycemic control, hyperphagia, impaired satiety, dyslipidemia (e.g., atherogenic dyslipidemia), hepatic steatosis (e.g., non-alcoholic fatty liver disease (e.g., non-alcoholic steatohepatitis))), psychiatric disorders (e.g., eating disorders (e.g., bulimia nervosa, binge eating disorder, night-time eating syndrome), substance related disorders (e.g., addiction disorders (e.g.

Abstract: A system on a chip (SoC) includes a digital signal processor (DSP) and a graphics processing unit (GPU) coupled to the DSP. The DSP is configured to receive a stream of received depth measurements and generate a virtual bowl surface based on the stream of received depth measurements. The DSP is also configured to generate a bowl to physical camera mapping based on the virtual bowl surface. The GPU is configured to receive a first texture and receive a second texture. The GPU is also configured to perform physical camera to virtual camera transformation on the first texture and on the second texture, based on the bowl to physical camera mapping, to generate an output image.

Abstract: Aspects of the disclosure relate to compositions and methods useful for delivering minigenes to a subject. Accordingly, the disclosure is based, in part, on isolated nucleic acids and gene therapy vectors, such as viral (e.g., rAAV) vectors, comprising one or more gene fragments encoding a therapeutic gene product, such as a protein or peptide (e.g., a minigene). In some embodiments, the disclosure relates to gene therapy vectors encoding a USH2A protein (e.g., the gene product of USH2A gene) or a portion thereof. In some embodiments, compositions described by the disclosure are useful for treating diseases associated with mutations in the USH2A gene, for example Usher Syndrome.

Abstract: Rapid, animal protein free, chromatographic processes and systems for obtaining high potency, high yield botulinum neurotoxin for research, therapeutic and cosmetic use.

Abstract: To perform Recovery Point Objective (RPO) driven backup scheduling, the illustrative data storage management system is enhanced in several dimensions. Illustrative enhancements include: streamlining the user interface to take in fewer parameters; backup job scheduling is largely automated based on several factors, and includes automatic backup level conversion for legacy systems; backup job priorities are dynamically adjusted to re-submit failed data objects with an “aggressive” schedule in time to meet the RPO; only failed items are resubmitted for failed backup jobs.

Abstract: A system accesses information regarding a topology of an arrangement of resources, where one of the resources is a multi-tiered resource having a plurality of layers. Based on the information regarding the topology of the arrangement of resources, the system selects one or more layers of the multi-tiered resource for deployment of a deception server that has a reduced security mechanism to act as a decoy to attract attackers of the system. The system deploys the deception server at the selected one or more layers of the multi-tiered resource.

Abstract: An apparatus is described. The apparatus includes a cover to enclose a junction between respective ends of first and second fluidic conduits. The first and second fluidic conduits transport a coolant fluid within an electronic system. The apparatus also includes a leak detection device to be located within a region that is enclosed by the cover when the junction is enclosed by the cover. The leak detection device is to detect a leak of the coolant fluid at the junction when the junction is enclosed by the cover. The first and second fluidic conduits extend outside the cover when the junction is enclosed by the cover. Another apparatus is also described. The other apparatus includes a leak detection device to detect a leak of coolant fluid from a specific component or junction in a liquid cooling system of an electronic system.

Abstract: Systems and methods include a set of delta copies received from cluster node replicas of a replica set and stored on a main data storage on the cloud. A cloud storage service internally replicates the data from the delta copies and provides fault-tolerance and high availability against storage failures. All cluster node replicas participate in a delta copies merge. Each replica writes their deltas to an independent location in a shared storage on the cloud. Then, the delta merge includes deltas from all replicas when building a new main storage. This ensures that the data from all replicas are included in the delta merge.

Abstract: The present invention provides for a method to deconstruct a biomass: the method comprising: (a) introducing a solvent comprising a polyamine, or a mixture of polyamines, to a biomass to dissolve at least part of solid biomass in the solvent, wherein the polyamine is a Bronsted or Lewis base, and/or the polyamine is a hydrogen bond donor and/or acceptor; (b) optionally introducing an enzyme and/or a microbe to the solubilized biomass mixture such that the enzyme and/or microbe produces a sugar from the solubilized biomass mixture; (c) optionally separating the sugar from the solubilized biomass mixture; and (d) optionally separating the lignan from the solubilized biomass mixture.