Patents by Inventor Hengmiao Cheng

Hengmiao Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZO[1,5]NAPHTHYRIDINE COMPOUNDS, THEIR PHARMACEUTICAL USE AND COMPOSITIONS
    Publication number: 20110190326
    Abstract: The present invention is directed to compounds of Formula (I), and to salts thereof, their synthesis, and their use as PI3-K? inhibitors and/or PI3-K?/mTOR dual inhibitors.
    Type: Application
    Filed: September 18, 2009
    Publication date: August 4, 2011
    Inventors: Hengmiao Cheng, Ted William Johnson, Jacqui Elizabeth Hoffman, Lisa Chen Guo, Zhengyu Liu
  • Triazolopyrazine derivatives
    Patent number: 7732604
    Abstract: The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: June 8, 2010
    Assignee: Pfizer Inc.
    Inventors: Hengmiao Cheng, Jingrong Jean Cui, Jacqui Elizabeth Hoffman, Lei Jia, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Bich Tran-Dubé
  • 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS
    Publication number: 20100137279
    Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).
    Type: Application
    Filed: February 9, 2010
    Publication date: June 3, 2010
    Applicant: Pfizer Inc.
    Inventors: Hengmiao Cheng, Dilip Bhumralkar, Klaus Ruprecht Dress, Jacqui Elizabeth Hoffman, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Michael Bruno Plewe, Khanh Tuan Tran
  • TRIAZOLOPYRAZINE DERIVATIVES
    Publication number: 20100105656
    Abstract: The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Application
    Filed: January 4, 2010
    Publication date: April 29, 2010
    Inventors: Hengmiao Cheng, Jingrong Jean Cui, Jacqui Elizabeth Hoffman, Lei Jia, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Bich Tran-Dubé
  • 4-methylpyridopyrimidinone compounds
    Patent number: 7696213
    Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).
    Type: Grant
    Filed: September 13, 2007
    Date of Patent: April 13, 2010
    Assignee: Pfizer Inc
    Inventors: Hengmiao Cheng, Dilip Bhumralkar, Klaus Ruprecht Dress, Jacqui Elizabeth Hoffman, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Michael Bruno Plewe, Khanh Tuan Tran
  • NOVEL COMPOUNDS OF SUBSTITUTED AND UNSUBTITUTED ADAMANTYL AMIDES
    Publication number: 20090093463
    Abstract: The present invention relates to compounds with the formula (I) or a pharmaceutically acceptable salt thereof: The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of 11-?-hsd-1, the method comprising administering to a mammal an effective amount of a compound of formula (I).
    Type: Application
    Filed: October 20, 2005
    Publication date: April 9, 2009
    Applicant: AGOURON PHARMACEUTICALS INC.
    Inventors: Hengmiao Cheng, Bridget McCarthy Cole
  • Triamide-substituted heterobicyclic compounds
    Patent number: 7482368
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: January 27, 2009
    Assignee: Pfizer Inc
    Inventors: Peter Bertinato, Brian Bronk, Alan E. Blize, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS
    Publication number: 20080090801
    Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).
    Type: Application
    Filed: September 13, 2007
    Publication date: April 17, 2008
    Inventors: Hengmiao Cheng, Dilip Bhumralkar, Klaus Dress, Jacqui Hoffman, Mary Johnson, Robert Kania, Phuong Le, Mitchell Nambu, Mason Pairish, Michael Plewe, Khanh Tran
  • Triamide-substituted heterobicyclic compounds
    Patent number: 7348355
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: March 25, 2008
    Assignee: Pfizer Inc.
    Inventors: Peter Bertinato, Alan E. Blize, Brian Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • TRIAZOLOPYRAZINE DERIVATIVES
    Publication number: 20070265272
    Abstract: The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Application
    Filed: May 8, 2007
    Publication date: November 15, 2007
    Inventors: Hengmiao Cheng, Jingrong Jean Cui, Jacqui Elizabeth Hoffman, Lei Jia, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Bich Tran-Dube
  • Novel compounds of amino sulfonyl derivatives
    Publication number: 20070027118
    Abstract: The present invention relates to compounds with formula (I) or a pharmaceutically acceptable salt thereof: wherein; T is a (4 to 10)-membered heterocyclyl and wherein R1, R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of the 11-?-hsd-1 enzyme.
    Type: Application
    Filed: April 6, 2006
    Publication date: February 1, 2007
    Inventors: Hengmiao Cheng, Stephan Cripps, Klaus Dress, Buwen Huang, Sajiv Nair, Yong Wang
  • Triamide-substituted heterobicyclic compounds
    Publication number: 20060194772
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Application
    Filed: February 10, 2006
    Publication date: August 31, 2006
    Inventors: Peter Bertinato, Alan Blize, Brian Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Triamide-substituted heterobicyclic compounds
    Publication number: 20050288335
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Application
    Filed: August 2, 2005
    Publication date: December 29, 2005
    Inventors: Peter Bertinato, Alan Blize, Brian Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Triamide-substituted heterobicyclic compounds
    Patent number: 6979692
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: December 27, 2005
    Assignee: Pfizer Inc.
    Inventors: Peter Bertinato, Alan E. Blize, Brian S. Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Novel compounds of proline and morpholine derivatives
    Publication number: 20050261290
    Abstract: The present invention relates to compounds with the formulas (I), (II), and (III), or a pharmaceutically acceptable salt thereof: wherein T is a (4 to 10)-membered heterocyclyl selected from the group consisting of and wherein R1, R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formulas (I), (II), and (III) and methods of treating a condition that is mediated by the modulation of the 11-?-hsd-1 enzyme, the method comprising administering to a mammal an effective amount of a compound of formulas (I), (II), and (III).
    Type: Application
    Filed: May 4, 2005
    Publication date: November 24, 2005
    Inventors: Hengmiao Cheng, Stephan Cripps, Klaus Dress, Jacqui Hoffman, Buwen Huang, Stanley Kupchinsky, Phuong Le, Sajiv Nair, Timothy Parrott, Christopher Smith, Yong Wang, Yi Yang
  • Triamide-substituted heterobicyclic compounds
    Patent number: 6949572
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: September 27, 2005
    Assignee: Pfizer Inc.
    Inventors: Peter Bertinato, Brian S. Bronk, Alan E. Blize, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Amino heterocyclyl inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
    Publication number: 20050148631
    Abstract: The present invention relates to compounds with the formula (I), or a pharmaceutically acceptable salt thereof: The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) or formula (II) and methods of treating a condition that is mediated by the modulation of 11-?-hsd-1, the method comprising administering to a mammal an effective amount of a compound of formula (I) or formula (II).
    Type: Application
    Filed: December 17, 2004
    Publication date: July 7, 2005
    Inventors: Hengmiao Cheng, Stephan Cripps, Martin Edwards, Theodore Johnson, Sajiv Nair, Michael Siu, Christopher Smith, Wendy Taylor, Yong Wang
  • Triamide-substituted heterobicyclic compounds
    Publication number: 20050080108
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1—R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Application
    Filed: August 13, 2003
    Publication date: April 14, 2005
    Inventors: Peter Bertinato, Alan Blize, Brian Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • 4"-substituted-9-deoxo-9A-AZA-9A-homoerythromycin a derivatives
    Publication number: 20040180842
    Abstract: The invention relates to a method of preparing compounds of the formula 1
    Type: Application
    Filed: March 26, 2004
    Publication date: September 16, 2004
    Applicant: Pfizer Inc
    Inventors: Brian Scott Bronk, Michael Anthony Letavic, Takushi Kaneko, Bingwei Vera Yang, Edward Alan Glazer, Hengmiao Cheng
  • 4?-substituted-9-deoxo-9a-aza-9a homoerythromycin a derivative
    Patent number: 6777393
    Abstract: The invention relates to a method of preparing compounds of the formula and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are antibacterial agents that may be used to treat various bacterial and protozoa infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial protozoa infections by administering the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1 and to intermediates useful in such preparation.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: August 17, 2004
    Assignee: Pfizer Inc.
    Inventors: Brian Scott Bronk, Michael Anthony Letavic, Takushi Kaneko, Bingwei Vera Yang, Edward Alan Glazer, Hengmiao Cheng