Patents by Inventor Hengmiao Cheng

Hengmiao Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triamide-substituted heterobicyclic compounds
    Publication number: 20040087625
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 1
    Type: Application
    Filed: August 13, 2003
    Publication date: May 6, 2004
    Applicant: Pfizer Inc
    Inventors: Peter Bertinato, Brian S. Bronk, Alan E. Blize, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Methods of making macrolides
    Patent number: 6727352
    Abstract: This invention relates to methods of preparing a compound of Formulae 2, 5 and 7, wherein R2-R5, R7, R9, R10 and R15 are defined herein.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: April 27, 2004
    Assignee: Pfizer, Inc.
    Inventors: Hengmiao Cheng, Chao Li
  • Triamide-substituted heterobicyclic compounds
    Patent number: 6720351
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
    Type: Grant
    Filed: June 20, 2002
    Date of Patent: April 13, 2004
    Assignee: Pfizer Inc.
    Inventors: Peter Bertinato, Alan E. Blize, Brian S. Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • 4''-Substituted-9-deoxo-9a-aza-9a homoerythromycin a derivative
    Publication number: 20040023896
    Abstract: The invention relates to a method of preparing compounds of the formula 1
    Type: Application
    Filed: October 18, 2002
    Publication date: February 5, 2004
    Applicant: Pfizer Inc.
    Inventors: Brian Scott Bronk, Michael Anthony Letavic, Takushi Kaneko, Bingwei Vera Yang, Edward Alan Glazer, Hengmiao Cheng
  • Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents
    Publication number: 20030236258
    Abstract: The present invention relates to compounds of the formula 1
    Type: Application
    Filed: January 14, 2003
    Publication date: December 25, 2003
    Applicant: Pfizer Inc.
    Inventors: Kristin M. Lundy, Hengmiao Cheng, Subas M. Sakya, Jin Li, Martha L. Minich, Chikara Uchida
  • Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents
    Patent number: 6649636
    Abstract: This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is (C1-C4)alkyl optionally substituted with halo, amino or an alkyl amino; R3 and R4 are each hydrogen, halo, (C1-C4)alkyl optionally substituted with halo and the like; and X1 to X4 are each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: November 18, 2003
    Assignee: Pfizer Inc.
    Inventors: Kazuo Ando, Martha L. Minich, Jin Li, Subas M. Sakya, Kristin M. Lundy, Hengmiao Cheng, Brian S. Bronk, Kiyoshi Kawamura, Tomoki Kato
  • Triamide-substituted heterobicyclic compounds
    Publication number: 20030187053
    Abstract: The invention relates to triamide MTP/ApoB inhibitors of the formula 1 1
    Type: Application
    Filed: June 20, 2002
    Publication date: October 2, 2003
    Applicant: Pfizer Inc.
    Inventors: Peter Bertinato, Alan E. Blize, Brian S. Bronk, Hengmiao Cheng, Jin Li, Hiep Huatan, Clive Mason
  • Novel macrolides
    Publication number: 20030109463
    Abstract: The invention relates to compounds of Formula 1 1
    Type: Application
    Filed: August 23, 2002
    Publication date: June 12, 2003
    Inventors: Hengmiao Cheng, Chao Li
  • Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents
    Patent number: 6531492
    Abstract: The present invention relates to compounds of the formula wherein R2, R3, R6 and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: March 11, 2003
    Assignee: Pfizer Inc.
    Inventors: Kristin M. Lundy, Hengmiao Cheng, Subas M. Sakya, Jin Li, Martha L. Minich, Chikara Uchida
  • Macrolides
    Patent number: 6518251
    Abstract: The invention relates to compounds of Formula 1 and to pharmaceutically acceptable salts, solvates, and prodrugs thereof, wherein X, Y, Z, R1, R2, R3, R4, and R5 are defined herein. The invention further relates to methods of making compounds of Formula 1 and to pharmaceutical compositions comprising compounds of Formula 1. The invention is also related to methods of treating diseases and disorders such as, but not limited to, bacterial and protozoal infections which comprise the administration of a compound of Formula 1, or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: February 11, 2003
    Assignee: Pfizer Inc.
    Inventors: Hengmiao Cheng, Chao Li
  • Acetylene derivatives as anti-inflammatory/analgesic agents
    Patent number: 6506779
    Abstract: The present invention relates to compounds of the formula wherein R1, R2, R3, R4, R5, R6, X and Y are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as arthritis, colon cancer, and Alzheimer's disease in mammals, preferably humans, dogs, cats and livestock.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 14, 2003
    Assignee: Pfizer Inc.
    Inventors: Hengmiao Cheng, Akiyoshi Kawai
  • 4?-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
    Patent number: 6420536
    Abstract: The invention relates to a method of preparing compounds of the formula and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are antibacterial agents that may be used to treat various bacterial and protozoa infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial protozoa infections by administering the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1 and to intermediates useful in such preparation.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: July 16, 2002
    Assignee: Pfizer Inc
    Inventors: Brian Scott Bronk, Michael Anthony Letavic, Takushi Kaneko, Bingwei Vera Yang, Edward Alan Glazer, Hengmiao Cheng
  • 4"-substituted-9-deoxo-9A-AZA-9A-homoerythromycin a derivatives
    Publication number: 20020061858
    Abstract: The invention relates to compounds of the formula 1
    Type: Application
    Filed: November 21, 2001
    Publication date: May 23, 2002
    Inventors: Brian Scott Bronk, Michael Anthony Letavic, Takushi Kaneko, Bingwei Vera Yang, Edward Alan Glazer, Hengmiao Cheng
  • Pyrazole ether derivatives as anti-inflammatory/analgesic agents
    Publication number: 20020058681
    Abstract: The present invention relates to compounds of the formula 1
    Type: Application
    Filed: March 2, 2001
    Publication date: May 16, 2002
    Inventors: Hengmiao Cheng, Subas Man Sakya, Jason Kenneth Dutra
  • Macrolide derivatives
    Patent number: 6100240
    Abstract: The invention relates to compounds of the formula I ##STR1## and to pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, Q, X, Y and Z are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I, methods of using said compounds of formula I in the treatment of infections, and methods of preparing said compounds of formula I.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: August 8, 2000
    Assignee: Pfizer Inc
    Inventors: Hengmiao Cheng, Robert John Rafka, Jason K. Dutra, Michael A. Letavic, Brian S. Bronk
  • 3,6-ketal and enol ether macrolide antibiotics
    Patent number: 6043226
    Abstract: This invention relates to compounds of formulas 1 and 2 ##STR1## and to pharmaceutically acceptable salts and solvates thereof, wherein X, X.sup.1, R.sup.1, R.sup.2, R.sup.7, R.sup.17 and R.sup.19 are as defined herein. The compounds of formulas 1 and 2 may be useful in the treatment of bacterial, parasitic and protozoal infections, as well as disorders related to bacterial, parasitic and protozoal infections, in mammals, fish and birds. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and 2 and to methods of treating bacterial, parasitic and protozoal infections by administering the compounds of formula 1 and 2.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: March 28, 2000
    Assignee: Pfizer Inc.
    Inventors: Kristin Marie Lundy, Hengmiao Cheng, Martha L. Minich, Subas Man Sakya, Peter Bertinato
  • C11 carbamates of macrolide antibacterials
    Patent number: 6043227
    Abstract: This invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof. The compounds of formula 1 are potent antibacterial agents that may be used to treat various bacterial infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating bacterial infections by administering the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1 and to intermediates useful in such preparation.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: March 28, 2000
    Assignee: Pfizer Inc.
    Inventors: Hengmiao Cheng, Michael Letavic, Carl B. Ziegler, Jr., Jason K. Dutra, Peter Bertinato, Brian S. Bronk