Patents by Inventor Henning Wilhelms
Henning Wilhelms has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6326378Abstract: The present invention relates to the method of treating leukemia, lymphoma or inhibiting the proliferation of cells with a compound of formula I.Type: GrantFiled: October 5, 2000Date of Patent: December 4, 2001Assignee: Roche Diagnostics GmbHInventors: Walter-Gunar Friebe, Wolfgang Schaumann, Otto-Henning Wilhelms
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Patent number: 6053311Abstract: A housing for storing disc-shaped information carriers, for example CD's, has a central part (14), two identical lid parts (10, 11), and a support plate (15) which extends from the central part and is situated between the lid parts. In order to increase the available space within the housing, the support plate (15) is flat on both sides and is asymmetrically positioned between the lid parts (10, 11) so as to form two spaces (17, 18) of different sizes between the lid parts and opposite sides of the support plate. Such spaces can accommodate information leaflets of different thickness.Type: GrantFiled: February 5, 1997Date of Patent: April 25, 2000Assignee: U.S. Philips CorporationInventors: Hermann Grobecker, Henning Wilhelm
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Patent number: 5855273Abstract: A housing with a retaining device is arranged on a base plate and comprises clamping studs which are arranged in a circle, which are radially resilient, and which have clamping surfaces facing radially outwards for gripping into a central opening of at least one disc-shaped information carrier, for example a CD. To avoid a destruction of the clamping elements in the case of impacts, rigid support studs with support surfaces facing radially outwards are provided between the clamping studs, and the diameter of the support surfaces arranged in a circle is somewhat smaller than the diameter of the central opening of the information carrier.Type: GrantFiled: May 14, 1997Date of Patent: January 5, 1999Assignee: U.S. Philips CorporationInventors: Hermann Grobecker, Henning Wilhelm
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Patent number: 5813526Abstract: A housing for storing a stack of at least two information discs such as CDs includes a central retaining device for engaging and securely fastening each of the discs. The retaining device consists of a plurality of clamping studs arranged in a circle, and with respective groups of studs being in respective planes, each such plane being for a respective disc. The studs are resilient in the radial direction and those in a given group engage the central opening of the disc to be stored in the relevant plane.Type: GrantFiled: January 13, 1997Date of Patent: September 29, 1998Assignee: U.S. Philips CorporationInventors: Hermann Grobecker, Henning Wilhelm
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Patent number: 5700500Abstract: The invention relates to a two-stage injection-molding machine with a fixed mold plate, a movable mold plate and a two-part intermediate assembly, arranged to be movable between said plates, and with a supply of injection-molding material for the intermediate assembly to supply the stages formed between the intermediate assembly and the mold plates with injection-molding material. In order to simplify the production of injection-molded parts of different colors in one and the same injection-molding process it is proposed, in accordance with the invention, that for each stage there has been provided a separate supply of injection-molding material via a separate main channel. In addition to the free choice of the color for each stage, it is possible to use various types of plastic per stage in one and the same injection-molding process.Type: GrantFiled: June 3, 1996Date of Patent: December 23, 1997Assignee: Polygram International Holding B.V.Inventor: Henning Wilhelm
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Patent number: 5547980Abstract: Bicyclic sulfones of the formula I ##STR1## in which Y is a halogen atom,Z is a halogen atom or hydrogen,m and n, that are different and represent an integer 0 or 1,A and B each represent hydrogen or together represent a valency bond,X.sub.1 and X.sub.2 each represent NR.sub.1 R.sub.2 or, if A and B represent a valency bond, one of the two residues X.sub.1 or X.sub.2 represents hydrogen and the other represents NR.sub.1 R.sub.2,R.sub.1 denotes a C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.2 -C.sub.6 alkenyl or a benzyl residue substituted if desired, by halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy or hydroxy andR.sub.2 denotes hydrogen or a residue from the definition of R.sub.1 orR.sub.1 and R.sub.2 together with the nitrogen atom form a heterocyclic ring which if desired, contains further heteroatoms and/or can be substituted by C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.Type: GrantFiled: February 28, 1994Date of Patent: August 20, 1996Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Erhard Reinholz, Henning Wilhelms
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Patent number: 5447934Abstract: Compounds of the formula I ##STR1## in which X.sup.1 and X.sup.2 the same or different, signify hydrogen, a C.sub.1 - to C.sub.6 -alkyl radical or a halogen atom or, insofar as they stand in neighbouring positions, together with the carbon atoms carrying them, form a condensed-on phenyl ring, and R signifies a possibly substituted carbocyclic or heterocyclic saturated or unsaturated radical, as well as their physiologically compatible salts, processes for their preparation, as well as medicaments which contain these compounds for the treatment of allergic diseases.Type: GrantFiled: March 18, 1994Date of Patent: September 5, 1995Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Henning Wilhelms
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Patent number: 5399575Abstract: Compounds of the formula I ##STR1## in which A signifies an alkylene radical with 1 to 3 carbon atoms or a group --CH.dbd.CH--, B an oxygen atom or a valency bond, m a whole number from 0 to 5, n the number 0 or 1, X a valency bond, an oxygen atom or a sulphur atom, Y a valency bond or a phenylene radical substituted, if desired, one or more times by C.sub.1 - to C.sub.6 -alkyl, C.sub.1 - to C.sub.6 -alkoxy, halogen, hydroxyl or aminocarbonyl, Z hydrogen, halogen, C.sub.1 - to C.sub.6 -alkyl or cyano and R a group CN, COOH, COOC.sub.1 - to C.sub.6 -alkyl, CONH-tetrazolyl, CON(OH)(C.sub.1 -C.sub.6 -alkyl) or 5-(1H)-tetrazolyl, as well as, for the case that Y represents a phenylene radical, also hydrogen, with the exception of the compound 4-[2-(4)-pyridinovinyl]-carboxymethoxybenzene, their physiologically compatible salts and processes for their preparation, as well as medicaments containing these compounds for the treatment of allergic diseases.Type: GrantFiled: June 14, 1993Date of Patent: March 21, 1995Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Wolfgang Kampe, Marcel Linssen, Otto-Henning Wilhelms
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Patent number: 5217990Abstract: The use is described of macrolactones, such as cladospolides and patulolides, as medicaments for the treatment of allergic-inflammatory diseases.Type: GrantFiled: August 19, 1991Date of Patent: June 8, 1993Assignee: Boehringer Mannheim GmbHInventors: Fritz Hansske, Otto-Henning Wilhelms, Heidrun Anke
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Patent number: 5116731Abstract: The present invention provides a one-step process for the detection of the presence of an allergy and for the specific detection of the allergen responsible for the allergy, in which the leukocytes of a sample to be investigated are incubated with an allergen or with another stimulation factor in an aqueous medium together with a chromogenic protease substrate and calcium ions, the liberated protease is reacted with the chromogen and the resulting chromophor is determined. The protease activity is measured kinetically after an incubation period by the increase of the chromophor concentration. The present invention also provides a reagent and a device for carrying out this process, as well as a process for the determination of antiallergic and anti-inflammatory substances. The device consists of a microtiter plate with a plurality of different reagents arranged in rows.Type: GrantFiled: May 9, 1989Date of Patent: May 26, 1992Assignee: Boehringer Mannheim GmbHInventor: Otto-Henning Wilhelms
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Patent number: 5025028Abstract: The present invention provides compounds of the general formula: ##STR1## wherein Ar is a phenyl radical optionally substituted by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, A is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 aliphatic hydrocarbon radical which is optionally substituted by a hydroxyl group, n is 0, 1 or 2, B is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 -aliphatic hydrocarbon radical and R is 5-(1H)-tetrazolyl, --CO--NH-tetrazolyl, ##STR2## Cn, SCN, OH, halogen, 5-(1H)-tetrazolylthio, ##STR3## or CO--O--NH--R.sub.1, wherein R.sub.Type: GrantFiled: January 17, 1990Date of Patent: June 18, 1991Assignee: Boehringer Mannheim GmbHInventors: Erhard Reinholz, Walter-Gunar Friebe, Wolfgang Kampe, Jurgen Mertin, Otto-Henning Wilhelms
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Patent number: 4906666Abstract: The present invention provides compounds of the general formula: ##STR1## wherein Ar is a phenyl radical optionally substituted by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, A is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 aliphatic hydrocarbon radical which is optionally substituted by a hydroxyl group, n is 0, 1 or 2, B is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 -aliphatic hydrocarbon radical and R is 5-(1H)-tetrazolyl, --CO--NH-tetrazolyl, ##STR2## CN, SCN, OH, halogen, 5-(1H)-tetrazolylthio, ##STR3## or CO--O--NH--R.sub.1, wherein R.sub.Type: GrantFiled: February 5, 1987Date of Patent: March 6, 1990Assignee: Boehringer Mannheim GmbHInventors: Erhard Reinholz, Walter-Gunar Friebe, Wolfgang Kampe, Jurgen Mertin, Otto-Henning Wilhelms
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Patent number: 4904666Abstract: The present invention provides pyrazolo[3,4-d]-pyrimidines of the general formula: ##STR1## wherein R.sub.1 is a C.sub.1 to C.sub.6 -alkyl radical, a C.sub.2 to C.sub.6 -alkenyl radical, a C.sub.3 to C.sub.7 -cycloalkyl radical or an aryl radical, R.sub.2 is a C.sub.2 to C.sub.6 -alkenyl radical, a C.sub.3 to C.sub.7 -cycloalkyl radical or an aralkyl or hetaralkyl radical with 1 to 6 carbon atoms in the alkyl moiety and substituted, if desired, one or more times by halogen, C.sub.1 to C.sub.6 -alkyl, hydroxyl, C.sub.1 to C.sub.6 -alkoxy, C.sub.1 to C.sub.3 -haloalkyl, C.sub.3 to C.sub.7 -alkoxy carbonyl, aminocarbonyl, C.sub.2 to C.sub.7 -alkylaminocarbonyl, C.sub.3 to C.sub.13 -dialkylaminocarbonyl, cyano or C.sub.1 to C.sub.6 -alkylthio and R.sub.3 is a hydrogen atom or a C.sub.2 to C.sub.6 -alkyl radical substituted, if desired, one or more times by hydroxyl or is a tetrahydrofuranyl or tetrahydropyranyl radical, with the proviso that R.sub.2 cannot be an unsubstituted benzyl radical when R.sub.Type: GrantFiled: April 14, 1988Date of Patent: February 27, 1990Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Wolfgang Kampe, Otto-Henning Wilhelms
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Patent number: 4853386Abstract: The present invention provides N.sup.6 -disubstituted purine derivatives of the general formula: ##STR1## wherein R.sub.1 and R.sub.4 are the same or different and each represents a hydrogen or halogen atom or an --NR.sub.6 R.sub.7 group, R.sub.2 and R.sub.3 are the same or different and each represents a C.sub.1 -C.sub.6 alkyl radical, a C.sub.2 -C.sub.6 alkenyl radical, a C.sub.3 -C.sub.7 cycloalkyl radical, a phenalkyl radical containing up to 4 carbon atoms in the alkyl moiety, which can be straight-chained or branched, the phenyl moiety of which can be substituted one or more times by halogen, hydroxyl, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio or trifluoromethyl; a furylmethyl or furylethyl radical, a thiophenemethyl or thiopheneethyl radical, a pyridylmethyl or pyridylethyl radical optionally substituted by a C.sub.1 -C.sub.4 alkyl radical, an indanyl radical or a tetrahydronaphthyl radical, R.sub.Type: GrantFiled: August 15, 1986Date of Patent: August 1, 1989Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Otto-Henning Wilhelms
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Patent number: 4760077Abstract: There is described the use of pyrrothine derivatives of the general formula I ##STR1## wherein R.sub.1 and R.sub.3 signify hydrogen or methyl, R.sub.2 hydrogen, methyl or an acyl group with 1 to 5 carbon atoms and X and Y signify hydrogen, an equivalent of a physiolgically acceptable cation or together a single bond, for the inhibition of the allergen-induced degranulation of peripheral leukocytes.Type: GrantFiled: May 15, 1986Date of Patent: July 26, 1988Assignee: Boehringer Mannheim GmbHInventors: Peter Stahl, Hans Seidel, Herbert Von der Eltz, Otto-Henning Wilhelms, Androniki Roesch
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Patent number: 4704381Abstract: The present invention is concerned with the use of adenosine derivatives for the treatment of allergic diseases, as well as for bronchosphatic and broncho-constrictive reactions brought about by inflammation. The above adenosine derivatives can be used alone or together with xanthine derivatives. The invention is further concerned with compositions containing compounds of adenosine derivatives and optionally compounds of xanthine derivatives together with appropriate pharmaceutical carriers.Type: GrantFiled: February 13, 1985Date of Patent: November 3, 1987Assignee: Boehringer Mannheim GmbHInventors: Wolfgang Schaumann, Otto-Henning Wilhelms, Androniki Roesch, Wolfgang Kampe
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Patent number: 4621098Abstract: The present invention provides thioethers of the general formula: ##STR1## wherein Ar is a phenyl radical which is optionally substituted one, two or three times by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, Q is an oxygen or sulphur atom or an NH group, A is a straight-chained or branched C.sub.2 -C.sub.8 alkylene radical which is optionally substituted by a hydroxyl group or can be interrupted by an ethenylene or ethynylene group, n is 0, 1 or 2, and R is a hydrogen atom or a straight-chained or branched alkyl radical which is optionally substituted one or more times by the same or different radicals selected from alkoxycarbonyl, alkoxy, hydroxyl, carboxyl or optionally substituted carbamoyl or amino; as well as the pharmacologically acceptable salts thereof, with the proviso that A cannot be ethylene when Ar is a phenyl radical, Q is an oxygen atom and R is the group --CH.sub.2 COOH.Type: GrantFiled: July 2, 1984Date of Patent: November 4, 1986Assignee: Boehringer Mannheim GmbHInventors: Robert Umminger, Walter-Gunar Friebe, Wolfgang Kampe, Androniki Roesch, Otto-Henning Wilhelms
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Patent number: 4592997Abstract: The present invention provides a process for the detection of the presence of an allergy and for the specific detection of the allergen responsible for the allergy, based on the cellular principle, wherein leukocytes of a sample to be investigated are incubated with an allergen or another stimulation factor of degranulation, such as anti-IgE, in an aqueous medium, the leukocytes are then separated off and the remaining solution is incubated with a compound of the general formula:Y--X--Cin which Y is an amino acid or a peptide containing 2 or 3 amino acids, the amino acids optionally carrying a conventional protective group on the amino end, X is arginine or lysine and C is a chromogenic residue, in the presence of a buffer effective at pH 6.3 to 8.0 and the liberation of the chromogenic residue is measured.Type: GrantFiled: March 17, 1983Date of Patent: June 3, 1986Assignee: Boehringer Mannheim GmbHInventors: Otto-Henning Wilhelms, Peter Stahl, Peter Wunderwald
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Patent number: 4428955Abstract: The present invention provides benzopyranyl ethers of the general formula: ##STR1## wherein A is an alkylene radical containing 2 to 4 carbon atoms and R is a hydrogen atom or an acyl radical; as well as the salts thereof with pharmacologically acceptable acids.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. Furthermore, the present invention is concerned with the use of these compounds for treating allergic diseases.Type: GrantFiled: April 27, 1982Date of Patent: January 31, 1984Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Wolfgang Kampe, Egon Roesch, Otto-Henning Wilhelms
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Patent number: 4427680Abstract: The present invention provides aryl ether derivatives of the general formula: ##STR1## wherein A is an oxygen atom or the group >N--R.sub.1, R.sub.1 being a hydrogen atom or a lower alkyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl radicals, R.sub.4 is a hydrogen atom or a hydroxyl group, R.sub.5 is a hydrogen atom or an acyl radical, R.sub.7 is a hydrogen atom, a lower alkyl radical or a lower alkanoyl radical and R.sub.8 is a hydrogen atom, a lower alkyl radical, a lower alkoxy radical or a hydroxyl group; and the pharmacologically acceptable salts thereof.The present invention also provides a process for the preparation of these compounds and pharmaceutical compositions containing them. It is also concerned with the use of these compounds for combating allergic diseases.Type: GrantFiled: February 8, 1982Date of Patent: January 24, 1984Assignee: Boehringer Mannheim GmbHInventors: Walter-Gunar Friebe, Werner Winter, Max Thiel, Androniki Roesch, Otto-Henning Wilhelms