Patents by Inventor Henning Wilhelms

Henning Wilhelms has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4382943
    Abstract: An aryl ether derivative of the formula ##STR1## in which A is an oxygen atom or an >N--R.sub.1 grouping,R.sub.1 is a hydrogen atom or a lower alkyl radical,B is an alkylene radical containing 2 to 4 carbon atoms,R.sub.2 and R.sub.3 each independently is a hydrogen or halogen atom, hydroxyl group or lower alkyl, lower alkoxy or lower alkanoyl radical,R.sub.4 is a hydrogen atom or an acyl radical, andn is an integer from 1 to 5,or a pharmacologically acceptable salt thereof, which possesses anti-allergic activity.
    Type: Grant
    Filed: July 6, 1981
    Date of Patent: May 10, 1983
    Assignee: Boehringer Mannheim GmbH
    Inventors: Werner Winter, Walter-Gunar Friebe, Androniki Roesch, Otto-Henning Wilhelms
  • Patent number: 4348401
    Abstract: An N-phenoxyalkylpiperidine derivative of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, an acyl radical or an optionally substituted aryl radical, R.sub.2 is a hydroxymethyl radical, a cyano group, an amidino group, an amidino group substituted by hydroxyl, a 1H tetrazol-5-yl radical or a --CO--R.sub.3 radical, R.sub.3 is a hydroxyl group, a lower alkoxy radical, an amino group, or an amino group substituted by a 1H-tetrazol-5-yl radical, X is an imino group or an oxymethyl radical, A is an alkylene radical containing 2 to 4 carbon atoms, and B is a valency bond or a 4-hydroxypyrimidin-2,5-diyl radical; or a pharmacologically acceptable salt thereof. The compounds exhibit anti-histaminic, anti-oedematous and anti-phlogistic activity.
    Type: Grant
    Filed: September 10, 1980
    Date of Patent: September 7, 1982
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter-Gunar Friebe, Wolfgang Kampe, Max Thiel, Wolfgang Schaumann, Otto-Henning Wilhelms
  • Patent number: 4330549
    Abstract: The present invention provides aryl ether derivatives of the general formula: ##STR1## wherein A is an oxygen atom or the group >N--R.sub.1, R.sub.1 being a hydrogen atom or a lower alkyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl radicals, R.sub.4 is a hydrogen atom or a hydroxyl group, R.sub.5 is a hydrogen atom or an acyl radical, R.sub.7 is a hydrogen atom, a lower alkyl radical or a lower alkanoyl radical and R.sub.8 is a hydrogen atom, a lower alkyl radical, a lower alkoxy radical or a hydroxyl group; and the pharmacologically acceptable salts thereof.The present invention also provides a process for the preparation of these compounds and pharmaceutical compositions containing them. It is also concerned with the use of these compounds for combating allergic diseases.
    Type: Grant
    Filed: December 17, 1979
    Date of Patent: May 18, 1982
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter-Gunar Friebe, Werner Winter, Max Thiel, Androniki Roesch, Otto-Henning Wilhelms
  • Patent number: 4284633
    Abstract: The present invention provides xanthine derivatives of the general formula: ##STR1## wherein one of the symbols R.sub.1 and R.sub.2 stands for a methyl radical and the other for a radical of the general formula: ##STR2## wherein R.sub.3 is a hydrogen atom or an acyl radical; and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them and is also concerned with the use thereof for the preparation of pharmaceutical compositions for the treatment of allergies.
    Type: Grant
    Filed: May 12, 1980
    Date of Patent: August 18, 1981
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter-Gunar Friebe, Max Thiel, Wolfgang Kampe, Otto-Henning Wilhelms, Androniki Roesch
  • Patent number: 4234585
    Abstract: A (4-substituted-piperazin-1-yl)-alkoxy-2-oxo-1,2-dihydroquinoline of the formula: ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 each independently is hydrogen or a lower alkyl radical,R.sub.4 is hydrogen, halogen, or a lower alkyl or lower alkoxy radical,n is 2, 3, 4 or 5 andA is a valency bond or a methylene radical optionally substituted by a phenyl radical,or a salt thereof, which exhibits anti-allergic and anti-hypertensive activity.
    Type: Grant
    Filed: June 4, 1979
    Date of Patent: November 18, 1980
    Assignee: Boehringer Mannheim GmbH
    Inventors: Werner Winter, Walter-Gunar Friebe, Wolfgang Kampe, Androniki Roesch, Otto-Henning Wilhelms
  • Patent number: 4232024
    Abstract: Anti-allergy novel 1-oxo-1H-pyrimido[6,1-b]benzthiazole derivatives of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each independently is hydrogen, halogen, hydroxy, nitro, trifluoromethyl, or lower alkyl, alkoxy or alkylthio, orR.sub.2 and R.sub.3 together are alkylenedioxy, andX is hydroxy, alkoxy or tetrazolyl-5-amino,or salts thereof, as well as their production by saponification of ##STR2## or tautomers thereof, followed by acidification.
    Type: Grant
    Filed: February 26, 1979
    Date of Patent: November 4, 1980
    Assignee: Boehringer Mannheim GmbH
    Inventors: Werner Winter, Herman Hindermayr, Egon Roesch, Androniki Roesch, Otto-Henning Wilhelms
  • Patent number: 4212866
    Abstract: Novel 9-[3-(4-amino-piperidino)-propyl]-adenine derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl radical,R.sub.2 is a hydrogen atom, an aryl radical, a lower alkyl radical, a hydroxy lower alkyl radical, or together with R.sub.1 and the nitrogen atom to which they are attached form a heterocyclic ring, andR.sub.3 is a hydrogen atom or an acyl radical,or salts thereof with pharmacologically acceptable acids, characterized by anti-allergic, anti-inflammatory and anti-oedematous activity.
    Type: Grant
    Filed: January 24, 1979
    Date of Patent: July 15, 1980
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter-Gunar Friebe, Max Thiel, Androniki Roesch, Otto-Henning Wilhelms, Wolfgang Schaumann
  • Patent number: 4086347
    Abstract: 9-[3-(4-Phenoxymethylpiperidino)-propyl]-adenines of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl radical,R.sub.2 is a hydrogen atom, a ower alkyl radical optionally substituted by hydroxyl, or a cycloalkyl radical, orR.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a heterocyclic ring, andR.sub.3 is a hydrogen atom, a halogen atom, a lower alkyl radical or a lower alkoxy radical,In the form of the free base or a salt thereof, exhibit anti-allergic, anti-inflammatory, anti-oedematous and anti-hypertensive activity.
    Type: Grant
    Filed: November 2, 1976
    Date of Patent: April 25, 1978
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter-Gunar Friebe, Max Thiel, Kurt Stach, deceased, by Werner Plattner, administrator, Otto-Henning Wilhelms, Erika VON Mullendorff, Gisbert Sponer