Abstract: A high pressure tool assembly includes a hand control valve mechanically connectable to a tool. An intensifier is fluidly connected to the hand control valve and to the tool. The intensifier increases pressure of an operating fluid to be supplied to the tool. A first fluid circuit conveying the first operating fluid is formed between the intensifier and the tool. A second fluid circuit conveying a second operating fluid is formed between the hand control valve and the intensifier. The first fluid circuit operates at a first pressure. The second fluid circuit operates at a second pressure. The first pressure is higher than the second pressure. The first fluid circuit is isolated from the second fluid circuit.

Abstract: A base assembly removably and adjustably receives a tool and includes a base and a wall extending outwardly from the base. First and second openings are disposed in the wall. First and second cutouts are disposed in the wall to receive the tool. A pivot pin is removably received by the first and second openings. The tool is removably disposed on the pivot pin. A locking ring is disposed on the pivot pin. The locking ring is in a locked position to prevent movement of the pivot pin and in an unlocked position to allow movement of the pivot pin, thereby allowing the tool to be easily moved between positions and securely locked in a desired position.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A base assembly removably and adjustably receives a tool and includes a base and a wall extending outwardly from the base. First and second openings are disposed in the wall. First and second cutouts are disposed in the wall to receive the tool. A pivot pin is removably received by the first and second openings. The tool is removably disposed on the pivot pin. A locking ring is disposed on the pivot pin. The locking ring is in a locked position to prevent movement of the pivot pin and in an unlocked position to allow movement of the pivot pin, thereby allowing the tool to be easily moved between positions and securely locked in a desired position.

Abstract: A base assembly removably and adjustably receives a tool and includes a base and a wall extending outwardly from the base. First and second openings are disposed in the wall. First and second cutouts are disposed in the wall to receive the tool. A pivot pin is removably received by the first and second openings. The tool is removably disposed on the pivot pin. A locking ring is disposed on the pivot pin. The locking ring is in a locked position to prevent movement of the pivot pin and in an unlocked position to allow movement of the pivot pin, thereby allowing the tool to be easily moved between positions and securely locked in a desired position.

Abstract: A base assembly removably and adjustably receives a tool and includes a base and a wall extending outwardly from the base. First and second openings are disposed in the wall. First and second cutouts are disposed in the wall to receive the tool. A pivot pin is removably received by the first and second openings. The tool is removably disposed on the pivot pin. A locking ring is disposed on the pivot pin. The locking ring is in a locked position to prevent movement of the pivot pin and in an unlocked position to allow movement of the pivot pin, thereby allowing the tool to be easily moved between positions and securely locked in a desired position.

Abstract: A base assembly removably and adjustably receives a tool and includes a base and a wall extending outwardly from the base. First and second openings are disposed in the wall. First and second cutouts are disposed in the wall to receive the tool. A pivot pin is removably received by the first and second openings. The tool is removably disposed on the pivot pin. A locking ring is disposed on the pivot pin. The locking ring is in a locked position to prevent movement of the pivot pin and in an unlocked position to allow movement of the pivot pin, thereby allowing the tool to be easily moved between positions and securely locked in a desired position.

Abstract: The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor ? subunits, by targeting HIF ? for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF ? subunit sequences which may modulate this interaction.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor ? subunits, by targeting HIF ? for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF ? subunit sequences which may modulate this interaction.

Abstract: The invention provides a compound of one of the formulae (A), (B), (C), (D), (E), (F) as herein defined, or a salt thereof, for use in the treatment of a condition associated with increased or decreased HIF levels or activity, or a condition in which an increase or decrease in HIF levels or activity may be beneficial.

Abstract: Use of xenon is described. Xenon is used as an organ and/or tissue and/or cell protectant in the manufacture of a pharmaceutical for the protection from injury of organs and/or tissue and/or cells that express HIF.

Abstract: The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor &agr; subunits, by targeting HIF &agr; for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF &agr; subunit sequence which may modulate this interaction.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: An electrical compression connector including a shell, a wedge and a terminal pin. The wedge is sized and shaped to be inserted into the shell to wedge conductors against opposite sides of the shell. The terminal pin includes a first section and a second section. The first section is sized and shaped to be inserted between the shell and the wedge. The second section includes a conductor receiving area which is sized and shaped to be compressed onto a conductor.

Abstract: The hot stick adaptor has two members that are adjustably movable relative to each other. A first one of the members has two separate first ratchet areas. A second one of the members has three separate second ratchet ares. A fastener and spring connect the two members to each other with one of the first ratchet areas and one of the second ratchet areas in interlocking engagement. The two members can be moved away from each other in a first direction, compressing the spring, to disengage the interlocking engagement and thereby allow the two members to be moved in a second direction.