Abstract: Provided herein are methods of treating immune-related disorders comprising administering to a patient suffering from the disorder a therapeutically effective amount of a LMP2-selective inhibitor and a therapeutically effective amount of a LMP7-selective inhibitor. Also provided herein are compositions comprising a LMP2-selective inhibitor and a LMP7-selective inhibitor.

Abstract: A powered fastener driver includes a cylinder and a drive piston within the cylinder being acted on by a driving force resulting from a pressure differential. The powered fastener further includes a drive blade coupled to the drive piston and operable to drive a fastener, and an adjustable valve for selectively introducing air from ambient atmosphere into the cylinder, thereby changing the pressure differential acting on the drive piston. By adopting a self-contained vacuum generating means as described above, the present invention does not rely on any external vacuum source and powered fastener driver can be used and carried with conveniently.

Abstract: A device for comminuting whole trees or brush type vegetation comprising a set of more than two rotatable substantially horizontally oriented comminution drum assemblies; said set of rotatable comminution drum assemblies being constructed and arranged in an angular orientation so that the uppermost rotatable comminution drum assembly in said set of more than two substantially horizontally oriented comminution drum assemblies first engages the top portion of the whole tree or brush type vegetation and the remaining rotatable comminution drum assemblies in said set of more than two substantially horizontally oriented comminution drum assemblies sequentially engage lower portions of the whole tree or brush type vegetation that exist immediately below the portions that are comminuted by each successive comminution drum assembly.

Abstract: Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.

Abstract: A powered fastener driver includes a cylinder and a drive piston within the cylinder being acted on by a driving force resulting from a pressure differential. The powered fastener further includes a drive blade coupled to the drive piston and operable to drive a fastener, and an adjustable valve for selectively introducing air from ambient atmosphere into the cylinder, thereby changing the pressure differential acting on the drive piston. By adopting a self-contained vacuum generating means as described above, the present invention does not rely on any external vacuum source and powered fastener driver can be used and carried with conveniently.

Abstract: Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.

Abstract: Provided herein is a peptide epoxyketone immunoproteasome inhibitor having a structure: Formula (I) wherein X— is a counterion, crystal forms, salts, and processes for making the same, and formulations thereof.

Abstract: A system for managing a power tool includes a tool implement and a tool base releasably attachable to the tool implement. The tool implement includes a working end, a memory storing an information parameter, and an electronic processor configures to transmit the information parameter. The tool base includes a base housing, an electric motor, a rotatable output shaft coupled to the electric motor, an electrical interface coupled to the electronic processor, and a controller including a first and second electronic processor. Through the electrical interface, the controller is configured to receive the information parameter, by the first and second processors, as first and second data, determine whether the first data and the second data agree, and enable a function of the motor of the tool base in response to determining that the first data and the second data agree.

Abstract: Disclosed herein are methods for preparing [(2S,3R)—N-[(2S)-3-(cyclopent-1-en-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound “G”): and precursors thereof.

Abstract: Provided herein are dipeptide and tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of proliferative diseases including cancer and autoimmune diseases.

Abstract: A powered fastener driver includes a cylinder and a drive piston within the cylinder being acted on by a driving force resulting from a pressure differential. The powered fastener further includes a drive blade coupled to the drive piston and operable to drive a fastener, and an adjustable valve for selectively introducing air from ambient atmosphere into the cylinder, thereby changing the pressure differential acting on the drive piston. By adopting a self-contained vacuum generating means as described above, the present invention does not rely on any external vacuum source and powered fastener driver can be used and carried with conveniently.

Abstract: A powered fastener driver includes a cylinder and a drive piston within the cylinder being acted on by a driving force resulting from a pressure differential. The powered fastener further includes a drive blade coupled to the drive piston and operable to drive a fastener, and an adjustable valve for selectively introducing air from ambient atmosphere into the cylinder, thereby changing the pressure differential acting on the drive piston. By adopting a self-contained vacuum generating means as described above, the present invention does not rely on any external vacuum source and powered fastener driver can be used and carried with conveniently.

Abstract: Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.

Abstract: Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.

Abstract: A device for comminuting whole trees or brush type vegetation comprising a set of more than two rotatable substantially horizontally oriented comminution drum assemblies; said set of rotatable comminution drum assemblies being constructed and arranged in an angular orientation so that the uppermost rotatable comminution drum assembly in said set of more than two substantially horizontally oriented comminution drum assemblies first engages the top portion of the whole tree or brush type vegetation and the remaining rotatable comminution drum assemblies in said set of more than two substantially horizontally oriented comminution drum assemblies sequentially engage lower portions of the whole tree or brush type vegetation that exist immediately below the portions that are comminuted by each successive comminution drum assembly.

Abstract: Provided herein are dipeptide and tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of proliferative diseases including cancer and autoimmune diseases.

Abstract: Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.

Abstract: A wireless communication system includes a private LTE base station, a commercial carrier LTE base station, and a mobile wireless communications device. The mobile wireless communications device includes an LTE transceiver, a memory, and a controller coupled to the LTE transceiver and the memory. The controller stores an assigned AC value in the memory based upon a priority of use characteristic value, stores a random AC value in the memory, and determines whether access is available to the private LTE base station or the commercial carrier LTE base station. When the private LTE base station is available for access, a connection is made based upon the assigned AC value and a private LTE barring value received from the private LTE base station. When the commercial carrier LTE base station is available for access, a connection is made based upon the random AC value and a commercial carrier barring value.

Abstract: A coating for an animal decoy or fishing lure with a surface reflection which closely matches the spectral reflectance pattern of the animal that it is designed to mimic, including both human-visible and ultraviolet wavelengths, with the intent of making the decoy or fishing lure appear more realistic to animals that can see in both the human-visible and ultraviolet spectrums.

Abstract: Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.