Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.

Abstract: A rotary die system includes a base structure configured to support first and second cylinders in a rotatable manner about parallel axes that jointly span a plane, the cylinders defining two respective contacting surfaces along which the cylinders touch, as well as two respective processing surfaces that are interspaced by a non-zero gap directed along an inter-axis direction along the plane; two first bearing blocks configured to enclose the first cylinder from opposite sides along the respective axis. Each of the first bearing blocks is composed of an inner block configured for accommodating a bearing of the first cylinder; an outer block with a cut-out accommodating the inner block; a tensioning element on the inner block, and flexure hinges that mechanically interconnect the inner and outer blocks, wherein the inner block, the outer block, and the flexure hinges in each first bearing block are jointly formed from a single body of solid material.

Abstract: A rolled material dispenser; including a roll supporting structure that supports a plurality of rolls of material, each roll of material having a width and a long axis, the roll supporting structure supporting the rolls of material with the long axes parallel and with a free end of the rolled material extending downwardly from each of the of rolls. The dispenser includes a pinch roller assembly located beneath the roll supporting structure. The pinch roller assembly is movable in a direction perpendicular to the long axes of the rolls of material and the pinch rollers have a second long axis oriented parallel to the first long axis. A conveyor is positioned below the pinch roller assembly and a material cutter assembly facilitates cutting the rolled material.

Abstract: A mesh to flexible screen frame laminator includes a first table with a horizontal surface and an alignment fence, a second table that is lower than the first table and a first pair of selectively driven heater rollers which are shiftable between a raised position and a lowered position relative to the first table. A cradle is located adjacent the first table and above the second table and at least a portion of the cradle is shiftable between a raised position and a lowered position, the raised position being substantially coplanar with the first table. A second pair of selectively driven heater rollers is shiftable between a raised position and a lowered position relative to the second table and is oriented transversely to the first pair of heater rollers. A third table is located adjacent the second table and at a height substantially coplanar with the second table.

Abstract: A flexible screen frame processor including a loading position that presents loading screen frame supports at which a partially formed flexible screen frame is supportable by an upper perimeter of the partially formed flexible screen frame and an end stripping position including at least one polymer coating stripper. A following welding position includes a welder and screen frame supports that support ends of the screen frame coaxially aligned. A post welding cleaning position includes weld spatter and flash cleaners. An unloading position includes unloading screen frame supports at which a welded and post-weld cleaned flexible screen frame is supportable by an upper perimeter of the welded flexible screen frame.

Abstract: A screw type linear actuator that includes a system for automatically fixing the nut in an axial position when it is retracted. When the system is commanded to operate the screw, the nut can automatically unlock. When the system screw is retracted fully, it automatically engages a mechanical lock. The lock does not require electrical power to remain engaged.

Abstract: The present disclosure relates to a flight control device that can be mounted to a body of a wing of an aircraft to reduce or eliminate backlash in electromechanical actuators (EMAs). The flight control device can include a flight control member and first and second actuators for moving the flight control member relative to the wing of the aircraft. The first and second actuators can be mechanically isolated from one another except for their mutual connection to the flight control member. The first and second actuators can cooperate to apply torsional loading to the flight control member about an axis of the flight control member to reduce or eliminate backlash.

Abstract: A method of treating aqueous, preferably concentrated, waste streams with a unique combination of steps in a way that is easily scalable and able to be used with batch or continuous flows. The method comprises at least the following steps: Adding at least one precipitating agent to the waste water to produce precipitated solids; and removing the precipitated solids from the waste water using a forward flushable membrane to remove the precipitate solids.

Abstract: Various flight control components can be operated through gearbox driven rotary actuators. In the event of a jam occurring the gearbox, the gearbox can be decoupled from a surrounding support housing to enable free-trailing or limited motion relative to the support housing. The motion may or may not be damped. Decoupling the gearbox enables the flight control component to move to a neutral or non-interfering position even when user control over the component has been lost.

Abstract: According to the method of the invention, a translational movement of the tibia of a patient is caused by a first motor (9b) for moving a thrust member (9a) of the patient's calf, and is measured by a first sensor (15a) located on the Tibial Tuberosity, Anterior (TTA). The tibia is caused to rotate by a second motor (12) for rotating a foot support (11b) of the patient, and is measured by a second sensor (14b) located as close as possible to the TTA. The respective operations of the first motor (9b) and of the second motor (12) are correlated by a control member, by being mutually controlled according to pre-set and reproducible force models.

Abstract: An electric motor-brake assembly includes a housing within which a rotor assembly, a stator assembly, and a brake assembly are disposed. The brake assembly is operable between an engaged state and a disengaged state. The rotor assembly is axially movable within the housing and is supported by bearings supporting both radial and axial loads. When the motor stator is de-energized, the brake assembly is in the engaged state to prevent the rotor assembly from rotating in at least one rotational direction. When the motor stator is energized, the brake assembly is in the disengaged state such that the rotor assembly is free to rotate. The brake assembly can include a friction pack that is engaged and disengaged by axial displacement of the rotor assembly.

Abstract: The invention relates to a protection dish (32) for a counterbore formed in an aircraft mechanical part, said protection dish (32) having an axial cross-section about an axis (A) having substantially the shape of a U, and comprising a substantially annular wall (34) of axis (A) and a substantially cylindrical rim (36) of axis (A) connected to an outer periphery of said substantially annular wall (34). The invention is characterised in that said dish (32) is configured to be deformed in response to an axial stress (F) of a determined intensity applied on the substantially annular wall (34) thereof from a first state, wherein the substantially cylindrical rim (36) has a first transverse dimension (E) relative to axis (A), to a second state, wherein the substantially annular wall (34) being deformed, the cylindrical rim (36) has a second transverse dimension (E?) relative to the axis (A) that is greater than the first transverse dimension (E) along a transverse direction (T) determined relative to axis (A).

Abstract: The present invention relates to disubstituted alkyne derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.

Abstract: Various flight control components can be operated through gearbox driven rotary actuators. In the event of a jam occurring the gearbox, the gearbox can be decoupled from a surrounding support housing to enable free-trailing or limited motion relative to the support housing. The motion may or may not be damped. Decoupling the gearbox enables the flight control component to move to a neutral or non-interfering position even when user control over the component has been lost.

Abstract: A screw type linear actuator that includes a system for automatically fixing the nut in an axial position when it is retracted. When the system is commanded to operate the screw, the nut can automatically unlock. When the system screw is retracted fully, it automatically engages a mechanical lock. The lock does not require electrical power to remain engaged.

Abstract: Embodiments of the invention provide for contextually related sharing of commentary for different portions of an information base. A method of the invention includes receiving a query for a portion of content in an information base and identifying a portion of different content in the information base that is related to the queried portion. The method also includes retrieving both commentary posted to the information base in respect to the queried portion, and also commentary posted to the information base in respect to the identified portion. Finally, the method includes transmitting the queried portion and the retrieved portion, but annotating the retrieved commentary in respect to the identified portion so as to direct a display of the commentary posted to the information base in respect to the different portion in a manner visually distinguishable from a display of commentary posted to the information base in respect to the queried portion.

Abstract: A method of treating aqueous, preferably concentrated, waste streams with a unique combination of steps in a way that is easily scalable and able to be used with batch or continuous flows. The method comprises at least the following steps: Adding at least one precipitating agent to the waste water to produce precipitated solids; and removing the precipitated solids from the waste water using a forward flushable membrane to remove the precipitate solids.

Abstract: The invention relates to a guide vane intended to be arranged in all or part of an air flow of an aircraft bypass turbomachine fan, the vane comprising an aerodynamic part equipped with at least one interior lubricant cooling passage delimited in part by an intrados wall and an extrados wall of the vane, there being flow-disturbing lugs, made as one piece with one of the intrados and extrados walls, passing across the passage. According to the invention, in any plane of section passing orthogonally through the lugs, the space defined between these lugs has a geometry defined exclusively by a set of annulus shapes of the same dimensions, partially overlapping one another and each in part delimiting at least two of these lugs.

Abstract: The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.

Abstract: Disclosed are various embodiments for generating a content page with markup language corresponding to user interface widgets. A user interface widget can generate markup language to be incorporated into the content page. The markup language can be analyzed to determine whether it contains a content identifier. The content identifier can be embedded within a portion of a URL. An analysis of the content identifier can be performed to determine whether the content identifier corresponds to expired content.