Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.

Abstract: Novel N-substituted-(dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of an bromoalkyl boronic acid with the purine, indole or pyrimidine base.

Abstract: Novel hydroxyalkylammonium-pyrimidine of the formula ##STR1## and nucleoside derivatives have been found to be useful as inhibitors of inflammatory cytokines. They can be used, inter alia, in the therapy of septic shock, cachexia, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis and AIDS. The compounds are typically prepared by reaction of an iodo substituted nucleoside with the appropriately substituted hydroxyalkylamine.

Abstract: A non-extrusion device for split annular well casing and tubing hanger compression seals has a flat annular body having truncated, radially-split cone portions forming through holes for receiving pins or bolts and for guiding a compressed elastomer seal between inner and outer tubing structures along a radial direction to prevent axial extrusion of the seal.

Abstract: The present invention is directed to novel taxol derivatives useful as anti-tumor agents. Also provided by this invention is pharmaceutical formulations and methods of treating mammalian tumors with the compounds of this invention.

Abstract: An annular metallic seal element for wellhead housings to provide a fluid-tight seal with a well casing that will withstand extreme temperatures and high pressures.

Abstract: A cooking device, comprises a base; a fulcrum mounted on the base; a support for carrying a pan, the support being mounted on the fulcrum and including first and second portions extending respectively from each side of the fulcrum a substantial distance; device for mounting the pan on the first portion; and an actuator operably associated with the second portion for periodically accelerating and decelerating rapidly the first portion about the fulcrum between first and second positions, thereby causing the pan to move upwardly and downwardly with the first portion and propel food placed therein into the air upon rapid upward deceleration and downward acceleration of the first portion and causing the food to be turned for uniform heating of different portions of the food.

Abstract: A device for catching roaches and other insects utilizing an electric shock to catch or kill such insects is disclosed. An electrical integrated circuit utilizing automatic on and off switching is used to enable roaches and insects to enter the device and then periodically shock them and kill them. The design provides safety, efficiency and lower cost without environmental pollution thereby permitting use around small children and pets. The device includes a cover which admits roaches and insects into the device and which includes openings that are sufficiently small to prevent entry of a child's hand or a pet's paws. When the cover is removed, a microswitch automatically cuts the electrical circuit off. The device includes a housing in which is located a conical downwardly and inwardly sloping surface on which is carried a helical pair of conductors connected to the electrical circuit.

Abstract: A food cooking device for cooking Oriental dishes is disclosed comprising a base and a cooking pan support means pivoted to the base. An acceleration and deceleration means is provided for rapidly accelerating upwardly from a starting position to at least the rear portion of the support means at an initial high velocity followed by a subsequent rapid deceleration, whereby when the cooking pan is positioned on the support means, it will move upwardly with the support means and propel food placed therein into the air upon rapid deceleration of the support means, thereby causing the food to be turned for uniform heating of different portions of the food.

Abstract: N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound N-Cyclobutylmethyl-3,14-dihydroxymorphinan has been found to possess potent agonist/antagonist activity as a non-narcotic analgesic. A new and efficient total synthesis of these compounds is described herein from the starting material 2-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline.

Abstract: N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound N-Cyclobutylmethyl-3,14-dihydroxymorphinan has been found to possess potent agonist/antagonist activity as a non-narcotic analgesic. A new and efficient total synthesis of these compounds is described herein from the starting material 2-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline.

Abstract: N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound N-Cyclobutylmethyl-3,14-dihydroxymorphinan has been found to possess potent agonist/antagonist activity as a non-narcotic analgesic. A new and efficient total synthesis of these compounds is described herein from the starting material 2-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline.

Abstract: The disclosed invention is to a compound of the formula: ##STR1## in which R.sup.2 is lower alkyl. These compounds are useful in the preparation of N-substituted-14-hydroxy-3-substituted morphinan derivatives which have been found to possess potent narcotic agonist or antagonist activity.

Abstract: N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound 3,14-dihydroxy-N-cyclopropylmethylmorphinan has been found to possess potent agonist-antagonist activity.

Abstract: This invention relates to a compound of formula I ##STR1## or a pharmaceutically acceptable salt thereof, in which R.sup.2 is a radical of the formula ##STR2## in which R.sup.a and R.sup.b are independently hydrogen or C.sub.1-6 alkyl, said C.sub.1-6 alkyl being optionally substituted with hydroxy, phosphono, phosphonooxy, carboxy or di(C.sub.1-6 alkyl) amino; or NR.sup.a R.sup.b together represents a radical of the formula ##STR3## in which y is one to three, and R.sup.a is as defined above; R.sup.p and R.sup.r are independently same or different C.sub.1-6 alkyl;R.sup.1 is hydrogen or a radical Z of the formula ##STR4## in which Q is --(CH.sub.2).sub.f --, optionally substituted with one to six same or different C.sub.1-6 alkyl or C.sub.3-6 cycloalkyl, or a carbon atom of said --(CH.sub.2).sub.f -- radical may also be a part of C.sub.3-6 cycloalkylidene;R.sup.3 and R.sup.4 are independently hydrogen or C.sub.1-6 alkyl, or R.sup.3 and R.sup.