Patents by Inventor Heping Shi

Heping Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10992338
    Abstract: A secure wireless IoT platform configured to provide secure channel hopping for transmitting or receiving messages over a television whitespace spectrum. The platform includes a client device and a base station in communication with a gateway device which provides internet access. A secret key is determined based on the transmission loss associated with the transmission and potentially a new parameter. A next hopping channel is determined in a safe manner to ensure secure communications between the multiple devices.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: April 27, 2021
    Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
    Inventors: Nissanka Arachchige Bodhi Priyantha, Deepak Vasisht, Ranveer Chandra, Heping Shi
  • Patent number: 10947206
    Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Grant
    Filed: April 15, 2018
    Date of Patent: March 16, 2021
    Assignees: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas System
    Inventors: Boyu Zhong, Lijun Sun, Heping Shi, Jing Li, Chuo Chen, Zhijian Chen
  • Publication number: 20210015941
    Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.
    Type: Application
    Filed: July 20, 2020
    Publication date: January 21, 2021
    Applicants: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas System
    Inventors: Zhijian CHEN, Heping SHI, Qi WEI, Chuo CHEN, Lijun SUN, Jian QIU, Youtong WU
  • Patent number: 10800435
    Abstract: A safety footboard for a rail transit station comprises a fixed frame base, a sliding frame, and a footboard member, the footboard member being fixed in the front of the sliding frame. The sliding frame is arranged within the fixed frame base, being in sliding connection with the fixed frame base, and horizontally extending from and retracting to the fixed frame base with the guidance of guide rails and guiding means. A driving motor is fixed on the fixed frame base, and racks are fixed on the sliding frame, the racks being driven by the driving motor, pushing or pulling the sliding frame to extend from or retract to the fixed frame base.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: October 13, 2020
    Assignee: SHANGHAI JIACHENG RAILWAY TRANSPORTATION SAFETY SYSTEM CORPORATION
    Inventors: Heping Shi, Xianao Yin, Chaoying Zhang, Jinliang Zhu
  • Publication number: 20200308216
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
    Type: Application
    Filed: June 16, 2020
    Publication date: October 1, 2020
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Zhijian CHEN, Lijun SUN, Jiaxi WU, Heping SHI, Chuo CHEN
  • Patent number: 10696710
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: June 30, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Zhijian Chen, Lijun Sun, Jiaxi Wu, Heping Shi, Chuo Chen
  • Publication number: 20200140477
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
    Type: Application
    Filed: December 13, 2019
    Publication date: May 7, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zhijian CHEN, Lijun SUN, Jiaxi WU, Heping SHI, Chuo CHEN
  • Patent number: 10633411
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: April 28, 2020
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Zhijian Chen, Lijun Sun, Jiaxi Wu, Heping Shi, Chuo Chen
  • Publication number: 20200102342
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
    Type: Application
    Filed: November 18, 2019
    Publication date: April 2, 2020
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zhijian CHEN, Lijun SUN, Jiaxi WU, Heping SHI, Chuo CHEN
  • Publication number: 20200010501
    Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
    Type: Application
    Filed: June 11, 2019
    Publication date: January 9, 2020
    Applicants: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas System
    Inventors: Boyu ZHONG, Heping SHI, Yuanwei DAI, Qi WEI, Chuo CHEN, Zhijian CHEN, Lijun SUN
  • Patent number: 10519188
    Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
    Type: Grant
    Filed: April 15, 2018
    Date of Patent: December 31, 2019
    Assignees: ImmuneSensor Therapeutics, Inc., The Board of Regents of the University of Texas System
    Inventors: Boyu Zhong, Lijun Sun, Heping Shi, Qi Wei, Yuanwei Dai, Chuo Chen, Zhijian Chen
  • Patent number: 10508129
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: December 17, 2019
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Zhijian Chen, Lijun Sun, Jiaxi Wu, Heping Shi, Chuo Chen
  • Publication number: 20190263851
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.
    Type: Application
    Filed: May 7, 2019
    Publication date: August 29, 2019
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zhijian CHEN, Lijun SUN, Jiaxi WU, Heping SHI, Chuo CHEN
  • Patent number: 10336786
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies and diagnostics.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: July 2, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Zhijian Chen, Lijun Sun, Jiaxi Wu, Heping Shi, Chuo Chen
  • Publication number: 20180362054
    Abstract: Disclosed is a safety footboard for a rail transit platform. The safety footboard for a rail transit station comprises a fixed frame base (401), a sliding frame (402), and a footboard member (403), the footboard member (403) being fixed in the front of the sliding frame. The sliding frame (402) is arranged within the fixed frame base (401), being in sliding connection with the fixed frame base, and horizontally extending from and retracting to the fixed frame base (401) with the guidance of guide rails and guiding means. A driving motor (404) is fixed on the fixed frame base (401), and racks (405) are fixed on the sliding frame (402), the racks (405) being driven by the driving motor, pushing or pulling the sliding frame (402) to extend from or retract to the fixed frame base (401). The safety footboard can effectively avoid potential safety hazards brought by a gap between a platform and a train door, and does not form obstruction to a moving train.
    Type: Application
    Filed: July 1, 2016
    Publication date: December 20, 2018
    Inventors: Heping SHI, Xianao YIN, Chaoying ZHANG, Jinliang ZHU
  • Publication number: 20180230177
    Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.
    Type: Application
    Filed: April 15, 2018
    Publication date: August 16, 2018
    Inventors: Boyu ZHONG, Lijun SUN, Heping SHI, Qi WEI, Yuanwei DAI, Chuo CHEN, Zhijian CHEN
  • Publication number: 20180230115
    Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
    Type: Application
    Filed: April 15, 2018
    Publication date: August 16, 2018
    Inventors: Boyu ZHONG, Lijun SUN, Heping SHI, Jing Li, Chuo CHEN, Zhijian CHEN
  • Publication number: 20170296655
    Abstract: Cyclic-GMP-AMP (cGAMP), including 2?,3?-cGAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies and diagnostics.
    Type: Application
    Filed: January 29, 2017
    Publication date: October 19, 2017
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zhijian CHEN, Lijun SUN, Jiaxi WU, Heping SHI, Chuo CHEN
  • Publication number: 20150343056
    Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies and diagnostics.
    Type: Application
    Filed: December 16, 2013
    Publication date: December 3, 2015
    Applicant: Board of Regents, The University of Texas System
    Inventors: Zhijian CHEN, Lijun SUN, Jiaxi WU, Heping SHI, Chuo CHEN
  • Publication number: 20100130129
    Abstract: Described is a WLAN/BT system with improved compatibility. It employs an adaptive algorithm that dynamically optimizes the WLAN data fragmentation size based on the current WLAN data rates such that the fragmented data packets fit the time slots allowed by the BT SCO stream gaps. The algorithm first uses system level information to acquire the concurrent BT traffic types to decide if TDM method needs to be enabled. Then it uses the smoothed WLAN date rate to calculate maximum fragmentation packet size consistent with current overall WLAN traffic.
    Type: Application
    Filed: November 25, 2008
    Publication date: May 27, 2010
    Inventors: Jue Chang, Yujie Zhu, Heping Shi, Wei Liu, Xinsi Lin, Kunquan Sun, Meng Zhao