Abstract: The disclosure described herein configures a client device for communication using dynamic spectrum access within a frequency spectrum, such as television white space (TVWS), using a determined location of the client device based on location information, such as from a global positioning system. A dynamic spectrum access database of channels is accessed based on the location information. Available channels are determined for the client device from the channels based on the location information. A list of the available channels for use by the client device are transmitted to the client device, thereby allowing narrowband communication over the channels.

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: The disclosure described herein configures a base station and client devices for communication using dynamic spectrum access within a frequency spectrum that includes selecting, from a list of available channels, a set of channels as active channels. The active channels include uplink channels and downlink channels, and the active channels are distributed among a plurality of base station radios of a base station. A different channel is assigned to different base station radios. At least one uplink channel and at least one downlink channel are assigned to a plurality of client devices based on locations the client devices, wherein at least some client devices have active channels in common. The client devices having the active channels in common are also grouped on shared channels and time slots assigned to the client devices in the group, thereby allowing narrowband communication over the channels by the client devices.

Abstract: The disclosure described herein configures a base station and client devices for communication using dynamic spectrum access within a frequency spectrum that includes selecting, from a list of available channels, a set of channels as active channels. The active channels include uplink channels and downlink channels, and the active channels are distributed among a plurality of base station radios of a base station. A different channel is assigned to different base station radios. At least one uplink channel and at least one downlink channel are assigned to a plurality of client devices based on locations the client devices, wherein at least some client devices have active channels in common. The client devices having the active channels in common are also grouped on shared channels and time slots assigned to the client devices in the group, thereby allowing narrowband communication over the channels by the client devices.

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2?3-cGAMP, 2?2-cGAMP, 3?2?-cGAMP and 3?3?-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies, and diagnostics.

Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

Abstract: The disclosure described herein configures a multi-narrowband transceiver for communication within the television white space (TVWS) frequency spectrum using a log periodic filter, wherein the log periodic filter comprises a plurality of filter elements each having a filter frequency increasing periodically in a same frequency increasing factor (K). Each filter of the plurality of filter elements is configured to filter out second harmonics in a defined frequency range. The disclosure determines a TVWS channel for the communication and switches to a filter element of the plurality of filter elements corresponding to the determined TVWS channel. Data is transmitted and/or received over the TVWS channel using the filter element, thereby allowing narrowband communication over the TVWS channel.

Abstract: The disclosure described herein configures a multi-narrowband transceiver for communication within the television white space (TVWS) frequency spectrum using a log periodic filter, wherein the log periodic filter comprises a plurality of filter elements each having a filter frequency increasing periodically in a same frequency increasing factor (K). Each filter of the plurality of filter elements is configured to filter out second harmonics in a defined frequency range. The disclosure determines a TVWS channel for the communication and switches to a filter element of the plurality of filter elements corresponding to the determined TVWS channel. Data is transmitted and/or received over the TVWS channel using the filter element, thereby allowing narrowband communication over the TVWS channel.

Abstract: Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.

Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.

Abstract: The disclosure described herein configures a base station and client devices for communication using dynamic spectrum access within a frequency spectrum that includes selecting, from a list of available channels, a set of channels as active channels. The active channels include uplink channels and downlink channels, and the active channels are distributed among a plurality of base station radios of a base station. A different channel is assigned to different base station radios. At least one uplink channel and at least one downlink channel are assigned to a plurality of client devices based on locations the client devices, wherein at least some client devices have active channels in common. The client devices having the active channels in common are also grouped on shared channels and time slots assigned to the client devices in the group, thereby allowing narrowband communication over the channels by the client devices.

Abstract: The disclosure described herein configures a multi-narrowband transceiver for communication within the television white space (TVWS) frequency spectrum using a log periodic filter, wherein the log periodic filter comprises a plurality of filter elements each having a filter frequency increasing periodically in a same frequency increasing factor (K). Each filter of the plurality of filter elements is configured to filter out second harmonics in a defined frequency range. The disclosure determines a TVWS channel for the communication and switches to a filter element of the plurality of filter elements corresponding to the determined TVWS channel. Data is transmitted and/or received over the TVWS channel using the filter element, thereby allowing narrowband communication over the TVWS channel.

Abstract: The disclosure described herein configures a client device for communication using dynamic spectrum access within a frequency spectrum, such as television white space (TVWS), using a determined location of the client device based on location information, such as from a global positioning system. A dynamic spectrum access database of channels is accessed based on the location information. Available channels are determined for the client device from the channels based on the location information. A list of the available channels for use by the client device are transmitted to the client device, thereby allowing narrowband communication over the channels.

Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.

Abstract: The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.

Abstract: A secure wireless IoT platform configured to provide secure channel hopping for transmitting or receiving messages over a television whitespace spectrum. The platform includes a client device and a base station in communication with a gateway device which provides internet access. A secret key is determined based on the transmission loss associated with the transmission and potentially a new parameter. A next hopping channel is determined in a safe manner to ensure secure communications between the multiple devices.

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.