Patents by Inventor Herbert Nar

Herbert Nar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions
    Patent number: 7429597
    Abstract: The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formula wherein B, X1 to X3 and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties. The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: September 30, 2008
    Assignee: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventors: Henning Priepke, Roland Pfau, Kai Gerlach, Uwe Ries, Wolfgang Wienen, Eckhart Bauer, Herbert Nar
  • Carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
    Patent number: 7425641
    Abstract: The present invention relates to carboxylic acid amides of general formula wherein R1 to R5, Ar, m and n are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof, the prodrugs and the salts thereof which have valuable properties. The compounds of the above general formula I wherein R5 denotes a cyano group are valuable intermediate products for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein R5 denotes one of the amidino groups mentioned in claim 1 have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: September 16, 2008
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Uwe Ries, Henning Priepke, Armin Heckel, Herbert Nar, Wolfgang Wienen, Jean Marie Stassen
  • NEW CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS
    Publication number: 20080146539
    Abstract: The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: December 19, 2007
    Publication date: June 19, 2008
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Henning PRIEPKE, Kai Gerlach, Roland Pfau, Norbert Hauel, Iris Kauffmann-Hefner, Georg Dahmann, Herbert Nar, Sandra Handschuh, Wolfgang Wienen, Annette Schuler-Metz
  • SUBSTITUTED PROLINAMIDES, MANUFACTURING, AND THE USE THEREOF AS MEDICAMENTS
    Publication number: 20080139605
    Abstract: The present invention relates to new substituted prolinamides of general formula (I) wherein D, L, E, G, J, M, R3, R4, R5 and R13 are defined as in the specification, the tautomers, the enantiomers, the diastereomers, the mixtures, and the salts thereof.
    Type: Application
    Filed: May 16, 2007
    Publication date: June 12, 2008
    Inventors: Kai Gerlach, Georg Dahmann, Herbert Nar, Roland Pfau, Henning Priepke, Annette Schuler-Metz, Wolfgang Wienen
  • CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF, AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
    Publication number: 20080132496
    Abstract: Substituted carboxylic acid amides of general formula wherein A, B, and R1 to R5 are as defined herein, and the tautomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, such as antithrombotic activity and factor Xa-inhibiting activity.
    Type: Application
    Filed: November 30, 2007
    Publication date: June 5, 2008
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: James Gillard, Sandra Ruth Handschuh, Herbert Nar, Roland Pfau, Henning Priepke, Wolfgang Wienen, Annette Mario Schuler-Metz, Eckhart Bauer, Georg Dahmann, Kai Gerlach
  • Carboxylic acid amides, the preparation thereof and their use as medicaments
    Patent number: 7371743
    Abstract: The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: May 13, 2008
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Henning Priepke, Kai Gerlach, Roland Pfau, Norbert Hauel, Iris Kauffmann-Hefner, Georg Dahmann, Herbert Nar, Sandra Handschuh, Wolfgang Wienen, Annette Schuler-Metz
  • SUBSTITUTED BIARYLS, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS
    Publication number: 20080051578
    Abstract: The present invention relates to compounds of general formula (I) wherein A, B, L, R1, R2, R3a and R3b are defined as in the specification, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: August 24, 2006
    Publication date: February 28, 2008
    Inventors: Georg Dahmann, Kai Gerlach, Roland Pfau, Henning Priepke, Wolfgang Wienen, Annette Schuler-Metz, Herbert Nar
  • Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions
    Patent number: 7326791
    Abstract: Substituted carboxylic acid amides of general formula wherein A, B, and R1 to R5 are as defined herein, and the tautomers and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, such as antithrombotic activity and factor Xa-inhibiting activity.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: February 5, 2008
    Assignee: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventors: James Gillard, Sandra Ruth Handschuh, Herbert Nar, Roland Pfau, Henning Priepke, Wolfgang Wienen, Annette Mario Schuler-Metz, Eckhart Bauer, Georg Dahmann, Kai Gerlach
  • BENZIMIDAZOLES, PROCESS FOR THEIR PREPARATION AND USE THEREOF AS MEDICAMENT
    Publication number: 20080015178
    Abstract: The present invention relates to new substituted benzimidazoles of general formula wherein R1 to R6 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: September 24, 2007
    Publication date: January 17, 2008
    Inventors: Kai GERLACH, Roland Pfau, Henning Priepke, Annette Schuler-Metz, Wolfgang Wienen, Sandra Handschuh, Herbert Nar
  • Statine derivatives for the treatment of Alzheimer's disease III
    Patent number: 7238774
    Abstract: The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: July 3, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Stefan Peters, Klaus Fuchs, Christian Eickmeier, Werner Stransky, Cornelia Dorner-Ciossek, Sandra Handschuh, Herbert Nar, Klaus Klinder, Marcus Kostka
  • New substituted thiophene carboxamides, process for their preparation and their use as medicaments
    Publication number: 20060293300
    Abstract: The present invention relates to new substituted thiophene-2-carboxylic acid amides of general formula wherein A, and R1 to R8c are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: May 10, 2005
    Publication date: December 28, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Roland Pfau, Henning Priepke, Kai Gerlach, Wolfgang Wienen, Annette Schuler-Metz, Herbert Nar, Sandra Handschuh, Georg Dahmann
  • New Substituted Pyrrolidinones and Their Use as Medicaments
    Publication number: 20060217435
    Abstract: The present invention relates to new substituted pyrrolidinones of general formula wherein A, X, B and R1 to R9 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: February 21, 2006
    Publication date: September 28, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Kai Gerlach, Henning Priepke, Roland Pfau, Georg Dahmann, Wolfgang Wienen, Annette Schuler-Metz, Herbert Nar
  • Statine derivatives for the treatment of Alzheimer's disease II
    Publication number: 20060160747
    Abstract: The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: November 7, 2005
    Publication date: July 20, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Stefan Peters, Klaus Fuchs, Christian Eickmeier, Werner Stransky, Cornelia Dorner-Ciossek, Sandra Handschuh, Herbert Nar, Klaus Klinder, Marcus Kostka
  • NEW SUBSTITUTED PYRROLIDINONES, THEIR MANUFACTURE AND THEIR USE AS MEDICAMENTS
    Publication number: 20060142263
    Abstract: The present invention relates to new substituted pyrrolidinones of general formula wherein A, X, B and R1 to R9 are as defined above, or a tautomer or salt thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: December 16, 2005
    Publication date: June 29, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Kai Gerlach, Henning Priepke, Roland Pfau, Wolfgang Wienen, Annette Schuler-Metz, Herbert Nar, Peter Kuehn, Georg Dahmann
  • Statine derivatives for the treatment of Alzheimer's disease III
    Publication number: 20060100158
    Abstract: The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: November 7, 2005
    Publication date: May 11, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Stefan Peters, Klaus Fuchs, Christian Eickmeier, Werner Stransky, Cornelia Dorner-Ciossek, Sandra Handschuh, Herbert Nar, Klaus Klinder, Marcus Kostka
  • Novel substituted thiophenecarboxamides, their preparation and their use as medicaments
    Publication number: 20060069082
    Abstract: The present invention relates to novel substituted thiophene-2-carboxamides of the general formula in which A, Ar and R1 to R5 are as defined in Claim 1, their tautomers, their enantiomers, their diastereomers, their mixtures and their salts, especially their physiologically acceptable salts with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: September 29, 2005
    Publication date: March 30, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Henning Priepke, Kai Gerlach, Roland Pfau, Wolfgang Wienen, Annette Schuler-Metz, Herbert Nar, Sandra Handschuh
  • Substituted aryl and heteroaryl derivatives, the preparation thereof and the use therof as pharmaceutical compositions
    Patent number: 7005437
    Abstract: The present invention relates to new substituted aryl and heteroaryl derivatives of general formula wherein A, Ar, n, X, Y1, Y2, Y3, Y4, R1 and R5 are defined as in claim 1, the prodrugs, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties. Thus, the compounds of the above general formula I wherein R5 does not contain a cyano group have, in particular, an antithrombotic effect and a selective factor Xa-inhibiting effect with generally improved compatibility. The compounds of the above general formula I wherein R5 contains a cyano group are valuable intermediate products for preparing the antithrombotic compounds of general formula I.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: February 28, 2006
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Uwe Ries, Herbert Nar, Wolfgang Wienen, Jean-Marie Stassen
  • Substituted ethane-1,2-diamines for the treatment of Alzheimer's disease
    Publication number: 20060025345
    Abstract: The invention relates to a compound of the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, A, B, and Y are defined as in the specification and claims and to its use for treating or preventing Alzheimer's disease and other similar diseases.
    Type: Application
    Filed: May 20, 2005
    Publication date: February 2, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Stefan Peters, Christian Eickmeier, Klaus Fuchs, Werner Stransky, Cornelia Dorner-Ciossek, Marcus Kostka, Sandra Handschuh, Margit Bauer, Herbert Nar, Klaus Bornemann, Klaus Klinder, Joerg Rademann, Steffen Weik
  • Substituted thiophene carboxamides
    Publication number: 20050277628
    Abstract: The present invention relates to new substituted thiophene-2-carboxylic acid amides of general formula wherein A, and R1 to R8c are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: May 10, 2005
    Publication date: December 15, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Roland Pfau, Henning Priepke, Kai Gerlach, Wolfgang Wienen, Annette Schuler-Metz, Herbert Nar, Sandra Handschuh
  • Benzimidazoles, process for their preparation and use thereof as medicament
    Publication number: 20050272792
    Abstract: The present invention relates to new substituted benzimidazoles of general formula wherein R1 to R6 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: June 7, 2005
    Publication date: December 8, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Kai Gerlach, Roland Pfau, Henning Priepke, Annette Schuler-Metz, Wolfgang Wienen, Sandra Handschuh, Herbert Nar