Patents by Inventor Herbert Nar

Herbert Nar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • New substituted thiophene carboxamides, process for their preparation and their use as medicaments
    Publication number: 20050256107
    Abstract: The present invention relates to new substituted thiophene-2-carboxylic acid amides of general formula wherein A, and R1 to R8c are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: May 10, 2005
    Publication date: November 17, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Roland Pfau, Henning Priepke, Kai Gerlach, Wolfgang Wienen, Annette Schuler-Metz, Herbert Nar, Sandra Handschuh
  • New carboxylic acid amides, the preparation thereof and their use as medicaments
    Publication number: 20050203078
    Abstract: The present invention relates to new substituted carboxylic acid amides of general formula wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.
    Type: Application
    Filed: February 11, 2005
    Publication date: September 15, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Henning Priepke, Kai Gerlach, Roland Pfau, Norbert Hauel, Iris Kauffmann-Hefner, Georg Dahmann, Herbert Nar, Sandra Handschuh, Wolfgang Wienen, Annette Schuler-Metz
  • Aromatic bicyclic compounds, preparation thereof and their use as pharmaceutical compositions
    Publication number: 20050107409
    Abstract: The present invention relates to new aromatic bicyclic compounds of general formula wherein Ar, X, Y and Z and R1 to R3 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof, the prodrugs thereof and the salts thereof, as well as their preparation and their use as pharmaceutical compositions. The compounds of the above general formula I have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
    Type: Application
    Filed: February 23, 2004
    Publication date: May 19, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Henning Priepke, Uwe Ries, Herbert Nar, Kai Gerlach, Roland Pfau, Georg Dahmann, Wolfgang Wienen
  • Carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20050065346
    Abstract: The present invention relates to carboxylic acid amides of general formula wherein R1 to R5, Ar, m and n are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof, the prodrugs and the salts thereof which have valuable properties. The compounds of the above general formula I wherein R5 denotes a cyano group are valuable intermediate products for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein R5 denotes one of the amidino groups mentioned in claim 1 have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
    Type: Application
    Filed: September 10, 2004
    Publication date: March 24, 2005
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Uwe Ries, Henning Priepke, Armin Heckel, Herbert Nar, Wolfgang Wienen, Jean Marie Stassen
  • Benzimidazole derivatives, a process for their manufacture and use as a medicine
    Patent number: 6855713
    Abstract: The invention concerns benzimidazole derivatives of the general formula (I) in which the radicals R1, R2, R3, X1 and A can have the meanings assigned to them in the specification, their prodrugs, processes for their production as well as the use of the benzimidazole derivatives as medicines, especially as medicines that have trypsin-inhibiting action.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: February 15, 2005
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Pascale Pouzet, Christoph Hoenke, Claudia Heine, Ralf Anderskewitz, Horst Dollinger, Herbert Nar, Hans Michael Jennewein, Bernd Disse
  • Substituted benzoic acid amides, their preparation and their use as pharmaceutical compositions
    Patent number: 6838565
    Abstract: Carboxylic acid amides of general formula having an antithrombotic activity and a factor Xa-inhibiting activity. Exemplary are: (a) N-[1-(3-amidino-phenyl)-2-(1H-tetrazol-5-yl)-ethyl]-4-(2,5-dihydro-pyrrol-1-yl-carbonyl)-3-methyl-benzamide, (b) N-[1-(3-amidino-phenyl)-2-(1H-tetrazol-5-yl)-ethyl]-3-methyl-4-(pyrrolidin-1-yl-carbonyl)-benzamide, (c) N-[1-(5-amidino-2-hydroxy-phenyl)-2-phenyl-ethyl]-3-methyl-4-(pyrrolidin-1-yl-carbonyl)-benzamide, and (d) N-[1-(5-amidino-2-hydroxy-phenyl)-2-(pyridin-3-yl)-ethyl]-3-methyl-4-(pyrrolidin-1-yl-carbonyl)-benzamide.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: January 4, 2005
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Uwe Ries, Henning Priepke, Wolfgang Wienen, Herbert Nar, Sandra Handschuh
  • Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions
    Publication number: 20040220169
    Abstract: The present invention relates to new substituted carboxylic acid amides of general formula 1
    Type: Application
    Filed: December 19, 2003
    Publication date: November 4, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: James Gillard, Sandra Ruth Handschuh, Herbert Nar, Roland Pfau, Henning Priepke, Wolfgang Wienen, Annette Mario Schuler-Metz, Eckhart Bauer, Georg Dahmann, Kai Gerlach
  • Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20040176603
    Abstract: The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formula 1
    Type: Application
    Filed: December 18, 2003
    Publication date: September 9, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Henning Priepke, Roland Pfau, Kai Gerlach, Uwe Ries, Wolfgang Wienen, Eckhart Bauer, Herbert Nar
  • Novel substituted benzoic acid amides, their preparation and their use as pharmaceutical compositions
    Publication number: 20040138309
    Abstract: Carboxylic acid amides of general formula 1
    Type: Application
    Filed: July 21, 2003
    Publication date: July 15, 2004
    Applicant: Boehringer Ingelheim
    Inventors: Uwe Ries, Henning Priepke, Wolfgang Wienen, Herbert Nar, Sandra Handschuh
  • New carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20040077729
    Abstract: Carboxylic acid amides of general formula 1
    Type: Application
    Filed: July 21, 2003
    Publication date: April 22, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Uwe Ries, Henning Priepke, Wolfgang Wienen, Herbert Nar, Sandra Handschuh
  • Benzimidazole derivatives, processes for preparing them and their use as pharmaceutical compositions
    Patent number: 6656956
    Abstract: Disclosed are carboxamide-substituted benzimidazole derivatives of general formula (I) wherein the groups X, R1, R2, R3 and R4 may have the meanings given in the claims and specification, processes for preparing them and the use of carboxamide-substituted benzimidazole derivatives as pharmaceutical compositions, particularly as pharmaceutical compositions with a tryptase-inhibiting activity.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: December 2, 2003
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Claudia Thies, Christine Braun, Ralf Anderskewitz, Horst Dollinger, Pascale Pouzet, Herbert Nar, Kai Hasselbach, Hans Michael Jennewein, Bernd Disse
  • Benzimidazoles with antithrombotic activity
    Patent number: 6593355
    Abstract: Novel benzimidazoles having antithrombotic activity. Exemplary are: (a) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(ethoxycarbonylmethylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimidazole, (b) 2-[4-(N-phenylcarbonylamidino)-phenylaminomethyl]-1-methyl-5-[1-(ethoxycarbonylmethylamino)-1-(2,5-dihydropyrrolocarbonyl)-ethyl]-benzimidazole, and (c) (R)-2-[4-(N-phenylcarbonylamidino)-phenylaminomethyl]-1-methyl-5-[1-(isobutyloxycarbonylmethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: July 15, 2003
    Assignee: Boehringer Ingelehim Pharma KG
    Inventors: Uwe Ries, Iris Kaufmann-Hefner, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Benzimidazole derivatives, a process for their manufacture and use as a medicine
    Publication number: 20030130265
    Abstract: The invention concerns benzimidazole derivatives of the general formula (I) 1
    Type: Application
    Filed: September 9, 2002
    Publication date: July 10, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Pascale Pouzet, Christoph Hoenke, Claudia Heine, Ralf Anderskewitz, Horst Dollinger, Herbert Nar, Hans Michael Jennewein, Bernd Disse
  • Benzimidazole derivatives, processes for preparing them and their use as pharmaceutical compositions
    Publication number: 20030105137
    Abstract: Disclosed are carboxamide-substituted benzimidazole derivatives of general formula (I) 1
    Type: Application
    Filed: February 6, 2002
    Publication date: June 5, 2003
    Inventors: Claudia Thies, Christine Braun, Ralf Anderskewitz, Horst Dollinger, Pascale Pouzet, Herbert Nar, Kai Hasselbach, Hans Michael Jennewein, Bernd Disse
  • Substituted aryl and heteroaryl derivatives, the preparation thereof and the use therof as pharmaceutical compositions
    Publication number: 20030045712
    Abstract: The present invention relates to new substituted aryl and heteroaryl derivatives of general formula 1
    Type: Application
    Filed: May 10, 2002
    Publication date: March 6, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Uwe Ries, Herbert Nar, Wolfgang Wienen, Jean-Marie Stassen
  • Benzimidazoles with antithrombotic activity
    Publication number: 20030004356
    Abstract: Novel benzimidazoles having antithrombotic activity.
    Type: Application
    Filed: July 3, 2002
    Publication date: January 2, 2003
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Uwe Ries, Iris Kaufmann-Hefner, Norbert Hauel, Henning Priepke, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Antithrombotic carboxylic acid amides
    Publication number: 20020183519
    Abstract: Carboxylic acid amides of formula 1
    Type: Application
    Filed: March 11, 2002
    Publication date: December 5, 2002
    Inventors: Herbert Nar, Henning Priepke, Uwe Ries, Jean Marie Stassen, Wolfgang Wienen
  • Substituted aryl and heteroaryl derivatives, their production and their use as medicines
    Patent number: 6479524
    Abstract: Compounds that prolong thrombin time. Exemplary are: (a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine, (b) rac-4-{3-[2,5-dimethyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine, and (c) 4-[3-(2,5-dimethyl-4-isopropylcarbonyl-phenyl)propargyl-amino]benzamidine.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: November 12, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Iris Kauffmann-Hefner, Norbert Hauel, Uwe Ries, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
  • Carboxylic acid amides having antithrombotic activity
    Publication number: 20020151595
    Abstract: Compounds with antithrombotic activity and factor Xa-inhibiting activity of the general formula: 1
    Type: Application
    Filed: January 17, 2002
    Publication date: October 17, 2002
    Inventors: Uwe Joerg Ries, Henning Priepke, Herbert Nar, Jean-Marie Stassen, Wolfgang Wienen
  • Antithrombotic compounds
    Publication number: 20020151534
    Abstract: Antithrombotic compounds of general formula 1
    Type: Application
    Filed: January 16, 2002
    Publication date: October 17, 2002
    Inventors: Uwe Joerg Ries, Henning Priepke, Herbert Nar, Jean-Marie Stassen, Wolfgang Wienen