Patents by Inventor Herbert T. Nagasawa

Herbert T. Nagasawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANALGESIC AND ANTI-ADDICTIVE COMPOSITIONS FOR TREATMENT OF CHRONIC PAIN AND OPIOID ADDICTION
    Publication number: 20220002238
    Abstract: The invention provides a compound of formula I and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the formula I compounds, as well as methods of using such as therapeutic agents for the treatment of pain-related disorders and diseases and in combination with other therapeutic agents.
    Type: Application
    Filed: November 6, 2019
    Publication date: January 6, 2022
    Applicant: Regents of the University of Minnesota
    Inventors: Carolyn A. FAIRBANKS, Herbert T. NAGASAWA, George L. WILCOX, Cristina D. PETERSON, Kelley F. KITTO
  • METHOD TO ENHANCE DELIVERY OF GLUTATHIONE AND ATP LEVELS IN CELLS
    Publication number: 20160082029
    Abstract: A therapeutic method is provided comprising treating a mammal subject to hypoxia with an amount of 2(R,S)-D-ribo-(1?,2?,3?,4?-tetrahydroxybutyl)thiazolidine-4(R)-carboxylic acid (RibCys) or a pharmaceutically acceptable salt thereof effective to both maintain, restore or increase both the ATP levels and the glutathione (GSH) levels in said tissue.
    Type: Application
    Filed: August 27, 2015
    Publication date: March 24, 2016
    Inventor: Herbert T. Nagasawa
  • Methods for reducing oxidative stress in a cell with a sulfhydryl protected glutathione prodrug
    Patent number: 9173917
    Abstract: The present invention relates to compositions and methods for reducing oxidative stress in a cell, increasing glutathione levels in a cell, increasing L-cysteine levels in a cell and reducing hepatocytotoxicity by contacting a cell with a sulfhydryl protected glutathione prodrug or a sulfhydryl protected cysteine prodrug.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: November 3, 2015
    Assignees: Max International, LLC, The United States of America as represented by the Department of Veteran Affairs
    Inventors: Herbert T. Nagasawa, Jonathan F. Cohen
  • Method to enhance delivery of glutathione and ATP levels in cells
    Patent number: 9144570
    Abstract: A therapeutic method is provided comprising treating a mammal subject to hypoxia with an amount of 2(R,S)-D-ribo-(1?,2?,3?,4?-tetrahydroxybutyl)thiazolidine-4(R)-carboxylic acid (RibCys) or a pharmaceutically acceptable salt thereof effective to both maintain, restore or increase both the ATP levels and the glutathione (GSH) levels in said tissue.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: September 29, 2015
    Assignee: Max International, LLC
    Inventor: Herbert T. Nagasawa
  • Compositions Comprising Sugar-Cysteine Products
    Publication number: 20150023941
    Abstract: The present invention provides compositions comprising sugar, cysteine, and/or sugar-cysteine products, methods of preparing the same, and/or using the same.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 22, 2015
    Inventors: David Bagley, Scott Momii, Scott Nagasawa, Herbert T. Nagasawa
  • COMPOSITIONS COMPRISING SUGAR-CYSTEINE PRODUCTS
    Publication number: 20140348811
    Abstract: The present invention provides compositions comprising sugar, cysteine, and/or sugar-cysteine products, methods of preparing the same, and/or using the same.
    Type: Application
    Filed: July 27, 2012
    Publication date: November 27, 2014
    Applicant: MAX INTERNATIONAL, LLC
    Inventors: Herbert T. Nagasawa, David Bagley, Scott Momii, Scott Nagasawa
  • Compositions comprising sugar-cysteine products
    Patent number: 8853170
    Abstract: The present invention provides compositions comprising sugar, cysteine, and/or sugar-cysteine products.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: October 7, 2014
    Assignee: Max International, LLC
    Inventors: David Bagley, Scott Momii, Scott Nagasawa, Herbert T. Nagasawa
  • Method To Enhance Delivery Of Glutathione And ATP Levels In Cells
    Publication number: 20130317072
    Abstract: A therapeutic method is provided comprising treating a mammal subject to hypoxia with an amount of 2(R,S)-D-ribo-(1?,2?,3?,4?-tetrahydroxybutyl)thiazolidine-4(R)-carboxylic acid (RibCys) or a pharmaceutically acceptable salt thereof effective to both maintain, restore or increase both the ATP levels and the glutathione (GSH) levels in said tissue.
    Type: Application
    Filed: August 2, 2013
    Publication date: November 28, 2013
    Applicant: Max International LLC
    Inventor: Herbert T. Nagasawa
  • Method to enhance delivery of glutathione and ATP levels in cells
    Patent number: 8501700
    Abstract: A therapeutic method is provided comprising treating a mammal subject to hypoxia with an amount of 2(R,S)-D-ribo-(1?,2?,3?,4?-tetrahydroxybutyl)thiazolidine-4(R)-carboxylic acid (RibCys) or a pharmaceutically acceptable salt thereof effective to both maintain, restore or increase both the ATP levels and the glutathione (GSH) levels in said tissue.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: August 6, 2013
    Assignee: Max International LLC
    Inventor: Herbert T. Nagasawa
  • THERAPEUTIC METHODS, COMPOSITIONS, AND COMPOUNDS
    Publication number: 20120329731
    Abstract: In one embodiment the invention provides a method of combating cyanide poisoning, which comprises administering to a subject a compound capable of releasing 3-mercapto-pyruvate in vivo. In other embodiments the invention also provides pharmaceutical compositions comprising a compound capable of releasing 3-mercaptopyruvate in vivo, as well as novel compounds that are capable of releasing 3-mercaptopyruvate in vivo.
    Type: Application
    Filed: October 13, 2011
    Publication date: December 27, 2012
    Inventors: Herbert T. Nagasawa, David J.W. Goon, Daune L. Crankshaw, Robert Vince
  • METHODS FOR REDUCING OXIDATIVE STRESS IN A CELL WITH A SULFHYDRYL PROTECTED GLUTATHIONE PRODRUG
    Publication number: 20120295855
    Abstract: The present invention relates to compositions and methods for reducing oxidative stress in a cell, increasing glutathione levels in a cell, increasing L-cysteine levels in a cell and reducing hepatocytotoxicity by contacting a cell with a sulfhydryl protected glutathione prodrug or a sulfhydryl protected cysteine prodrug.
    Type: Application
    Filed: July 12, 2012
    Publication date: November 22, 2012
    Applicants: Department of Veterans Affairs, Max International, LLC
    Inventors: Herbert T. Nagasawa, Jonathan F. Cohen
  • Compositions And Beverages Comprising Nutrients, Vitamins, Sugars, Cysteine, And/Or Sugar-Cysteine Products
    Publication number: 20110287109
    Abstract: The present invention provides compositions comprising vitamins, minerals, nutrients, sugar, cysteine, and/or sugar-cysteine products, methods of preparing the same, and/or using the same.
    Type: Application
    Filed: May 23, 2011
    Publication date: November 24, 2011
    Applicant: MAX INTERNATIONAL, LLC
    Inventors: David Bagley, Scott Momii, Scott Nagasawa, Herbert T. Nagasawa
  • Methods Of Preparing Thiazolidines
    Publication number: 20110184185
    Abstract: The present invention provides methods of preparing thiazolidines, and in particular methods of preparing ribose-cysteine.
    Type: Application
    Filed: January 28, 2011
    Publication date: July 28, 2011
    Applicant: MAX INTERNATIONAL, LLC
    Inventors: Herbert T. Nagasawa, Kurt Wachholder
  • Compositions Comprising Sugar-Cysteine Products
    Publication number: 20110183927
    Abstract: The present invention provides compositions comprising sugar, cysteine, and/or sugar-cysteine products, methods of preparing the same, and/or using the same.
    Type: Application
    Filed: January 28, 2011
    Publication date: July 28, 2011
    Applicant: MAX INTERNATIONAL, LLC
    Inventors: David Bagley, Scott Momii, Scott Nagasawa, Herbert T. Nagasawa
  • THERAPEUTIC METHODS, COMPOSITIONS AND COMPOUNDS
    Publication number: 20090197865
    Abstract: In one embodiment the invention provides a method of combating cyanide poisoning, which comprises administering to a subject a compound capable of releasing 3-mercapto-pyruvate in vivo. In other embodiments the invention also provides pharmaceutical compositions comprising a compound capable of releasing 3-mercaptopyruvate in vivo, as well as novel compounds that are capable of releasing 3-mercaptopyruvate in vivo.
    Type: Application
    Filed: June 28, 2007
    Publication date: August 6, 2009
    Inventors: Herbert T. Nagasawa, David J.W. Goon, Daune L. Crankshaw, Robert Vince
  • METHODS FOR REDUCING OXIDATIVE STRESS IN A CELL WITH A SULFHYDRYL PROTECTED CLUTATHIONE PRODRUG
    Publication number: 20090069249
    Abstract: The present invention relates to compositions and methods for reducing oxidative stress in a cell, increasing glutathione levels in a cell, increasing L-cysteine levels in a cell and reducing hepatocytotoxicity by contacting a cell with a sulfhydryl protected glutathione prodrug or a sulfhydryl protected cysteine prodrug.
    Type: Application
    Filed: August 12, 2008
    Publication date: March 12, 2009
    Inventors: Herbert T. Nagasawa, Jonathan F. Cohen
  • METHOD TO ENHANCE DELIVERY OF GLUTATHIONE AND ATP LEVELS IN CELLS
    Publication number: 20090042822
    Abstract: A therapeutic method is provided comprising treating a mammal subject to hypoxia with an amount of 2(R,S)-D-ribo-(1?,2?,3?,4?-tetrahydroxybutyl)thiazolidine-4(R)-carboxylic acid (RibCys) or a pharmaceutically acceptable salt thereof effective to both maintain, restore or increase both the ATP levels and the glutathione (GSH) levels in said tissue.
    Type: Application
    Filed: July 30, 2008
    Publication date: February 12, 2009
    Applicant: Bioceuticals, Inc.
    Inventor: Herbert T. Nagasawa
  • Methods for reducing oxidative stress in a cell with a sulfhydryl protected glutathione prodrug
    Publication number: 20040229815
    Abstract: The present invention relates to compositions and methods for reducing oxidative stress in a cell, increasing glutathione levels in a cell, increasing L-cysteine levels in a cell and reducing hepatocytotoxicity by contacting a cell with a sulfhydryl protected glutathione prodrug or a sulfhydryl protected cysteine prodrug.
    Type: Application
    Filed: December 30, 2003
    Publication date: November 18, 2004
    Inventors: Herbert T. Nagasawa, Jonathan F. Cohen
  • N-terminal D(-)-penicillamine peptides as aldehyde sequestration agents
    Patent number: 6686336
    Abstract: The invention provides a compound of formula I: wherein R1-R3 have any of the values described in the specification; or a salt thereof. The compounds are useful as aldehyde sequestration agents (e.g., in the treatment of alcohol-related diseases). The invention also provides compositions comprising such compounds as well as therapeutic methods comprising their administration.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: February 3, 2004
    Assignee: Federal Government as represented by the Department of Veterans Affaires
    Inventor: Herbert T. Nagasawa
  • N-terminal D(-)-penicillamine peptides as aldehyde sequestration agents
    Publication number: 20010041789
    Abstract: The invention provides a compound of formula I: 1
    Type: Application
    Filed: December 22, 2000
    Publication date: November 15, 2001
    Inventor: Herbert T. Nagasawa