Abstract: A passive inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. The inhaler comprises a metallic piercing member with two piercing elements extending at least essentially in V-shape away from each other and being at least essentially flat.

Abstract: A method of sealing parts of a plastic capsule by forming a weld seam in an overlapping region of the parts of the capsule, wherein the capsule comprises a capsule cap having an open end and a capsule body having an open end, and capsules formed by such method. The capsules produced by the process according to the invention are disposable and preferably contain a single dose of a pharmaceutical formulation in the form of a powder or liquid intended to be administered by inhalation and are suitable by their form and function for use in powder inhalers or liquid nebulizers for producing aerosols. Aerosols thus produced can be inhaled, for example, in order to administer a pharmaceutical formulation to the lungs.

Abstract: The invention relates to pharmaceutical active substances, active substance mixtures and formulations for use as an aerosol in propellant-containing [1.1.1.2-tetrafluoroethane (HFC-134a) or 1.1.1.2.3.3.3-heptafluoropropane(HFC-227)] metered-dose aerosols and the metered-dose aerosols for administering these active substances, active substance mixtures and formulations.

Abstract: A passive inhaler (1) for delivery of a powder-form inhalation formulation from a blister strip (2) with a plurality of blister pockets (3) is proposed. The inhaler comprises an impaction element (31) onto which the air stream can impact together with entrained inhalation formulation for better deagglomeration. Alternatively, the inhaler comprises an oscillating and/or vibrating device (35) for better de-agglomeration of the inhalation formulation. Alternatively or additionally, the inhaler comprises one or two mixing means for generating swirls, preferably with opposite rotation directions.

Abstract: A passive inhaler for delivery of a powder-form inhalation formulation from a blister strip with a plurality of blister pockets is proposed. The inhaler has a flow resistance of at least 75000 Pa1/2s/m3.

Abstract: A passive inhaler (1) for delivery of a powder-form inhalation formulation from a blister strip (2) with a plurality of blister pockets (3) is proposed. The inhaler comprises a metallic piercing member (7) with two piercing elements (25) extending parallel to each other and inclined to a lid (27) of a blister pocket to be punctured.

Abstract: In an inhaler for administering a powdery medicament in the form of an inhalable substance, substance formulation or mixture, a blister cavity to be opened by piercing elements (11) is mounted in the lower part (1) of a housing (2), which is composed of an upper part (6), designed as mouthpiece and with an inhalation channel (16), and of the lower part (1), which comprises an air inlet opening (9). The inhalation channel (16) of the upper part (6) of the housing has a unit (15) for dispersing the powdery medicament, said unit (15) being connected to the piercing elements (11), wherein the upper part (6) of the housing can be moved relative to the lower part (1) of the housing in order to open the blister cavity.

Abstract: A dispensing device for dispensing powder as a spray is disclosed. The dispensing device comprises a duct through which the powder is dispensable by gas pressure for de-agglomerating the powder. The duct is angled by at least about 90 degrees at a diversion portion and/or diverted into two opposite directions at a fork portion so that the powder is impacted on to or sheared by a solid surface for powder de-agglomeration.

Abstract: A device (1) for testing the seal between the lips of a user and a mouthpiece (10) during inhalation. The mouthpiece is connected to an inhalation channel (11) provided with a first flowmeter (12), and the device has an stray air channel (21) which extends around the lips and which is provided with a second flowmeter (22).

Abstract: An inhaler for inhaling powdered pharmaceutical compositions from capsules includes: a lower part; a plate which can be latched to the lower part and with which the lower part can be closed off; a capsule holder for receiving the capsules, this holder being adapted to be lowered into the lower part; a mouthpiece latchable to the plate; a lid which covers the mouthpiece in a closed position and latches it by means of a closure element, the lower part, the plate, the mouthpiece and the lid being hinged together by means of a single joint; and an actuating member which can be moved out a resting position and thereby interacts with at least one pin which can be made to pierce the capsule holder.

Abstract: The invention relates to a nozzle system for a delivery device for liquids, wherein the nozzle system comprises a nozzle and a device which fixes the nozzle in the delivery device. The delivery device, an atomizer, has a liquid reservoir from which a liquid is forced through the nozzle under pressure. The nozzle fixing means may itself be secured by a second fixing, e.g., in the form of a check nut, or the fixing may itself be a check nut. According to the invention the fixing means on the nozzle outlet side has a specific geometry which minimizes the proportion of dispensed liquid deposited on the fixing means. Preferably, the present invention is part of a propellant-free device for nebulizing pharmaceutical liquids.

Abstract: A mouthpiece for an inhaler for administering a drug in the form of substances, substance formulations or substance mixtures that can be inhaled comprises an inhalation channel (4) for coupling to a chamber for receiving the drug. At least one component (10) having an aerodynamic cross-section is arranged in the inhalation channel (4).

Abstract: An inhaler for propellant-free atomization of a medicament preparation. The inhaler produces an aerosol at low speed. The inhaler is combined with an add-on device for intermediate storage of the aerosol produced, so as to allow easier inhalation, particularly for children.

Abstract: The invention relates to a nozzle system for a delivery device for liquids, which comprises a nozzle and a device which fixes the nozzle in the delivery device. The device has a liquid reservoir from which a liquid is forced through a nozzle under pressure to deliver the liquid. The nozzle is secured by a holder on the delivery device. This holder may itself be secured by a second holder, e.g. in the form of a check nut, or the check nut itself may be the holder. According to the invention at least part of the outer surface of the holding device is micro- or nanostructured.

Abstract: The present invention provides, for the first time, a process that meets the needs of the drug industry for measuring the particle size of nebulized aerosols simultaneously or one after another by the laser diffraction method and the cascade impactor method which is known in the art. In this way it is possible to bring the reliability of the results of the laser diffraction process according to the invention into conformity with that of the cascade impactor, and thereby obtain a process which combines the advantages of the rapid laser diffraction process with the accuracy of the otherwise time-consuming cascade impactor method. In addition to the process, apparatus for carrying out the process are also disclosed.

Abstract: The invention is a medicament magazine having at least one medicament chamber for use in a powder inhaler, wherein the magazine is formed from two foil strips applied to one another and the at least one medicament chamber is formed between the foil strips. The medicament chambers have an internal structure (3) which comprises in its interior a space for receiving a powdered medicament and stabilises this inner space against external mechanical influences. In another embodiment in which the internal structure preferably also has a stabilising function, the structure has means for opening one foil strip. In addition, the medicament chamber contains a retaining device which holds the internal structure on the medicament magazine after the medicament chamber has been opened.

Abstract: The invention relates to a nozzle system for a delivery device for liquids, which comprises a nozzle and a device which fixes the nozzle in the delivery device. The device has a liquid reservoir from which a liquid is forced through a nozzle under pressure to deliver the liquid. The nozzle is secured by a holder on the delivery device. This holder may itself be secured by a second holder, e.g. in the form of a check nut, or the check nut itself may be the holder. According to the invention at least part of the outer surface of the holding device is micro- or nanostructured.

Abstract: The invention concerns a medicine dispensation device, in particular a multi-dose powder inhalator, for the dispensing of individual doses of medicine as depicted in exemplary FIG. 1. Therein a number of medicine chambers are contained in a medicine magazine shaped like a continuous loop. The medicine chambers form groups in such a manner that a mouthpiece reaches the different groups by an essentially complete rotation of the medicine magazine. This enables several medicine chambers—typically one, two or three—to be situated between two successive intake positions, which allows for a high density of medicine chambers and thus creates an inhalation device, which can be handled comfortably even when containing a great number of individual doses.

Abstract: A dispensing device, a storage device and a method are proposed for dispensing a formulation as a spray. The formulation is dispensed by means of a gas stream. To improve the dispensing effect, pressure pulses are generated in the gas stream and/or the direction of gas flow alternates. The formulation is dispensed through a duct. The duct is connected to a storage chamber containing the formulation via a sharp edge or transition portion.

Abstract: The invention relates to a medicament dispensing device, particularly a multi-dose powder inhaler, a medicament magazine thereof, and a method of removing a medicament from the medicament magazine as depicted in exemplary FIG. 1. The inhaler has a mouthpiece (9) and an air channel (4) connected thereto, as well as a medicament magazine with at least one medicament chamber containing a powdered medicament. A drive current is produced in the air channel, while a vacuum flow (5?) can be produced by the drive current and a constriction formed in the air channel. This narrowest part of the air channel that produces the vacuum flow is connected to a removal opening (2) which communicates with a control opening (3), in order to form an emptying current through the control opening via the removal opening. In a preferred embodiment the at least one medicament chamber including the control opening, the removal opening and a fill opening are housing in the one-piece medicament magazine.