Abstract: The invention relates to a medicament magazine with a plurality of doses of medicament, wherein the magazine is formed from a single foil strip in which pouches (2) for holding a medicament are formed. The foil strip comprises for transporting the strip openings (4) on at least one side for the engagement of transporting pins. The foil strip has a certain width in the region of the pouches, which is less than the width of the foil in other regions, and the openings are arranged in this broader part of the foil strip. The invention also relates to a method and a device for opening a medicament magazine of this kind, the device preferably being constructed as a segmented wheel.

Abstract: Disclosed herein are methods for measuring the particle size distribution of a pharmaceutical aerosol, including methods utilizing laser diffraction.

Abstract: A locking-stressing-mechanism with spring-actuated output drive and a counter with which an apparatus of this kind is fitted, accommodated in a two part housing the two parts of which are mounted to be rotatable relative to each other, can be blocked by means of a pre-stressed leaf spring. The leaf spring is initially accommodated in a recess in the wall of one housing part. As soon as the permitted number of actuations has been reached a push rod pushes the leaf spring out of its resting position. The leaf spring then jumps into a recess in the wall of the other housing part and the two housing parts can no longer be rotated relative to each other. The push rod may be mounted on the pointer of the counter. This blocking device can only be overcome by the application of a force which is sufficient to destroy the device. The device is suitable for blocking a high pressure atomiser or a needleless injector with which a fluid is atomised to form an aerosol or a fluid is injected into a biological tissue.

Abstract: The invention relates to a nozzle system for a delivery device for liquids, wherein the nozzle system comprises a nozzle and a device which fixes the nozzle in the delivery device. The delivery device, an atomizer, has a liquid reservoir from which a liquid is forced through the nozzle under pressure. The nozzle fixing means may itself be secured by a second fixing, e.g., in the form of a check nut, or the fixing may itself be a check nut. According to the invention the fixing means on the nozzle outlet side has a specific geometry which minimizes the proportion of dispensed liquid deposited on the fixing means. Preferably, the present invention is part of a propellant-free device for nebulizing pharmaceutical liquids.

Abstract: The invention relates to a nozzle system for a delivery device for liquids, wherein the nozzle system comprises a nozzle and a device which fixes the nozzle in the delivery device. The delivery device, an atomiser, has a liquid reservoir from which a liquid is forced through the nozzle under pressure. The nozzle fixing means may itself be secured by a second fixing, e.g., in the form of a check nut, or the fixing may itself be a check nut. According to the invention the fixing means on the nozzle outlet side has a specific geometry which minimizes the proportion of dispensed liquid deposited on the fixing means. Preferably, the present invention is part of a propellant-free device for nebulizing pharmaceutical liquids.

Abstract: A dispensing device for dispensing powder as a spray is disclosed. The dispensing device comprises a duct through which the powder is dispensible by gas pressure for de-agglomerating the powder. The duct is angled by at least about 90 degrees at a diversion portion and/or diverted into two opposite directions at a fork portion so that the powder is impacted on to or sheared by a solid surface for powder de-agglomeration.

Abstract: The invention relates to pharmaceutical active substances, active substance mixtures and formulations for use as an aerosol in propellant-containing [1.1.1.2-tetrafluoroethane (HFC-134a) or 1.1.1.2.3.3.3-heptafluoropropane(HFC-227)] metered-dose aerosols and the metered-dose aerosols for administering these active substances, active substance mixtures and formulations.

Abstract: The invention relates to a package for pharmaceutical compositions, mixtures or formulations for use in a powder inhaler.

Abstract: An inhaler for inhaling powdered medicament from capsules is described. Once the capsule has been placed in the capsule holder (3), the patient can press an actuating member (8), which interacts with at least one pin (9) adapted to be pushed into the capsule holder (3), causing the medicament to be released. In a preferred embodiment, the actuating member (8) is constructed as a multi-functional actuating member (8a) wherein, in a first functional position, the closure element (6) can be disengaged from the lower part (1) in order to pivot the cover (5), and wherein, in a second functional position, the mouthpiece (4) engaging with the plate (2) can be released from the plate (2) in such a way that the mouthpiece (4) can be pivoted away from the lower part (1).

Abstract: A process which can be used in the laboratory or on an industrial scale for cleaning the inner wall of hard gelatine capsules, in which the sealed capsules are cleaned with a powder formulation.

Abstract: Disclosed herein are methods for measuring the particle size distribution of a pharmaceutical aerosol, including methods utilizing laser diffraction.

Abstract: The invention relates to a powder inhaler with at least one specially sharpened needle, to ensure the precise piercing or cutting open of capsules and hence the optimum delivery of powdered medicament compositions, medicament formulations or medicament mixtures, as well as ensuring that little effort is needed to perforate or cut open the capsule.

Abstract: A process which can be used in the laboratory or on an industrial scale for cleaning the inner wall of hard gelatine capsules, in which the sealed capsules are cleaned with a powder formulation.

Abstract: An inhaler for inhaling powdered medicament from capsules is described. Once the capsule has been placed in the capsule holder (3) the patient can press an actuating member (8), which interacts with at least one pin (9) adapted to be pushed into the capsule holder (3), causing the medicament to be released. In a preferred embodiment, the actuating member (8) is constructed as a multi-functional actuating member (8a) wherein, in a first functional position, the closure element (6) can be disengaged from the lower part (1) in order to pivot the cover (5), and wherein, in a second functional position, the mouthpiece (4) engaging with the plate (2) can be released from the plate (2) in such a way that the mouthpiece (4) can be pivoted away from the lower part (1).

Abstract: The present invention provides, for the first time, a process that meets the needs of the drug industry for measuring the particle size of nebulised aerosols simultaneously or one after another by the laser diffraction method and the cascade impactor method which is known in the art. In this way it is possible to bring the reliability of the results of the laser diffraction process according to the invention into conformity with that of the cascade impactor, and thereby obtain a process which combines the advantages of the rapid laser diffraction process with the accuracy of the otherwise time-consuming cascade impactor method. In addition to the process, apparatus for carrying out the process are also disclosed.

Abstract: An inhaler for inhaling powdered pharmaceutical compositions from capsules is described, the capsules being plalced before use in a capsule holder disposed in the inhaler. Once the capsule has been inserted in the capsule holder the patient can press an actuating member (7) which can be moved out of a resting position, thereby cooperating with at least one pin which can stuck into the capsule holder. The capsule is pierced by means of the minimum of one pin and the pharmaceutical composition is released. The aim is to further improve such inhalers in terms of their operating comfort.

Abstract: The present invention relates to capsules for housing pharmaceutical preparations for powder inhalers with increased medicinal product safety and capsules for pharmaceutical preparations for powder inhalers with improved adaption to use in powder inhalers. The capsules consist of non-water-soluble, hydrophobic plastics, which themselves do not substantially influence the pharmaceutical quality of the contents, but improve the usability of the filled capsules in respect of their operation, the period of use and/or the geographical location of their use and are advantageous in various steps from manufacture to use.

Abstract: An inhaler is described for inhaling powdered medicament from capsules which are placed in a capsule holder (3) provided in the inhaler before use. Once the capsule has been placed in the capsule holder (3) the patient can press an actuating member (8), which can be set in motion from a resting position and thereby interacts with at least one pin (9) adapted to be pushed into the capsule holder (3). By means of the minimum of one pin the capsule is pierced and the medicament is released. The intention is to improve inhalers of this kind in terms of ease of operation.

Abstract: The present invention provides, for the first time, a process that meets the needs of the drug industry for measuring the particle size of nebulised aerosols simultaneously or one after another by the laser diffraction method and the cascade impactor method which is known in the art. In this way it is possible to bring the reliability of the results of the laser diffraction process according to the invention into conformity with that of the cascade impactor, and thereby obtain a process which combines the advantages of the rapid laser diffraction process with the accuracy of the otherwise time-consuming cascade impactor method. In addition to the process, apparatus for carrying out the process are also disclosed.

Abstract: A method of sealing parts of a plastic capsule by forming a weld seam in an overlapping region of the parts of the capsule, wherein the capsule comprises a capsule cap having an open end and a capsule body having an open end, the method comprising: (a) holding the capsule cap and the capsule body in a capsule holder comprising a first holding part and a second holding part which can be guided synchronously with one another, wherein the first holding part interlockingly surrounds the capsule cap and the second holding part interlockingly surrounds the capsule body; (b) closing the capsule holder holding the capsule cap and the capsule body so that the open end of the capsule cap and the open end of the capsule body form a sealed cavity therebetween and form an overlapping region, wherein the overlapping region is not covered by the capsule holder, to obtain a closed capsule; and (c) welding the closed capsule using an energy beam of hot gas or laser light on the overlapping region by forming the weld seam ther