Abstract: The present invention provides a preventative/therapeutic agent for cancer capable of selectively and effectively killing cancer cells. A medicament of the present invention prepared by combining at least one selected from a substance that inhibits the activity of an enzyme belonging to the acyl-CoA synthase family and a substance that inhibits expression of a gene for an enzyme belonging to the acyl-CoA synthase family, with at least one selected from a substance that inhibits the activity of fatty acid synthase and a substance that inhibits expression of a fatty acid synthase gene and the like can be used as a preventative/therapeutic agent for cancer capable of selectively and effectively killing cancer cells.

Abstract: A compound or its salt inhibiting the activity of a protein having an amino acid sequence which is the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, an extracellular domain of the protein above, an antibody, an antisense polynucleotide, etc. are usable as insulin-sensitizing agents and preventives and/or remedies for diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension, heart disease, and so on.

Abstract: The present invention provides a prophylactic/therapeutic agent for cancer or the like, an agent for promoting apoptosis of cancer cells, an agent for suppressing proliferation of cancer cells, and the like, which comprises a compound or its salt that inhibits an activity of a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, a compound or its salt that inhibits the expression of a gene for the protein, an antisense polynucleotide comprising the entirety or part of a nucleotide sequence complementary or substantially complementary to a nucleotide sequence of a polynucleotide encoding the protein or its partial peptide, an antibody against the protein, or the like.

Abstract: A compound or salt thereof that inhibits the activity of a protein that has an amino acid sequence that is the same or substantially the same as the amino acid sequence shown by SEQ ID NO: 1, a compound or salt thereof that inhibits the expression of the gene for this protein, an antisense polynucleotide that contains a base sequence that is complementary or substantially complementary to the base sequence of a polynucleotide encoding the aforementioned protein or a partial peptide thereof, or that contains a portion of such a base sequence, an antibody against the aforementioned protein, etc., can be used as agents for preventing/treating, for example, cancer, and as agents for promoting cancer cell apoptosis. Protein that has an amino acid sequence that is the same or substantially the same as the amino acid sequence shown by SEQ ID NO: 1, etc., is useful for screening for compounds and salts thereof that act to prevent/treat, for example, cancer.

Abstract: A rust-preventive water-oil separating cleaner composition contacts a part to be cleaned to which an oil attaches. The composition separates the oil from the part, while providing the part with a rust-preventive property, thus forming an oil layer containing the oil.

Abstract: The method of glossing a solid surface by forming a film thereon has the steps of: preparing a film-forming coating liquid containing at least an isocyanate compound having two or more isocyanate groups, a synthetic resin having a functional group which reacts with the isocyanate group, and an organic solvent; coating the film-forming coating liquid onto the solid surface; and forming a film on the solid surface after coating. The weight of the film-forming coating liquid is adjusted during coating so that after the film is formed, the film has a thickness from 0.1 to 5 ?m.

Abstract: A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or to GLUT4 (glucose transporter 4). The compound that inhibits the binding of the protein of the present invention to IRAP or GLUT4 is useful as a preventive/remedy for diseases, e.g., hyperglycemia, diabetes mellitus, etc.

Abstract: The present invention provides preventive/therapeutic agents for arteriosclerosis, diabetes mellitus, etc., which comprise glucosylceramide or (and) lactosylceramide synthase inhibitors, expression inhibitors for glucosylceramide or (and) lactosylceramide synthase genes, methods and kits for screening the preventive/therapeutic agents, and so on.

Abstract: A rust-preventive water-oil separating cleaner composition contacts a part to be cleaned to which an oil attaches. The composition separates the oil from the part, while providing the part with a rust-preventive property, thus forming an oil layer containing the oil.

Abstract: A hydrophilic treatment composition containing a surfactant having a branched chain, a silicate compound expressed by the following general formula (1), at least one moiety selected from silane coupling agents expressed by the following general formulae (2) and (3), an organic solvent, a catalyst and water. (wherein, in formula (1), R1 may be identical or different, and respectively are a hydrogen atom or an alkyl group having 1-3 carbon atoms, and m is an integer from 1-40.

Abstract: There are disclosed a method and apparatus for applying a strippable paint to a large-sized product finished with a sprayed coating, such as an automobile, to form a protective film on the surface of the coating. The product is conventionally kept in stock for a period of time before it is shipped. Contaminations such as dust are washed away from the surface of the product. Then, the strippable paint is applied, preliminarily dried, and non-preliminarily dried to form the protective film out of the strippable paint on the surface of the coating. This protective film is formed easily, appropriately, and reliably. The obtained protective film has a uniform and sufficient thickness. Even if the surface contains unapplied regions to which the paint should not be applied, the paint can be applied to the whole surface of the coating while avoiding the unapplied regions according to the invention. The application can be performed easily and reliably without leaving unapplied portions around the unapplied regions.

Abstract: There are disclosed a method and a apparatus for applying a strippable paint to a large-sized product finished with a sprayed coating, such as an automobile, to form a protective film on the surface of the coating. The product is conventionally kept in stock for a period of time before it is shipped. Contaminations such as dust are washed away from the surface of the product. Then, the strippable paint is applied, preliminarily dried, and non-preliminarily dried to form the protective film out of the strippable paint on the surface of the coating. This protective film is formed easily, appropriately, and reliably. The obtained protective film has a uniform and sufficient thickness. Even if the surface contains unapplied regions to which the paint should not be applied, the paint can be applied to the whole surface of the coating while avoiding the unapplied regions according to the invention. The application can be performed easily and reliably without leaving unapplied portions around the unapplied regions.

Abstract: A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or to GLUT4 (glucose transporter 4). The compound that inhibits the binding of the protein of the present invention to IRAP or GLUT4 is useful as a preventive/remedy for diseases, e.g., hyperglycemia, diabetes mellitus, etc.

Abstract: A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or to GLUT4 (glucose transporter 4). The compound that inhibits the binding of the protein of the present invention to IRAP or GLUT4 is useful as a preventive/remedy for diseases, e.g., hyperglycemia, diabetes mellitus, etc.

Abstract: A compound or its salt inhibiting the activity of a protein having an amino acid sequence which is the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, an extracellular domain of the protein above, an antibody, an antisense polynucleotide, etc. are usable as insulin-sensitizing agents and preventives and/or remedies for diabetes, obesity, hyperlipemia, arteriosclerosis, hypertension, heart disease, and so on.

Abstract: To provide a coating material composition which is capable of forming a coating film that restores the surface of an organic structural member provided for the interior or exterior of a mobile body or a stationary article such as a furnished household equipment to almost its initial good-looking appearance and protects the surface thereof to keep its good-looking appearance.

Abstract: It is an object of the present invention to provide an IRAP-binding protein. Specifically, the present invention provides the IRAP-binding protein, pharmaceuticals comprising the protein, a method for screening a compound inhibiting binding of the protein to IRAP, and a compound obtained by the screening method.

Abstract: A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or to GLUT4 (glucose transporter 4). The compound that inhibits the binding of the protein of the present invention to IRAP or GLUT4 is useful as a preventive/remedy for diseases, e.g., hyperglycemia, diabetes mellitus, etc.

Abstract: A composition for peelable coating, which composition exhibits excellent properties such as film-formability and water resistance and can be dried at ambient temperature without any particular heating, to thereby provide excellent coating performance. The composition contains a core/shell copolymer including an acrylic copolymer portion A having a high glass transition temperature of 30° C.-70° C. and an acrylic copolymer portion B having a low glass transition temperature of 5° C. to −30° C. and being formed through multi-step polymerization. The core/shell copolymer is made up of 5-40 wt. % of the acrylic copolymer portion A and 60-95 wt. % of the acrylic copolymer portion B, on the basis of the total amount of the portion A and the portion B. The acrylic copolymer portion A and the acrylic copolymer portion B contain the same hard-polymer-providing monomer unit and soft-polymer-providing monomer unit.

Abstract: There are disclosed a method and a machine for applying a strippable paint to a large-sized product finished with a sprayed coating, such as an automobile, to form a protective film on the surface of the coating. The product is kept in stock and will be shipped. Contaminations such as dust are washed away from the surface of the product. Then, the strippable paint is applied, preliminarily dried, and non-preliminarily dried to form the protective film out of the strippable paint on the surface of the coating. This protective film is formed easily, appropriately, and certainly. The obtained protective film has a uniform and sufficient thickness. Even if the surface contains unapplied regions to which the paint should not be applied, the paint can be applied to the whole surface of the coating while avoiding the unapplied regions. The application can be performed easily and certainly without leaving unapplied portions around the unapplied regions.