Patents by Inventor Hidekazu Tokuhara

Hidekazu Tokuhara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compound
    Patent number: 10106556
    Abstract: The present invention provides a compound having an MAGL inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like. The present invention relates a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: October 23, 2018
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Shuhei Ikeda, Tatsuki Koike, Jumpei Aida, Makoto Fushimi, Tomokazu Kusumoto, Hideyuki Sugiyama, Masako Miyazaki, Hidekazu Tokuhara, Yasushi Hattori, Makoto Kamata
  • Heterocyclic compounds and their use as retinoid-related orphan receptor (ROR) gamma-T inhibitors
    Patent number: 10093629
    Abstract: Provided are heterocyclic compounds having a ROR?t inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: October 9, 2018
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Tsuneo Oda, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Yoshiyuki Fukase, Tomoya Yukawa, Shoji Fukumoto
  • Heterocyclic compound
    Patent number: 10053468
    Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. wherein each symbol is as defined in the specification.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: August 21, 2018
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Hiroyuki Watanabe, Shoji Fukumoto, Tsuneo Oda, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Yoshiyuki Fukase, Tomoya Yukawa
  • HETEROCYCLIC COMPOUND
    Publication number: 20180079756
    Abstract: The present invention provides a compound having an MAGL inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like. The present invention relates a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.
    Type: Application
    Filed: March 29, 2016
    Publication date: March 22, 2018
    Inventors: Shuhei IKEDA, Tatsuki KOIKE, Jumpei AIDA, Makoto FUSHIMI, Tomokazu KUSUMOTO, Hideyuki SUGIYAMA, Masako MIYAZAKI, Hidekazu TOKUHARA, Yasushi HATTORI, Makoto KAMATA
  • HETEROCYCLIC COMPOUND
    Publication number: 20170283406
    Abstract: The present invention provides a compound having an MAGL inhibitory action, and useful as an agent for the prophylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancerous pain, neurogenic pain etc.), epilepsy, depression and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
    Type: Application
    Filed: March 30, 2017
    Publication date: October 5, 2017
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Shuhei Ikeda, Hideyuki SUGIYAMA, Jumpei AIDA, Hidekazu TOKUHARA, Tomohiro OKAWA, Yuya OGURO, Minoru NAKAMURA, Masataka MURAKAMI
  • HETEROCYCLIC COMPOUNDS AND THEIR USE AS RETINOID-RELATED ORPHAN RECEPTOR (ROR) GAMMA-T INHIBITORS
    Publication number: 20170144973
    Abstract: Provided are heterocyclic compounds having a ROR?t inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
    Type: Application
    Filed: June 30, 2015
    Publication date: May 25, 2017
    Applicant: Takenda Pharmaceutical Company Limited
    Inventors: Satoshi YAMAMOTO, Junya SHIRAI, Tsuneo ODA, Mitsunori KONO, Atsuko OCHIDA, Takashi IMADA, Hidekazu TOKUHARA, Yoshihide TOMATA, Naoki ISHII, Michiko TAWADA, Yoshiyuki FUKASE, Tomoya YUKAWA, Shoji FUKUMOTO
  • Heterocyclic compound
    Patent number: 9650343
    Abstract: The present invention provides a heterocyclic compound having a ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: May 16, 2017
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Tsuneo Oda, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Yoshiyuki Fukase, Tomoya Yukawa, Shoji Fukumoto
  • Heterocyclic compound
    Patent number: 9630924
    Abstract: The present invention provides a heterocyclic compound having a ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: April 25, 2017
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Tsuneo Oda, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Yoshiyuki Fukase, Tomoya Yukawa, Shoji Fukumoto
  • AMIDE COMPOUND
    Publication number: 20170107240
    Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. In the formula (I), each symbol is as defined in the specification.
    Type: Application
    Filed: July 2, 2014
    Publication date: April 20, 2017
    Inventors: Satoshi Yamamoto, Junya Shirai, Mitsunori Kono, Yoshihide Tomata, Ayumu Sato, Atsuko Ochida, Yoshiyuki Fukase, Shoji Fukumoto, Tsuneo Oda, Hidekazu Tokuhara, Naoki Ishii, Yusuke Sasaki
  • 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (MAGL) inhibitors
    Patent number: 9624170
    Abstract: The present invention aims to provide a compound having an MAGL inhibitory action, and useful as a prophylactic or therapeutic agent for neurodegenerative diseases (e.g., Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis and the like), anxiety disorder, pain (e.g., inflammatory pain, carcinomatous pain, nervous pain and the like), epilepsy and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
    Type: Grant
    Filed: December 25, 2014
    Date of Patent: April 18, 2017
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Tatsuki Koike, Makoto Fushimi, Jumpei Aida, Shuhei Ikeda, Tomokazu Kusumoto, Hideyuki Sugiyama, Hidekazu Tokuhara
  • HETEROCYCLIC COMPOUND
    Publication number: 20170050974
    Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. wherein each symbol is as defined in the specification.
    Type: Application
    Filed: July 2, 2014
    Publication date: February 23, 2017
    Inventors: Satoshi Yamamoto, Junya Shirai, Hiroyuki Watanabe, Shoji Fukumoto, Tsuneo Oda, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Yoshiyuki Fukase, Tomoya Yukawa
  • Heterocyclic compound
    Patent number: 9573903
    Abstract: The present invention provides a heterocyclic compound having a ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: February 21, 2017
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Tsuneo Oda, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Yoshiyuki Fukase, Tomoya Yukawa, Shoji Fukumoto
  • 4-(PIPERRAZIN-1-YL)-PYRROLIDIN-2-ONE COMPOUNDS AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS
    Publication number: 20160318864
    Abstract: The present invention aims to provide a compound having an MAGL inhibitory action, and useful as a prophylactic or therapeutic agent for neurodegenerative diseases (e.g., Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis and the like), anxiety disorder, pain (e.g., inflammatory pain, carcinomatous pain, nervous pain and the like), epilepsy and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
    Type: Application
    Filed: December 25, 2014
    Publication date: November 3, 2016
    Inventors: Tatsuki KOIKE, Makoto FUSHIMI, Jumpei AIDA, Shuhei IKEDA, Tomokazu KUSUMOTO, Hideyuki SUGIYAMA, Hidekazu TOKUHARA
  • HETEROCYCLIC COMPOUND
    Publication number: 20160176822
    Abstract: The present invention provides a heterocyclic compound having a ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
    Type: Application
    Filed: February 26, 2016
    Publication date: June 23, 2016
    Inventors: Satoshi YAMAMOTO, Junya SHIRAI, Tsuneo ODA, Mitsunori KONO, Atsuko OCHIDA, Takashi IMADA, Hidekazu TOKUHARA, Yoshihide TOMATA, Naoki ISHII, Michiko TAWADA, Yoshiyuki FUKASE, Tomoya YUKAWA, Shoji FUKUMOTO
  • HETEROCYCLIC COMPOUND
    Publication number: 20160176873
    Abstract: The present invention provides a heterocyclic compound having a ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
    Type: Application
    Filed: February 26, 2016
    Publication date: June 23, 2016
    Inventors: Satoshi YAMAMOTO, Junya SHIRAI, Tsuneo ODA, Mitsunori KONO, Atsuko OCHIDA, Takashi IMADA, Hidekazu TOKUHARA, Yoshihide TOMATA, Naoki ISHII, Michiko TAWADA, Yoshiyuki FUKASE, Tomoya YUKAWA, Shoji FUKUMOTO
  • HETEROCYCLIC COMPOUND
    Publication number: 20160176872
    Abstract: The present invention provides a heterocyclic compound having a ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
    Type: Application
    Filed: February 26, 2016
    Publication date: June 23, 2016
    Inventors: Satoshi YAMAMOTO, Junya SHIRAI, Tsuneo ODA, Mitsunori KONO, Atsuko OCHIDA, Takashi IMADA, Hidekazu TOKUHARA, Yoshihide TOMATA, Naoki ISHII, Michiko TAWADA, Yoshiyuki FUKASE, Tomoya YUKAWA, Shoji FUKUMOTO
  • Heterocyclic compound
    Patent number: 9365520
    Abstract: The present invention provides a heterocyclic compound having a ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: June 14, 2016
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Tsuneo Oda, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Yoshiyuki Fukase, Tomoya Yukawa, Shoji Fukumoto
  • HETEROCYCLIC COMPOUND AND USE THEREOF
    Publication number: 20160046601
    Abstract: Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
    Type: Application
    Filed: October 28, 2015
    Publication date: February 18, 2016
    Inventors: Takanobu KUROITA, Yasuhiro IMAEDA, Kouichi IWANAGA, Naohiro TAYA, Hidekazu TOKUHARA, Yoshiyuki FUKASE
  • HETEROCYCLIC COMPOUND
    Publication number: 20160002169
    Abstract: The present invention provides a heterocyclic compound having a ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
    Type: Application
    Filed: June 30, 2015
    Publication date: January 7, 2016
    Inventors: Satoshi YAMAMOTO, Junya SHIRAI, Tsuneo ODA, Mitsunori KONO, Atsuko OCHIDA, Takashi IMADA, Hidekazu TOKUHARA, Yoshihide TOMATA, Naoki ISHII, Michiko TAWADA, Yoshiyuki FUKASE, Tomoya YUKAWA, Shoji FUKUMOTO
  • Heterocyclic compound and use thereof
    Patent number: 9221836
    Abstract: Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: December 29, 2015
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Takanobu Kuroita, Yasuhiro Imaeda, Kouichi Iwanaga, Naohiro Taya, Hidekazu Tokuhara