Patents by Inventor Hidekazu Tokuhara

Hidekazu Tokuhara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC COMPOUND AND USE THEREOF
    Publication number: 20150191486
    Abstract: Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
    Type: Application
    Filed: March 23, 2015
    Publication date: July 9, 2015
    Inventors: Takanobu KUROITA, Yasuhiro IMAEDA, Kouichi IWANAGA, Naohiro TAYA, Hidekazu TOKUHARA, YOSHIYUKI FUKASE
  • Heterocyclic compound and use thereof
    Patent number: 9045436
    Abstract: Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: June 2, 2015
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Takanobu Kuroita, Yasuhiro Imaeda, Kouichi Iwanaga, Naohiro Taya, Hidekazu Tokuhara
  • Substituted pyrido[2,3-]pyrimidines as delta-5-desaturase inhibitors
    Patent number: 9023858
    Abstract: The present invention provides a compound useful for the prophylaxis or treatment of eicosanoid-associated diseases such as atherosclerosis, atherothrombosis, diabetes, obesity, asthma, fever, pain, cancer, rheumatism, osteoarthritis, atopic dermatitis and the like, and having superior pharmacological action, physicochemical properties and the like. The present invention relates to a compound represented by the following formula: wherein each symbol is as defined in the specification, or a salt thereof.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: May 5, 2015
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Nobuyuki Matsunaga, Hideo Suzuki, Kouhei Asano, Hidekazu Tokuhara, Takeshi Yamamoto, Rei Okamoto
  • Heterocyclic compound and use thereof
    Patent number: 8664380
    Abstract: Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: March 4, 2014
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Takanobu Kuroita, Yasuhiro Imaeda, Kouichi Iwanaga, Naohiro Taya, Hidekazu Tokuhara
  • Heterocyclic compound and use thereof
    Patent number: 8466282
    Abstract: Compounds represented by the formulas (I) (II) wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: June 18, 2013
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Takanobu Kuroita, Yasuhiro Imaeda, Kouichi Iwanaga, Naohiro Taya, Hidekazu Tokuhara, Yoshiyuki Fukase
  • FUSED HETEROCYCLIC COMPOUND AND APPLICATION THEREOF
    Publication number: 20130131050
    Abstract: The present invention provides a compound useful for the prophylaxis or treatment of eicosanoid-associated diseases such as atherosclerosis, atherothrombosis, diabetes, obesity, asthma, fever, pain, cancer, rheumatism, osteoarthritis, atopic dermatitis and the like, and having superior pharmacological action, physicochemical properties and the like. The present invention relates to a compound represented by the following formula: wherein each symbol is as defined in the specification, or a salt thereof.
    Type: Application
    Filed: July 22, 2011
    Publication date: May 23, 2013
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Nobuyuki Matsunaga, Hideo Suzuki, Kouhei Asano, Hidekazu Tokuhara, Takeshi Yamamoto, Rei Okamoto
  • HETEROCYCLIC COMPOUND AND USE THEREOF
    Publication number: 20120264733
    Abstract: Compounds represented by the formulas wherein each symbol is as defined in the specification, and a prodrug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
    Type: Application
    Filed: April 13, 2012
    Publication date: October 18, 2012
    Inventors: Takanobu KUROITA, Yasuhiro Imaeda, Kouichi Iwanaga, Naohiro Taya, Hidekazu Tokuhara, Yoshiyuki Fukase
  • HETEROCYCLIC COMPOUND AND USE THEREOF
    Publication number: 20110178057
    Abstract: Compounds represented by the formulas (I) (II) wherein each symbol is as defined in the specification, and a pro-drug thereof have a superior renin inhibitory activity, and are useful as agents for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension and the like.
    Type: Application
    Filed: June 17, 2009
    Publication date: July 21, 2011
    Inventors: Takanobu Kuroita, Yasuhiro Imaeda, Kouichi Iwanaga, Naohiro Taya, Hidekazu Tokuhara, Yoshiyuki Fukase
  • Substituted imidazole compound and use thereof
    Publication number: 20090227560
    Abstract: The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof or a prodrug thereof. The compound of the present invention has a superior renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.
    Type: Application
    Filed: July 11, 2008
    Publication date: September 10, 2009
    Inventors: Takanobu Kuroita, Tsuneo Oda, Yasutomi Asano, Naohiro Taya, Kouichi Iwanaga, Hidekazu Tokuhara, Yoshiyuki Fukase
  • Substituted imidazole compound and use thereof
    Publication number: 20090156612
    Abstract: The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof or a prodrug thereof. The compound of the present invention has a superior renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.
    Type: Application
    Filed: April 23, 2008
    Publication date: June 18, 2009
    Inventors: Takanobu Kuroita, Tsuneo Oda, Yasutomi Asano, Naohiro Taya, Kouichi Iwanaga, Hidekazu Tokuhara, Yoshiyuki Fukase