Patents by Inventor Hideki Kubota
Hideki Kubota has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11542287Abstract: Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.Type: GrantFiled: November 27, 2020Date of Patent: January 3, 2023Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Shinya Yano, Kenta Saito, Hideki Kubota
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Patent number: 11485747Abstract: An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction. A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R10 represents a group represented by formula (2): —O—R11—X-A??(2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).Type: GrantFiled: October 20, 2020Date of Patent: November 1, 2022Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Shinya Yano, Hideki Kubota
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Patent number: 11149066Abstract: Provided is a compound that can promote angiogenesis by inhibiting the function of TSP1, and is useful for the treatment or prophylaxis of diseases such as critical limb ischemia.Type: GrantFiled: September 13, 2017Date of Patent: October 19, 2021Assignees: DAIICHI SANKYO COMPANY, LIMITED, PEPTIDREAM INC.Inventors: Takahiro Yamaguchi, Yutaka Mori, Hironao Saito, Hideki Kubota, Akihiro Furukawa, Eri Otsuka, Yutaka Ishigai, Hiroshi Ijiri, Patrick Reid
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Patent number: 10981940Abstract: The invention is to develop a protecting group that does not solidify or insolubilize a compound in which a functional group has been protected, and facilitates separation and purification after a reaction.Type: GrantFiled: November 10, 2017Date of Patent: April 20, 2021Assignee: SEKISUl MEDICAL CO., LTD.Inventors: Shinya Yano, Hideki Kubota
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Publication number: 20210079028Abstract: Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.Type: ApplicationFiled: November 27, 2020Publication date: March 18, 2021Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shinya YANO, Kenta SAITO, Hideki KUBOTA
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Publication number: 20210040128Abstract: An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction. A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R01 represents a group represented by formula (2): —O—R11—X-A??(2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).Type: ApplicationFiled: October 20, 2020Publication date: February 11, 2021Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shinya YANO, Hideki KUBOTA
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Patent number: 10870667Abstract: Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.Type: GrantFiled: November 27, 2018Date of Patent: December 22, 2020Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Shinya Yano, Kenta Saito, Hideki Kubota
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Patent number: 10851120Abstract: An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction. A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R10 represents a group represented by formula (2): —O—O—R11—X-A??(2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).Type: GrantFiled: June 19, 2017Date of Patent: December 1, 2020Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Shinya Yano, Hideki Kubota
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Publication number: 20200325163Abstract: Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.Type: ApplicationFiled: November 27, 2018Publication date: October 15, 2020Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shinya YANO, Kenta SAITO, Hideki KUBOTA
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Patent number: 10756733Abstract: A first separator that prevents a pair of electrodes from short-circuiting each other is provided on end parts of the pair of electrodes in a longitudinal direction thereof, a first molded resin part that covers the first separator is provided on an end part of an insulation tube in a longitudinal direction thereof, a part of the first separator) on one side in a direction intersecting the longitudinal direction and another part of the first separator on the other side in the direction intersecting the longitudinal direction are each exposed to outside. When the first separator is embedded in the first molded resin part through insert molding, the first separator can be supported by a lower mold and an upper mold, portions of the first separator supported by the pair of molds at this time are portions exposed to outside.Type: GrantFiled: October 31, 2018Date of Patent: August 25, 2020Assignee: MITSUBA CorporationInventors: Mitsuhiro Okada, Hideki Kubota, Minori Shoda, Koji Yamauchi, Yasuhiro Orihara, Takabumi Oikawa
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Patent number: 10711493Abstract: The disclosure makes an insulating component and a sensor bracket to be an integrally molded article, simplifies the manufacturing process and cuts down the cost. A sensor holder and a sensor bracket made of a resin are made to be an integrally molded article, wherein the sensor holder inside which a pair of electrodes are arranged, and the sensor bracket made of a resin which holds the sensor holder and is attached to a tailgate. During an operation of filling a molten resin to a cavity, a part of the sensor holder is melted by the molten resin, and thus integrating the sensor holder and the molten resin, therefore, the two components can be structurally and firmly integrated. Accordingly, a touch sensor unit which endures long-term use can be obtained.Type: GrantFiled: March 21, 2018Date of Patent: July 14, 2020Assignee: MITSUBA CorporationInventors: Yasuhiro Orihara, Naruhito Ogino, Hideki Kubota, Mitsuhiro Okada
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Publication number: 20200131230Abstract: Provided is a compound that can promote angiogenesis by inhibiting the function of TSP1, and is useful for the treatment or prophylaxis of diseases such as critical limb ischemia.Type: ApplicationFiled: September 13, 2017Publication date: April 30, 2020Applicants: Daiichi Sankyo Company, Limited, PeptiDream Inc.Inventors: Takahiro YAMAGUCHI, Yutaka MORI, Hironao SAITO, Hideki KUBOTA, Akihiro FURUKAWA, Eri OTSUKA, Yutaka ISHIGAI, Hiroshi IJIRI, Patrick REID
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Patent number: 10508124Abstract: To develop a protecting group that facilitates separation and purification, after reaction, of a compound including a protected functional group, without solidifying or insolubilizing the compound.Type: GrantFiled: July 24, 2017Date of Patent: December 17, 2019Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Shinya Yano, Toshihiro Mori, Hideki Kubota
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Publication number: 20190308997Abstract: The invention is to develop a protecting group that does not solidify or insolubilize a compound in which a functional group has been protected, and facilitates separation and purification after a reaction.Type: ApplicationFiled: November 10, 2017Publication date: October 10, 2019Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shinya YANO, Hideki KUBOTA
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Publication number: 20190263842Abstract: To develop a protecting group that facilitates separation and purification, after reaction, of a compound including a protected functional group, without solidifying or insolubilizing the compound.Type: ApplicationFiled: July 24, 2017Publication date: August 29, 2019Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shinya YANO, Toshihiro MORI, Hideki KUBOTA
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Patent number: 10370878Abstract: The disclosure provides a touch sensor unit. A conductive component is arranged between a pair of electrodes which are arranged inside an insulating tube, and the conductive component includes: a body section, which extends in a longitudinal direction of the insulating tube; and a convex section, which is arranged on an outer circumference of the body section, extends along the longitudinal direction of the body section, and sinks into the pair of electrodes. Short circuit or non-short circuit and so on of the electrodes can be detected by detecting the resistance value of the conductive component. Merely by inserting the conductive component into one end in the longitudinal direction of the electrodes, the pair of electrodes are electrically connected, and only the convex section sinks into the pair of electrodes, therefore the insertion load of the conductive component can be reduced, and the terminal treatment can be simplified.Type: GrantFiled: March 21, 2018Date of Patent: August 6, 2019Assignee: MITSUBA CorporationInventors: Yasuhiro Orihara, Hideki Kubota, Minori Shoda, Mitsuhiro Okada
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Publication number: 20190225631Abstract: An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction.Type: ApplicationFiled: June 19, 2017Publication date: July 25, 2019Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shinya YANO, Hideki KUBOTA
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Publication number: 20190149151Abstract: A first separator that prevents a pair of electrodes from short-circuiting each other is provided on end parts of the pair of electrodes in a longitudinal direction thereof, a first molded resin part that covers the first separator is provided on an end part of an insulation tube in a longitudinal direction thereof, a part of the first separator) on one side in a direction intersecting the longitudinal direction and another part of the first separator on the other side in the direction intersecting the longitudinal direction are each exposed to outside. When the first separator is embedded in the first molded resin part through insert molding, the first separator can be supported by a lower mold and an upper mold, portions of the first separator supported by the pair of molds at this time are portions exposed to outside.Type: ApplicationFiled: October 31, 2018Publication date: May 16, 2019Applicant: MITSUBA CorporationInventors: MITSUHIRO OKADA, HIDEKI KUBOTA, MINORI SHODA, KOJI YAMAUCHI, YASUHIRO ORIHARA, TAKABUMI OIKAWA
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Publication number: 20180283058Abstract: The disclosure provides a touch sensor unit. A conductive component is arranged between a pair of electrodes which are arranged inside an insulating tube, and the conductive component includes: a body section, which extends in a longitudinal direction of the insulating tube; and a convex section, which is arranged on an outer circumference of the body section, extends along the longitudinal direction of the body section, and sinks into the pair of electrodes. Short circuit or non-short circuit and so on of the electrodes can be detected by detecting the resistance value of the conductive component. Merely by inserting the conductive component into one end in the longitudinal direction of the electrodes, the pair of electrodes are electrically connected, and only the convex section sinks into the pair of electrodes, therefore the insertion load of the conductive component can be reduced, and the terminal treatment can be simplified.Type: ApplicationFiled: March 21, 2018Publication date: October 4, 2018Applicant: MITSUBA CorporationInventors: YASUHIRO ORIHARA, HIDEKI KUBOTA, MINORI SHODA, MITSUHIRO OKADA
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Publication number: 20180274269Abstract: The disclosure makes an insulating component and a sensor bracket to be an integrally molded article, simplifies the manufacturing process and cuts down the cost. A sensor holder and a sensor bracket made of a resin are made to be an integrally molded article, wherein the sensor holder inside which a pair of electrodes are arranged, and the sensor bracket made of a resin which holds the sensor holder and is attached to a tailgate. During an operation of filling a molten resin to a cavity, a part of the sensor holder is melted by the molten resin, and thus integrating the sensor holder and the molten resin, therefore, the two components can be structurally and firmly integrated. Accordingly, a touch sensor unit which endures long-term use can be obtained.Type: ApplicationFiled: March 21, 2018Publication date: September 27, 2018Applicant: MITSUBA CorporationInventors: YASUHIRO ORIHARA, NARUHITO OGINO, HIDEKI KUBOTA, MITSUHIRO OKADA