Patents by Inventor Hideki Kubota

Hideki Kubota has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060194803
    Abstract: This invention relates to an anti-dementia agent which uses a BEC 1 potassium channel inhibitor as the active ingredient. It was proved that the BEC 1 potassium channel inhibitor has an action to improve learning disorder and is useful as a preventive or therapeutic agent for diseases, preferably dementia, in which the BEC 1 potassium channel is considered to be concerned. Illustratively, it was confirmed by an in vivo test that the BEC 1 potassium channel inhibitor has an action to improve learning disorder. Also, it was found that a compound having 2,4,6-triamino-1,3,5-triazine has a BEC 1 potassium channel inhibitory action.
    Type: Application
    Filed: February 3, 2003
    Publication date: August 31, 2006
    Inventors: Hideki Kubota, Takeshi Suzuki, Masanori Miura, Eiichi Nakai, Kiyoshi Yahiro, Akira Miyake, Shinobu Nakatou, Kazuhiro Nakatou
  • Publication number: 20050239780
    Abstract: The invention has succeeded in settling the aforementioned problems by finding that a novel tetrahydropyran derivative has excellent apo B-related lipoprotein secretion-inhibiting activity.
    Type: Application
    Filed: May 29, 2003
    Publication date: October 27, 2005
    Inventors: Akira Suga, Hideki Kubota, Masanori Miura, Daisuke Sasuga, Hiroshi Moritani
  • Publication number: 20050234109
    Abstract: Provided are novel compounds having an inhibitory activity against production or secretion of ?-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.
    Type: Application
    Filed: December 27, 2002
    Publication date: October 20, 2005
    Applicant: Daiichi Pharmaceutical Co. Ltd.
    Inventors: Takanori Yasukouchi, Masayuki Ito, Hideki Kubota, Satoru Miyauchi, Masanori Saito
  • Publication number: 20050227989
    Abstract: The present invention provides a genus of polycyclic thiazoles that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
    Type: Application
    Filed: April 13, 2005
    Publication date: October 13, 2005
    Applicants: ICAgen, Inc., Astellas Pharma Inc.
    Inventors: Xiaodong Wang, Kerry Spear, Alan Fulp, Darrick Seconi, Takeshi Suzuki, Takahiro Ishii, Ayako Moritomo, Hideki Kubota
  • Patent number: 6245796
    Abstract: A tricyclic pyrrole or pyrazole derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof, which shows strong affinity and selectivity for the 5-HT2C receptor and is useful for the treatment of central nervous system diseases such as sexual disorders, eating disorders, anxiety, depression and sleeping disorders. (In the above formula, each symbol means as follows; Y ring: an unsaturated five-membered ring which may have 1 to 3 of one or more types of hetero atom(s) each selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom or an unsaturated six-membered ring having 1 or 2 nitrogen atom(s), X: a bond or a carbon atom, a double bond or a single bond, V: a nitrogen atom or a group represented by a formula CH, and A: a straight or branched lower alkylene group which may be substituted with a halogen atom or a cycloalkyl group).
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: June 12, 2001
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Kyoichi Maeno, Ken-ichi Kazuta, Hideki Kubota, Itsuro Shimada, Tetsuya Kimizuka, Shuichi Sakamoto, Fumikazu Wanibuchi
  • Patent number: 6136810
    Abstract: This invention relates to compounds (I) or pharmaceutically acceptable salts thereof, having a function to inhibit type IV phosphodiesterase (PDE) ##STR1## [X: an oxygen atom or a sulfur atom, R.sup.1 : a lower alkyl group, a cycloalkyl-lower alkyl group or a cycloalkyl group,R.sup.2 : a hydrogen atom, a halogen atom, a lower alkyl group, a halogeno-lower alkyl group, a hydroxy-lower alkyl group, a mercapto-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkylthio-lower alkyl group, a lower alkanoyloxy-lower alkyl group, a lower alkanoylthio-lower alkyl group, a lower alkanoyl-lower alkyl group, a hydroxyimino-lower alkyl group, a lower alkoxyimino-lower alkyl group, a cycloalkyl group, an aryl group or a lower alkanoyl group,R.sup.3 : a hydrogen atom, a halogen atom or a lower alkyl group,R.sup.4 : a hydrogen atom or a lower alkyl group,R.sup.
    Type: Grant
    Filed: April 30, 1998
    Date of Patent: October 24, 2000
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Kazuhisa Takayama, Hiroyuki Hisamichi, Masahiro Iwata, Hideki Kubota, Motonori Aoki
  • Patent number: 5681954
    Abstract: A compound represented by formula (I): ##STR1## wherein Q represents an aryl group, a heterocyclic group, a diarylmethyl group, an aralkyl group composed of an aryl group and an alkylene group, an alkyl group or a cycloalkyl group, in which the aryl group, heterocyclic group, and the aryl moiety of the diarylmethyl group and aralkyl group may be substituted with one or more substituents; R represents a bicyclic, substituted, nitrogen-containing heterocyclic group or a substituted phenyl group, in which the nitrogen-containing heterocyclic group is composed of a 5-membered, substituted, aromatic or saturated ring containing one or two nitrogen atoms and a 6-membered ring; and Z represents an alkylene group, an alkenylene group, an alkylene group, a carbonyl group, an alkylene group containing a carbonyl group or an oxalyl group, or a salt thereof.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: October 28, 1997
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Kenjiro Yamamoto, Atsushi Hasegawa, Hideki Kubota, Masahiro Ando, deceased, Hitoshi Yamaguchi