Patents by Inventor Hideki Taniguchi
Hideki Taniguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170183621Abstract: The present invention provides a culture method for culturing, in recesses (10), a population including two or more cells including a cell derived from a stem cell and a mesenchymal cell. The cell derived from a stem cell is a cell obtained by differentiating a stem cell in vitro. The cell is a cell of one or more types selected from the group consisting of an endodermal cell, an ectodermal cell, and a mesodermal cell. The population is cultured in the recesses (10) together with a vascular cell or a secretor factor. Each recess (10) includes a space in which cells are movable. When a volume of the space is represented by V mm3 and the number of mesenchymal cells seeded in the space is represented by N, V is 400 or less and N/V is in a range from 35 to 3000.Type: ApplicationFiled: May 29, 2015Publication date: June 29, 2017Applicants: KURARAY Co., Ltd., Public University Corporation Yokohama City UniversityInventors: Yoko EJIRI, Hideki TANIGUCHI, Takanori TAKEBE
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Publication number: 20170159024Abstract: The present invention provides a means for reconstituting tissues and organs having mature functions. A method of preparing a tissue or an organ, comprising coculturing an organ cell with a vascular endothelial cell and a mesenchymal cell, generating an organ bud, transplanting the organ bud into a non-human animal, and then isolating from the non-human animal the transplanted organ bud-derived tissue or organ.Type: ApplicationFiled: October 18, 2016Publication date: June 8, 2017Applicant: Public University Corporation Yokohama City UniversityInventors: Hideki TANIGUCHI, Takanori TAKEBE
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Publication number: 20170067014Abstract: The present invention finds out find out the requirements necessary for preparing a cell condensate in vitro from a large number of cells (several ten thousand to several million cells) and provides a method of forming a cell condensate for self-organization which is capable of realizing complex higher structures (such as liver and kidney) and interactions with other organs. A method of preparing a cell condensate in vitro, comprising culturing a mixture of cells and/or tissues of a desired type in a total cell count of 400,000 or more and 100,000 to 400,000 mesenchymal cells to form a cell condensate of 1 mm or more in size. A cell condensate prepared by the above-described method. A method of preparing a three-dimensional tissue structure, comprising allowing self-organization of a cell condensate prepared by the above-described method to form a three-dimensional tissue structure that has been provided with higher structures.Type: ApplicationFiled: February 26, 2015Publication date: March 9, 2017Applicants: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVER SITY, NATIONAL UNIVERSITY CORPORATION SAITAMA UNIVERSITYInventors: Takanori TAKEBE, Hideki TANIGUCHI, Hiroshi YOSHIKAWA
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Patent number: 9532554Abstract: The present invention provides (1) a method for producing a non-human animal having a humanized liver, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, (2) a non-human animal having a humanized liver, produced by the method, (3) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using the animal, (4) a method for producing human hepatocytes, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, and (5) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using human hepatocytes produced by the method.Type: GrantFiled: September 28, 2012Date of Patent: January 3, 2017Assignee: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITYInventors: Hideki Taniguchi, Yun-Wen Zheng
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Patent number: 9428721Abstract: Provided is a cell culture method whereby an in vivo function can be sustained over a long period of time and culture can be conducted using the minimum number of cells required. The cell culture method includes culturing undifferentiated cells in a layered state in a partitioned micro-space and obtains differentiated cells. When screening a pharmaceutical agent, undifferentiated cells capable of differentiating into liver cells, intestinal epithelial cells, nerve cells, myocardial cells and vascular endothelial cells are preferred. Particularly, in the prediction of pharmacokinetics or the like for humans, human cells are preferred.Type: GrantFiled: February 5, 2009Date of Patent: August 30, 2016Assignees: Public University Corporation Yokohama City University, KURARAY Co., Ltd.Inventors: Hideki Taniguchi, Yun-Wen Zheng, Go Tazaki, Tomoko Kosaka, Hitoshi Tsuruta, Motohiro Fukuda
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Publication number: 20160177270Abstract: The present invention provides a method of constituting a tissue construct in vitro using a tissue without depending on scaffold materials. A method of integrating a biological tissue with a vascular system in vitro, comprising coculturing a biological tissue with vascular cells and mesenchymal cells. A biological tissue which has been integrated with a vascular system by the above-described method. A method of preparing a tissue or an organ, comprising transplanting the biological tissue described above into a non-human animal and differentiating the biological tissue into a tissue or an organ in which vascular networks have been constructed. A method of regeneration or function recovery of a tissue or an organ, comprising transplanting the biological tissue described above into a human or a non-human animal and differentiating the biological tissue into a tissue or an organ in which vascular networks have been constructed.Type: ApplicationFiled: July 15, 2014Publication date: June 23, 2016Applicant: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY- UNIVERSITYInventors: Takanori TAKEBE, Hideki TANIGUCHI, Yoshinobu TAKAHASHI
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Publication number: 20160160175Abstract: To provide a cell culture kit including cultured living cells of various donors, and a manufacturing method thereof. The cell culture kit includes a culture plate and living cells cultured thereon. The culture plate includes a plurality of microchambers (33) and living cells derived from various donors are adhered to surfaces of the plurality of microchambers (33). Specifically, living cells D1, D2, and D3 derived from various donors are adhered to the plurality of microchambers (33). In each microchamber (33), living cells derived from one donor or living cells derived from various donors may be cultured. The living cells derived from various donors are adhered and cultured in the cell culture kit as a whole, which makes it possible to provide a cell culture kit to conduct a test using cells derived from various donors.Type: ApplicationFiled: January 29, 2016Publication date: June 9, 2016Applicants: KURARAY CO., LTD., Public University Corp. Yokohama City UniversityInventors: Yoko ITCHODA, Go Tazaki, Motohiro Fukuda, Hitoshi Tsuruta, Hideki Taniguchi
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Publication number: 20160137962Abstract: A culture chamber includes a plurality of recesses (10) each formed of a bottom portion (11) and an opening portion (12). The bottom portion (11) has a hemispherical shape and the opening portion (12) is defined by a wall that surrounds an area from a boundary between the opening portion (12) and the bottom portion (11) to an end of each of the recesses (10), the wall having a taper angle in a range from 1 degree to 20 degrees. An equivalent diameter of the boundary is in a range from 50 ?m to 2 mm and a depth from a bottom of the bottom portion (11) to the end of each of the recesses is in a range from 0.6 or more times to 3 or less times the equivalent diameter, and the wall defining the opening portion (12) forms a surface continuous to the bottom portion (11).Type: ApplicationFiled: June 5, 2014Publication date: May 19, 2016Applicants: KURARAY Co., Ltd., Public University Corporation Yokohama City UniversityInventors: Yoko EJIRI, Satoru AYANO, Naoto FUKUHARA, Hideki TANIGUCHI, Takanori TAKEBE
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Publication number: 20160122722Abstract: A tissue structure for enabling comprehensive understanding of gene patterns of mature cells and a method of preparing the tissue structure are provided. A tissue structure is obtained by co-culturing an endodermal, ectodermal, or mesodermal cell derived from a stem cell and at least one cell and/or factor selected from the group consisting of a vascular cell, a mesenchymal cell, a factor secreted by a vascular cell, a factor secreted by a mesenchymal cell, and a factor secreted when both a vascular cell and a mesenchymal cell exist. A value obtained by assay of a plurality of functions using a Pearson product-moment correlation coefficient is closer to a value of a cell or biological tissue sampled from an adult than a value of a cell or biological tissue sampled from a fetus.Type: ApplicationFiled: June 9, 2014Publication date: May 5, 2016Applicants: KURARAY Co., Ltd., Public University Corporation Yokohama City UniversityInventors: Yoko EJIRI, Satoru AYANO, Naoto FUKUHARA, Hideki TANIGUCHI, Takanori TAKEBE
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Publication number: 20160046903Abstract: The present invention provides a method for preparing chondrocytes which enable construction of a cartilage tissue, the method being capable of solving the problems with conventional methods. A method for preparing chondrocytes, comprising co-culturing chondrogenic cells with vascular cells. A composition for cartilage regenerative therapy, comprising chondrocytes prepared by the above-described method. A method of screening for drugs effective as pharmaceuticals, comprising using chondrocytes prepared by the above-described method, a cartilage tissue formed from the chondrocytes and/or cells derived from the cartilage tissue. A method for preparing a matrix produced by chondrocytes, comprising using chondrocytes prepared by the above-described method, a cartilage tissue formed from the chondrocytes and/or cells derived from the cartilage tissue. A method for cartilage regeneration, comprising transplanting chondrocytes prepared by the above-described method into an organism to form a cartilage tissue.Type: ApplicationFiled: March 20, 2014Publication date: February 18, 2016Applicant: PUBLIC UNIVERSITY CORPARATION YOKOHAMA CITY UNIVERSITYInventors: Hideki TANIGUCHI, Takanori TAKEBE, Shinji KOBAYASHI
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Patent number: 8996913Abstract: The data transfer control device of the present invention is capable of improving data transfer efficiency while discarding error data, a DMA parameter storing control unit (1112) temporarily stores parameters to a store resource; a data processing unit (1201) performs error detection processing for data that is transferred; a DMA parameter return control unit (1122) causes parameters used at transfer time of data for which the processing result in the error detection processing was an error to be returned as parameters for subsequent data transfer use from the store resource; and a completion notification delay control unit (1121), with regard to the parameters, causes the completion notification to a host system that indicates that data transfer has completed normally for each of the parameters to wait for normal completion of data transfer that uses parameters that had been set earlier than each of the first-mentioned parameters.Type: GrantFiled: July 13, 2011Date of Patent: March 31, 2015Assignee: Panasonic Intellectual Property Management Co., Ltd.Inventors: Masaaki Harada, Yuusaku Ohta, Satoru Kuriki, Satomi Amano, Hideki Taniguchi
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Patent number: 8959261Abstract: A data transfer control device 1061 includes a read pointer update unit 5004 updating a value of a global read pointer RPg with a value of a local read pointer (first local read pointer) RPl1 held by a local read pointer hold unit 5007 when completion of data transfer is recognized and a position, in an order of reading descriptors, of a descriptor D3010a indicated by the local read pointer RPl1 is earlier than positions of descriptors D3010b and D3010c respectively indicated by local read pointers (second local read pointers) RPl2 and RPl3 held by the other data transfer control devices 1062 and 1063.Type: GrantFiled: January 25, 2011Date of Patent: February 17, 2015Assignee: Panasonic Intellectual Property Management Co., Ltd.Inventors: Yuusaku Ohta, Masaaki Harada, Satoru Kuriki, Satomi Amano, Hideki Taniguchi
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Publication number: 20140289877Abstract: The present invention provides a means for reconstituting tissues and organs having mature functions. A method of preparing a tissue or an organ, comprising coculturing an organ cell with a vascular endothelial cell and a mesenchymal cell, generating an organ bud, transplanting the organ bud into a non-human animal, and then isolating from the non-human animal the transplanted organ bud-derived tissue or organ.Type: ApplicationFiled: September 27, 2012Publication date: September 25, 2014Inventors: Hideki Taniguchi, Takanori Takebe
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Publication number: 20140230080Abstract: The present invention provides (1) a method for producing a non-human animal having a humanized liver, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, (2) a non-human animal having a humanized liver, produced by the method, (3) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using the animal, (4) a method for producing human hepatocytes, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, and (5) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using human hepatocytes produced by the method.Type: ApplicationFiled: September 28, 2012Publication date: August 14, 2014Applicant: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITYInventors: Hideki Taniguchi, Yun-Wen Zheng
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Publication number: 20130124929Abstract: The data transfer control device of the present invention is capable of improving data transfer efficiency while discarding error data, a DMA parameter storing control unit (1112) temporarily stores parameters to a store resource; a data processing unit (1201) performs error detection processing for data that is transferred; a DMA parameter return control unit (1122) causes parameters used at transfer time of data for which the processing result in the error detection processing was an error to be returned as parameters for subsequent data transfer use from the store resource; and a completion notification delay control unit (1121), with regard to the parameters, causes the completion notification to a host system that indicates that data transfer has completed normally for each of the parameters to wait for normal completion of data transfer that uses parameters that had been set earlier than each of the first-mentioned parameters.Type: ApplicationFiled: July 13, 2011Publication date: May 16, 2013Applicant: PANASONIC CORPORATIONInventors: Masaaki Harada, Yuusaku Ohta, Satoru Kuriki, Satomi Amano, Hideki Taniguchi
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Publication number: 20130071932Abstract: Provided is a method that achieves control of embryoid body size and can induce differentiation in a state where the embryoid body size is controlled, by using a cell culture chamber having a plurality of microchambers formed therein. A culture method for causing differentiation of pluripotent mammalian cells uses a cell culture chamber (10) having a plurality of microchambers (11) formed on a culture surface. The cell culture chamber (10) has a culture surface formed of spaces in which the microchambers (11) have a space structure with a height of 10 ?m to 500 ?m and a bottom area of 100 ?m2 to 1 mm2. The culture method for causing differentiation of pluripotent mammalian cells includes culturing pluripotent mammalian cells to obtain a cell population at least partially differentiated into endoderm lineage cells, by using the cell culture chambers (10).Type: ApplicationFiled: March 23, 2011Publication date: March 21, 2013Applicants: Public University Corporation Yokohama City University, KURARAY Co., Ltd.Inventors: Yoko Itchoda, Go Tazaki, Masaya Hosoda, Motohiro Fukuda, Hideki Taniguchi, Yun-Wen Zheng, Keisuke Sekine
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Patent number: 8278488Abstract: The present invention relates to a process for producing a tertiary amine in the presence of a catalyst containing copper and at least one element selected from the group consisting of elements belonging to Groups 2, 3, 7 and 12 of the Periodic Table (long form of the periodic table), said process including the steps of (a) reducing an amide compound in a hydrogen atmosphere; and (b) introducing a dialkyl amine containing a linear or branched alkyl group having 1 to 6 carbon atoms into a reaction product obtained in the step (a), and treating the reaction product with the dialkyl amine. The present invention provides a process for producing high-purity aliphatic tertiary amines containing a less amount of by-products by reducing aliphatic acid amides under moderate conditions using a chromium-free catalyst, as well as a process for producing amine derivatives such as amine oxide by using the aliphatic tertiary amines, with a good productivity in an economical manner.Type: GrantFiled: August 7, 2008Date of Patent: October 2, 2012Assignee: Kao CorporationInventors: Michio Terasaka, Tetsuaki Fukushima, Hideki Taniguchi, Masaharu Jono
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Publication number: 20120233372Abstract: A data transfer control device 1061 includes a read pointer update unit 5004 updating a value of a global read pointer RPg with a value of a local read pointer (first local read pointer) RP11 held by a local read pointer hold unit 5007 when completion of data transfer is recognized and a position, in an order of reading descriptors, of a descriptor D3010a indicated by the local read pointer RP11 is earlier than positions of descriptors D3010b and D3010c respectively indicated by local read pointers (second local read pointers) RP12 and RP13 held by the other data transfer control devices 1062 and 1063.Type: ApplicationFiled: January 25, 2011Publication date: September 13, 2012Inventors: Yuusaku Ohta, Masaaki Harada, Satoru Kuriki, Satomi Amano, Hideki Taniguchi
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Patent number: 8208791Abstract: An authoring device includes: a separator for separating a video stream and an audio stream from the input stream; a multiplexer for multiplexing the video stream and the audio stream to generate content information and further generating control information for managing stream reproduction, generating, from content information and control information, incomplete disc image data which is a series of data basically based on a predetermined format and in which a part of reproduction control information defined by a predetermined format is missing, and further generating analysis information required for generating the missing part of the reproduction control information; and a disc image completing section for completing the incomplete disc image data by referencing the analysis information after generation of the incomplete disc image data.Type: GrantFiled: August 5, 2005Date of Patent: June 26, 2012Assignee: Panasonic CorporationInventors: Yoshifumi Kawaguchi, Hideki Taniguchi
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Publication number: 20110217725Abstract: To provide a cell culture kit including cultured living cells of various donors, and a manufacturing method thereof. The cell culture kit includes a culture plate and living cells cultured thereon. The culture plate includes a plurality of microchambers (33) and living cells derived from various donors are adhered to surfaces of the plurality of microchambers (33). Specifically, living cells D1, D2, and D3 derived from various donors are adhered to the plurality of microchambers (33). In each microchamber (33), living cells derived from one donor or living cells derived from various donors may be cultured. The living cells derived from various donors are adhered and cultured in the cell culture kit as a whole, which makes it possible to provide a cell culture kit to conduct a test using cells derived from various donors.Type: ApplicationFiled: October 23, 2009Publication date: September 8, 2011Applicants: Kuraray Co., Ltd., Public University Corp. Yokohama City UniversityInventors: Yoko Itchoda, Go Tazaki, Motohiro Fukuda, Hitoshi Tsuruta, Hideki Taniguchi